Excretory Profile of 4-Bromo-2,5-dimethoxy-phenethylamine (2C-B) in Rat
JOURNAL OF HEALTH SCIENCE April 1, 2003 T. Kanamori, K. Tsujikawa, Yoshihito Ohmae et al. 27 citations
After oral administration of 10 mg/kg of the psychoactive substance 2C-B to male Wistar rats, the main metabolite found in urine was 5-O-desmethyl-N-acetyl-2C-B, accounting for 13.2% of the dose. Other urinary metabolites included 2-O-desmethyl-N-acetyl-2C-B (5.8%), 2-O-desmethyl-2C-B (3.5%), a carboxylic acid compound (1.9%), 5-O-desmethyl-2C-B (1.2%), and an alcoholic compound (0.8%). Only 0.2% of the original 2C-B was excreted unchanged in urine. In faeces, only two acetylated metabolites were detected. Most hydroxyl-containing urinary metabolites were recovered as conjugates.