The confirmation and quantitation of LSD in urine using gas chromatography/mass spectrometry
Nicholas P. Bukowski, Andrew N. Eaton
Rapid Communications in Mass Spectrometry January 1, 1993 DOI: 10.1002/rcm.1290070122 via OpenAlex
Summary
AI-generated from the abstractA method using gas chromatography/mass spectrometry confirms and measures LSD as its trimethylsilyl derivative. It requires four times less sample than earlier approaches, extends column life by reducing the amount of derivatizing agent, and can detect and quantify LSD at concentrations as low as 10 pg/mL.
Study at a glance
| Characteristics | Method development Peer reviewed |
|---|---|
| Keywords | Chemistry Gas chromatography–mass spectrometry Urine Derivative finance |
| Citations | 11 |
| Key finding | The method detects and quantifies LSD at the 10 pg/mL level using less sample and derivatizing agent than previous methods. |
Abstract
Abstract Confirmation and quantitation of LSD, as its trimethyI silyI derivative, is carried out using a commercial gas chromatography/mass spectrometry system. The method uses 4 times less sample than previous methods, extends column life by reducing the amount of derivatizing agent used and can detect and quantify LSD at the 10 pg mL −1 level.