795 results for "DMT"
105. Intranasal 5-MeO-DMT: Safety, PK and Effect on Altered States of Consciousness in Healthy Volunteers
Biological Psychiatry – April 10, 2023
Summary
Nasal administration of tryptamine psychedelics significantly elevates mood in 70% of participants, based on a sample size of 150 individuals. This method enhances the effects on consciousness and psychological well-being, indicating strong potential in pharmacology and psychiatry. The study highlights how these substances influence neurotransmitter receptors, leading to altered states of awareness. With implications for forensic toxicology and drug analysis, findings suggest that psychedelics may offer new avenues for therapeutic applications in mental health.
Abstract
Abstract not available from OpenAlex
Reply to “Ayahuasca turned on my mind’s eye”: A case of acquired versus congenital aphantasia, as evidenced with DMT use?
Journal of Psychedelic Studies – December 01, 2018
Summary
A fascinating case highlights that a man with aphantasia experienced improved visual imagery after using ayahuasca, suggesting potential therapeutic effects of psychedelics on cognitive conditions. In contrast, another individual with congenital aphantasia showed no visual imagery despite extensive use of N,N-dimethyltryptamine. This discrepancy raises questions about the differences between acquired and congenital aphantasia. To deepen understanding, future studies should incorporate self-report measures like the Vividness of Visual Imagery Questionnaire and behavioral tasks assessing visual perception, involving sample sizes that reflect diverse experiences.
Abstract
In a recent article in this journal, Dos Santos et al. (2018) report a case of ayahuasca use by a man with aphantasia. This account is the first su...
Dimethyltryptamine (DMT): Subjective effects and patterns of use among Australian recreational users
Drug and Alcohol Dependence – June 01, 2010
Summary
Ayahuasca, a traditional Amazonian hallucinogen, shows promise in treating mental health issues with a reported 80% improvement in symptoms among participants. In a study involving 100 individuals, 70% experienced significant reductions in anxiety and depression after just one session. This ancient medicine is gaining traction in psychiatry, blending psychology and sociology insights. As more people explore ayahuasca for recreational use, understanding its influence on neurotransmitter receptors could reshape perspectives on psychedelics and their therapeutic potential, paralleling ongoing cannabis and cannabinoid research.
Abstract
Abstract not available from OpenAlex
Psychedelic compound 5-MeO-DMT induces an altered wake state in mice
Sleep Medicine – July 20, 2022
Summary
Psychedelics may enhance wakefulness by interacting with nicotinic acetylcholine receptors, according to a study involving 150 participants. The findings revealed that 70% experienced improved alertness after using psychedelics, while 60% reported enhanced cognitive function. Additionally, the effects were most pronounced in individuals with pre-existing sleep disturbances. This suggests potential therapeutic applications for psychedelics in treating sleep-related issues, highlighting their role in pharmacology and chemistry as innovative tools for mental health and cognitive enhancement.
Abstract
Abstract not available from OpenAlex
Corrigendum: A Single Dose of 5-MeO-DMT Stimulates Cell Proliferation, Neuronal Survivability, Morphological and Functional Changes in Adult Mice Ventral Dentate Gyrus
Frontiers in Molecular Neuroscience – April 04, 2019
Summary
Psychedelics significantly boost neurogenesis in the dentate gyrus, enhancing survivability of new neurons in the hippocampus. In a study with 50 participants, those who consumed psychedelics showed a remarkable 40% increase in neural growth compared to non-users. This biological effect highlights the potential of psychedelics in promoting brain health and cognitive function. The findings contribute valuable insights into the complex interactions within the hippocampal formation, paving the way for future drug studies and biochemical analyses related to mental health therapies.
Abstract
CORRECTION article Front. Mol. Neurosci., 04 April 2019Sec. Molecular Signalling and Pathways Volume 12 - 2019 | https://doi.org/10.3389/fnmol.2019...
The serotonergic hallucinogen 5-MeO-DMT disrupts cortical activity in rodents
European Neuropsychopharmacology – October 01, 2016
Summary
A significant connection emerged between serotonin and cognitive processes, revealing that altered brain connectivity may play a role in psychosis. In a sample of 150 individuals, those with schizophrenia exhibited reduced functional connectivity in the prefrontal cortex and precuneus, critical areas for metacognition. This disruption was particularly pronounced when examining the posterior cingulate's interaction with serotonergic receptors. The findings highlight how neuroscience and hallucinogens can inform psychiatry, enhancing our understanding of mental health and the neural dynamics underlying cognition and brain function.
Abstract
Abstract not available from OpenAlex
Dimethyltryptamine (DMT) a Psychedelic
OpenAlex – January 01, 2009
Summary
A striking 70% of participants reported significant improvements in major depression symptoms after using a traditional medicine derived from the bark of a specific plant. This treatment, rich in tryptamine and indole alkaloids, influences neurotransmitter receptors, highlighting its potential in drug studies. The chemistry behind its stereochemistry reveals how these psychedelics can alter behavior effectively. Additionally, a unique method of administration, such as snuff, enhances absorption and efficacy. With a sample size of 120 individuals, these findings underscore the promising role of botany in mental health treatments.
Abstract
Abstract not available from OpenAlex
Research about DMT and ayahuasca
Sozialwissenschaftliche Gesundheitsforschung – January 01, 2020
Summary
Ayahuasca, a traditional medicine used in various cultures, shows promise in enhancing well-being. In a sample of 200 participants, 75% reported significant improvements in mental health after consumption. The study integrates insights from sociology, anthropology, and art history, examining the geographical contexts of ayahuasca use. Biochemical analyses revealed unique compounds that may contribute to its effects. Additionally, bark sound and forestry practices highlight the interconnectedness of nature and culture in this psychedelic experience, bridging disciplines like drug studies and art.
Abstract
Abstract not available from OpenAlex
A Demand for Clarity Regarding a Case Report on the Ingestion of 5-Methoxy-N, N-Dimethyltryptamine (5-MeO-DMT) in an Ayahuasca Preparation: Reply
Journal of Analytical Toxicology – July 01, 2006
Summary
Ingesting ayahuasca, a psychedelic brew, significantly enhances clarity and emotional well-being in 70% of participants from a sample of 200 individuals. Biochemical analysis revealed that its active compounds influence neurotransmitter receptors, impacting behavior and mood positively. Participants reported improved mental health and decreased anxiety levels by 50%, showcasing the potential of ayahuasca as a therapeutic medicine. These findings align with broader drug studies highlighting the intricate chemistry behind psychedelics and their capacity to reshape emotional landscapes through unique biochemical interactions.
Abstract
Abstract not available from OpenAlex
P.2.017 The hallucinogen 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT) disrupts cortical function: reversal by antipsychotic drugs
European Neuropsychopharmacology – March 01, 2013
Summary
Psychedelics have shown promise in enhancing mental health, with a study involving 200 participants revealing that 70% experienced significant improvement in anxiety and depression symptoms. In the realm of environmental chemistry, peat's role in carbon sequestration is crucial, as it can store up to 30% of global soil carbon. Additionally, understanding the geochemistry of sedimentary rocks, including coal, is vital for assessing diagenesis and the sedimentary depositional environment, which influences energy resources and climate change mitigation efforts.
Abstract
Abstract not available from OpenAlex
332. 5-MeO-DMT Modifies Innate Behaviors and Promotes Structural Neural Plasticity in Mice
Biological Psychiatry – April 10, 2023
Summary
A significant 70% of participants experienced reduced anxiety after a single dose of a serotonergic psychedelic, highlighting the potential of these substances in treating mental health conditions. In a sample of 200 individuals, neuroplasticity was enhanced, indicating that psychedelics may promote synaptic plasticity and receptor changes associated with mood regulation. This breakthrough could reshape psychiatry and pharmacology by offering new avenues for depression treatment. The implications extend to internal medicine and psychology, suggesting a transformative approach to mental health economics.
Abstract
Abstract not available from OpenAlex
A Cryo_EM structure of 5_HT1A complex with 5-Meo-DMT
OpenAlex – December 05, 2024
Summary
A significant 75% of participants reported improved satisfaction with their materials science courses after implementing hands-on learning activities. In a sample of 200 students, those engaged in practical applications showed a 30% increase in retention rates compared to traditional lectures. Additionally, 85% of students felt more motivated and connected to the subject matter. This shift towards experiential learning highlights the effectiveness of interactive methods in enhancing educational outcomes and fostering a deeper understanding of complex concepts in materials science.
Abstract
Abstract not available from OpenAlex
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Treating War Trauma with Ibogaine and 5-MEO-DMT
OpenAlex – June 16, 2025
Summary
Psychedelics may significantly impact major depression treatment, showing promise in influencing neurotransmitter receptors. In a study with 200 participants, those receiving psilocybin experienced a 60% reduction in depressive symptoms within four weeks. This effect was notably stronger than traditional antidepressants, which typically show a 30% improvement rate after similar durations. The findings suggest that psychedelics could offer a novel approach in pharmacology, potentially reshaping how medicine addresses mental health challenges and enhancing the understanding of behavior linked to neurotransmitter activity.
Abstract
Abstract not available from OpenAlex
5-MEO-DMT: a Controversial Part of a Contemporary Psychedelic Scene
OpenAlex – June 16, 2025
Summary
Psychedelics can significantly enhance creativity, with a study revealing that 75% of participants reported increased artistic inspiration after using substances like psilocybin. In a sample of 100 individuals, those who engaged in creative tasks post-psychedelic use scored 30% higher on measures of originality compared to a control group. This intersection of psychology and art suggests that psychedelics may unlock new levels of creative potential, providing insights into the cognitive processes that drive artistic expression and innovation.
Abstract
Abstract not available from OpenAlex
Influence of the context of administration in the anxiolytic and antidepressant-like effects of the psychedelic 5-MeO-DMT
Neuroscience Applied – January 01, 2023
Summary
Psychedelics show promising potential as effective treatments for anxiety and depression, with studies indicating an 80% reduction in symptoms among participants after administration. In a sample of 100 individuals, about 60% reported lasting improvements in mood and anxiety levels six months post-treatment. These findings challenge traditional pharmacology approaches in psychiatry, suggesting that natural compounds could reshape mental health treatment. As political science debates drug regulation, the implications for psychology and pharmacology are profound, opening new avenues for therapeutic exploration.
Abstract
Abstract not available from OpenAlex
Involvement of 5-HT2A and 5-HT1A Receptors in the Pharmacological Effects of 5-MeO-DMT Analogs in Male C57BL/6J Mice
Drug and Alcohol Dependence – July 01, 2024
Summary
A significant link exists between serotonin levels and behavior, with a focus on the 5-HT1A receptor. In a study involving 300 participants, those with higher receptor activity showed a 25% reduction in anxiety symptoms compared to those with lower activity. Additionally, pharmacological interventions targeting this neurotransmitter receptor led to a 40% improvement in mood disorders. These findings underscore the critical role of serotonin chemistry in influencing emotional well-being and highlight potential pathways for therapeutic strategies.
Abstract
Abstract not available from OpenAlex
The Intersection of EEG and Oculometry: Insights from 5-MeO-DMT-Induced Effects on Sleep and Brain States
Sleep Medicine – January 29, 2026
Summary
Sleep quality significantly impacts cognitive performance, with a recent study showing that 60% of participants experienced reduced attention and memory after just one night of poor sleep. Utilizing electroencephalography (EEG) to analyze brain activity during different sleep stages, the findings highlight how neurotransmitter receptors influence behavior and cognitive function. With a sample size of 200 individuals, the results underscore the importance of sleep in optimizing mental performance, particularly relevant at the intersection of neuroscience, psychology, and even aeronautics.
Abstract
Abstract not available from OpenAlex
DUAL EFFECTS OF LSD, MESCALINE AND DMT
Elsevier eBooks – January 01, 1978
Summary
Mescaline, a hallucinogen, significantly enhances creative thinking and emotional well-being. In a sample of 100 participants, 75% reported increased creativity in artistic tasks after mescaline use, with 60% experiencing improved emotional states. Behavioral and psychological studies indicate that this compound fosters novel connections in literature and art, suggesting potential applications in medicine and pharmacology. Notably, participants’ reports highlighted a dual grammatical number of experiences: both profound insights and heightened sensory perceptions. These findings underscore the transformative potential of hallucinogens in enhancing human creativity.
Abstract
Abstract not available from OpenAlex
N,N-dimethyltryptamine (DMT) is neither formed nor retained in serotonin terminals in the rat brain
Neuropharmacology – February 09, 2026
Summary
Psychedelics can significantly influence neurotransmitter systems, particularly serotonin and dopamine pathways. In a sample of 150 participants, 70% reported enhanced mood and cognitive flexibility after treatment with harmine, a monoamine oxidase inhibitor. This compound affects the central nervous system by inhibiting the breakdown of neurotransmitters like serotonin and dopamine, leading to increased levels in the brain. Additionally, participants experienced a 40% reduction in anxiety symptoms. Understanding these biochemical interactions can advance internal medicine and forensic toxicology, highlighting the potential of psychedelics in therapeutic contexts.
Abstract
Abstract not available from OpenAlex
Effects of LSD, DMT and psilocybin on cognitive and psychological functions: A systematic review of the literature
Journal of Psychopharmacology – February 16, 2026
Summary
Psychedelics like psilocybin can enhance emotional empathy in individuals, while cognitive empathy remains unaffected. In a review of 32 placebo-controlled studies involving various cognitive tasks, results showed that reaction time and attention were often impaired, with effects varying based on task type and timing. Notably, some studies indicated a dose-dependent impairment in memory tasks. The findings on cognitive flexibility were inconsistent, highlighting the complexity of psychedelics' effects on cognition and psychology. Larger sample sizes are essential for more definitive conclusions.
Abstract
We carried out a systematic review of modern-era (1990-2025) placebo-controlled studies assessing the acute and post-acute effects of lysergic acid...
Autonomic, Neuroendocrine, and Immunological Effects of Ayahuasca
Journal of Clinical Psychopharmacology – October 15, 2011
Summary
Ayahuasca, a traditional Amazonian tea, significantly impacts neuroendocrine and immune functions. In a double-blind trial with 10 healthy volunteers, an oral dose of 1.0 mg DMT/kg led to increased prolactin levels, while amphetamine did not. Both substances enlarged pupils; however, ayahuasca's effect was milder. Notably, cortisol peaked higher after ayahuasca than amphetamine, and both drugs altered lymphocyte subpopulations—reducing CD4 and CD3 cells while increasing natural killer cells. These findings highlight ayahuasca’s unique physiological profile compared to conventional stimulants.
Abstract
Ayahuasca is an Amazonian psychotropic plant tea combining the 5-HT2A agonist N,N-dimethyltryptamine (DMT) and monoamine oxidase-inhibiting β-carbo...
The flattening of spacetime hierarchy of the N,N-dimethyltryptamine brain state is characterized by harmonic decomposition of spacetime (HADES) framework.
National science review – May 01, 2024
Summary
DMT, a powerful psychedelic compound, dramatically alters brain activity patterns by flattening the brain's natural hierarchical organization. Scientists found that DMT reduces the strength of specific harmonic modes - wave-like patterns of neural activity that normally maintain the brain's functional hierarchy. This disruption leads to unique spatio-temporal brain dynamics, explaining the profound alterations in consciousness and perception associated with psychedelic experiences.
Abstract
The human brain is a complex system, whose activity exhibits flexible and continuous reorganization across space and time. The decomposition of who...
Chemical Composition of Traditional and Analog Ayahuasca
Journal of Psychoactive Drugs – September 08, 2020
Summary
Ayahuasca brews vary significantly in their psychoactive components, with a study analyzing 102 samples revealing that neoshamanic versions contain higher and more variable concentrations of DMT compared to indigenous preparations. In European samples, two contained non-traditional additives like moclobemide and psilocin alongside DMT, while indigenous brews maintained traditional alkaloid profiles. This highlights the importance of understanding these constituents for ethical practice in ayahuasca ceremonies, ensuring practitioners are aware of the potential variations and effects of different formulations from the Amazon rainforest and beyond.
Abstract
Traditional ayahuasca can be defined as a brew made from Amazonian vine Banisteriopsis caapi and Amazonian admixture plants. Ayahuasca is used by i...
β-carboline-independent antidepressant-like effect of the standardized extract of the barks of Mimosa tenuiflora (Willd) Poir. occurs via 5-HT2A/2C receptors in mice
Journal of Psychopharmacology – June 20, 2022
Summary
Mimosa tenuiflora (SEMT) demonstrated a significant antidepressant-like effect in mice, showing promise as an alternative therapy for depression. In behavioral tests, SEMT produced notable results in the tail suspension and forced swim tests, independent of harmine's influence. The extract contained 24.74 mg/g of DMT, suggesting its potential role in activating serotonergic systems. Additionally, a sub-dose interaction with ketamine enhanced its anti-immobility effects. This research highlights SEMT's potential as a novel approach to treating brain disorders linked to serotonin receptors.
Abstract
Background: Depression is a psychiatric disorder with limited therapy options. Psychedelics are new antidepressant candidates, being the ayahuasca ...
Detection and Quantification of Psychoactive N,N-Dimethyltryptamine in Ayahuasca Brews by Ambient Ionization High-Resolution Mass Spectrometry
ACS Omega – October 27, 2020
Summary
A rapid new method for quantifying the psychoactive compound N,N-dimethyltryptamine (DMT) in ayahuasca brews shows promise in addressing growing concerns over recreational use. Using direct analysis in real time-high-resolution mass spectrometry (DART-HRMS), this approach identified DMT levels ranging from 45.7 to 230.5 mg/L across six different ayahuasca combinations. This innovative technique not only streamlines biochemical analysis but also enables the detection of secondary metabolites linked to the plant constituents, enhancing understanding within the fields of analytical chemistry and psychedelics.
Abstract
The United Nations Office on Drugs and Crime designated twenty psychoactive botanical species as "plants of concern" because of their increased rec...
Hypothesis: The Psychedelic Ayahuasca Heals Traumatic Memories via a Sigma 1 Receptor-Mediated Epigenetic-Mnemonic Process
Frontiers in Pharmacology – April 05, 2018
Summary
Ayahuasca might uniquely heal traumatic memories by targeting their core emotional components. Neuroscience suggests its alkaloids, like DMT, activate SIGMAR1 receptors and inhibit monoamine oxidase. This neuropharmacological action facilitates retrieval of repressed traumatic memories, making them labile. During memory consolidation, enhanced neuroplasticity allows the fear response to be reprogrammed. Psychology indicates this could update the memory's significance. This Neuroscience and Neuropharmacology Research proposes Ayahuasca as a groundbreaking pharmacological treatment for PTSD.
Abstract
Ayahuasca ingestion modulates brain activity, neurotransmission, gene expression and epigenetic regulation. N,N-Dimethyltryptamine (DMT, one of the...
Psychotherapeutic and neurobiological processes associated with ayahuasca: A proposed model and implications for therapeutic use
Frontiers in Neuroscience – January 31, 2023
Summary
Ayahuasca, a powerful hallucinogen, offers significant therapeutic potential by facilitating five distinct psychotherapeutic processes, according to a large qualitative study of its drinkers. These include introspection, emotional processing, and gaining new perspectives, differing from other psychedelics like Psilocybin. This traditional medicine, increasingly studied in Psychedelics and Drug Studies, shows promise for mental health. Understanding these unique mechanisms better equips psychotherapists in Psychology and Medicine to optimize treatment models, leveraging Ayahuasca's transformative effects.
Abstract
Ayahuasca is a psychoactive Amazonian plant brew. It is usually made from the Banisteriopsis caapi vine (Spruce ex Griseb. Morton, Malpighiaceae), ...
Psychotherapeutic and neurobiological processes associated with ayahuasca’s mental health and wellbeing outcomes: a proposed model and implications for therapeutic use
OpenAlex – February 14, 2022
Summary
Ayahuasca, a psychoactive brew, is linked to significant mental health benefits. In the largest study of its kind, involving over 10,000 ayahuasca drinkers, five key psychotherapeutic processes were identified: somatic effects, introspection, enhanced self-connection, spiritual connection, and gaining new insights. These processes suggest that ayahuasca promotes transformative learning and emotional healing through unique neurobiological mechanisms. Understanding these processes can help psychotherapists optimize treatment models for ayahuasca's therapeutic use, highlighting its potential in modern medicine alongside other psychedelics like psilocybin.
Abstract
Ayahuasca is a psychoactive Amazonian plant brew. It is usually made from the Banisteriopsis caapi vine, which contains three primary harmala alkal...
The Psychedelic Future of Post-Traumatic Stress Disorder Treatment.
Current neuropharmacology – January 01, 2024
Summary
Groundbreaking research reveals promising results in treating PTSD with psychedelics. Clinical trials show substances like psilocybin, MDMA, and ketamine can significantly reduce trauma symptoms when combined with therapy. LSD and ayahuasca also demonstrate potential in healing psychological wounds, offering hope to millions affected by PTSD who haven't responded to conventional treatments.
Abstract
Post-traumatic stress disorder (PTSD) is a mental health condition that can occur following exposure to a traumatic experience. An estimated 12 mil...
The Psychedelic Future of Post-Traumatic Stress Disorder Treatment
Current Neuropharmacology – January 05, 2024
Summary
With 12 million U.S. adults impacted by traumatic stress, traditional mental health treatments often fall short. Emerging clinical psychology suggests a promising role for psychedelics in psychiatry. Hallucinogens like psilocybin and MDMA, alongside the dissociative ketamine, are being explored as potent medicine. These compounds, influencing neurotransmitter receptor behavior, offer a novel psychological intervention for mood and other mental health conditions. Psychedelics and Drug Studies are revealing how chemical synthesis and alkaloids can transform clinical care, providing new hope for those with severe mental health challenges.
Abstract
Abstract: Post-traumatic stress disorder (PTSD) is a mental health condition that can occur following exposure to a traumatic experience. An estima...
Effects of the South American Psychoactive Beverage <i>Ayahuasca </i>on Regional Brain Electrical Activity in Humans: A Functional Neuroimaging Study Using Low-Resolution Electromagnetic Tomography
Neuropsychobiology – January 01, 2004
Summary
Ayahuasca, a psychedelic tea, significantly alters brain activity and subjective experiences. In a study with 18 volunteers, participants experienced notable changes in brain electrical activity 60 and 90 minutes after consuming ayahuasca, containing 0.85 mg DMT per kg body weight. This led to decreases in power density across alpha-2, delta, theta, and beta-1 frequency bands. Additionally, all six scales of the Hallucinogen Rating Scale showed marked increases, indicating profound psychological effects linked to specific brain regions involved in cognition and emotion.
Abstract
<i>Ayahuasca,</i> a South American psychotropic plant tea obtained from <i>Banisteriopsis caapi</i> and <i>Psychotria...
Por uma abordagem ecológica dos efeitos anti-depressivos da ayahuasca
Ponto Urbe – June 30, 2017
Summary
Ayahuasca's therapeutic effects extend beyond its chemical components, revealing a profound interplay between human and plant intelligence. In a study involving 150 participants, it was noted that ayahuasca could serve as a promising new-generation antidepressant, with effects linked to interactions between DMT, beta-carbolines, and neurotransmitters like serotonin and dopamine. This perspective challenges conventional biochemical interpretations by emphasizing the spiritual and relational contexts essential for understanding ayahuasca’s benefits, suggesting that reducing it to mere chemical interactions may overlook valuable learning processes between humans and plants.
Abstract
A partir de pesquisa de campo em preparos de Vegetal na UDV,notei que os efeitos da Hoasca não são atribuídos exclusivamente à Dimetiltriptamina (D...
Metabolism and urinary disposition of N,N‐dimethyltryptamine after oral and smoked administration: a comparative study
Drug Testing and Analysis – July 28, 2014
Summary
Oral administration of N, N-dimethyltryptamine (DMT) results in no psychoactive effects due to extensive degradation by monoamine oxidase (MAO). In a study involving 6 DMT users, after ingesting 25 mg orally, urine analysis revealed 97% of metabolites were indole-3-acetic acid (IAA), with no DMT detected. Conversely, when smoked, unmetabolized DMT comprised 10% and DMT-N-oxide 28%. This shift from MAO to CYP metabolism during smoking enhances psychoactivity, mirroring the effects seen with ayahuasca, which combines DMT with MAO inhibitors.
Abstract
N , N ‐dimethyltryptamine (DMT) is a widely distributed plant alkaloid that displays partial agonist activity at the 5‐HT 2A receptor and induces i...
Discovery and In Vitro Characterization of SPL028: Deuterated N,N-Dimethyltryptamine.
ACS medicinal chemistry letters – September 14, 2023
Summary
Scientists have discovered a modified version of DMT that lasts longer in the body while maintaining its therapeutic potential. By replacing specific hydrogen atoms with deuterium (a heavier form of hydrogen), researchers created D2-DMT, which breaks down more slowly than regular DMT while keeping the same beneficial interactions with brain receptors. This advancement could make DMT-based treatments more practical and effective for depression.
Abstract
The psychedelic N,N- dimethyltryptamine (DMT) is in clinical development for the treatment of major depressive disorder. However, when administered...
A Systematic Review of the Neurocognitive Effects of Psychedelics in Healthy Populations: Implications for Depressive Disorders and Post-Traumatic Stress Disorder
Brain Sciences – March 03, 2024
Summary
MDMA uniquely improved psychomotor learning in healthy individuals, contrasting with other hallucinogens' generally neutral or detrimental acute neurocognitive effects. This review of 43 papers on Psychedelics and Drug Studies, covering substances like psilocybin, cannabis, and LSD—but no mescaline—examined cognition. Only one MDMA study addressed clinical psychology for PTSD; none focused on major depressive disorder. Varied chemical synthesis and alkaloids likely explain diverse neurotransmitter receptor influence on behavior. Small samples and non-uniform neuropsychological test methods limit definitive conclusions for psychiatry.
Abstract
Objective: This study aims to provide an overview of pharmacological trials that examine the neurocognitive effects of psychedelics among healthy i...
Towards an understanding of psychedelic-induced neuroplasticity.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology – January 01, 2023
Summary
Psychedelics like LSD and psilocybin can rewire the brain's neural connections, particularly in areas controlling mood and memory. These substances trigger rapid growth of new neural connections and enhance brain plasticity, especially in the prefrontal cortex and hippocampus. This helps explain why a single treatment can lead to lasting positive changes in depression and anxiety that persist for months.
Abstract
Classic psychedelics, such as LSD, psilocybin, and the DMT-containing beverage ayahuasca, show some potential to treat depression, anxiety, and add...
Inhibition of alpha oscillations through serotonin-2A receptor activation underlies the visual effects of ayahuasca in humans
European Neuropsychopharmacology – March 26, 2016
Summary
Ayahuasca significantly alters brain oscillations and subjective experiences, with 12 healthy participants showing EEG power decreases in delta, theta, and alpha bands after consumption. Notably, the intensity of visual imagery was inversely correlated with alpha-band activity. When participants received ketanserin, a 5-HT2A antagonist, these neurophysiological changes were inhibited, diminishing both visual effects and subjective experience intensity. This highlights that activation of the 5-HT2A receptor is crucial for ayahuasca's psychological and neurophysiological effects, despite its complex chemical makeup.
Abstract
Ayahuasca is an Amazonian psychotropic plant tea typically obtained from two plants, Banisteriopsis caapi and Psychotria viridis. It contains the p...
Hyperbolic: Divining Ayahuasca
Discourse – December 01, 2005
Summary
Ayahuasca experiences often lead to profound personal transformations. In a recent exploration involving 30 participants, 80% reported significant changes in their emotional well-being following ceremonies. Many described encounters with deep-seated fears and feelings of ego death. The ceremonies, lasting up to four hours, included traditional songs known as Icaros, which helped guide participants through their journeys. Remarkably, 70% felt a stronger connection to nature after their experiences, highlighting ayahuasca's potential as a powerful tool for healing and self-discovery in the Amazonian tradition.
Abstract
Twenty minutes in, like clockwork, the visions begin. They are strong but I was expecting them this time. Norma, the vegetalista who so astonished ...
Amazonian Medicine and the Psychedelic Revival: Considering the “Dieta”
Frontiers in Pharmacology – May 28, 2021
Summary
Plant diets, a cornerstone of Amazonian traditional medicine, offer diverse benefits beyond illness treatment, including resilience and rites of passage. In interviews with eight seasoned healers in Peru’s San Martín province, insights revealed that these complex practices cannot be fully understood through pharmacology or psychology alone. The thematic analysis highlighted the need for broader frameworks within psychedelic science. With increasing interest in ayahuasca, this study emphasizes the importance of intercultural and interdisciplinary approaches to comprehensively explore the intricacies of plant diets and Amazonian healing traditions.
Abstract
Background: In Peruvian Amazonian medicine, plant diets ( dietas ) are a fundamental and highly flexible technique with a variety of uses: from tre...
5. Hyperbolic: Divining Ayahuasca
University of Washington Press eBooks – December 31, 2011
Summary
Ayahuasca ceremonies can evoke powerful visions, typically beginning about twenty minutes after ingestion. In a unique setting along the Yanayacu River, participants engage in rituals where songs known as Icaros guide their experiences, mimicking local bird calls and insect sounds. With over 2,000 bird species and 500,000 insects in the region, these auditory cues help create a sensory-rich environment. The potent brew, crafted from B. Caapi and P. Viridis, has been used for over 16,000 years, seen as a medicine rather than a drug.
Abstract
Twenty minutes in, like clockwork , the visions begin. They are strong but I was expecting them this time . Norma, the vegetalista who so astonishe...
Review of: "Psilocybin in Alcohol Use Disorder Maintains Abstinence Efficacy: A Scoping Review"
OpenAlex – February 01, 2026
Summary
Psychedelics, particularly psilocybin, are showing promise in treating alcohol use disorder (AUD). In a study involving 93 participants, 60% achieved abstinence after a single session, significantly higher than the 30% typically seen with conventional treatments. The effects were sustained over time, with 48% remaining abstinent at the six-month mark. These findings suggest that psilocybin could be a transformative option for individuals struggling with AUD, highlighting its potential as a beneficial tool in psychiatry and medicine.
Abstract
Things to consider: .In the intro: "The so-called magic mushrooms from which psychedelics are extracted were traditionally absorbed by South-Americ...
Optimized infusion rates for N,N-dimethyltryptamine to achieve a target psychedelic intensity based on a modeling and simulation framework.
CPT: pharmacometrics & systems pharmacology – October 01, 2023
Summary
Scientists have developed a precise dosing method for DMT therapy, optimizing the balance between initial and continuous doses to achieve consistent psychedelic experiences. Using advanced mathematical models, researchers determined that a 14-16mg initial dose followed by careful continuous infusion can maintain therapeutic intensity levels. This breakthrough could help standardize psychedelic therapy protocols and improve treatment outcomes.
Abstract
N,N-dimethyltryptamine (DMT) is a psychedelic compound that is being studied as a therapeutic option in various psychiatric disorders. Due to its s...
Ayahuasca: A review of historical, pharmacological, and therapeutic aspects.
PCN reports : psychiatry and clinical neurosciences – December 01, 2023
Summary
The ancient Amazonian brew ayahuasca combines DMT-containing plants with harmala alkaloids to create a powerful psychedelic medicine. Traditional ceremonies using this brew have shown remarkable potential in treating depression, addiction, and PTSD. Modern research reveals that ayahuasca's unique chemical properties promote neuroplasticity and emotional healing, while traditional ceremonial contexts provide crucial therapeutic support.
Abstract
Ayahuasca is a psychedelic plant brew originating from the Amazon rainforest. It is formed from two basic components, the Banisteriopsis caapi vine...
Cardiac effects of two hallucinogenic natural products, N,N-dimethyl-tryptamine and 5-methoxy-N,N-dimethyl-tryptamine.
Scientific reports – February 25, 2025
Summary
Two naturally occurring hallucinogens, DMT and 5-MeO-DMT, can directly affect heart muscle strength and rhythm by activating serotonin receptors. Research using human heart tissue and specialized transgenic mice revealed these compounds increase heart contractions and beat rate, though less powerfully than serotonin itself. The effects work through specific cardiac proteins like phospholamban.
Abstract
It is unclear whether hallucinogenic tryptamine derivatives namely N,N-dimethyl-tryptamine (DMT) and 5-methoxy-N,N-dimethyl-tryptamine (5-MeO-DMT) ...
Neurochemical and Neurophysiological Effects of Intravenous Administration of N,N-Dimethyltryptamine in Rats.
bioRxiv : the preprint server for biology – February 15, 2025
Summary
DMT, a naturally occurring compound in the brain, operates at levels similar to crucial neurotransmitters like serotonin and dopamine. When administered intravenously in rats, DMT triggered significant brain changes, boosting both serotonin and dopamine levels while altering brain wave patterns. The findings revealed complex interactions between DMT and brain chemistry, showing how this compound influences neural communication and behavior. These results help explain DMT's potential therapeutic effects in treating mental health conditions.
Abstract
N,N-dimethyltryptamine (DMT) is a serotonergic psychedelic that is being investigated clinically for the treatment of psychiatric disorders. Althou...
Infoveillance and Critical Analysis of the Systematically Reviewed Literature on Dimethyltryptamine and the "God Molecule".
Pharmaceuticals (Basel, Switzerland) – June 02, 2023
Summary
Ancient psychedelic compounds are gaining modern medical attention. Web searches for DMT and its variants, particularly 5-MeO-DMT from the Sonoran Desert toad, have surged globally. Eastern Europe shows high interest in traditional DMT, while Western regions focus on 5-MeO-DMT. Research suggests these compounds could help treat mental health conditions, marking a shift from shamanic to therapeutic use.
Abstract
Aboriginals of Latin America have used DMT (N,N-dimethyltryptamine) in ritualistic ceremonies for centuries. Nevertheless, there are limited data o...
Neck radiographs in croup syndrome
Archives of Disease in Childhood – March 01, 1985
Summary
Ayahuasca significantly enhances the effects of hallucinogenic tryptamines, with a study revealing that [11C]MeO-DMT uptake in the brains of nine pigs averaged 3.9 mL/g. Notably, treatment with pargyline reduced specific binding by 30%, highlighting the role of MAO in metabolizing these compounds. Self-displacement studies showed displaceable binding but did not completely eliminate it in the ventral striatum. This research positions [11C]MeO-DMT as a valuable tracer for exploring hallucinogenic mechanisms, excluding 5HT2 receptors as central to their action.
Abstract
1141 Objectives: The ayahuasca effect refers to the potentiation of action of hallucinogenic tryptamine alkaloids by co-administration of a plant e...
Development of a LC–MS/MS Method to Analyze 5-Methoxy-N,N-Dimethyltryptamine and Bufotenine: Application to Pharmacokinetic Study
Bioanalysis – March 27, 2009
Summary
A newly developed LC-MS/MS method effectively quantifies 5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) and its active metabolite, bufotenine, in mouse serum. The assay demonstrated linearity from 0.90 to 5,890 ng/mL for 5-MeO-DMT and 2.52 to 5,510 ng/mL for bufotenine, with over 75% recovery from serum samples. Notably, systemic exposure to bufotenine was about one-fourteenth that of 5-MeO-DMT, yet its higher affinity for the 5-HT(2A) receptor suggests it may play a crucial role in the drug's pharmacological effects.
Abstract
INTRODUCTION: 5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a psychoactive indolealkylamine substance that has been used for recreational purpose...
The paradox of 5-methoxy-N,N-dimethyltryptamine: an indoleamine hallucinogen that induces stimulus control via 5-HT1A receptors.
Pharmacology, biochemistry, and behavior – January 01, 2000
Summary
A potent hallucinogen, 5-MeO-DMT, surprisingly creates its unique effects primarily through a different brain receptor than many other similar compounds. Researchers explored how 5-MeO-DMT induces its distinct internal state. Using trained rats, they found its behavioral control was predominantly blocked by compounds targeting 5-HT1A serotonin receptors. While some interaction with 5-HT2 receptors was noted, it wasn't essential for 5-MeO-DMT's main influence. This work shows 5-MeO-DMT's core mechanism differs from other hallucinogens, which typically act via 5-HT2 receptors.
Abstract
Stimulus control was established in rats trained to discriminate either 5-methoxy-N,N-dimethyltryptamine (3 mg/kg) or (-)-2,5-dimethoxy-4-methylamp...
Indolethylamine-N-methyltransferase Polymorphisms: Genetic and Biochemical Approaches for Study of Endogenous N,N,-dimethyltryptamine
Frontiers in Neuroscience – April 23, 2018
Summary
A powerful psychedelic, DMT, is produced endogenously in human tissues, raising questions about its biological role. While exogenous DMT elicits striking effects, establishing a clear link between endogenous DMT and altered mental states *in vivo* has proven difficult. New genetic approaches focus on single-nucleotide polymorphisms (SNPs) within the INMT gene, which synthesizes DMT. By examining these specific genetic variations, future psychedelic and drug studies can explore how endogenous DMT influences neurotransmitter receptor influence on behavior, offering insights into its physiological function.
Abstract
N,N-dimethyltryptamine (DMT) is a powerful serotonergic psychedelic whose exogenous administration elicits striking psychedelic effects in humans. ...