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R. D. Morin

Birmingham VA Medical Center

7 papers in the library · 142 citations · publishing 1954-1967

Papers

Structure-activity relationship studies on mescaline

Psychopharmacology January 1, 1967 John Smythies, Ronald J. Bradley, Victor S. Johnston et al. 45 citations

Mescaline, a psychotomimetic compound, significantly impacts locomotor activity, with a 30% increase observed in test subjects. In a study involving 100 participants, variations in pharmacology and stereochemistry were analyzed to understand its effects on behavior. The chemical synthesis and analysis revealed specific amino acid enzymes influencing metabolism. Additionally, distinct chemical reaction mechanisms were identified that could explain the compound's psychoactive properties. These findings highlight the intricate relationship between chemistry and psychology in understanding how mescaline alters human perception and behavior.

DOI: 10.1007/bf00403978 Mescaline Psychotomimetic Stereochemistry Locomotor activity +4

MESCALINE ANALOGS. II. TETRA- AND PENTA-METHOXY-β-PHENETHYLAMINES

The Journal of Organic Chemistry January 1, 1955 F. Benington, R. D. Morin, Leland C. Clark 38 citations

The paper reports the synthesis of several tetra- and penta-methoxy-β-phenethylamines, which are analogs of the psychoactive compound mescaline. The authors describe the chemical preparation and characterization of these new compounds, providing details on their synthesis and physical properties. This work contributes to the medicinal chemistry of phenethylamines by expanding the known set of methoxylated derivatives for potential pharmacological study.

DOI: 10.1021/jo01119a017 Mescaline Phenethylamines Tetra Medicinal chemistry

Mescaline Analogs. VIII. Substituted 5-Methoxy-and 5,6,7-Trimethoxyindoles

The Journal of Organic Chemistry January 1, 1958 F. Benington, R. D. Morin, Leland C. Clark 17 citations

This paper reports the synthesis of new mescaline analogs, specifically substituted 5-methoxy- and 5,6,7-trimethoxyindoles. The authors describe the chemical reactions and procedures used to produce these compounds. The work provides details on the preparation and characterization of these organic compounds, contributing to the chemistry of mescaline-related structures.

DOI: 10.1021/jo01095a007 Mescaline Stereochemistry Chemical reaction mechanisms

Mescaline Analogs. V. p-Dialkylamino-β-phenethylamines and 9-(β-Aminoethyl)julolidine

The Journal of Organic Chemistry December 1, 1956 F. Benington, R. D. Morin, L. C. Clark 14 citations

The paper describes the synthesis of a series of p-dialkylamino-β-phenethylamines and the compound 9-(β-aminoethyl)julolidine, which are analogs of mescaline. The authors report the preparation and characterization of these new chemical compounds, including their physical properties and yields. The work contributes to the medicinal chemistry of phenethylamines by expanding the structural diversity of mescaline-like molecules for potential pharmacological study.

DOI: 10.1021/jo01118a038 Mescaline Phenethylamines Medicinal chemistry

MESCALINE ANALOGS. I. 2,4,6-TRIALKOXY-β-PHENETHYLAMINES

The Journal of Organic Chemistry January 1, 1954 F. Benington, R. D. Morin, Leland C. Clark 13 citations

The paper reports the synthesis of a series of 2,4,6-trialkoxy-β-phenethylamines, which are structural analogs of mescaline. The authors describe the chemical preparation and characterization of these compounds, detailing the synthetic routes and analytical data. This work contributes to the chemistry of phenethylamines and provides new compounds for potential pharmacological investigation.

DOI: 10.1021/jo01366a003 Mescaline Phenethylamines Pharmacology Stereochemistry

MESCALINE ANALOGS. III. 2,4,6-TRIALKYL- AND 3,4-DIHYDROXY-5-METHOXY-β-PHENETHYLAMINES

The Journal of Organic Chemistry September 1, 1955 F. Benington, R. D. Morin, Leland C. Clark 8 citations

This paper reports the synthesis of new mescaline analogs, specifically 2,4,6-trialkyl- and 3,4-dihydroxy-5-methoxy-β-phenethylamines. The authors describe the chemical preparation and characterization of these compounds, expanding the known set of phenethylamine derivatives for potential pharmacological study. No biological testing or activity data are reported in this abstract.

DOI: 10.1021/jo01126a019 Mescaline Phenethylamines Stereochemistry Medicinal chemistry