Forensic science international
December 17, 2003
Kenji Tsujikawa, Tatsuyuki Kanamori, Yuko Iwata et al.
79 citations
Hallucinogenic mushrooms circulating in Japan were analyzed using scanning electron microscopy and high-performance liquid chromatography. Psilocybe cubensis contained psilocin (0.14–0.42%) and psilocybin (0.37–1.30%) in the whole mushroom, with higher concentrations in the cap than the stem. Copelandia species contained psilocin (0.43–0.76%) and psilocybin (0.08–0.22%) in the whole mushroom, again with more alkaloid in the cap. Psilocybe cubensis is psilocybin-rich, while Copelandia is psilocin-rich. The combination of SEM and optical microscopy was effective for observing characteristic fungal tissues such as basidiomycetes, spores, cystidia, and basidia.
Journal of analytical toxicology
March 1, 2002
Tatsuyuki Kanamori, Hiroyuki Inoue, Yuko Iwata et al.
61 citations
In rats, the psychoactive compound 2C-B is broken down into at least six distinct breakdown products through two main metabolic pathways. One pathway converts 2C-B into an aldehyde, which is then further processed into an alcohol and a carboxylic acid. The other pathway produces metabolites where a methyl group is removed from either the 2- or 5-position of the molecule, followed by acetylation of the amino group. These findings indicate that the body metabolizes 2C-B through multiple chemical changes, resulting in a variety of metabolites that are excreted in urine.
Forensic science international
December 20, 2006
Kenji Tsujikawa, Hiroyuki Mohri, Kenji Kuwayama et al.
51 citations
Chemical analysis of seven Amanita mushrooms sold in Japan (five Amanita muscaria and two Amanita pantherina) and four products labeled as extracts of A. muscaria found that the mushrooms contained the dissociative compounds ibotenic acid and muscimol at varying levels, with caps having higher concentrations than stems and flesh more than cuticle. In contrast, the extract products contained little to none of these compounds but instead held other psychoactive substances, including tryptamines, monoamine oxidase inhibitors, and tropane alkaloids, indicating adulteration.
Xenobiotica
November 3, 2008
Tatsuyuki Kanamori, Kenji Kuwayama, Kenji Tsujikawa et al.
11 citations
Alpha-methyltryptamine (AMT), a psychoactive tryptamine analogue, is metabolized in rats into at least four distinct compounds. After oral administration of 10 mg/kg to male Wistar rats, urine collected over 24 hours was enzymatically hydrolyzed, extracted, and analyzed by gas chromatography/mass spectrometry. The detected metabolites were 2-oxo-AMT, 6-hydroxy-AMT, 7-hydroxy-AMT, and 1'-hydroxy-AMT. These findings identify specific metabolic pathways for AMT, which may inform understanding of its pharmacological effects and duration of action.