Frontiers in psychology
January 1, 2024
Olga Tymofiyeva, Benjamin S Sipes, Tracy Luks et al.
7 citations
A 12-week mindfulness-based intervention (TARA) in healthy adolescents aged 14–18 increased white matter connectivity in interoceptive brain networks, including the right insula and right putamen. These brain changes were linked to improved sleep quality and emotional well-being. The intervention was delivered remotely and showed high feasibility and safety. The TARA group, but not controls, had significantly better sleep quality and increased insula node strength associated with emotional well-being. A white matter interoception network strengthened after TARA. The findings suggest TARA may improve psychological health in adolescents by enhancing structural connectivity in interoceptive regions.
Biochemical and biophysical research communications
July 8, 2025
Jiaxin Tian, Yanhong Xie, Sen Ye et al.
6 citations
A single acute dose of S-ketamine (10 mg/kg) given to mice with post-stroke depression (PSD) alleviated depressive-like behaviors for at least five days. The treatment reduced pro-inflammatory cytokines in the medial prefrontal cortex, increased dendritic spine density and synaptic proteins (SYP, PSD-95), and upregulated brain-derived neurotrophic factor (BDNF) along with related signaling molecules (TrkB, p-Akt, p-Erk, p-CaMKII, p-CREB). These findings suggest S-ketamine acts through anti-inflammatory, synaptic enhancing, and BDNF pathway modulating effects, offering promise for PSD treatment.
Psychophysiology
June 1, 2025
Yanfen Zhen, Pei Liu, Lin Jiang et al.
2 citations
Adolescents who engage in nonsuicidal self-injury (NSSI) show deficits in cognitive control, reflected in lower accuracy and sensitivity on an emotional go/no-go task, along with reduced P3 amplitude and theta power measured by EEG. A brief 10-minute deep breath meditation intervention, but not natural breath meditation, restored the decreased no-go theta power in these adolescents. Resting-state EEG microstate D, which reflects attention network activation, differed between meditation strategies and predicted NSSI remission one month later. The findings identify inhibition deficits and specific neural markers (P3, theta power, microstate D) that may aid diagnosis, track intervention effects, and forecast outcomes.
BMC psychology
July 23, 2025
Pei Liu, Buddahavamsa Yang Li, Juan Liu et al.
1 citation
A twelve-week program combining loving-kindness meditation and mindfulness of breathing appears feasible for adolescents who engage in nonsuicidal self-injury (NSSI) and their parents. Among 28 adolescents, NSSI behavior decreased significantly at the end of the program and at a three-month follow-up, and depressive symptoms decreased significantly at three months. Parents reported improved emotion regulation and parenting attitudes, and both adolescents and parents perceived better parent-child relationships. Satisfaction with the intervention was high (4.27 out of 5), and adolescent dropout was modest (14.2%), though parent dropout was 33%. Qualitative feedback indicated positive attitudes but challenges in sustaining practice. A larger randomized controlled trial is needed to confirm effectiveness.
British journal of hospital medicine (London, England : 2005)
June 25, 2025
Jizheng Zhang, Jiaming Zheng, Xiaohua Sun et al.
Children who received esketamine before bronchoalveolar lavage under general anesthesia had significantly lower postoperative stress indicators than those who received no preoperative medication. In a matched analysis of 46 children per group, all measured stress responses were reduced. The findings suggest that preoperative esketamine can ease stress and improve recovery in pediatric patients undergoing this procedure.