A new LC-MS/MS method was developed to simultaneously extract LSD, iso-LSD, 2-oxo-3-hydroxy-LSD, and 1-propionyl-LSD from hair samples. The method was applied to hair from 18 suspected LSD users. Segmental hair analysis showed LSD concentrations decreasing from the proximal to the distal end, while 1 P-LSD was not detected in any hair segments. The authors report concentrations of LSD and iso-LSD in human hair from 18 LSD users, but note that interpreting hair analysis results for LSD remains difficult.
Children who received esketamine before bronchoalveolar lavage under general anesthesia had significantly lower postoperative stress indicators than those who received no preoperative medication. In a matched analysis of 46 children per group, all measured stress responses were reduced. The findings suggest that preoperative esketamine can ease stress and improve recovery in pediatric patients undergoing this procedure.