Psychopathology
January 1, 2017
Luís Madeira, Sergio Carmenates, Cristina Costa et al.
31 citations
People with panic disorder report anomalous self-experiences—disturbances in the sense of self—at levels comparable to those seen in schizophrenia, though the specific patterns differ. In a study of 47 panic disorder patients and 47 healthy controls, patients scored much higher on the Examination of Anomalous Self Experiences (average 17.94 vs. 1.00 in controls). These experiences included common forms of derealization and depersonalization, which may reflect defensive psychological processes rather than a fundamental disturbance of the minimal self. The findings support the idea that basic-self-disturbance is specific to schizophrenia, while panic disorder involves a different, less profound type of self-alteration that can resemble schizophrenia-like phenomena but requires careful differentiation.
Nature Medicine
June 14, 2023
Carolina Seybert, Gonçalo Cotovio, Luís Madeira et al.
24 citations
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Schizophrenia research
September 1, 2019
Luís Madeira, Elizabeth Pienkos, Teresa Filipe et al.
18 citations
People with first-episode psychosis often experience profound changes in how they perceive the world around them—including alterations in space, time, and other people—alongside disturbances in their sense of self. In a study comparing 24 outpatients with first-episode psychosis to 24 healthy controls, those with psychosis scored significantly higher on both the Examination of Anomalous World Experience (EAWE) and the Examination of Anomalous Self Experience (EASE). Scores on the two measures were strongly correlated, even after accounting for overlapping items. The types of world-experience anomalies varied widely among patients. These findings suggest that anomalous world experiences are a relevant feature of first-episode psychosis and may be linked to the self-disturbances thought to underlie schizophrenia spectrum disorders.
Philosophies
August 24, 2023
Nuno Azevedo, Miguel Oliveira Da Silva, Luís Madeira
11 citations
Psychedelics, which produce powerful mental effects by activating 5HT-2A receptors in the brain, were researched in the 1950s and 1960s until their criminalization. Their renewed clinical investigation as therapeutic tools for psychiatric disorders raises deontological ethical questions for clinicians, patients, and society. A review of 42 articles from 2017 to 2022 concludes that psychedelics must be culturally contextualized, epistemic harm minimized and represented to ensure informed consent. Open data and commissions are needed to guarantee safe and equal distribution.
Psychopathology
January 1, 2025
Stefan Jerotić, Janko Nešić, Vuk Vuković et al.
3 citations
Psychopharmacology is often reduced to treating biological symptoms while ignoring patients' subjective, embodied experience. This paper proposes an enactive and embodied framework that integrates phenomenology, neuroscience, and physiology to understand how psychotropic drugs affect the entire lived body—altering emotional processing, perception, existential feelings, and the embodied sense of self. Medications shape how patients engage with their environment, which in turn influences the embodied system. The clinician's role is to mediate these embodied changes, supporting patients through shifts in self-perception and relationality. The authors advocate for phenomenological drug profiles and patient-centered interventions that account for subjective and embodied changes alongside clinical efficacy.