ED95 of Ciprofol Combined with Esketamine or Sufentanil in Elderly Patients Undergoing Endoscopic Submucosal Dissection: A Dose-Finding and Randomized Controlled Trial
Drug Design Development and Therapy February 1, 2026 Xiaoxue Qin, Hui Jiang, Yan Xie et al. 1 citation
In elderly patients undergoing endoscopic submucosal dissection, the estimated 95% effective dose of ciprofol when combined with esketamine was 0.276 mg/kg, and when combined with sufentanil was 0.244 mg/kg. Induction time was shorter with esketamine, and during the procedure this group had lower rates of hypoxia and hypotension and less fluctuation in blood pressure and heart rate. However, time to full alertness was longer with esketamine. No significant differences were seen in the need for rescue sedation or analgesia. These findings are exploratory and strategy-specific, not evidence of superiority.