Sueli Moreira Mello

Poison Control Center, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil.

2 papers in the library · 25 citations · publishing 2018-2021

Papers

Effect of Ritualistic Consumption of Ayahuasca on Hepatic Function in Chronic Users

Journal of Psychoactive Drugs December 22, 2018 Sueli Moreira Mello, Paula Christiane Soubhia, Gabriela de Oliveira Silveira et al. 15 citations

Ayahuasca, a beverage made from Banisteriopsis caapi and Psychotria viridis, contains monoamine oxidase inhibitors and N,N-dimethyltryptamine, which produces visionary effects. Despite concerns about liver injury from oral consumption, this study measured biochemical markers of liver damage in 22 volunteers who had consumed ayahuasca at least twice monthly for over a year. No significant changes were found in alanine aminotransferase, aspartate aminotransferase, bilirubin, creatinine, urea, lactate dehydrogenase, alkaline phosphatase, or gamma glutamyl transferase. Chronic ayahuasca use in a religious setting apparently does not impair hepatic function.

DOI: 10.1080/02791072.2018.1557355 Ayahuasca Decoction Context archaeology Harmaline +6

Kinetic profile of N,N-dimethyltryptamine and β-carbolines in saliva and serum after oral administration of ayahuasca in a religious context.

Drug testing and analysis March 1, 2021 Rafael Lanaro, Sueli Moreira Mello, Kelly Francisco da Cunha et al. 10 citations

After consuming ayahuasca, alkaloids such as DMT and β-carbolines reach higher peak concentrations and overall exposure in saliva than in serum, while their mean residence time is 1.5 to 3 times longer in serum. A statistical model suggests that serum concentrations can be predicted from saliva concentrations, though individual variability is large. Saliva offers a fast, noninvasive way to detect these alkaloids and could aid in identifying recreational use of similar compounds that pose intoxication risks.

DOI: 10.1002/dta.2955 Full text Ayahuasca Dimethyltryptamine Saliva Serum +1