Schizophrenia Bulletin
August 5, 2020
Pantelis Leptourgos, Martin Fortier-Davy, Robin Carhart‐Harris et al.
88 citations
A multidisciplinary working group reviewed evidence on the similarities and differences between hallucinations induced by psychedelics and those occurring in schizophrenia-spectrum disorders, examining data from pharmacology, brain imaging, phenomenology, and anthropology. The authors highlight both shared features and distinct characteristics across these scales, and attempt to integrate findings using computational approaches. They conclude with recommendations for future research, emphasizing the need for further study to clarify the relationship between these types of hallucinations.
Schizophrenia Bulletin
August 8, 2018
T. M. Luhrmann, Ben Alderson‐day, Vaughan Bell et al.
74 citations
Trauma can contribute to voice-hearing but is not necessary for it. This article uses ethnographic and other data to show multiple pathways to voice-hearing in both clinical and nonclinical populations, excluding known causes like drugs or epilepsy. Trauma sometimes plays a major role, sometimes a minor role, and sometimes no role at all. Distinct phenomenological patterns in voice-hearing may reflect different salience of trauma for those who hear voices.
ACS Chemical Neuroscience
August 24, 2022
Manoj K. Doss, Frederick S. Barrett, Philip R. Corlett
21 citations
A critique of a Nature Medicine paper claiming psilocybin therapy reduces brain network modularity in depressed patients, an effect not seen with the SSRI S-citalopram. The authors identify multiple problems: inconsistent reporting of the primary clinical outcome, statistical flaws including a one-tailed test and a nonsignificant interaction, regression to the mean, ambiguous interpretation of resting-state fMRI data, and a missing reference to a similar study that undermines the justification for a one-tailed test. These issues cast doubt on the uniqueness and impact of the original findings and the media hype they generated.
July 3, 2023
Hugh McGovern, Hilary Jane Grimmer, Manoj K. Doss et al.
12 citations
preprint
Psychedelics can reorient beliefs, but they may also lead to false insights and false beliefs. A review of laboratory research on false insights and false memories is connected to belief formation under psychedelics through the active inference framework. Psychedelics increase both the quantity and subjective intensity of insights and beliefs, including false ones. Future research should aim to minimize the risk of false and potentially harmful beliefs arising from psychedelics. Understanding this risk is crucial for safely leveraging the therapeutic potential of psychedelics.
Journal of Psychopharmacology
November 30, 2016
Benjamin Kelmendi, Philip R. Corlett, Mohini Ranganathan et al.
11 citations
No Summary
September 15, 2021
Hugh McGovern, Pantelis Leptourgos, Brendan Hutchinson et al.
4 citations
preprint
Renewed interest in psychedelics has sparked debate about whether and how they alter human beliefs. In clinical and social-cognitive contexts, psychedelic use may lead to profound and sometimes lasting belief changes. Rather than creating entirely new beliefs, psychedelics may instead shift how affect and others' suggestions influence the way beliefs are formed. Baseline beliefs, such as expectations about psychedelics' effects, might color both acute experiences and longer-term changes. To harness psychedelics' potential for clinical use and human flourishing, these possibilities require empirical investigation.
April 28, 2022
Manoj K. Doss, Frederick S. Barrett, Philip R. Corlett
1 citation
preprint
A critical commentary identifies problems in a previously published study on psilocybin therapy. The authors argue that the original paper drew unsupported causal conclusions from correlational data, failed to account for placebo effects and participant expectations, and used statistical methods that inflated the apparent strength of the findings. The commentary suggests the original study's claims about psilocybin's therapeutic mechanisms are not justified by the evidence presented.
Nature Mental Health
June 1, 2026
George E. Chapman, Philip R. Corlett, Stephen M. Fleming et al.
Fixed, false beliefs called delusions are a core feature of psychotic disorders, but why they remain fixed is not well understood. This review proposes a clearer vocabulary for describing delusion fixity—using the terms conviction, incorrigibility, persistence, and stability—and examines factors from diagnosis, psychopathology, psychodynamics, social context, cognition, metacognition, and cognitive neuroscience that may influence fixity. The authors present a working model of delusion fixity and call for interdisciplinary longitudinal studies to better understand it and to improve therapeutic strategies.