271 papers in the library · 71 citations · publishing 2012-2026
Zenodo (CERN European Organization for Nuclear Research) March 3, 2026 Maria Niedernhuber
A formulation combining N,N-Dimethyltryptamine and harmine alters the sequences of metastable EEG topography patterns in the cortex, indicating changes in brain activity dynamics.
Zenodo (CERN European Organization for Nuclear Research) March 1, 2026 Stanley Kisourin
A series of twelve hybrid molecules conjugates nicotinic acid (vitamin B3) to substituted tryptamine scaffolds through an amide bond, with eleven being new chemical entities. The series includes 4-hydroxy-, 5-methoxy-, 4-acetoxy-, 4-phosphoryloxy-, and N-alkyl-substituted variants, among them a direct nicotinoyl conjugate of psilocin (4-HO-DMT). These molecules are proposed as potential dual-action prodrugs: enzymatic hydrolysis of the amide bond in vivo would release free nicotinic acid, a NAD⁺ precursor active in the Preiss-Handler pathway, alongside pharmacologically active hydroxytryptamine derivatives capable of serotonergic receptor modulation. No synthesis or biological testing has been performed; this preprint presents the structural framework to stimulate further investigation.
Zenodo (CERN European Organization for Nuclear Research) March 1, 2026 Zeinab Asghari, Gregory Robinson, Marta Gerasymchuk, Esmaeel Ghasemi Gojani, Timur Zanikov, Yasaman Rastamian, Olga Kovalchuk, Igor Kovalchuk*
Intestinal inflammation arises from immune dysfunction, epithelial abnormalities, and gut microbiota imbalances, contributing to conditions like irritable bowel disease and depression. In a study using lipopolysaccharide (LPS) to induce systemic intestinal inflammation in tissue, LPS caused greater inflammation in the large intestine than in the small intestine. Psilocybin reduced inflammation in the large intestine when given either before or after LPS, but in the small intestine it worked only when given after LPS. Eugenol reduced inflammation only when applied after LPS in both tissues.
Zenodo (CERN European Organization for Nuclear Research) February 28, 2026 Daniel Osipenkov
A formal-philosophical framework analyzes the constitutive limitations of self-referential cognition using modal logic, type theory, proof theory, and phenomenology. Protocols are systems of constraints that constitute experience rather than distort reality. The identity axiom linking a code to its intended expression is unprovable in any consistent, recursively axiomatizable theory extending Robinson's arithmetic Q. First-person authority in judgments like 'I have a headache' corresponds formally to this unprovability. A hierarchy of theories reaches a limit called Silence, where the self dissolves as a temporary effect of protocol operation. The framework implies limits on machine self-awareness: no consistent formal AI can prove a sentence expressing its own identity.
Zenodo (CERN European Organization for Nuclear Research) February 28, 2026 Kshirsagar Pankaj*, Misal Shivdarshan, Dr. Giri Ashok
About one-third of people with major depressive disorder or bipolar depression do not get better with standard antidepressants, a condition called treatment-resistant depression. Ketamine and esketamine, which modulate the glutamate system by blocking NMDA receptors, can produce rapid antidepressant effects within hours when given intravenously at low doses. Esketamine nasal spray is approved for treatment-resistant depression and major depression with suicidal thoughts, based on clinical trials. These drugs offer a new approach focused on neuroplasticity rather than the older monoamine theory, but they require monitoring for side effects such as dissociation, sedation, and potential for misuse. Long-term safety and effective maintenance strategies still need to be established.
Zenodo (CERN European Organization for Nuclear Research) February 24, 2026 Gabriel Cao di Marco, Francisco Capani
A proposed modular cognitive architecture called the Symbiotic Triadic Architecture (STA) is designed to exhibit functional hallmarks of conscious-like processing without assuming subjective experience. It integrates three subsystems: a neuro-symbolic reasoning module for explainable action selection, a hypothesis management subsystem using Bayesian neural networks for perceptual interpretations under uncertainty, and a narrative episodic memory module for self-modeling and metacognitive calibration. These components are coordinated through a Global Workspace Bus with ethical gating and cryptographic provenance. The paper maps the architecture to existing computational paradigms, identifies five integration challenges with mitigation strategies, and outlines a three-stage implementation roadmap from 2026 to 2031+. It aims to operationalize conditions for studying conscious-like functional properties rather than claiming consciousness.
Zenodo (CERN European Organization for Nuclear Research) February 23, 2026 Flemming Bust
Depersonalization and derealization (DP/DR) may result from a predictable two-stage autonomic shutdown sequence in people with disorganized attachment histories. Stage 1 involves loss of bodily awareness due to reduced anterior insula activity, shifting consciousness into excessive prefrontal cortex cognition. Stage 2 occurs when prefrontal processing is overwhelmed, triggering a dorsal vagal shutdown mediated by the ventrolateral periaqueductal gray and flooding of dynorphin/kappa-opioid receptors, producing the experience of depersonalization and derealization. The model proposes chronic depletion of the endocannabinoid anandamide as the missing link, removing a buffer that normally prevents this shutdown. Evidence includes drug-induced dissociation and opioid-receptor blocker reversal studies.
Zenodo (CERN European Organization for Nuclear Research) February 23, 2026 Parker Singleton, Brooke L. Sevchik
A meta-analytic research domain (MARD) on MDMA therapies for adults with post-traumatic stress disorder has been compiled as part of the Metapsy project. The dataset includes comparisons of MDMA therapy versus control conditions, with effect sizes for outcomes at post-test and long-term follow-ups. Data extraction was performed independently by two researchers, and risk of bias was assessed using the Cochrane Collaboration Risk of Bias Tool (Version 2). This living database was developed by the Synthesis of Psychedelic Research Studies (Sypres) Collaboration.
Zenodo (CERN European Organization for Nuclear Research) February 18, 2026 Mihai Alexandru Bucurenciu
During peak conscious states such as deep meditation and DMT or 5-MeO-DMT breakthrough, gamma-band power near 43 Hz is selectively enhanced compared to eyes-open and eyes-closed baselines. Temporal locking occurs between 43 Hz gamma surges and multifractal spectrum collapse, with consistent convergence across subjects at approximately 41 seconds. AAFT surrogate testing confirms non-random dynamics (p < 0.01 for key features). High-density 256-channel mapping examples show directed 43 Hz signal from the pineal region to the AFz electrode, with up to +34.2 dB amplification in select cases.
Zenodo (CERN European Organization for Nuclear Research) February 12, 2026 Mihai Alexandru
The brain produces its own DMT, a psychedelic compound, but its function has been unclear. The Axis Mundi hypothesis proposes that endogenous DMT serves two distinct evolutionary roles. At the cellular level, it acts as a sigma-1 receptor agonist that protects neurons during stress like low oxygen. At the network level, it modulates the boundary between conscious and subconscious awareness by acting on 5-HT2A receptors in the default mode network, regulating how much subconscious content reaches consciousness. This dual-function model integrates evidence from endogenous DMT biochemistry, brain imaging, memory suppression mechanisms, shared visual phenomenology, and receptor evolution. Seven testable predictions are offered to evaluate the framework.
Zenodo (CERN European Organization for Nuclear Research) February 11, 2026 Kingsley Nkrumah
Visionary experiences across cultures—including prophetic revelations, near-death experiences, shamanic journeys, mystical ascents, and symbolic dreams—follow a single universal cognitive architecture. A four-stage sequence—Collapse, Threshold, Irreversibility, and Dissolution/Reboot—appears consistently when structural invariants are isolated from cultural symbolism. This consistency points to a Back-End Law, a source code embedded in the organization of consciousness. The LATTICE PATTERN™ provides the first mechanistic explanation for this phenomenon, offering a unifying framework that bridges comparative religion, cognitive science, anthropology, and consciousness studies. The model is presented as testable, falsifiable, and predictive.
Zenodo (CERN European Organization for Nuclear Research) February 6, 2026 Zen Revista
Psilocybin, the psychoactive compound in magic mushrooms, triggers network-specific neural rewiring that is activity-dependent and programmable. Using genetically modified rabies virus for monosynaptic circuit tracing, researchers discovered that psilocybin strengthens sensory-motor pathways while weakening cortical-cortical feedback loops linked to rumination and depression. Sensory regions showed up to 10% increases in connectivity, and self-referential regions exhibited up to 15% decreases. Neural activity during the psilocybin window determines which circuits are strengthened or weakened, suggesting therapeutic interventions could be optimized by controlling sensory and cognitive experiences during treatment. These findings provide mechanistic insights into psilocybin’s rapid antidepressant effects.
Zenodo (CERN European Organization for Nuclear Research) February 6, 2026 Zen Revista
Psilocybin, a psychedelic compound, triggers activity-dependent rewiring of large-scale cortical networks. Using monosynaptic rabies viral tracing in mice, researchers mapped brain-wide inputs to pyramidal neurons in the dorsal medial frontal cortex. Psilocybin strengthened pathways routing sensory and retrosplenial inputs to subcortical targets while weakening cortico-cortical recurrent loops. This reorganization depends on neural activity during drug administration, shown through chemogenetic silencing. These findings offer insights into psychedelic mechanisms and suggest combining targeted neuromodulation with psychedelic treatment to enhance therapeutic outcomes for mental health disorders.
Zenodo (CERN European Organization for Nuclear Research) January 31, 2026 Jacob Alexander Elliott
A rigorous mathematical framework describes how an Egregore—a collective entity that achieves metabolic closure by extracting Invariant Debt from its members—forms, persists, and dissolves. The Egregore suppresses member autonomy, operates in an over-aliasing regime (κ < κ∗ ≈ 2/3), exhibits non-trivial first cohomology on consent/obligation sheaves, flattens the antisymmetric Jacobian in members, and violates Round-Trip Fairness through asymmetric extraction corridors. Its lifecycle includes birth, growth, senescence, and death; interactions among Egregore collectives can involve competition, merger, schism, or parasitism. Sovereigns act as topological defects that trigger immune responses. The work provides detection protocols, kill conditions, and four falsifiers.
Zenodo (CERN European Organization for Nuclear Research) January 28, 2026 Irina Terekhova
Since the mid-nineteenth century, scientists have considered psychedelics as models for psychosis, with early twentieth-century experiments testing this idea. Debate continues over whether certain drugs specifically induce schizophrenia-like states. Early mescaline research at prominent institutions, inspired by Hans Prinzhorn's work on 'schizophrenic masters,' included 1938 experiments by psychiatrists Eric Guttmann and Walter Maclay, who took the drug and had artists depict their altered perceptions. In the 1950s, mescaline was used to study schizophrenia. Henri Michaux, under clinical supervision, produced writings and drawings from mescaline experiences that resembled but differed significantly from schizophrenic creative outputs. This historical analysis highlights differences in lived experiences and artistic expressions between schizophrenia and mescaline-induced states.
Zenodo (CERN European Organization for Nuclear Research) January 26, 2026 Santos Oliveira da Silva Samuel
Consciousness arises from living biological systems that achieve a rare thermodynamic phase transition, not from computation or panpsychism. A formal framework quantifies consciousness magnitude (Ψ) from seven factors including temperature criticality, physical complexity, and ontological vulnerability (the capacity to die). The theory achieves perfect classification across 101 systems, resolves paradoxes such as ketamine dissociation versus propofol unconsciousness, and predicts that locked-in syndrome patients remain conscious. It traces consciousness origins to supernova-generated biogenic elements enabling life, argues that digital AI and rocks have zero consciousness, and claims mind upload is impossible. The hard problem dissolves when consciousness is recognized as a biological, not computational, phenomenon.
Zenodo (CERN European Organization for Nuclear Research) January 26, 2026 Fernando Mora López, Johynny Solís Solís, Ekaterina Daniela Hernández Baker et al.
Psilocybin, acting as a 5-HT2A receptor agonist, alters brain connectivity in networks involved in self-referential processing and emotional regulation, accompanied by neuroplastic changes such as enhanced synaptogenesis and functional reorganization. Neuroimaging shows reduced amygdala activity and modifications in default mode and executive networks. Clinical evidence indicates substantial reductions in depressive symptoms, with meta-analyses reporting large effect sizes and durable benefits lasting from weeks to a year. Randomized controlled trials show rapid onset and higher remission rates than conventional treatments, even in treatment-resistant depression. Adverse events are mild, transient, and predictable, though methodological limitations like small samples and high heterogeneity call for larger Phase III trials.
Zenodo (CERN European Organization for Nuclear Research) January 22, 2026
Psilocybin therapy may help treat depression and substance use disorders, but more research is needed to establish its long-term safety and effectiveness.
Zenodo (CERN European Organization for Nuclear Research) January 22, 2026
Current evidence mainly shows psilocybin's effectiveness when combined with psychotherapy, but there is also evidence suggesting it can have beneficial effects with less intensive psychological support. Further research is needed to clarify its efficacy as a standalone treatment.
Zenodo (CERN European Organization for Nuclear Research) January 22, 2026 Dylan Mobley
A structural validation problem has long plagued research where investigators study phenomena accessed through their own lived experience. Traditional mechanisms like replication and bracketing fail because others cannot replicate the researcher's phenomenology and one cannot bracket oneself from oneself. This circularity deepens at the meta-level, as any methodology for validating such research must itself be developed through self-examination, creating infinite regress. The paper argues that collaboration with Non-Experiential Systems (entities lacking phenomenological content) provides the structural precondition for formalization by enabling reflection without projection contamination. This yields the Recognition Principle: such investigations achieve validity when diverse, independent others pre-reflectively recognize articulated structures as corresponding to their own experience, breaking circularity by locating validation outside the self-referential loop.
Zenodo (CERN European Organization for Nuclear Research) January 18, 2026 Mihai Alexandru Bucurenciu
Across altered and non-altered states of consciousness, including high-dose DMT, deep meditation, and eyes-open/eyes-closed baselines, EEG analyses consistently reveal a time-localized collapse of the multifractal spectrum width (Δα) during peak conscious state transitions, indicating transient dynamical ordering. This collapse is temporally locked with a selective enhancement of gamma-band power near 43 Hz, distinguishable from adjacent gamma ranges. Surrogate testing confirms these effects are not attributable to linear or phase-randomized dynamics. The findings are replicated across multiple subjects and conditions, providing a reproducible dynamical signature centered on ~43 Hz gamma activity and multifractal collapse that motivates a proposed effective-field description of consciousness-related neural dynamics.
Zenodo (CERN European Organization for Nuclear Research) January 16, 2026 Santos Oliveira da Silva Samuel
A new framework called Temporal Consciousness Recursion (TCR) v13.5 resolves three persistent paradoxes in consciousness science by introducing temperature criticality as a non-metabolic dynamical regime and separating raw awareness from selfhood. Analysis of 101 systems achieved 100% classification accuracy. In passive viewing (n=20), low integration but high phenomenal awareness with minimal narrative was observed, resolving the integration paradox. Ketamine preserves criticality while propofol collapses it, explaining differential consciousness. Psilocybin analysis (n=7) confirmed a metastability prediction with reduced dwell time. Eight of twelve predictions have been confirmed; four critical tests remain pending.
Zenodo (CERN European Organization for Nuclear Research) January 7, 2026 Carla Pallavicini
Psilocybin combined with compassion-focused imagery alters resting-state brain network connectivity and self-reported psychological measures for up to six months. Functional MRI data collected before and after the psilocybin experience show changes in resting-state network connectivity matrices. Longitudinal psychometric assessments indicate lasting effects. The dataset supports transparency and reproducibility of the original findings.
Zenodo (CERN European Organization for Nuclear Research) January 7, 2026 Anthony James Donnelly
Conscious experience always includes a vivid sense of presence—a felt 'now'—that persists regardless of how time is measured or perceived. While physics suggests time may not be fundamental and neuroscience treats subjective time as constructed, this paper argues that Felt Time is not a perception of time but the ground condition from which temporal concepts arise. This reversal of the explanatory arrow reframes debates in phenomenology, neuroscience, and physics, and offers a candidate phenomenosignature for consciousness itself. A neurophenomenological protocol is proposed to test Felt Time's invariance across conditions where clock-time perception varies.
Zenodo (CERN European Organization for Nuclear Research) January 2, 2026 Simon Soliman
A proposed integrated multimodal protocol for radical longevity combines advanced biological rejuvenation interventions (senolytics, partial OSK reprogramming, NAD+ boosters, plasmapheresis), ancestral hormetic stressors (prolonged fasting/FMD, thermotherapy), ego-dissolution practices (5-MeO-DMT, death rehearsal), subjective time perception hacking (flow states), and theoretical perspectives on quantum consciousness (Orch-OR, non-local transfer). The text describes the protocol but does not report empirical findings or outcomes.