In two independent trials with normal volunteers, 2,5-dimethoxy-4-methyl-amphetamine (the active chemical in the hallucinogenic drug STP) produced mild euphoria at low doses. Doses above 3 milligrams caused pronounced hallucinogenic effects lasting about 8 hours, similar to those from hallucinogenic doses of lysergic acid diethylamide, mescaline, and psilocybin. The compound is chemically related to both mescaline and amphetamine, about 100 times more potent as a hallucinogen than mescaline, and only one-thirtieth as potent as lysergic acid diethylamide. Chlorpromazine did not accentuate its psychological effects.
In a double-blind study, normal subjects given small doses of DOM (a hallucinogen related to mescaline and amphetamine, also known as STP) and its ethyl homologue DOET experienced increased self-awareness and mild euphoria without hallucinogenic or psychotomimetic effects. Both drugs freed up word associations without impairing memory or concentration; DOM even enhanced performance on serial learning tasks. DOM did not affect visual discrimination but altered perception of tachistoscopically presented TAT cards.