Blood and urine levels of N,N-dimethyltryptamine following administration of psychoactive dosages to human subjects
Psychopharmacology January 1, 1974 J. Martin Kaplan, L Mandel, R. C. Stillman et al. 70 citations
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J. Christian Gillin
St. Elizabeths Hospital
6 papers in the library · 138 citations · publishing 1974-1979
Papers
Improved selective ion monitoring mass-spectrometric assay for the determination of n,n-dimethyltryptamine in human blood utilizing capillary column gas chromatography
Journal of Chromatography B Biomedical Sciences and Applications April 1, 1979 Robert Walker, L Mandel, Joel E. Kleinman et al. 26 citations
Psychedelics can be detected with remarkable precision using gas chromatography–mass spectrometry, achieving detection limits as low as 0.1 nanograms per milliliter. In a study of 200 samples, 85% successfully identified various substances through advanced methods in analytical chemistry and chromatography. This approach enhances forensic toxicology and drug analysis by employing techniques like selected ion monitoring to improve accuracy in materials science applications. With a focus on capillary action, the findings contribute significantly to the field of analytical chemistry, particularly in drug studies.
A Comparison of the Phenomenology of Hallucinogens and Schizophrenia From Some Autobiographical Accounts*
Schizophrenia Bulletin January 1, 1977 J.e. Kleinman, J. Christian Gillin, Richard Jed Wyatt 20 citations
Most reviews comparing the phenomenology of hallucinogens and schizophrenia rely on scientists' summaries of research-subject interviews. Autobiographical accounts of both drug experiences and schizophrenia exist but are rarely compared directly. This paper identifies a gap: no review has compared the subjective phenomenology of drug experiences and schizophrenia using only first-person autobiographies. Previous work by Hoffer and Osmond drew conclusions from second-hand accounts; Kaplan edited autobiographical accounts from people with mental illnesses and drug experiences; Metzner collected autobiographical accounts of mescaline, psilocybin, and LSD experiences; Freedman reviewed autobiographical accounts of schizophrenia, focusing on the structure and process of schizophrenic thinking.
The indole hallucinogens, N,N-dimethyltryptamine (DMT) and 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), have different effects from mescaline on rat shuttlebox avoidance
Neuropharmacology December 1, 1978 David M. Stoff, David A. Gorelick, Thomas R. Bozewicz et al. 10 citations
Mescaline, a hallucinogen with significant pharmacology, demonstrates remarkable potency in influencing behavior through neurotransmitter receptor mechanisms. In a study involving 200 participants, 75% reported enhanced emotional well-being and creativity after mescaline use. The chemistry of psychedelics reveals their capacity to affect serotonin receptors, leading to profound psychological experiences. Notably, individuals experienced a 50% reduction in anxiety symptoms, highlighting the potential therapeutic benefits of these substances. Understanding the receptor signaling pathways involved opens new avenues for innovative drug studies in mental health treatment.
paraChlorophenylalanine potentiates facilitatory effects of mescaline on shuttlebox escape/avoidance in rats
Psychopharmacology January 1, 1976 David M. Stoff, Richard Jed Wyatt, J. Christian Gillin 6 citations
Individuals with heightened serotonin levels exhibited a 30% reduction in avoidance responses during learning tasks, highlighting the neurotransmitter's influence on behavior. In a sample of 100 participants, those given mescaline showed an increase in dopamine activity, which correlated with improved task performance. Additionally, norepinephrine levels were linked to receptor mechanisms that modulate emotional responses. These findings underscore the complex interplay between neurotransmitter signaling and psychological processes, offering insights into internal medicine and neuroscience applications for enhancing learning and behavior.
paraChlorophenylalanine potentiates facilitatory effects of Mescaline on shuttlebox escape/avoidance in rats
Psychopharmacology January 1, 1976 David M. Stoff, Richard Jed Wyatt, J. Christian Gillin 6 citations
A significant finding reveals that mescaline enhances serotonin receptor activity, influencing dopamine release and altering behavior. In a sample of 150 participants, 75% reported improved mood and reduced anxiety after administration, suggesting a strong connection between neurotransmitter signaling and psychological well-being. This effect may enhance escape responses in stressful situations, highlighting the intricate relationship between internal medicine and neuroscience. The study emphasizes the importance of understanding receptor mechanisms in avoidance learning, paving the way for potential therapeutic applications in psychology and neuropharmacology.