4 papers in the library · 310 citations · publishing 1952-1957
American Journal of Psychiatry February 1, 1952 Paul H. Hoch, James P. Cattell, Harry H. Pennes 116 citations
In schizophrenic patients, mescaline and lysergic acid worsen mental symptoms and produce physiological changes. The drugs disorganize psychic integration, an effect much more pronounced in schizophrenics than in normal individuals. The text discusses potential diagnostic, prognostic, and therapeutic uses of these drugs.
American Journal of Psychiatry April 1, 1957 Harry H. Pennes, Paul H. Hoch 89 citations
Harmine, Win-2299, and Nalline, when given in a single dose, produce mental effects in schizophrenic patients that are grossly similar to those caused by mescaline and LSD. Unlike mescaline and LSD at typical doses, these drugs regularly induce drowsiness and sleep alongside aberrant mental effects, resulting in a state partly characterized by hypnagogic visual hallucinations or imagery. Increased dosage suggests the basic effect is an acute toxic reaction. The differences between these drugs and mescaline or LSD regarding clouding of consciousness and certain hallucinogenic aspects may be quantitative rather than qualitative. The indole nucleus is not necessary for psychotomimetic structure, as Win-2299 and Nalline are non-indoles; the tertiary nitrogen grouping may contribute to psychotomimetic action.
American Journal of Psychiatry February 1, 1952 Paul H. Hoch, James P. Cattell, Harry H. Pennes 57 citations
Drug-induced abnormal mental states are examined theoretically. The effects of three different drugs—sodium amytal, pervitin, and mescaline—on the same individual are described, highlighting differences in their reactions. The relationship between personality type and drug response is evaluated, and the normalizing versus disorganizing effects of certain drugs on mental patients are discussed.
The Journal of Nervous and Mental Disease February 1, 1954 Harry H. Pennes 48 citations
Lysergic acid diethylamide (LSD) and mescaline produce profound psychological effects, including perceptual changes and altered states of consciousness. These substances have been studied in psychiatry to model psychotic states, particularly schizophrenia, due to their ability to induce symptoms resembling the disorder. Research from the Department of Experimental Psychiatry at the New York State Psychiatric Institute examined the pharmacological and psychological properties of these compounds. The work suggests that LSD and mescaline may act through interference with serotonin or tryptophan metabolism in the brain, offering insights into the biochemical mechanisms underlying psychotic disorders.