Effect of 5, 6-dihydroxytryptamine on the head twitches induced by 5-HTP, 5-HT, mescaline and fludiazepam in mice
Journal of Pharmacy and Pharmacology September 1, 1978 Mitsutaka Nakamura, Hideaki Fukushima 25 citations
In mice, the compound 5,6-dihydroxytryptamine (5,6-DHT) suppressed head-twitch responses caused by 5-HTP, 5-HT, mescaline, and fludiazepam. The effect varied by drug: 5,6-DHT strongly inhibited twitches from 5-HTP and 5-HT, moderately inhibited those from mescaline, and weakly inhibited those from fludiazepam. These results suggest that head twitches induced by these substances involve different serotonergic mechanisms.