Archives of General Psychiatry
January 1, 1971
William H. Mcglothlin
116 citations
A follow-up survey of 247 people who had taken LSD in experimental or psychotherapeutic settings found little evidence of lasting changes in personality, beliefs, values, attitudes, or behavior across the whole sample. Twenty-three percent reported later nonmedical use of LSD and attributed more personality changes to the drug, but compulsive patterns of use rarely developed. The drug's effects appear to become less attractive with continued use, making long-term use almost always self-limiting.
Archives of General Psychiatry
December 1, 1969
William H. Mcglothlin
51 citations
Two animal experiments show that large doses of LSD can cause long-lasting changes in brain function that persist well beyond the time the drug is normally eliminated from the body. Cats given a single dose of 80 µg/kg showed disrupted conditioned responses and brain wave changes lasting 20 days. Squirrel monkeys given daily doses of 10 to 40 µg/kg required four to six months after stopping the drug to regain their previous skill level on difficult visual size discrimination tasks. A replication using a larger sample and doses from 10 to 100 µg/kg found similar impairment lasting several weeks.
JAMA
June 1, 1970
William H. Mcglothlin
40 citations
In 121 pregnancies where mothers received low, infrequent medical doses of LSD, the rates of spontaneous abortion, premature birth, and birth defects were within normal ranges. For a smaller group of 27 pregnancies where LSD was taken both medically and nonmedically, the rate of spontaneous abortion was above average. Spontaneous abortions occurred significantly more often when the mother took LSD compared to when only the father did, but the data do not establish a clear causal link.
The Journal of Nervous and Mental Disease
September 1, 1964
William H. Mcglothlin, Sidney Cohen, Marcella S. Mcglothlin
27 citations
A single dose of LSD lowered anxiety and reduced dogmatism and projection of aggression in normal adults one week later, compared with a control group. The study involved 15 experimental and 14 comparison subjects, mostly professional research personnel. No gains were found in tests of fluency, flexibility, or originality beyond what practice alone produced. Attempts to replicate earlier findings on word-association changes after LSD were inconclusive due to differences between subject samples.
American Journal of Psychiatry
November 1, 1969
Lewis L. Judd, W.w. Brandkamp, William H. Mcglothlin
16 citations
Chromosome analyses in a single-blind study of heavy LSD users (current and former) and drug-free controls found no significant differences in chromosome breakage rates among the groups. Mean breakage rates were 1.8 percent or less for all three groups, failing to support earlier claims that LSD ingestion increases chromosome aberrations compared to a normal control population. The authors call for a more controlled longitudinal study.