Measurement of Lysergic Acid Diethylamide (LSD) in Human Plasma by Gas Chromatography/Negative Ion Chemical Ionization Mass Spectrometry*
Journal of Analytical Toxicology May 1, 1990 Damon I. Papac, Rodger L. Foltz 45 citations
A method originally developed to measure LSD in urine was adapted for use with plasma. After adding a deuterium-labeled version of LSD as an internal standard, the plasma is extracted and the drug is converted to a derivative for analysis by gas chromatography combined with negative ion chemical ionization mass spectrometry. The assay produced a linear response for concentrations between 0.1 and 3.0 ng/mL. When applied to a male volunteer who took 1 microgram of LSD per kilogram of body weight orally, the peak plasma concentration reached 1.9 ng/mL three hours after dosing, and the apparent plasma half-life was 5.1 hours.