2 results for "Meta-analysis: what did research on anxiety find in april 2026?"

Characterising the clinical associations of hallucinogen persisting perception disorder: a retrospective cohort study

Translational Psychiatry April 24, 2026 Matt Butler, Ellen Moore, James Rucker et al. 1 citation

Hallucinogen persisting perception disorder (HPPD) involves episodes of altered perception after past psychoactive drug use, causing distress and impairment. In a large retrospective cohort study using electronic health records from 25,778 individuals diagnosed with HPPD, high rates of prior comorbidities were found, including depressive episodes (29.2%), anxiety disorders (26.2%), chronic pain (15.9%), headache syndromes (14.7%), post-viral fatigue (12.3%), ADHD (6.6%), and fibromyalgia (6.7%). Anxiety and functional somatic syndromes were more common in HPPD patients than in psychedelic-using controls. Anxiety (odds ratio 1.5) and post-viral fatigue (odds ratio 1.9) predicted HPPD development among psychedelic users. After diagnosis, HPPD was associated with increased risk of subsequent functional somatic syndromes (odds ratio 2.0) and psychiatric disorders (odds ratio 1.4) compared to psychedelic-using controls.

DOI: 10.1038/s41398-026-04042-1 Full text Anxiety disorder Major depressive disorder Fibromyalgia Retrospective cohort study +11

Single exposure to Ayahuasca reverses chronic stress effects on sociability, anxiety, cortisol, and BDNF in zebrafish

Psychopharmacology April 14, 2026 Guilherme Lodetti, Antonio Inserra, Henrique Redivo et al.

A single exposure to ayahuasca reversed behavioral and biochemical changes caused by 14 days of unpredictable chronic stress in adult zebrafish. Stressed fish showed impaired sociability, anxiety-like behavior, hyperactivity, elevated whole-body cortisol, and reduced whole-brain BDNF. Ayahuasca restored sociability, reduced anxiety-like behavior and hyperactivity, normalized cortisol levels, and increased BDNF. These findings suggest ayahuasca can reverse stress-induced behavioral and neuroendocrine alterations, supporting further clinical studies for chronic stress.

DOI: 10.1007/s00213-026-07058-z Full text Chronic stress Zebrafish Antidepressant Neurotrophic factors +13