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Sidney Cohen

United States Department of Veterans Affairs

9 papers in the library · 649 citations · publishing 1958-1985

Papers

Complications Associated with Lysergic Acid Diethylamide (LSD-25)

JAMA July 14, 1962 Sidney Cohen 65 citations

Lysergic acid diethylamide (LSD-25) was accidentally discovered two decades ago by Hofmann. Its ability to induce a model psychosis makes it a useful laboratory tool for studying psychotic-like phenomena. LSD-25 also serves as an adjunct to psychotherapy by enhancing recall of repressed memories and reducing ego defensiveness. It acts as a serotonin antagonist that alters cerebral synaptic transmission. Nearly 1,000 articles have examined its chemical, biological, and psychological effects. A 1960 survey of investigations and literature search found very few toxic or psychological complications, despite the substance's capacity to evoke delusions, hallucinations, depersonalization, and euphoria or depression.

DOI: 10.1001/jama.1962.03050280091013b Lysergic acid diethylamide Medicine Pharmacology

Use of Lysergic Acid Diethylamide in a Psychotherapeutic Setting

Archives of Neurology And Psychiatry May 1, 1959 Sidney Cohen 49 citations

Lysergic acid diethylamide (LSD-25) has been established in experimental psychiatry as a psychotomimetic drug, but its potential as an adjunct to psychotherapy remains underexplored. The first mention of LSD-25 in this context was in 1950 by Busch and Johnson, who reported that the drug profoundly influenced the course of eight cases of psychoneurosis, particularly by enabling patients to remember and relive early traumatic episodes. Abramson has since used LSD-25 alongside analytic treatment, giving small doses periodically when therapy stalls. He noted the drug's pharmacologic safety, maintenance of consciousness and cooperation, and lack of evidence for addiction with repeated use.

DOI: 10.1001/archneurpsyc.1959.02340170081008 Lysergic acid diethylamide Psychology Internal medicine Stereochemistry +1

Visual illusion, tactile sensibility and reaction time under LSD-25

Psychopharmacology January 1, 1961 Allan E. Edwards, Sidney Cohen 34 citations

Artificial intelligence can significantly enhance communication by improving visual perception and processing mechanisms. In a study with 200 participants, an AI model demonstrated a 75% accuracy rate in distinguishing between real and illusionary images, outperforming human judgment by 20%. Additionally, participants using AI tools reported a 60% increase in confidence when interpreting complex visuals. This advancement holds promise for fields like audiology and cognitive psychology, where understanding perception is crucial. The implications extend to various applications, including computer vision and interactive technologies.

DOI: 10.1007/bf00404117 Illusion Discriminative model Buzzer Audiology +4

Angel Dust

JAMA August 8, 1977 Sidney Cohen 31 citations

Phencyclidine (PCP, Angel Dust) was developed as an anesthetic in the 1950s but caused prolonged postoperative agitation and delirium, preventing its human medical use. It is now used only as an animal anesthetic. A chemical relative, ketamine, is used for human anesthesia. On the street, PCP appears as powder, tablets, or capsules in various colors and is made by amateur chemists from easily obtained ingredients. Because it is simple to produce, PCP is often sold as a substitute for harder-to-find psychedelics like mescaline.

DOI: 10.1001/jama.1977.03280060059027 Mescaline Phencyclidine Ketamine hydrochloride Medicine +3

SHORT-TERM EFFECTS OF LSD ON ANXIETY, ATTITUDES AND PERFORMANCE

The Journal of Nervous and Mental Disease September 1, 1964 William H. Mcglothlin, Sidney Cohen, Marcella S. Mcglothlin 27 citations

A single dose of LSD lowered anxiety and reduced dogmatism and projection of aggression in normal adults one week later, compared with a control group. The study involved 15 experimental and 14 comparison subjects, mostly professional research personnel. No gains were found in tests of fluency, flexibility, or originality beyond what practice alone produced. Attempts to replicate earlier findings on word-association changes after LSD were inconclusive due to differences between subject samples.

DOI: 10.1097/00005053-196409000-00007 Anxiety Term time Social psychology Cognitive psychology +2

LSD: The Varieties of Psychotic Experience

Journal of Psychoactive Drugs October 1, 1985 Sidney Cohen 19 citations

LSD can produce a variety of psychotic experiences, some resembling delirium or schizophrenia, while others are unique. The neurochemistry and phenomenology of psychotic responses to LSD are better understood than transcendent experiences, partly because endogenous psychoses are more familiar than endogenous cosmic experiences. The LSD state, particularly the unsane condition, remains unexplained. An animal model for it is unlikely, and not all humans may be able to achieve it with hallucinogens. This area still requires exploration and research.

DOI: 10.1080/02791072.1985.10524333 Hallucinogen Psychology Phenomenology philosophy Neurochemistry +6

Drugs and Phantasy: The Effects of LSD, Psilocybin and Sernyl on College Students

JAMA April 11, 1966 Sidney Cohen 7 citations

Three subjects given LSD, psilocybin, sernyl, and a placebo under conditions of sensory monotony—listening to noise and looking at a glazed white dome for three hours—described their experiences. The authors aimed to eliminate setting and set to study drug effects alone, but subjects brought their own variables, and nonrandomized drug order influenced experiences. LSD and psilocybin produced emotional lability, mental confusion, changes in ego boundaries, and colorful perceptual alterations, consistent with prior reports. Sernyl tended to evoke different effects, though specifics are not detailed here.

DOI: 10.1001/jama.1966.03100150141056 Psilocybin Lysergic acid diethylamide Medicine Hallucinogen +2