The drugs JB-336, psilocybin, ibogaine, and bufotenine all substantially reduced aggressiveness in isolated mice and suppressed muricide (mouse-killing) behavior in rats. The magnitude of this anti-aggressive effect depended on how long the animals had been isolated, the time elapsed since drug injection, and the specific behavioral test employed.
LSD, mescaline, and Sernyl each alter aggression and killing behavior differently depending on the species and dose. LSD reduced aggressiveness in isolated mice. Mescaline strongly reduced aggression in mice but had no effect in rats. Sernyl slightly decreased the killing reaction in rats and either decreased or increased aggression in mice depending on the dose level.