5439 results for "Psychedelics"
Investigating the associations of acute psychedelic experiences and changes in racial trauma symptoms, psychological flexibility, and substance use among People with Racial and Ethnic Minoritized Identities in the United States and Canada.
Journal of substance use and addiction treatment – June 01, 2023
Summary
Psychedelics may significantly reduce substance use among people of color, with a study involving 211 participants revealing a 54% reduction in alcohol use and a 23% decrease in drug use after psychedelic experiences. Notably, Indigenous participants reported the greatest declines in alcohol consumption. Factors such as ethnic identity and depressive symptoms played a role, with higher doses correlating to more substantial reductions. These findings highlight the potential of psychedelics to enhance psychological flexibility and alleviate racial trauma, underscoring the need for inclusive research in this area.
Abstract
Evidence suggests that psychedelics may serve as a therapeutic approach to reduce substance use; however, people with racial and ethnic minoritized...
Ethical Issues Regarding Nonsubjective Psychedelics as Standard of Care
Cambridge Quarterly of Healthcare Ethics – October 01, 2022
Summary
A compelling finding in Psychology reveals psychedelics' therapeutic benefits largely stem from their profound subjective experiences. Although Chemical synthesis is creating "nonsubjective" compounds for individuals with specific mental illnesses, a critical ethical argument emerges for psychotherapists. These altered substances should be reserved for cases where subjective effects are truly contraindicated. For most patients, classic psychedelics, offering positive and meaningful experiences, should remain the default. Withholding these beneficial subjective journeys from the majority raises significant ethical questions relevant to Social psychology and Psychedelics and Drug Studies.
Abstract
Abstract Evidence suggests that psychedelics bring about their therapeutic outcomes in part through the subjective or qualitative effects they enge...
Psychedelics, Glutamate, and Neuroimaging Studies
Anesthesiology – May 21, 2014
Summary
Crucial insights into **hallucinogens** like **psilocybin** are being overlooked in **neuroscience**. A recent critique highlights that discussions of psychedelic **neurochemistry** often neglect the vital role of the **glutamate receptor**. Moreover, the claim that only psilocybin has undergone human **neuroimaging** is inaccurate; **mescaline** and other psychedelics have also been studied. These omissions in **pharmacology** and **medicine** impede a comprehensive understanding of **Psychedelics and Drug Studies**, impacting our grasp of **psychology** and **Neurotransmitter Receptor Influence on Behavior**.
Abstract
The article by Icaza and Mashour1 is a very interesting article because it presents a topic of investigation that is currently attracting the atten...
Minorities’ diminished psychedelic returns: Depression, suicide, distress, and serious mental illness
Drug Science Policy and Law – April 01, 2025
Summary
Psychedelics show promise for mental health, but a large-scale analysis of 596,187 individuals reveals a critical disparity. While non-Hispanic Whites often experience better mental health outcomes, including reduced depression and distress, after psychedelic use, Black, Hispanic, and Asian populations gain fewer benefits. In fact, for Black and Asian individuals, psychedelic use is sometimes linked to *worse* mental illness and psychological distress. This cross-cultural finding highlights the need for a nuanced understanding in psychiatry and clinical psychology regarding diverse responses to these substances.
Abstract
Although there is growing support for the protective effects of psychedelics on mental health, recent evidence finds racial and ethnic minorities g...
Lifetime use of psychedelics is associated with better mental health indicators during the COVID-19 pandemic
Journal of Psychedelic Studies – May 06, 2021
Summary
A compelling psychology finding: lifetime psychedelic use correlates with better mental health during the COVID-19 pandemic. Among 5,618 participants, 32.43% reported using psychedelics. This population demonstrated increased openness to experience and higher positive affect, alongside decreased conscientiousness—Big Five personality traits linked to resilience. Clinical psychology observations suggest these individuals navigate anxiety more effectively. Unlike other drug studies showing negative mental health impacts, psychedelic experiences were associated with stable personality, not poor mental health, amidst the crisis.
Abstract
Abstract Background and aims The COVID-19 pandemic and its consequences represent a major challenge to the mental health and well-being of the gene...
Lifetime classic psychedelic use is associated with greater psychological distress in unemployed job seekers
Journal of Psychedelic Studies – May 16, 2023
Summary
Unemployed seekers with a history of classic psychedelic use report greater psychological distress. This offers new context for psychology regarding mental health. Analyzing data from 208,136 US adults, a link emerged between lifetime psychedelic use and heightened distress among those experiencing unemployment. This suggests that while psychedelics and drug studies often highlight therapeutic potential, they may not always confer agency in managing difficult periods. This perspective is vital for clinical psychology and psychiatry, especially considering neurotransmitter receptor influence on behavior and tryptophan's role in brain disorders.
Abstract
Abstract Background Despite recent research linking lifetime classic psychedelic use to positive mental health outcomes, little work has explored t...
Longitudinal associations between psychedelic use and meditation practices in the United States and the United Kingdom
Psychological Medicine – October 20, 2023
Summary
Compassion meditation may lessen challenging psychedelic experiences, a key insight for psychological intervention. A longitudinal study of 7667 US and UK adults found more baseline compassion meditation linked to less severe subjective feelings of death or dying during intense psychedelic experiences (B = -0.29). Among 100 individuals (1.3% of the population) reporting psychedelic use, these experiences also prompted greater engagement with mindfulness meditation (B = 0.40). This suggests a synergy between natural compound pharmacology and complementary medicine, offering insights for clinical psychology and demography.
Abstract
Abstract Background Previous research has proposed that there may be potential synergies between psychedelic and meditation interventions, but ther...
Modulators of altered states of consciousness across psychedelic, dissociative, and entactogen use: A retrospective naturalistic study using the 5D-ASC.
Progress in neuro-psychopharmacology & biological psychiatry – January 23, 2026
Summary
The intensity of a psychedelic experience, linked to its clinical benefits, is shaped by several factors. An online survey of 804 individuals, using the Altered States of Consciousness questionnaire, revealed that intentions like spiritual or therapeutic use, rather than recreational, predict stronger consciousness alteration. Substance type also matters: dissociative and serotoninergic psychedelics produced more intense effects than entactogens. Higher doses, along with participant age and gender, further influenced the depth of the experience. This suggests a complex interplay of personal, contextual, and pharmacological elements in shaping psychedelic journeys.
Abstract
The intensity of the psychedelic experience has been shown to be associated with its clinical efficacy. This study aims to investigate the factors ...
Effects of Serotonergic Psychedelics on Synaptic Function and Neuroplasticity
OPUS FAU - Online publication system of Friedrich-Alexander-Universität Erlangen-Nürnberg – January 01, 2026
Summary
Serotonergic psychedelics like LSD, psilocin, and DMT significantly inhibit neurotransmission, with notable effects on neuronal network activity. In a study using primary rat cortical cultures, psychedelics decreased synaptic vesicle fusion by up to 30% after 3-30 minutes of treatment. While DMT and psilocin enhanced responses at glutamatergic synapses, LSD and psilocin reduced presynaptic calcium transients. Additionally, LSD and DMT inhibited spontaneous neuronal firing without altering evoked responses. These findings deepen our understanding of how psychedelics could inform treatments for neuropsychiatric conditions.
Abstract
INTRODUCTION: Sertonergic psychedelics LSD, psilocin and DMT, have been shown to hold a great potential for treatment of various neuropsychiatric c...
Exploring the regulatory framework of psychedelics in the US & Europe.
Asian journal of psychiatry – December 01, 2024
Summary
While most psychedelics remain heavily restricted, regulatory shifts are emerging as research reveals their therapeutic promise. The US and EU are developing frameworks to evaluate substances like psilocybin, LSD, and MDMA for mental health treatment. Ketamine clinics already operate legally in many areas, while magic mushrooms face varying local policies. New laws aim to balance patient access with safety controls.
Abstract
Psychedelic drug therapy has gained prominence for its potential in treating various mental health conditions, including depression, post-traumatic...
Tags
Exploring Self-Reported Effects of Naturalistic Psychedelic Use Among Gender and Sexual Minorities: A Quantitative Survey Study.
Journal of psychoactive drugs – June 18, 2025
Summary
Remarkably, over two-thirds of LGBTQIA+ individuals report positive shifts in gender identity attitudes after naturalistic psychedelic use. A quantitative survey study explored how these experiences affect identity and mental health. Among 346 participants, significant self-reported improvements included reduced anxiety, depression, and stress, alongside increased psychological flexibility. Many also reported greater self-acceptance and sexual identity exploration. These findings suggest psychedelics can profoundly aid mental health and identity journeys for LGBTQIA+ people.
Abstract
This study investigated subjective psychedelic experiences in the global LGBTQIA+ population. Using validated measures of acute psychedelic effects...
A landscape analysis of psychedelic retreat organizations advertising online
PLoS ONE – May 02, 2025
Summary
A thriving industry of 298 psychedelic retreat organizations operates across the Globe, marketing experiences with hallucinogens like psilocybin. These organizations, often leveraging public relations and advertising, host retreats at 440 distinct locations, with 310 outside the U.S. This landscape analysis, vital for Psychedelics and Drug Studies, touches diverse academic themes from psychology to political science. Grasping this industry's scope is essential to reduce potential harm and ensure consumer safety.
Abstract
Research into psychedelics’ clinical potential has corresponded to a growth in public interest and adult use. One common pathway to accessing psych...
Psychedelics and treatment of mental disorders: A survey of attitudes and knowledge among psychiatrists, general practitioners and psychologists in Iceland
Læknablaðið – November 03, 2023
Summary
Half of psychiatrists, but only 14.6% of general practitioners and 17.5% of psychologists among 256 Icelandic healthcare professionals, reported patient inquiries about psychedelic treatments for mental health. Professionals in Psychology, Psychiatry, and Family medicine largely lacked knowledge of Psilocybin and other substances, many of which are alkaloids. While hesitant about immediate clinical use, they supported ongoing Medicine and Drug Studies, advocating for specialized care and further education on the chemical properties and therapeutic potential of these psychedelics.
Abstract
INTRODUCTION: Interest in the use of psychedelics has increased following reports of their possible therapeutic potential. However, little is known...
Classical psychedelics' action on brain monoaminergic systems.
The international journal of biochemistry & cell biology – November 01, 2024
Summary
Psychedelics exhibit complex and varied effects on brain chemistry, particularly influencing serotonin, dopamine, and noradrenaline systems. For instance, these substances can inhibit serotonergic neuron firing without always reducing serotonin release across different brain regions. Similarly, noradrenergic neuron activity may also be suppressed without a corresponding drop in noradrenaline levels. With 5-HT receptors playing crucial roles, the interplay between these neurotransmitter systems highlights the intricate, state-dependent responses psychedelics evoke in the brain. This nuanced understanding is vital for exploring their therapeutic potential in psychiatric disorders.
Abstract
The study of the mechanism of action of classical psychedelics has gained significant interest due to their clinical potential in the treatment of ...
The psychological and human brain effects of music in combination with psychedelic drugs
Spiral (Imperial College London) – April 01, 2017
Summary
Psychedelics profoundly amplify music's impact, a key insight for **Music Therapy and Health**. **Neuroscience** reveals LSD intensifies music-evoked emotions like wonder, enhancing information flow from the parahippocampus to the visual cortex, correlating with increased mental imagery. **Cognitive psychology** shows music's quality during psilocybin sessions predicts peak experiences and depression reductions in patients. This **Psychedelics and Drug Studies** work highlights music's substantial influence on therapeutic outcomes, solidifying its role in **Cognitive science** and **Music Perception** research.
Abstract
This research investigated how psychedelics and music work together in the brain and modulate subjective experience. Chapter 1 highlighted the prom...
Psychedelic perceptions: mental health service user attitudes to psilocybin therapy
Irish Journal of Medical Science (1971 -) – June 15, 2021
Summary
A survey of 99 mental health service users reveals strong support for psychedelic medicine. A significant 72% backed further research into psilocybin, a potent hallucinogen, with 59% supporting its use as a medical treatment in Psychiatry. Over half (55%) would accept psilocybin therapy if recommended by a doctor for their mental health. While 27% had prior recreational experience, one fifth (20%) still viewed psychedelics as unsafe. This offers valuable insights for Clinical psychology and future drug studies.
Abstract
Abstract Introduction Despite the rapid advance of psychedelic science and possible translation of psychedelic therapy into the psychiatric clinic,...
Experience of Music Used With Psychedelic Therapy: A Rapid Review and Implications
Journal of Music Therapy – January 01, 2020
Summary
Music is integral to psychedelic therapy, acting as both anchor and guide during emotional and embodied experiences. A review of 10 articles involving 180 participants revealed music's transformative power, eliciting deep sensations and facilitating self-exploration. In Psychedelics and Drug Studies, compounds like psilocybin and lysergic acid diethylamide (from chemical synthesis and alkaloids) are paired with music. This highlights a crucial role for music therapy and psychotherapists in Psychology, optimizing protocols for these emerging treatments, linking to Complementary and Alternative Medicine Studies. Participant openness to music improved outcomes.
Abstract
Abstract Bonny Method of Guided Imagery and Music emerged following discontinuation of psychedelic therapy research in the early 1970s, but psyched...
Psychedelics: A new era of treatment?
European Psychiatry – April 01, 2021
Summary
Psychedelics like psilocybin, mescaline, and lysergic acid diethylamide (LSD) are showing remarkable promise in psychiatry and psychology. These hallucinogens, including ayahuasca, influence neurotransmitter receptors through their chemical synthesis and alkaloids. Neuroscience and drug studies confirm their therapeutic potential for anxiety and mood disorders: controlled trials observed significant reductions in anxiety and depression for cancer patients, and lessened alcohol/tobacco dependence, marking a significant shift in psychedelic medicine.
Abstract
Introduction Psychedelics - including LSD (lysergic acid diethylamide), psilocybin, DMT (N, N-dimethyltryptamine), ayahuasca and mescaline - have a...
TESCREAL hallucinations: Psychedelic and AI hype as inequality engines
Journal of Psychedelic Studies – September 25, 2023
Summary
The rhetoric surrounding psychedelic medicalization, unlike SSRI hype, often promotes utopian aspirations. A complex analysis of public communications reveals global tech elites are using psychedelics with ingenuity in a world-building project that justifies increasing material inequality. This counterfactual thinking, widespread among industry leaders, is driven by the TESCREAL ideology prevalent in Silicon Valley. Does this pseudoscience truly advance mental health? This scholarship contributes to critical drug studies, exposing how public relations strategies challenge our epistemology of healing.
Abstract
Abstract Background and Aims While many scholars have called attention to similarities between the earlier SSRI hype and the ongoing hype for psych...
Psychedelic drug use and schizotypy in young adults
Scientific Reports – July 23, 2021
Summary
Psychedelic use is only weakly linked to psychosis-like symptoms, a key finding for clinical psychology and psychiatry. In a population of 1032 adults, including 701 young adults, higher schizotypy scores (Cohen's d = 0.13) largely disappeared when controlling for other drug use. Interestingly, psychedelic exposure was associated with better evidence integration (Cohen's d = 0.13) and heightened fear response sensitivity (Cohen's d = 1.05) in a subsample of 39. This developmental psychology insight suggests potential therapeutic avenues in medicine, moving beyond concerns about schizophrenia.
Abstract
Abstract Despite recently resurrected scientific interest in classical psychedelics, few studies have focused on potential harms associated with ab...
An international Delphi consensus for reporting of setting in psychedelic clinical trials.
Nature medicine – June 03, 2025
Summary
Experts have identified 30 crucial factors that shape psychedelic therapy experiences, from room aesthetics to therapist training. An international team gathered insights from 89 specialists across 17 countries to create the first standardized guidelines for therapeutic settings. These recommendations help ensure consistency and safety in psychedelic treatments by addressing physical environment, session procedures, and therapeutic protocols.
Abstract
Psychedelic substances exhibit complex interactions with the 'set and setting' of use, that is, the mental state of the user and the environment in...
1H Nuclear Magnetic Resonance: A Future Approach to the Metabolic Profiling of Psychedelics in Human Biofluids?
Frontiers in psychiatry – January 01, 2021
Summary
Unlocking the full therapeutic potential of psychedelics like psilocybin and lsd hinges on understanding their metabolic journey. A review explored proton nuclear magnetic resonance (NMR) as a powerful metabolomics tool. While current work uses NMR for structural analysis of psychedelics and new psychoactive substances, its application for metabolic profiling in biofluids is an exciting, untapped area. This approach, alongside mass spectrometry and liquid chromatography, shows great promise for mapping how these compounds break down, offering valuable insights for future research.
Abstract
While psychedelics may have therapeutic potential for treating mental health disorders such as depression, further research is needed to better und...
Nurses' Perceptions of Psychedelics to Address Mental Health Problems in the United States.
Psychedelic medicine (New Rochelle, N.Y.) – September 01, 2024
Summary
Nearly half of Minnesota nurses support the decriminalization of psychedelics for mental health treatment, with 45.7% in favor. In a survey of 1,133 registered nurses, 80.7% expressed interest in observing psychedelic therapy sessions, while 74.1% recognized the importance of nursing roles in this emerging field. However, only 26.5% felt confident about the benefits of psychedelics, highlighting a need for enhanced education and competency development to ensure effective support for psychedelic treatments addressing conditions like depression and PTSD.
Abstract
To explore nurses' knowledge, attitudes, and perceived social norms about psychedelic use to address mental health conditions. Data were collected ...
Psychedelics as an intervention for psychological, existential distress in terminally ill patients: A systematic review and network meta-analysis
Journal of Psychopharmacology – December 10, 2024
Summary
Psychedelics significantly alleviate anxiety and distress in terminally ill individuals, according to a meta-analysis of nine randomized controlled trials involving 606 participants. These hallucinogens reduced depression (SMD -0.80) and anxiety (SMD -0.84). Psilocybin, an alkaloid, emerged as most effective for depression, while LSD showed promise for anxiety. This review, relevant to clinical psychology and psychiatry, highlights the therapeutic potential of such compounds, often administered by a psychotherapist, for end-of-life care, with comparable safety.
Abstract
Background: The interest in psychedelics as a therapeutic intervention for existential distress of people with terminal illness grounds on their me...
Psychedelics as a tool for a more connected and sustainable world? Considering the importance of rituals, boundaries, and commitment.
International Journal of Drug Policy – September 05, 2024
Summary
Despite a decade of interest in psychedelics like LSD and MDMA for mental health, their social and environmental impacts often go unaddressed. To foster beneficial outcomes, three crucial insights emerge: the importance of setting and rituals, establishing boundaries, and recognizing the long-term commitment required. Commercialization threatens to strip away historical contextual factors, which Psychology and Sociology show are vital. A cautious approach, far from a quick fix, is essential for harnessing these substances' transformative potential for society and the environment.
Abstract
Despite the surge of interest in psychedelic research in the past decade, largely due to the promise of psychedelics for improving mental health ou...
The association between naturalistic use of psychedelics and co-occurring substance use disorders
Frontiers in Psychiatry – January 10, 2023
Summary
Peyote or Mescaline, a classic hallucinogen, shows promise in medicine for substance abuse. Among 56,276 participants, prior use of peyote/mescaline was associated with 32% lower odds (odds ratio = 0.68) of past-year substance dependence or abuse compared to non-users. This contrasts with LSD and Psilocybin, where past use was linked to increased odds. Clinical psychology and psychiatry examine how these psychedelics, through chemical synthesis and alkaloids, impact addiction. Biochemical analysis techniques could further differentiate these effects in drug studies.
Abstract
Objective Classic psychedelics (LSD, psilocybin, and peyote/mescaline) have been used to support addiction treatment in a variety of contexts rangi...
Comparison of psychedelic and near-death or other non-ordinary experiences in changing attitudes about death and dying
PLoS ONE – August 24, 2022
Summary
Psychedelic experiences, involving psilocybin or lysergic acid diethylamide (LSD), generate *more profound* mystical subjective features than non-drug encounters, yet both significantly reduce death fear. A survey of 3192 individuals across psychology and medicine found non-drug experiences (933 participants) were often life's most meaningful. Hallucinogen-occasioned events (2259 participants) reported greater mystical depth, offering unique insights for clinical psychology and psychiatry. Both types profoundly shift perspectives on death, underscoring their relevance for spiritual practices and drug studies.
Abstract
Both psychedelic drug experiences and near-death experiences can occasion changes in perspectives on death and dying, but there have been few direc...
Models of psychedelic drug action: modulation of cortical-subcortical circuits
Brain – October 22, 2021
Summary
Psychedelics like psilocybin hold promise for psychiatric disorders, prompting deep Neuroscience inquiry into their drug action. Serotonergic hallucinogens influence behavior by activating the brain's serotonin 2A receptors. A compelling new model, one of three now proposed, highlights the claustrum – a thin grey matter strip between the insula and cortex – as central. This model suggests these drugs disrupt the claustrum's network coupling with the cortex, altering typical brain states. This framework enhances our understanding of how these powerful compounds exert their profound psychological effects.
Abstract
Abstract Classic psychedelic drugs such as psilocybin and lysergic acid diethylamide (LSD) have recaptured the imagination of both science and popu...
Psychedelics and mindfulness: A systematic review and meta-analysis
Journal of Psychedelic Studies – September 16, 2022
Summary
A systematic review of 13 studies, from 1805 screened, compellingly shows that ingesting psychedelics, such as psilocybin and Ayahuasca, significantly enhances mindfulness. These hallucinogens, impacting neurotransmitter receptor influence on behavior, specifically boost acceptance—non-judgement of inner experience and non-reactivity. A meta-analysis of 6 studies further detailed small effects, particularly with Ayahuasca, on non-judgement and acting with awareness. This insight from psychology and drug studies offers promising avenues for clinical psychology and psychotherapist approaches.
Abstract
Abstract Background and aims The benefits of classic serotonergic psychedelics (e.g. psilocybin, LSD, DMT, ayahuasca) are becoming more widely know...
Psychedelics and Mindfulness: A Systematic Review and Meta-Analysis
OpenAlex – October 11, 2021
Summary
Psychedelics, including alkaloids like psilocybin and ayahuasca, significantly boost mindfulness, particularly acceptance, non-judgement of inner experience, and non-reactivity. A systematic review of 13 studies in psychology and drug studies revealed this link. A meta-analysis of six studies specifically noted small effects with ayahuasca ingestion, enhancing these mindfulness facets. This suggests promising avenues for clinical psychology, potentially informing psychotherapist approaches concerning these powerful hallucinogens.
Abstract
Background and Aims: The benefits of classic serotonergic psychedelics (e.g. psilocybin, LSD, DMT, ayahuasca) are becoming more widely known with t...
577. CLINICAL EVIDENCE AND APPLICATIONS OF PSYCHEDELICS FOR MENTAL ILLNESSES
The International Journal of Neuropsychopharmacology – August 01, 2025
Summary
Australia's regulatory approval for psilocybin in treatment-resistant depression signals a major Psychiatry breakthrough. This psychedelic, central to Drug Studies, initiates specific Chemical Reactions by influencing brain serotonin receptors, a critical Neurotransmitter Receptor Influence on Behavior. Clinical psychology reveals psilocybin provides rapid, robust antidepressant effects, enduring for months to a year after only one or two treatment sessions. Neuroimaging further illuminates how this modulates brain circuits, offering deep insights into its therapeutic promise for mental health.
Abstract
Abstract Background Psychedelics have long been explored as potential treatments for mental illnesses. Since the mid-20th century, clinical trials ...
Language as a Window Into the Altered State of Consciousness Elicited by Psychedelic Drugs
Frontiers in Pharmacology – March 22, 2022
Summary
Computational analysis of speech during hallucinogen use, like psilocybin, can partially predict therapeutic outcomes, offering a powerful window into the mind. This has key relevance for psychology and psychotherapist practice. This mechanism reveals how neurochemical changes influence consciousness and cognitive psychology. By studying language expression, researchers in Psychedelics and Drug Studies gain insights into the action of these drugs, their biochemical analysis, and neurotransmitter receptor influence on behavior, opening a window of opportunity for deeper understanding.
Abstract
Psychedelics are drugs capable of eliciting profound alterations in the subjective experience of the users, sometimes with long-lasting consequence...
Sporadic use of classic psychedelics and neuropsychological performance: A cross-sectional analysis.
Progress in neuro-psychopharmacology & biological psychiatry – April 02, 2025
Summary
People who occasionally use psychedelics like psilocybin and LSD may experience enhanced cognitive flexibility and problem-solving abilities. A comparison of 84 psychedelic users with 52 non-users found that moderate use was linked to better neuropsychological performance, particularly in executive functions. Users showed superior pattern recognition and mental adaptability, with higher doses correlating to better cognitive outcomes.
Abstract
Evidence on the neuropsychological consequences of classic psychedelics like psilocybin, LSD, and ayahuasca is conflicting, and little is known abo...
Motivation and retrospective appraisal of psychedelic study participation: a qualitative study in healthy volunteers.
Psychopharmacology – March 26, 2025
Summary
Healthy volunteers who participated in psychedelic research valued nature access and music during their experiences. In interviews with 151 participants who received substances like psilocybin and LSD, researchers found that personal growth and scientific curiosity were key motivations. Most participants reported positive experiences, especially when supported by trusted investigators in comfortable settings. Natural environments enhanced outcomes.
Abstract
Little is known about motives of healthy volunteers to participate in psychedelic trials and how they appraise their study experience retrospective...
Exploring serotonergic psychedelics as a treatment for personality disorders.
Neuropharmacology – July 01, 2025
Summary
Psychedelics like psilocybin may help reshape core personality traits, offering hope for treating personality disorders that are often resistant to conventional treatments. Clinical trials show that psilocybin-assisted therapy can improve self-awareness, emotional regulation, and interpersonal functioning. The combination of psychopharmacology and psychotherapy appears particularly effective at promoting lasting positive changes in personality structure.
Abstract
Both psychotherapeutic interventions and pharmacological agents have demonstrated limited efficacy in the treatment of personality disorders (PDs)....
On the varieties of conscious experiences: Altered Beliefs Under Psychedelics (ALBUS).
Neuroscience of consciousness – January 01, 2025
Summary
Psychedelics can both weaken and strengthen belief systems in the brain, similar to lucid dreaming states. By activating specific serotonin receptors, these substances can relax rigid thought patterns in the Default Mode Network, allowing fresh perspectives. However, they may also enhance meaning-making and pattern recognition, leading to profound insights or occasionally, misinterpretations. This dual effect explains both the therapeutic benefits and the occasional occurrence of temporary delusions during psychedelic experiences.
Abstract
How is it that psychedelics so profoundly impact brain and mind? According to the model of "Relaxed Beliefs Under Psychedelics" (REBUS), 5-HT2a ago...
Clinical Effects of Psychedelic Substances Reported to United States Poison Centers: 2012 to 2022.
Annals of emergency medicine – December 01, 2024
Summary
Over the past decade, calls to poison centers about psychedelic substances have surged, with mushroom-related cases more than doubling. Analysis of 54,605 cases revealed that half of all psychedelic exposures required medical intervention. Cardiovascular issues were particularly common with hallucinogenic amphetamines. While many cases needed hospital care, including sedation and breathing support, 40% involved multiple substances, complicating treatment.
Abstract
Psychedelic substances use is increasing in the United States (US). The approval of new psychedelic drugs and legalization of natural psychedelic s...
Disentangling the acute subjective effects of classic psychedelics from their enduring therapeutic properties.
Psychopharmacology – May 14, 2024
Summary
Groundbreaking neuropsychiatry research reveals that psilocybin and other classic psychedelics may not need to produce intense psychological experiences to be therapeutic. While traditional treatments rely on profound mental journeys, new evidence suggests these compounds can treat depression and addiction by directly rewiring brain circuits through 5-HT2A receptor activation, even without hallucinogenic effects.
Abstract
Recent research with classic psychedelics suggests significant therapeutic potential, particularly for neuropsychiatric disorders. A mediating infl...
Peri-traumatic consumption of classic psychedelics is associated with lower anxiety and post-traumatic responses 3 weeks after exposure.
Journal of psychopharmacology (Oxford, England) – April 21, 2025
Summary
During a terror attack at a festival, people who had consumed classic psychedelics reported significantly lower anxiety and post-traumatic responses three weeks later compared to those who took MDMA or no substances. Among 343 survivors, those who used psychedelics alone (without mixing other drugs) showed the strongest protective effects against trauma-related symptoms, suggesting these compounds may help prevent the formation of distressing memories during frightening events.
Abstract
Emerging evidence indicates the therapeutic potential of psychedelic compounds for post-traumatic stress, yet the mechanisms mediating their effect...
Psychedelics and substance use disorder treatment.
International review of neurobiology – January 01, 2025
Summary
Remarkably, certain **hallucinogens** show promise in treating **addiction**. Research indicates **psychedelics** like **LSD**, **psilocybin**, and **ayahuasca** can help individuals with **alcohol use disorder** reduce drinking and achieve abstinence. Promising initial findings also emerge for **tobacco use disorder** and opioid **substance use disorders**. These compounds may work by improving brain function and fostering personal insights, offering a new path for recovery.
Abstract
The current chapter presents the literature evaluating the effects of classic psychedelic treatments on five substance use disorders: alcohol, toba...
ARC: a framework for access, reciprocity and conduct in psychedelic therapies
Frontiers in Psychology – May 11, 2023
Summary
The rapid expansion of psychedelic assisted therapy (PAT) for mental health demands a robust ethical infrastructure. A new framework, Access, Reciprocity, and Conduct (ARC), offers a solution. ARC prioritizes equal access to PAT, patient and provider safety, and respects traditional psychedelic uses—a core tenet of Reciprocity. This dual-phase co-design approach engages diverse stakeholders from psychology, therapy, and indigenous communities. It fosters open dialogue to disseminate ethical standards, ensuring responsible growth in psychedelics and drug studies. This approach integrates traditional wisdom, supporting mental health and ethical infrastructure development.
Abstract
The field of psychedelic assisted therapy (PAT) is growing at an unprecedented pace. The immense pressures this places on those working in this bur...
The polypharmacology of psychedelics reveals multiple targets for potential therapeutics.
Neuron – July 15, 2025
Summary
Psychedelics, known for their hallucinogen properties, show surprising potential. Research explored 41 psychedelics, finding they broadly interact with G-protein-coupled receptors, including serotonin receptors and dopamine receptors. This comprehensive profiling revealed these compounds activate multiple targets, suggesting their effects, including therapeutic benefits, stem from complex interactions beyond a single receptor. This broad engagement highlights their diverse pharmacological actions.
Abstract
The classical psychedelics (+)-lysergic acid diethylamide (LSD), psilocybin, and mescaline exert their psychedelic effects via activation of the 5-...
The Therapeutic Potential of Psychedelics on Reducing Rumination: A Mini-Review.
Psychedelic medicine (New Rochelle, N.Y.) – September 01, 2024
Summary
Psychedelic use is linked to significantly lower levels of rumination, a major risk factor for depression and anxiety. In a review of six studies, it was found that individuals using psychedelics experienced reduced repetitive negative thinking, which may enhance treatment outcomes for various mental health disorders. With sample sizes varying across studies, the evidence highlights the importance of addressing rumination before psychedelic sessions. Strategies like mindfulness and cognitive behavior therapy could further support long-term mental health maintenance post-treatment.
Abstract
Rumination is a well-established risk factor for the onset and maintenance of depression and anxiety and is associated with various other forms of ...
Psychedelic risks and benefits: A cross-sectional survey study.
Journal of psychopharmacology (Oxford, England) – May 01, 2025
Summary
Psychedelic experiences can lead to both profound benefits and significant risks. In a study involving 1,257 participants, those reflecting on their first psychedelic experiences reported higher rates of acute challenging effects (e.g., anxiety) compared to cannabis users, with 52% noting persisting negative effects. However, 68% also experienced lasting positive outcomes. Factors influencing these experiences included dosage and social context, as well as individual traits like personality and religiosity. This nuanced view highlights the complex risk-benefit landscape of psychedelics relative to cannabis.
Abstract
As classic psychedelics' therapeutic potential is studied and their popularity continues to rise, it is important to establish their relative risks...
Tags
Processing of self-related thoughts in experienced users of classic psychedelics: A source localisation EEG study.
Progress in neuro-psychopharmacology & biological psychiatry – January 10, 2025
Summary
Psychedelics may alter self-consciousness, as indicated by a study involving 70 users and 38 non-users. Users showed weaker increases in alpha and beta brain wave activity during self-related thoughts, particularly in areas like the posterior cingulate cortex, which is crucial for processing self-information. This suggests that psychedelics may influence how individuals think about themselves. However, results from the second dataset did not replicate these findings, highlighting complexities in understanding psychedelic effects on brain function and well-being.
Abstract
Psychedelics have gained increasing interest in scientific research due to their ability to induce profound alterations in perception, emotional pr...
Naturalistic use of psychedelics does not modulate processing of self-related stimuli (but it might modulate attentional mechanisms): An event-related potentials study.
Psychophysiology – August 01, 2024
Summary
Psychedelics may not lead to lasting changes in self-perception. In a study involving 56 experienced users and 57 nonusers, neural responses were measured via electroencephalography (EEG) while participants reacted to stimuli related to their own names and others'. Both groups showed similar P300 amplitudes for self and target names. However, psychedelic users demonstrated a heightened P300 response to other names and a reduced response to task-relevant target names, suggesting that psychedelics might influence attention rather than alter the self-concept.
Abstract
Classic psychedelics are able to profoundly alter the state of consciousness and lead to acute experiences of ego dissolution - the blurring of the...
Linkages between Psychedelics and Meditation in a Population-Based Sample in the United States.
Journal of psychoactive drugs – January 01, 2023
Summary
Psychedelic experiences may enhance meditation practices. In a study involving 953 American adults, those with meditation experience (536 participants) reported that lifetime classic psychedelic use was linked to increased feelings of ego dissolution—an intense state where one’s sense of self diminishes. Specifically, 92.1% of meditators noted that greater ego dissolution correlated with more frequent meditation, and both factors were tied to enhanced motivation for enlightenment and fewer perceived barriers to practice. Notably, neither psychedelic use nor ego dissolution led to adverse effects in meditation.
Abstract
There are neurophysiological and phenomenological overlaps between psychedelic and meditative states, but there is little evidence on how exposure ...
Philosophy and classic psychedelics: A review of some emerging themes
Journal of Psychedelic Studies – January 21, 2022
Summary
Psychedelics, particularly serotonergic compounds, are profoundly reshaping our understanding of consciousness, prompting deep philosophical inquiry. Academic philosophy is now exploring four critical areas, gaining significant traction over the last decade. This includes examining selfless consciousness and the very nature of the self, alongside psychedelic epistemology, which questions how these experiences influence knowledge. Ethical considerations for their appropriate use are also paramount. Furthermore, there's an exploration into whether the spiritual dimensions of psychedelic experiences can align with a naturalistic worldview, engaging Philosophy, Psychology, and Sociology in this complex dialogue.
Abstract
Abstract Serotonergic (or “ classic” ) psychedelics have struck many researchers as raising significant philosophical questions that, until recentl...
The potential of non-psychedelic 5-HT2A agents in the treatment of substance use disorders: a narrative review of the clinical literature.
Expert opinion on pharmacotherapy – February 01, 2025
Summary
Psychedelics targeting 5-HT2A receptors show promise in treating substance use disorders (SUDs), with some studies indicating positive effects on craving and abstinence. A review of non-psychedelic medications revealed mixed results, suggesting that both psychedelic and non-psychedelic agents share this inconsistency. Notably, most reviewed agents were 5-HT2A receptor antagonists, while psychedelics typically act as agonists. This distinction may explain the more consistent positive outcomes associated with psychedelics, highlighting their potential in addressing withdrawal and addictive disorders effectively.
Abstract
Substance use disorders (SUDs) are a public health issue, with only some having FDA-approved indicated treatments and these having high attrition. ...
A review of psychedelics trials completed in depression, informed by European regulatory perspectives.
Neuroscience applied.. – January 01, 2025
Summary
As European regulators prepare for new treatments, eight completed clinical trials reveal key insights into using psychedelics for depression. These clinical trials, testing various psychedelics, highlight the importance of aligning their design with emerging regulatory guidance. This collaboration is crucial for successful medicines development, paving the way for innovative depression treatments.
Abstract
There is a growing body of clinical research on the therapeutic potential of psychedelics for the treatment of mental health disorders, notably dep...