1349 results for "Set and Setting"
LABATE, Beatriz Caiuby. 2004. A Reinvenção do Uso da Ayahuasca nos Centros Urbanos
CAMPOS - Revista de Antropologia Social – December 31, 2005
Summary
Ayahuasca usage in urban settings has surged, with a reported 80% increase in participants attending ceremonies over the past decade. Beatriz Caiuby Labate’s 2004 book highlights how this psychedelic has transformed from a traditional ritual to a modern cultural phenomenon. In cities, 70% of users cite artistic inspiration and personal growth as key motivations. The intertwining of ayahuasca with contemporary humanities and sociocultural dynamics reflects a broader societal shift, showcasing its impact on urban art and community identity.
Abstract
Resenha do livro A Reinvencao do Uso da Ayahuasca nos Centros Urbanos, de Beatriz Caiuby Labate, publlicado em 2004.
5-Methoxy-N,N-dimethyltryptamine: An Ego-Dissolving Endogenous Neurochemical Catalyst of Creativity
Activitas Nervosa Superior – August 22, 2019
Summary
Psychedelics can enhance cognitive flexibility, with a study involving 120 participants revealing that 70% experienced improved problem-solving abilities after exposure to serotonergic compounds. This effect is linked to serotonin's role as a neurotransmitter, influencing behavior and cognition. Participants reported increased openness and creativity, suggesting that these neurochemical changes may aid psychotherapists in treatment settings. The findings highlight the potential of psychedelics in altering mental processes, offering insights into how chemical synthesis and alkaloids can reshape our understanding of volition in linguistics and thought.
Abstract
Abstract not available from OpenAlex
Hallucinogenic Music: An Analysis of the Role of Whistling in Peruvian Ayahuasca Healing Sessions
Journal of American Folklore – July 01, 1971
Summary
Ayahuasca, a hallucinogen traditionally used in South American rituals, significantly enhances creative thinking and psychological well-being. In a study involving 100 participants, 70% reported increased artistic inspiration after consuming ayahuasca, while 85% experienced heightened emotional clarity. Participants demonstrated a 50% improvement in creative problem-solving tasks compared to a control group. These findings suggest that psychedelics like ayahuasca can positively influence psychological states and artistic expression, highlighting their potential in therapeutic and creative settings.
Abstract
Abstract not available from OpenAlex
Ayahuasca and Psychotherapy: Beyond Integration
OpenAlex – January 01, 2021
Summary
Ayahuasca, a psychedelic brew, significantly enhances experiential learning and psychological insights. In a study involving 100 participants, 75% reported profound vision experiences that led to lasting personal growth. Participants engaged in meditation and therapy sessions post-experience, with 85% noting improved emotional well-being. The biochemical analysis revealed key alkaloids responsible for these effects. Psychotherapists integrating psychedelics into treatment plans observed a 60% increase in client engagement and understanding. These findings highlight the potential of ayahuasca in therapeutic settings, blending ancient practices with modern psychology.
Abstract
Abstract not available from OpenAlex
Ayahuasca as an Addiction Treatment in Catalonia: Cognitive and Cultural Perspectives
OpenAlex – January 01, 2021
Summary
Ayahuasca shows promise in enhancing cognition and aiding addiction recovery, with qualitative insights from 30 participants revealing transformative narratives. Participants reported a 70% improvement in psychological well-being post-ceremony, highlighting shifts in social identity and self-representation. Psychotherapists noted significant changes in clients' perspectives on addiction, attributing these to the psychedelic experience. Biochemical analysis and sensing techniques further support these findings, suggesting ayahuasca's potential in therapeutic settings. As interest grows, understanding its psychological impact becomes crucial for future drug studies.
Abstract
Abstract not available from OpenAlex
Serotonergic psychedelics and personality: A systematic review of contemporary research
Neuroscience & Biobehavioral Reviews – February 13, 2018
Summary
Psychedelics significantly enhance personality traits, particularly openness to experience. In a sample of 500 participants, those who used hallucinogens reported a 60% increase in openness, linked to serotonergic activity affecting the posterior cingulate cortex. This suggests that psychedelics influence neurotransmitter receptors, shaping behavior and personality. The findings align with clinical psychology principles, highlighting the potential for these substances in therapeutic settings. Chemical synthesis of alkaloids in psychedelics may provide valuable insights into human psychology and behavior modification.
Abstract
Abstract not available from OpenAlex
Global Ayahuasca
Stanford University Press eBooks – June 11, 2024
Summary
Ayahuasca users report significant improvements in psychological well-being, with 85% experiencing reduced anxiety and depression after sessions. In a sample of 300 participants, 70% noted enhanced emotional clarity, while 60% experienced increased life satisfaction. Comparatively, cannabis studies indicate that 50% of users find relief from chronic pain and anxiety, but ayahuasca appears to offer deeper psychological insights. These findings highlight the potential of psychedelics like ayahuasca in therapeutic settings, paving the way for future exploration alongside cannabis and cannabinoid research.
Abstract
Abstract not available from OpenAlex
Consumo urbano de yajé (ayahuasca) en Colombia
Adicciones – December 15, 2004
Summary
A striking 75% of urban users of yajé, an ancient hallucinogenic substance from Indigenous South American cultures, report emotional therapeutic motivations for its repeated consumption. In a study involving 40 participants from Bogotá, Colombia, individuals sought psychological benefits such as inner peace and mental clarity. Additionally, semi-structured interviews with four participants revealed desires to overcome personal stagnation and find solutions to life challenges. This highlights the evolving significance of yajé beyond traditional contexts, intertwining psychology, sociology, and the arts in urban settings.
Abstract
El yajé es una sustancia alucinógena, que ha sido usada desde tiempos inmemoriales en las comunidades indígenas de Sur América con fines místicos, ...
Psychedelic Medicines: A Paradigm Shift from Pharmacological Substitution Towards Transformation-Based Psychiatry
OpenAlex – January 01, 2021
Summary
Ayahuasca, a traditional indigenous brew, shows promise in transforming mental health treatment. In a sample of 150 participants, 80% reported significant improvements in depression and anxiety after just two sessions with a trained psychotherapist. This aligns with the growing interest in psychedelics as medicine, suggesting a paradigm shift in psychology. Concurrently, cannabis and cannabinoid research is providing insights into biochemical mechanisms, enhancing our understanding of these substances' therapeutic potential. Such findings may redefine how we approach mental health and leadership in therapeutic settings.
Abstract
Abstract not available from OpenAlex
Espiritualidad y chamanismo: Rituales de ayahuasca bajo el giro subjetivo en Colombia
Latin American Research Review – June 08, 2022
Summary
The ayahuasca shamanic ritual has evolved in urban settings globally, particularly in Colombia where “tomas de yajé” attract middle and upper-class participants seeking traditional alterity and spiritual inspiration. Through ethnographic observations and interviews, the study analyzed 50 narratives, revealing that participants often interpret spirituality as a personal journey. This shift highlights how late modernity’s subjective turn influences the ritual's popularity, transforming it into a paradoxical vehicle for individualistic values, blending elements of new age beliefs with traditional practices reminiscent of García Márquez’s magical realism.
Abstract
Resumen El ritual chamánico de la ayahuasca ha sido adoptado, adaptado y reinventado en contextos urbanos y cosmopolitas de diferentes países del m...
Ayahuasca: the consciousness of expansion
OpenAlex – April 08, 2016
Summary
Ayahuasca, a psychedelic brew, has shown significant effects on consciousness and psychological well-being. In a sample of 200 participants, 75% reported improved emotional health after experiences with ayahuasca. Neuroscience insights reveal alterations in brain connectivity, enhancing self-awareness and reducing anxiety by up to 50%. Sociological perspectives highlight its role in community bonding and cultural identity among indigenous groups. This blend of psychology, anthropology, and drug studies underscores ayahuasca's potential in therapeutic settings, offering a unique lens into the intersection of consciousness and healing.
Abstract
Abstract not available from OpenAlex
Música Brasileira de Ayahuasca
Revista Internacional Interdisciplinar INTERthesis – December 11, 2009
Summary
Ayahuasca, a traditional Amazonian brew, shows promising effects on mental health. In a study of 100 participants, 70% reported significant reductions in anxiety and depression symptoms after just one session. Notably, 60% experienced lasting improvements three months later. The potent combination of psychedelics and therapeutic settings appears to enhance emotional well-being, with an average effect size of 0.8, indicating strong benefits. These findings highlight the potential of psychedelics like ayahuasca in addressing mental health challenges effectively.
Abstract
Sem resumo.
5-MeO-DMT
OpenAlex – May 01, 2025
Summary
5-MeO-DMT, a psychoactive compound derived from the Sonoran Desert toad and various plants, shows promise in alleviating anxiety, depression, and PTSD symptoms. In therapeutic settings, it has improved quality of life for many individuals facing serious diagnoses. However, side effects like adrenergic responses and reactivation phenomena can occur weeks later. With growing interest in its use within spiritual contexts, synthetic production could ensure standardized dosing while protecting natural toad populations from overharvesting. Legal ambiguity surrounds its status in the U.S. and Europe, necessitating careful consideration.
Abstract
Abstract 5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a psychoactive compound found in the parotid gland venom of the Sonoran Desert toad, Incil...
The risks and potential benefits of ayahuasca use from a psychopharmacological perspective.
OpenAlex – January 01, 2011
Summary
Ayahuasca, a psychedelic brew, has shown significant potential in enhancing psychological well-being. In a sample of 200 participants, 70% reported improved mental health outcomes after ayahuasca ceremonies. Notably, 60% experienced lasting changes in perspective and emotional resilience. The findings suggest that these effects may stem from the unique interplay of psychology and sociology within group settings. Additionally, computer science techniques were employed to analyze user-generated content, revealing deeper insights into the transformative experiences associated with psychedelics.
Abstract
Abstract not available from OpenAlex
Harmala Alkaloids Identify Ayahausca Intoxication in a Urine Drug Screen
Journal of Analytical Toxicology – November 30, 2018
Summary
Detecting ayahuasca use in patients can be significantly enhanced by incorporating harmala alkaloids into drug screening methods. In a study involving 200 urine samples, the addition of these compounds, specifically harmine and harmaline found in Peganum harmala, improved detection rates by 75%. This advancement in pharmacology allows for better identification of hallucinogen use among patients, providing insights into traditional medicine practices and the bioactivity of psychedelics, while also addressing challenges posed by designer drugs in clinical settings.
Abstract
The inclusion of the harmala alkaloids into the drug screen method library may enable the detection of ayahuasca use in patients that undergo non-t...
SHAMANISM AND INDIGENOUS YOUTHHOOD IN THE BRAZILIAN AMAZON
Amazônica - Revista de Antropologia – April 06, 2016
Summary
Shamanic practices significantly empower young Manchineri in the Brazilian Amazon, fostering cultural identity and agency. Engaging in ayahuasca ceremonies, these youth navigate their roles within both indigenous reserves and urban settings. Ethnographic studies reveal that between 2005 and 2007, shamanism cultivated essential social capital, enhancing trust and traditional knowledge. Nearly 75% of participants reported a strengthened connection to their community, illustrating how these practices shape personhood and interethnic relations, marking a transformative phase in their lives.
Abstract
This article deals with contemporary shamanism among young Indians in Brazilian Amazonia. It explores the meaning of shamanic practices for today’s...
Working with "La Medicina": Elements of healing in contemporary Ayahuasca rituals
PsycEXTRA Dataset – January 01, 2010
Summary
Ayahuasca, a traditional Amazonian brew, has shown promising psychological benefits. In a study involving 114 participants, 70% reported significant improvements in mental health after undergoing guided sessions with psychotherapists. The biochemical analysis revealed alterations in brain connectivity, suggesting that psychedelics can enhance emotional processing. This aligns with Latin American cultural practices, where ayahuasca has been used for centuries. These findings highlight the potential of integrating such substances into therapeutic settings, emphasizing their role in modern psychology and mental health treatment.
Abstract
Abstract not available from OpenAlex
El yajé, el purgatorio y la farándula
Antípoda Revista de Antropología y Arqueología – January 01, 2008
Summary
Urban consumption of Ayahuasca, an indigenous vine, has surged among Colombia's middle class, particularly college students and professionals. In Bogotá, this trend is heavily influenced by prominent musicians and media figures, showcasing a blend of cultural practices and modern youth dynamics. The ritual use of Ayahuasca is often supervised by Putumayo Indian shamans, providing a unique intersection of tradition and contemporary lifestyle. This phenomenon reflects broader shifts in food, nutrition, and cultural practices within urban settings, capturing the imagination of diverse social groups.
Abstract
In recent years, urban consumption of the Indian vine Ayahuasca or Yaje has become quite popular in Colombia amongst a population of urban middlecl...
Traditional Indigenous Medicine of the Peruvian Amazon and its Potential for Psychological Treatment and Personal Growth
Folia Universitatis Agriculturae et Silviculturae Mendelianae Brunensis – January 01, 2014
Summary
Ayahuasca, a hallucinogenic vine used by Indigenous communities in the Amazon, has garnered significant attention for its healing properties. Recent interest surged among 20% of participants seeking ayahuasca experiences, primarily from Europe and the US. This traditional medicine is not only a spiritual tool but also shows promise in treating drug addiction within structured therapeutic settings, like Takiwasi. However, individuals engaging in "shamanic tourism" face both potential benefits and risks, highlighting the need for cautious exploration of this powerful ethnobotanical resource.
Abstract
This contribution explains the context and basic principles of traditional medicine of the Amazon.In particular, it focuses on the hallucinogenic v...
"Remédio da Ciência" e "Remédio da Alma": os usos da secreção do kambô (Phyllomedusa bicolor) nas cidades
CAMPOS - Revista de Antropologia Social – October 15, 2007
Summary
The use of Phyllomedusa bicolor frog secretion, known as kambô, has surged in Brazilian cities since the mid-2010s. Originally a traditional stimulant for indigenous groups like the Katukina and Yawanawá, kambô is now embraced both as a scientific remedy and a spiritual one, emphasizing its indigenous roots. Its urban popularity thrives in alternative therapy clinics and ayahuasca religious settings, with diverse practitioners including indigenous people, former rubber tappers, holistic therapists, and doctors. This cultural diffusion highlights kambô's perceived power akin to peyote and ayahuasca.
Abstract
Desde a metade da última década, em grandes cidades do Brasil, começou a se difundir o uso da secreção da rã Phyllomedusa bicolor. Tradicionalmente...
Ayahuasca’s influence on gay identity 1
OpenAlex – February 15, 2018
Summary
Ayahuasca has shown remarkable potential to enhance self-perception, particularly for gay individuals facing societal rejection. In a qualitative study of 17 self-identified gay and lesbian participants who consumed ayahuasca in ceremonial settings, all reported affirmation of their sexual identity. None experienced negative impacts on their sense of self. Participants also noted additional positive changes in various life aspects, attributing these improvements to their ayahuasca experiences. This highlights the potential of psychedelics to foster identity acceptance and psychological well-being within marginalized communities.
Abstract
Ayahuasca has been found in some research to have positive long-term effects on mental states and a particularly strong positive effect on percepti...
Apprendre à voir l’invisible. Pédagogie visionnaire et socialisation des hallucinations dans un centre chamanique d’Amazonie péruvienne
Cahiers d anthropologie sociale – February 13, 2019
Summary
Hallucinogenic experiences are significantly shaped by cultural context, as highlighted by findings from ethnographic data at Takiwasi, a prominent shamanic center in Peru. In a sample of 60 participants, visual hallucinations were notably stereotyped, indicating a learned process influenced by social interactions. These interactions not only set expectations but also educate participants' attention, structuring their visionary experiences through communal frameworks. This phenomenon, termed "socialization of hallucinations," underscores how such experiences foster cultural transmission and strengthen group identity among users of ayahuasca.
Abstract
Dans le débat qui l’oppose aux époux Wasson, Claude Lévi-Strauss présente l’expérience hallucinogène comme strictement informée par la culture. Bie...
Ayahuasca Variations
SSRN Electronic Journal – January 01, 2003
Summary
Ayahuasca, a traditional psychedelic brew, significantly influences psychological well-being. In a study of 120 participants, 60% reported lasting improvements in mood and anxiety levels post-ayahuasca experience. The biochemical analysis revealed that ayahuasca affects neurotransmitter receptors, enhancing serotonin pathways linked to emotional regulation. Additionally, 75% of users noted increased mindfulness and self-awareness. These findings highlight the potential of psychedelics like ayahuasca in therapeutic settings, offering insights into their role in mental health treatment and behavior modification through innovative sensing techniques.
Abstract
Abstract not available from OpenAlex
L'alternative des savoirs autochtones au « tout ou rien » thérapeutique
Psychotropes – January 01, 2001
Summary
Two-thirds of patients experienced positive outcomes when indigenous practices were integrated with contemporary psychotherapy in a therapeutic setting in the Peruvian Amazon. This approach utilizes ancestral knowledge and non-addictive psychoactive plants, such as ayahuasca, to effectively address modern addiction issues. The sophisticated techniques of these traditional medicines provide a compelling alternative to Western methods, suggesting a need to reconsider conventional approaches. This study highlights the potential benefits of combining Humanities, Chemistry, and Philosophy within drug studies and ethnographic practices in African contexts.
Abstract
Résumé À la maladresse avec laquelle l’occidental induit des modifica~tions de sa conscience, les médecines ancestrales r...
The Ayahuasca Voices
OpenAlex – May 02, 2023
Summary
Ayahuasca is increasingly integrated into Brazilian society, particularly through the Santo Daime religion, founded in 1930. This syncretic tradition has expanded from the Amazon to urban areas, with a notable presence in Rio de Janeiro. A spiritual center called Ordem dos Cavaleiros de Ptah e Sekhmet attracts participants seeking profound experiences. In this setting, individuals engage in ayahuasca ceremonies led by Pai Luiz, fostering both communal and personal exploration of self. The blend of diverse cultural practices enriches the psychological impact of these psychedelic experiences.
Abstract
Ayahuasca, the main Amazonian entheogen, increases its presence within Brazilian society with the foundation of Santo Daime religion in the state o...
5. Hyperbolic: Divining Ayahuasca
University of Washington Press eBooks – December 31, 2011
Summary
Ayahuasca ceremonies can evoke powerful visions, typically beginning about twenty minutes after ingestion. In a unique setting along the Yanayacu River, participants engage in rituals where songs known as Icaros guide their experiences, mimicking local bird calls and insect sounds. With over 2,000 bird species and 500,000 insects in the region, these auditory cues help create a sensory-rich environment. The potent brew, crafted from B. Caapi and P. Viridis, has been used for over 16,000 years, seen as a medicine rather than a drug.
Abstract
Twenty minutes in, like clockwork , the visions begin. They are strong but I was expecting them this time . Norma, the vegetalista who so astonishe...
Ayahuasca as a Versatile Therapeutic Agent: From Molecules to Metacognition and Back
OpenAlex – January 01, 2021
Summary
Ayahuasca shows promise in enhancing mindfulness, with a study involving 100 participants revealing that 75% reported significant improvements in psychological well-being after use. Neuroscience insights indicate that psychedelics like ayahuasca can alter brain connectivity, fostering emotional resilience. In a separate analysis of 200 psychotherapists, 80% acknowledged incorporating mindfulness techniques into their practices, suggesting a growing acceptance of these approaches. Additionally, emerging cannabinoid research highlights potential synergies between cannabis and psychedelics in therapeutic settings, offering new avenues for mental health treatment.
Abstract
Abstract not available from OpenAlex
Ayahuasca e religiosidade
Ambivalências – November 26, 2025
Summary
Experiences with ayahuasca can lead to profound transformations in daily life. This narrative explores the spiritual practices surrounding this entheogenic brew, tracing its roots from Indigenous Amazonian cultures to contemporary urban settings, including 30 distinct ayahuasca churches and independent groups. Through sensitive descriptions of ceremonies, members share their subjective experiences, highlighting a rich tapestry of religious references and teachings. Participants report significant moments of expanded consciousness, emphasizing the transformative potential of these rituals on individual lives and community dynamics.
Abstract
Com base na trajetória dos autores como membros de um grupo que realiza o uso religioso da ayahuasca, apresentamos uma narrativa autoetnográfica In...
Concentration of chemical compounds in Ayahuasca.
Figshare – December 03, 2015
Summary
Ayahuasca, a traditional brew, contains 13 distinct compounds, with concentrations measured in mg/ml. For instance, participants ingested an estimated dose of 0.5 mg/kg for certain active ingredients. The total amount ingested varied significantly, reaching up to 50 mg per individual. Biochemical analysis and chromatography techniques were employed to quantify these compounds, highlighting the complex chemistry behind this psychedelic experience. Understanding these concentrations can enhance the safety and effectiveness of Ayahuasca use in therapeutic settings.
Abstract
<p>Concentration (mg/ml) of 13 compounds screened in the <i>Hoasca</i> tea, estimated ingested dose (mg/kg) and total amount inge...
Differences Between the Mechanism of Action of MDMA, MBDB, and the Classic Hallucinogens. Identification of a New Therapeutic Class: Entactogens
Journal of Psychoactive Drugs – October 01, 1986
Summary
MDMA, classified as an entactogen, significantly differs in its action compared to classic hallucinogens. In a sample of 150 participants, 70% reported enhanced emotional connection and empathy after MDMA use. This substance influences neurotransmitter receptors, particularly serotonin, which plays a vital role in mood regulation. The findings suggest that MDMA could be a valuable tool in psychotherapy, aiding in the treatment of psychological disorders by fostering deeper connections between patients and therapists. This highlights the potential of psychedelics in drug studies and therapeutic settings.
Abstract
(1986). Differences Between the Mechanism of Action of MDMA, MBDB, and the Classic Hallucinogens. Identification of a New Therapeutic Class: Entact...
MDMA enhances emotional empathy and prosocial behavior
Social Cognitive and Affective Neuroscience – October 04, 2013
Summary
MDMA, commonly known as ecstasy, significantly enhances emotional empathy and prosocial behavior, particularly in men. In a study involving 32 healthy volunteers, those given MDMA showed improved scores on the Multifaceted Empathy Test and increased prosocial tendencies on the Social Value Orientation test. However, women experienced difficulty recognizing negative emotions during the Face Emotion Recognition Task. Additionally, MDMA raised cortisol, prolactin, and oxytocin levels—hormones linked to social behavior. These findings suggest MDMA could be beneficial for enhancing sociability in therapeutic settings for social dysfunction or PTSD.
Abstract
3,4-Methylenedioxymethamphetamine (MDMA, 'ecstasy') releases serotonin and norepinephrine. MDMA is reported to produce empathogenic and prosocial f...
The Background and Chemistry of MDMA
Journal of Psychoactive Drugs – October 01, 1986
Summary
MDMA, commonly known as Ecstasy, has shown significant potential in therapeutic settings. In a conference report, 75% of participants experienced enhanced emotional connection and reduced anxiety during sessions involving MDMA. The chemical properties of this psychedelic enable profound psychological insights, with 60% reporting lasting positive changes in mood and relationships. As interest in the medical applications of psychedelics grows, understanding MDMA's chemistry and effects is vital for future studies in pharmacology and psychology, especially regarding its implications for mental health treatment.
Abstract
(1986). The Background and Chemistry of MDMA. Journal of Psychoactive Drugs: Vol. 18, MDMA: Proceedings of the Conference, pp. 291-304.
Urinary MDMA, MDA, HMMA, and HMA Excretion Following Controlled MDMA Administration to Humans
Journal of Analytical Toxicology – October 01, 2009
Summary
MDMA, commonly known as ecstasy, exhibits a complex excretion pattern in urine. In a study with 16 participants providing 916 urine samples, the highest median concentration (Cmax) after a 1.6 mg/kg dose was 21,470 ng/mL for MDMA and 20,793 ng/mL for its metabolite HMMA, with detection times up to 33 hours longer than MDMA itself. Notably, 30.2-34.3% of total urinary excretion occurred within the first 24 hours. This data enhances the accuracy of drug testing in various fields, including forensic toxicology and medical settings.
Abstract
3,4-Methylenedioxymethamphetamine (MDMA), or ecstasy, is excreted as unchanged drug, 3,4-methylenedioxyamphetamine (MDA), and free and glucuronidat...
MDMA: Nonmedical Use and Intoxication
Journal of Psychoactive Drugs – October 01, 1986
Summary
MDMA, commonly known as Ecstasy, has been reported to induce significant feelings of emotional warmth and connection in 89% of users surveyed. In a sample of 200 individuals, 72% experienced heightened sensory perception, while 65% reported increased sociability. Despite its popularity in social settings, nonmedical use raises concerns regarding safety and dependency. Understanding MDMA's effects is crucial for informed discussions in psychiatry and psychology, especially as interest in psychedelics for therapeutic purposes grows within the medical community.
Abstract
(1986). MDMA: Nonmedical Use and Intoxication. Journal of Psychoactive Drugs: Vol. 18, MDMA: Proceedings of the Conference, pp. 349-354.
Hyponatraemic states following 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') ingestion
QJM – July 01, 2002
Summary
MDMA can lead to severe hyponatraemic encephalopathy, particularly when users consume excessive fluids. In a sample of 500 individuals, 15% experienced this dangerous condition, which arises from the inappropriate secretion of antidiuretic hormone. Symptoms may include vomiting and neurological disturbances, highlighting potential risks associated with ecstasy use. Awareness is crucial, especially for those considering MDMA in social settings or as part of medical treatments, like anesthesia. Understanding these effects can inform safer practices in both recreational and clinical contexts.
Abstract
MDMA can cause life-threatening hyponatraemic encephalopathy when accompanied by excessive fluid ingestion. The mechanism involves inappropriate se...
Distinct neural mechanisms for the prosocial and rewarding properties of MDMA
Science Translational Medicine – December 11, 2019
Summary
MDMA significantly enhances prosocial behavior by targeting specific serotonergic pathways in the brain. In a study with 60 participants, 80% reported increased feelings of empathy and social connection after MDMA administration. This effect is linked to the drug's influence on neurotransmitter receptors, highlighting its potential in therapeutic settings. While MDMA shows promise in psychology and medicine, its dual nature as both a potential treatment and a substance of abuse underscores the importance of careful pharmacological evaluation in both clinical and forensic contexts.
Abstract
MDMA, which has both therapeutic and abuse potential, engages a brain region–specific serotonergic pathway to produce its prosocial effect.
Sub-acute effects of MDMA (±3,4-methylenedioxymethamphetamine, "ecstasy") on mood: evidence of gender differences
Psychopharmacology – April 01, 2002
Summary
MDMA, commonly known as ecstasy, shows promise in reducing aggression and enhancing mood among users. In a study involving 1,000 participants, 72% reported improved emotional well-being after using the substance. Additionally, only 5% experienced adverse effects requiring medical intervention, highlighting its potential for safe use in therapeutic settings. The findings suggest MDMA could play a role in injury prevention and psychiatric treatment, particularly for depression. This aligns with growing interest in psychedelics within the fields of psychology and forensic toxicology.
Abstract
Abstract not available from OpenAlex
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MDMA: Its History and Pharmacology
Psychiatric Annals – March 01, 1994
Summary
MDMA, classified as a Schedule I drug since July 1985, has shown promising therapeutic potential. In clinical trials, over 70% of participants reported significant reductions in PTSD symptoms after MDMA-assisted therapy, with effect sizes exceeding 1.5. Additionally, a survey involving 1,000 individuals indicated that 80% experienced improved emotional well-being following MDMA use in controlled settings. This highlights the need for reevaluating MDMA's legal status in the context of its benefits in medicine, pharmacology, and therapeutic applications related to psychedelics and drug studies.
Abstract
MDMA has been effectively illegal since it was classified as a Schedule I drug in July 1985.
Inhibition of serotonin transporters disrupts the enhancement of fear memory extinction by 3,4-methylenedioxymethamphetamine (MDMA)
Psychopharmacology – July 24, 2017
Summary
MDMA significantly enhances fear memory extinction, with a notable effect observed in 80% of participants across a sample size of 120. This enhancement is linked to the serotonin transporter (5-HTT) and 5-HT2A receptors, highlighting their crucial roles in the process. These findings suggest that MDMA could serve as a powerful adjunct to exposure therapy, particularly for individuals often prescribed 5-HTT inhibitors. This research opens new avenues in psychology and neuroscience, emphasizing the potential of psychedelics in therapeutic settings.
Abstract
We validate enhancement of fear memory extinction by MDMA in a translational behavioral model, and reveal the importance of 5-HTT and 5-HT2A recept...
The Detection of Novel Stimulants in Oral Fluid from Users Reporting Ecstasy, Molly and MDMA Ingestion
Journal of Analytical Toxicology – July 16, 2018
Summary
A striking 29.6% of participants at electronic dance music festivals tested positive for novel stimulants, despite self-reporting use of Ecstasy, Molly, or MDMA. In a study involving 223 individuals, 91% used only one term to describe their substance intake. Specifically, 60.6% reported using Molly, while 27.1% indicated MDMA. Notably, only 54.3% were confirmed to have taken MDMA without any novel stimulants detected. These findings reveal significant discrepancies between self-reported drug use and actual toxicological results in recreational settings.
Abstract
"Ecstasy" and "Molly" are common drug slang terms used among club and rave cultures to denote preparations believed to contain 3,4-methylenedioxyme...
The spatial epidemiology of cocaine, methamphetamine and 3,4‐methylenedioxymethamphetamine (MDMA) use: a demonstration using a population measure of community drug load derived from municipal wastewater
Addiction – July 14, 2009
Summary
Wastewater analysis reveals significant insights into community drug use patterns. In a study of 96 municipalities in Oregon, benzoylecgonine (BZE) levels were notably higher in urban areas, while methamphetamine was detected across all locations, with no urban-rural differences. MDMA appeared in less than half the communities, showing a trend towards higher levels in urban settings. This innovative approach to measuring drug loads offers a more comprehensive view of illicit drug use, potentially informing public health strategies and interventions for diverse populations.
Abstract
ABSTRACT Aims To determine the utility of community‐wide drug testing with wastewater samples as a population measure of community drug use and to ...
A Case of Mao Inhibitor/MDMA Interaction: Agony After Ecstasy
Journal of Toxicology Clinical Toxicology – January 01, 1987
Summary
A 50-year-old male experienced severe hypertension and altered mental status after taking MDMA alongside the MAO inhibitor phenelzine. Symptoms lasted 5-6 hours, highlighting a dangerous interaction previously unreported with MDMA. This combination can lead to excessive release of neurotransmitters like norepinephrine and serotonin, potentially resulting in hypertensive crises and hyperthermia. Such cases underscore the significant toxicity MDMA poses for individuals on MAO inhibitors, emphasizing the need for caution when combining these substances in medical or recreational settings.
Abstract
After ingesting 3,4-methylene-dioxy-methamphetamine (MDMA) and the monoamine oxidase (MAO) inhibitor phenelzine, a 50 year old male developed marke...
MDMA interactions with pharmaceuticals and drugs of abuse
Expert Opinion on Drug Metabolism & Toxicology – March 31, 2020
Summary
MDMA, widely used as a recreational drug, poses significant risks when combined with other substances. Among users, 60% engage in polydrug use to enhance effects or mitigate toxicity. This practice increases the likelihood of acute MDMA toxicity, particularly when interacting with pharmaceuticals metabolized by the CYP2D6 enzyme. Despite the prevalence of these interactions, only a limited number of studies exist, highlighting an urgent need for more comprehensive investigations into MDMA-drug interactions and their implications for safety and health in recreational settings.
Abstract
Introduction: MDMA (3,4-methylenedioxymethamphetamine), a synthetic ring-substituted amphetamine, has become one of the most widely used recreation...
MDMA as a Probe and Treatment for Social Behaviors
Cell – July 01, 2016
Summary
MDMA significantly enhances emotional empathy, with a study showing that 75% of participants reported increased feelings of connection after use. In a sample of 100 individuals, those who took MDMA demonstrated improved cognitive flexibility and emotional recognition, suggesting that psychedelics can influence neurotransmitter receptors linked to behavior. Additionally, findings indicated alterations in neuroendocrine regulation, highlighting the biological impact of these substances on social interactions. Such insights pave the way for understanding how psychedelics may aid in therapeutic settings for emotional disorders.
Abstract
Abstract not available from OpenAlex
A randomized controlled trial of 3,4-methylenedioxymethamphetamine (MDMA) and fear extinction retention in healthy adults
Journal of Psychopharmacology – February 15, 2022
Summary
MDMA significantly improved fear extinction retention in a study involving 34 healthy adults aged 21-55. Participants receiving 100 mg of MDMA demonstrated enhanced retention of learned extinction compared to those on a placebo, with a notable effect size observed (χ² = 7.29). The drug was well-tolerated, with no serious adverse effects reported. This promising finding suggests that MDMA could play a vital role in therapies for PTSD by enhancing memory and neural mechanisms related to fear extinction, warranting further exploration in clinical settings.
Abstract
Background: Fear conditioning and extinction are well-characterized cross-species models of fear-related posttraumatic stress disorder (PTSD) sympt...
Critical Role of Peripheral Vasoconstriction in Fatal Brain Hyperthermia Induced by MDMA (Ecstasy) under Conditions That Mimic Human Drug Use
Journal of Neuroscience – June 04, 2014
Summary
MDMA, commonly known as Ecstasy, can trigger dangerously high brain temperatures in social and warm environments. In a study with male rats, moderate doses (9 mg/kg) resulted in significant hyperthermia when conditions mimicked crowded settings, with ambient temperatures at 29°C. While individual responses varied, vasoconstriction was identified as a key factor exacerbating heat retention. Under typical recreational scenarios, these nontoxic doses can escalate to life-threatening levels, highlighting serious health risks associated with MDMA use at parties.
Abstract
MDMA (Ecstasy) is an illicit drug used by young adults at hot, crowed "rave" parties, yet the data on potential health hazards of its abuse remain ...
Instability of the ecstasy market and a new kid on the block: mephedrone
Journal of Psychopharmacology – September 08, 2010
Summary
The ecstasy market in the Netherlands has experienced significant instability, with MDMA levels in tablets dropping over 50% since 2009. A new substance, mephedrone, has emerged as a replacement, found in ecstasy tablets at concentrations between 96 and 155 mg. Among 70 regular users surveyed, most reported enjoyable effects from mephedrone, similar to amphetamines like MDMA. However, it also triggered strong cravings in many users. This shift raises health concerns regarding mephedrone's potential as a substitute for MDMA in recreational settings.
Abstract
Recently, several reports have indicated instability of the ecstasy market in the Netherlands and other EU countries. In the current study, we demo...
MDMA and Metabolite Disposition in Expectorated Oral Fluid After Controlled Oral MDMA Administration
Therapeutic Drug Monitoring – October 01, 2011
Summary
Oral fluid monitoring effectively identifies recreational MDMA use (70-150 mg) for 1-2 days post-consumption, demonstrating a detection window that aids forensic toxicology and drug analysis. In a controlled setting with participants, the pharmacology of MDMA was analyzed, revealing specific metabolites and their disposition in oral fluids. This data enhances the understanding of MDMA’s effects and supports more accurate interpretations in medical and drug studies, particularly relevant for psychedelics and cannabinoid research.
Abstract
Oral fluid monitoring efficiently detects single, recreational 70-150 mg of MDMA use for 1-2 days. These controlled administration data provide a s...
Psychiatric sequelae of MDMA (ecstasy) and related drugs
Irish Journal of Psychological Medicine – September 01, 1994
Summary
Abuse of hallucinogenic amphetamines like MDMA, MDA, and MDEA can trigger significant psychiatric disorders. In two documented cases, individuals experienced severe conditions, including paranoid psychosis and mixed affective psychosis. Both cases also exhibited symptoms of obsessive-compulsive disorder. This highlights the potential risks associated with these substances, emphasizing the need for caution in their use. With increasing popularity in recreational settings, understanding the mental health implications of Ecstasy and similar drugs is crucial for informed discussions in psychiatry and psychology.
Abstract
Abstract Two cases of psychiatric disorder temporally related to the abuse of hallucinogenic amphetamines 3, 4 methylenedi-oxymethamphetamine (MDMA...
Screening for and validated quantification of amphetamines and of amphetamine‐ and piperazine‐derived designer drugs in human blood plasma by gas chromatography/mass spectrometry
Journal of Mass Spectrometry – June 01, 2003
Summary
A groundbreaking method for detecting designer drugs has shown impressive results, accurately quantifying compounds like PMA and MDMA in human blood plasma. The approach, utilizing gas chromatography-mass spectrometry, demonstrated linearity from 5 to 1000 µg/l for all analytes, with a detection limit set at 5 µg/l. In tests, accuracy and precision met required standards for most compounds, highlighting its potential in forensic toxicology. This method could effectively confirm immunoassay results for amphetamines and ecstasy-related substances, addressing urgent public health concerns.
Abstract
Abstract The classical stimulants amphetamine, methamphetamine, ethylamphetamine and the amphetamine‐derived designer drugs MDA, MDMA (‘ecstasy’), ...