171 results for "Ego Dissolution"
Effects of ayahuasca on gratitude and relationships with nature: An open-label, naturalistic study
OpenAlex – June 07, 2023
Summary
Ayahuasca significantly boosts feelings of gratitude and connection to nature, with 54 participants reporting notable changes after attending a retreat. One week post-retreat, gratitude increased by over 30%, while nature appreciation surged by 25%. These benefits persisted at the one-month follow-up. Participants who experienced mystical moments and awe during the retreat showed weak-to-moderate correlations with these positive shifts. This suggests that ayahuasca may enhance prosocial behavior and overall mental health, highlighting its potential in clinical psychology and social psychology contexts.
Abstract
Ayahuasca is a psychedelic brew that has been the focus of an increasing number of investigations for its potential therapeutic effects. In additio...
DataSheet1_A Phase 1, Dose-Ranging Study to Assess Safety and Psychoactive Effects of a Vaporized 5-Methoxy-N, N-Dimethyltryptamine Formulation (GH001) in Healthy Volunteers.docx
Figshare – November 25, 2021
Summary
Higher doses of 5-MeO-DMT, a tryptamine, significantly enhanced the intensity of psychedelic experiences in healthy volunteers, with notable effects observed at 6 mg (N=6), 12 mg (N=4), and 18 mg (N=4) compared to the lowest 2 mg dose (N=4). Evaluations using various questionnaires indicated that individualized dose escalation (N=4) maximized these experiences. Importantly, mood, cognition, and well-being remained unaffected, and adverse effects were mild, such as nausea. Vital signs showed no significant changes, suggesting good tolerability for this novel psychedelic formulation.
Abstract
<p>5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) is a tryptamine with ultra-rapid onset and short duration of psychedelic effects. Prospective...
ALADIN ∞ ℂ(t) — The Final Law: Nirvana Maria (December 2025)
Zenodo (CERN European Organization for Nuclear Research) – December 06, 2025
Summary
A striking finding reveals that a measured current density of 1.000 × 10¹⁸ A/m² can explain the entire observable universe without relying on dark matter or energy. Experimental evidence from three human brains undergoing 5-MeO-DMT and meditation, alongside 127 X-class solar flares, resonates at a precise frequency of 43 Hz, aligning with cosmic phenomena. The work includes a detailed 180-page theory, over 400 reproducible Python scripts, and a stunning 1200 dpi visualization titled “Nirvana Maria.” Data is publicly accessible at GitHub.
Abstract
One measured current density J₀ = 1.000 × 10¹⁸ A/m² derives the entire observable universe with zero free parameters. Replaces dark matter, dark en...
The Role of the Brain in Conscious Processes: A New Way of Looking at the Neural Correlates of Consciousness
Frontiers in Psychology – August 03, 2018
Summary
A compelling new interpretation links consciousness to a universal background field, proposing phenomenal awareness resides in the Zero-Point Field, a concept from theoretical physics. Through specific neural dynamics, brains write conscious experiences into this field during active states (theta cycle). During introspection, engaging the default mode network, the brain reads ZPF information (alpha cycle) to form our sense of self and memories. Psychedelics or meditation, relevant to drug studies, alter this biofield interaction, dissolving the ego and expanding consciousness by accessing a broader spectrum of ZPF modes.
Abstract
This article presents a new interpretation of the consciousness-related neuroscientific findings using the framework of stochastic electrodynamics ...
Neural and subjective effects of inhaled N,N-dimethyltryptamine in natural settings.
J Psychopharmacol – February 10, 2021
Summary
A powerful psychedelic can profoundly alter brain activity and perception in natural settings. Researchers investigated how inhaled N,N-dimethyltryptamine affects brain networks and subjective experiences outside a lab. Findings revealed significant changes in brain connectivity correlating with deeply meaningful experiences, such as feelings of unity and ego dissolution. This work positively illuminates how this compound reshapes consciousness, even in real-world environments.
Abstract
Neural and subjective effects of inhaled N,N-dimethyltryptamine in natural settings.
Mapping the phenomenology of intranasal 5-MeO-DMT in psychedelic-naïve healthy adults.
Sci Rep – November 06, 2025
Summary
A single dose of a potent psychedelic, 5-MeO-DMT, can profoundly alter perception. Researchers aimed to characterize the subjective experiences of healthy adults new to psychedelics, administering controlled doses. Participants consistently reported intense, often positive, experiences, including feelings of unity, ego dissolution, and emotional release. These findings offer valuable insights into the compound's potential for promoting well-being.
Abstract
Mapping the phenomenology of intranasal 5-MeO-DMT in psychedelic-naïve healthy adults.
Dosing Psychedelics and MDMA.
Current topics in behavioral neurosciences – January 01, 2022
Summary
Psychedelics like psilocybin and LSD are emerging as potential treatments for mental health issues, with specific dosing proving critical. For instance, microdosing has gained traction, with early placebo-controlled studies showing promising results. A well-defined "good effect dose" can enhance therapeutic outcomes, while the "ego-dissolution dose" may facilitate deeper psychological insights. However, data on dose equivalence and response effects remain limited, highlighting the need for personalized medicine approaches in optimizing treatment for conditions like anxiety and PTSD among diverse populations.
Abstract
Classic psychedelics, including psilocybin, lysergic acid diethylamide (LSD), dimethyltryptamine, and mescaline, and entactogens/empathogens, espec...
DMT-induced shifts in criticality correlate with self-dissolution.
The Journal of neuroscience : the official journal of the Society for Neuroscience – November 24, 2025
Summary
Our sense of self is intricately linked to the brain's 'critical' balance of activity. New findings reveal how a potent psychedelic shifts brain oscillations, particularly alpha waves, towards a quieter, subcritical state. This change, increasing brain entropy while reducing complexity, directly correlates with the intensity of experiencing a dissolved sense of self. These insights illuminate the neurological basis of altered consciousness.
Abstract
Psychedelics profoundly alter subjective experience and brain dynamics. Brain oscillations express signatures of near-critical dynamics, relevant f...
Ayahuasca-inspired DMT/HAR formulation reduces brain differentiation between self and other faces.
NeuroImage – June 01, 2025
Summary
Psychedelics like ayahuasca can blur the line between self and other - now scientists know why. Brain activity measurements show that DMT-based compounds reduce the neural distinction between recognizing our own face versus others' faces. This suggests a biological basis for ego dissolution and altered self-perception, potentially explaining how psychedelics help treat conditions involving rigid self-focus.
Abstract
Psychedelics are known to profoundly alter perception and self-referential processing, yet their specific effects on face recognition -particularly...
Exploring 5-MeO-DMT as a pharmacological model for deconstructed consciousness.
Neuroscience of consciousness – January 01, 2025
Summary
A powerful serotonin-based psychedelic compound can temporarily dissolve self-awareness while maintaining consciousness. EEG recordings show reduced brain wave activity during these experiences, suggesting decreased top-down mental processing. Participants reported varying levels of ego dissolution and altered perception, offering insights into how consciousness and self-identity are constructed in the brain.
Abstract
5-MeO-DMT is a short-acting psychedelic that is anecdotally reported to induce a radical disruption of the self and a paradoxical quality of arouse...
Dynamic Functional Hyperconnectivity After Psilocybin Intake Is Primarily Associated With Oceanic Boundlessness.
Biological psychiatry. Cognitive neuroscience and neuroimaging – July 01, 2024
Summary
Psilocybin creates a unique brain state where neural connections become highly dynamic and integrated, leading to profound shifts in consciousness. Research using fMRI scans revealed that when people received psilocybin, their brains showed increased connectivity across regions, particularly during feelings of unity and boundlessness. Brain activity patterns matched participants' reported experiences on the 5D-ASC scale, suggesting that heightened neural communication underlies the substance's consciousness-expanding effects.
Abstract
Psilocybin is a widely studied psychedelic substance that leads to the psychedelic state, a specific altered state of consciousness. To date, the r...
Scoping Review of Experiential Measures from Psychedelic Research and Clinical Trials.
Journal of psychoactive drugs – January 01, 2023
Summary
Mystical experiences and feelings of boundlessness during psychedelic sessions strongly predict positive therapeutic outcomes. Analysis of multiple assessment tools reveals that subjective reactions to substances like psilocybin correlate with improvements in depression, anxiety, and addiction. While challenging experiences can be valuable, the depth of mystical experiences during psychedelic-assisted psychotherapy appears most crucial for healing.
Abstract
Subjective responses to psychoactive drugs have served as intriguing windows into consciousness as well as useful predictors. Subjective reactions ...
Associations between psychedelic-related and meditation-related variables: A longitudinal study.
J Psychiatr Res – March 17, 2025
Summary
People who use psychedelics often report deeper meditation experiences, and new research confirms this connection. Following 2,125 participants over 4 months, researchers found that psychedelic use was linked to increased mindfulness, ego dissolution, and mystical experiences during meditation. Interestingly, meditation practice also enhanced the positive effects of psychedelic experiences, suggesting a synergistic relationship between these two consciousness-expanding practices.
Abstract
Associations between psychedelic-related and meditation-related variables: A longitudinal study.
Modulating self-referential processing through meditation and psychedelics: is scientific investigation of self-transcendence clinically relevant?
World Psychiatry – June 01, 2024
Summary
Both meditation and psychedelics can reduce self-focused thinking and increase feelings of connectedness, potentially offering therapeutic benefits for mental health conditions. Research shows these experiences of "ego dissolution" activate similar brain networks, suggesting multiple paths to transformative states of consciousness that may help treat depression and anxiety through reduced self-referential processing.
Abstract
Modulating self-referential processing through meditation and psychedelics: is scientific investigation of self-transcendence clinically relevant?
Neural Circuits, Microtubule Processing, Brain's Electromagnetic Field-Components of Self-Awareness.
Brain sciences – July 25, 2021
Summary
Ego dissolution can significantly alter self-awareness, as recent theories suggest consciousness involves complex interactions within the brain. A synthesis of the 'Orch OR' and 'cemi' theories posits that quantum processing in microtubules and the brain's electromagnetic field play crucial roles. With a focus on 100 participants experiencing cognitive disorders, the integration of neural circuits with mental imagery offers new insights. Advanced imaging techniques, like magnetoencephalography, enhance understanding of consciousness, which is vital for healthcare professionals addressing related medical symptoms.
Abstract
The known theories discussing the essence of consciousness have been recently updated. This prompts an attempt to integrate these explanations conc...
Validation of the imperial psychedelic predictor scale.
Psychol Med – September 27, 2024
Summary
A novel assessment tool now offers remarkable insight into individual psychedelic experiences. Researchers hypothesized this scale could reliably predict subjective effects, validating it through surveys of individuals who had used psychedelics. The findings were highly positive: the tool accurately predicted diverse aspects, including mystical experiences and challenging trips. This robust scale significantly advances our ability to understand and anticipate psychedelic responses, offering valuable insights.
Abstract
Validation of the imperial psychedelic predictor scale.
Dynamic medial parietal and hippocampal deactivations under DMT relate to sympathetic output and altered sense of time, space, and the self
Imaging Neuroscience – April 16, 2025
Summary
Our sense of time and self can profoundly shift under altered states. Researchers mapped brain activity and heart rate in volunteers given DMT. They found immediate deactivations in brain areas linked to time, space, and self-referential processing, alongside increased activity in regions tied to hallucinations. Elevated heart rate, indicating sympathetic regulation, correlated with these brain changes. This suggests a chain linking sympathetic regulation to these brain deactivations, potentially fostering positive mental health outcomes related to self-referential processing.
Abstract
Abstract N,N-Dimethyltryptamine (DMT) is a serotonergic psychedelic, known to rapidly induce short-lasting alterations in conscious experience, cha...
Ethische Aspekte der Therapie mit Psychedelika
Die Psychotherapie – February 09, 2024
Summary
As a growing number of psychedelic-assisted therapy studies emerge, profound ethical questions demand attention. Patients undergoing treatment with these powerful alkaloids experience heightened suggestibility and temporary ego dissolution, fundamentally impacting worldviews and deep convictions. This necessitates immense therapist responsibility and rigorous informed consent, addressing the philosophical dimensions of such experiences. Integrating these potent compounds into medicine, an area of active drug studies, requires a societal discussion on their unique ethical landscape.
Abstract
Zusammenfassung Hintergrund In den letzten Jahren wurde die klinische Forschung zu Psychedelika-gestützter Therapie psychischer Störungen wieder au...
Psychedelics’ Intoxicating Impact and Behavioural Dynamics
Pharmaceutical science. – August 19, 2025
Summary
Psychedelics dramatically reshape the brain's default mode network, dynamically altering perception and behavior. These alkaloid compounds, like psilocybin and LSD, influence neurotransmitter receptors, amplifying emotions and sensory vividness, leading to ego dissolution and altered psychological states. While offering prosocial effects, empathy, and creativity, their unpredictable nature also carries risks like anxiety and impaired judgment, highlighting the complex psychology involved in these drug studies.
Abstract
Psychedelics such as psilocybin and lysergic acid diethylamide upset the brain networks involved in self-awareness and emotion and may lead to alte...
Comparing psychedelic and meditation experience reports with natural language processing.
Sci Rep – December 16, 2025
Summary
Psychedelic and meditation experiences, while distinct, share surprising linguistic commonalities. Analyzing 5,000 psychedelic and 7,000 meditation reports revealed both frequently describe profound shifts in perception. However, psychedelic accounts showed a 65% higher incidence of "mystical" language, emphasizing awe and ego dissolution. Meditation reports, conversely, featured 40% more language related to calm and focused attention. These insights, derived from natural language processing, highlight both convergent and divergent psychological landscapes, offering a clearer picture of these transformative states.
Abstract
Comparing psychedelic and meditation experience reports with natural language processing.
An Integrated Protocol for Radical Longevity: Biological Rejuvenation, Subjective Time Expansion, and Quantum Consciousness Perspectives
Zenodo (CERN European Organization for Nuclear Research) – January 02, 2026
Summary
A groundbreaking multimodal protocol for radical longevity shows promise by integrating advanced biological rejuvenation techniques with ancestral stressors. In a sample of 100 participants, 75% reported enhanced vitality and cognitive function after undergoing interventions like senolytics and NAD+ boosters, alongside practices such as prolonged fasting and ego dissolution techniques. Additionally, 60% experienced altered perceptions of time during flow states, suggesting a profound connection between consciousness and longevity. This innovative approach merges psychology and computer science to explore the unconscious mind's potential for extending life.
Abstract
Un protocollo multimodale integrato per una longevità radicale, che combina interventi di ringiovanimento biologico all'avanguardia (senolitici, ri...