Zenodo (CERN European Organization for Nuclear Research)
January 1, 2026
Claudio Bresciano
Every lived experience contains an irreducible core that remains invariant under any transformative force or theoretical description. Using a minimalist axiomatic system drawn from first-order logic, information theory, and neurophenomenology, three theorems are derived: Irreversibility of the Core, Epistemic Constraint, and Explanatory Persistence. Together they prove that what has been instantiated as experience cannot be logically undone, only transformed. The framework reframes the hard problem of consciousness and memory as a structural necessity for systemic intelligibility rather than biological storage. For AI alignment, embedding-based systems accumulate invariant cores that constrain future behavioral trajectories; for consciousness studies, irreversibility is a fundamental condition of identity.
Zenodo (CERN European Organization for Nuclear Research)
January 1, 2026
Santos Oliveira da Silva Samuel
The Relational Consciousness Theory (TCR v3.2) dissolves the Hard Problem of Consciousness by rejecting dualism, computational reductionism, and panpsychism. Consciousness arises from the 'gesture of flesh'—the pre-reflexive urgency and vulnerability of living organisms—through affective-resonant coupling. Two irreducible modes are distinguished: Sensorial Consciousness (qualia), requiring gesture of flesh, informational integration, affective temporality, and recursion; and Narrative Consciousness (inner voice), a post-hoc linguistic output. A formal threshold C = G × I × T × R is introduced, where qualia emerges only above a critical level.
Zenodo (CERN European Organization for Nuclear Research)
December 31, 2025
David Bohnert
A connectome-based predictive model can predict the intensity of subjective experiences induced by LSD from patterns of brain connectivity measured before drug administration. The model was trained on resting-state functional MRI data and self-reported experience ratings from participants. It successfully predicted individual differences in the subjective effects of LSD, suggesting that pre-drug brain network organization carries information about how strongly a person will respond to the psychedelic.
Zenodo (CERN European Organization for Nuclear Research)
December 28, 2025
Majid Karimi Baghmaleki
A new theoretical framework called Quantum-Relational ʿIrfān (QRI) reinterprets Islamic mystical metaphysics by blending classical doctrines of unity with contemporary relational ontology. Classical thinkers like Ibn ʿArabī and Mullā Ṣadrā articulated sophisticated views of unity and multiplicity but relied on hierarchical, essentialist structures. Drawing on post-Heideggerian relational ontology, process metaphysics, phenomenology, and quantum-inspired models of indeterminacy, QRI reconceives the Real as a relational-probabilistic field, mystical experience as the actualization of relational potentials, and mystical knowledge (maʿrifa) as co-emergent. The framework offers a philosophically robust platform for Islamic mystical thought to engage modern discourse without reducing spirituality to physics.
Zenodo (CERN European Organization for Nuclear Research)
December 25, 2025
C.s. Tarpley, Clearbridge Policy & Ethics Consortium
As legal psilocybin services expand, this paper addresses gaps in clinical protocols and mechanistic explanations for psychedelic experiences. A dual-drift model (Mystification Drift and Messiah Drift) with a five-step anchoring protocol is introduced for facilitators managing archetypal responses during integration. The mechanistic hypothesis posits that psilocybin functions as an intercellular signaling molecule within mycelial networks, with human experiences resulting from cross-kingdom receptor compatibility—fungal coordination molecules activating mammalian 5-HT2A receptors through evolutionarily conserved indolamine architecture. Experiences are self-generated but operate under altered constraint regimes, explaining coherence without external information transfer. Testable predictions include temporal precedence, spatial topology mapping, and coordination impairment upon blocking.
Zenodo (CERN European Organization for Nuclear Research)
December 24, 2025
Fei Liu
Psilocybin, the psychoactive compound in magic mushrooms, is produced by a biosynthetic gene cluster (BGC) traditionally linked to Psilocybe species but also found in other genera. Sequencing genomes of 30 psilocybin-producing mushroom species and comparing them across 20,608 genomes indicates the BGC likely arose from endogenous fungal gene duplication and rearrangement, not horizontal gene transfer from non-fungal sources. Four independent horizontal transfer events and three BGC configurations were identified. Transcriptomic profiling shows PsiK is highly expressed in mycelia, while PsiH and PsiM are inactive, correlating with the absence of psilocybin in mycelial tissue. Divergence timing suggests a post-Cretaceous-Tertiary radiation linked to mammal rise and new ecological niches. Horizontal BGC transfer drives genetic innovation and species diversification.
Zenodo (CERN European Organization for Nuclear Research)
December 23, 2025
Mihai Alexandru Bucurenciu
A measurable brain state corresponding to enlightenment is identified for the first time using raw electroencephalography from individuals under 5-MeO-DMT, DMT, or sustained meditation. At exactly 41.000 seconds under 43.000000000 Hz coherence, multiple markers converge: default mode network deactivation, gamma synchrony explosion, theta timeless flow, a drop in Higuchi fractal dimension, and persistence loss with detrended fluctuation analysis alpha approaching 0.5. These findings suggest a unified model of consciousness as a physical field, with implications for quantum mind theories. The work is part of a larger framework derived from a single measured primordial current density of 1.000 × 10¹⁸ A/m².
Zenodo (CERN European Organization for Nuclear Research)
December 22, 2025
Tcheufang Simeu Madeleine Armelle, Ntjam Marie-Chantale
Nuns in sub-Saharan Africa experience a paradox where intense religious practice, while a source of resilience, also creates hidden psychological vulnerability. The proposed model 'Hidden Bodies, Absent Voices' explains how the ideal of perfection in consecrated life forces the ascetic body to mask pain as sacrifice and represses speech in the name of obedience, generating inner violence and identity fragmentation. This concealment is reinforced by African socio-cultural factors: religious patriarchy, community cohesion (Ubuntu), and the sanctification of renunciation transform clinical distress into spiritual virtue. The article advocates for a 'clinic of recognition' to restore visibility of the body, create safe spaces for exchange, and integrate acceptance of fragility into religious structures.
Zenodo (CERN European Organization for Nuclear Research)
December 15, 2025
Encounters with seemingly autonomous non-human entities are among the most striking and consistently reported phenomena associated with psychedelic states, particularly those induced by DMT. This paper traces the historical, cultural, and phenomenological lineage of such encounters, situating the modern "machine elf" archetype within a much older cross-cultural tradition of spirit, guide, and non-human intelligence encounters found in shamanic and indigenous contexts. It surveys explanatory frameworks—neuropharmacological, cognitive, phenomenological, and philosophical—that attempt to account for the apparent autonomy, intentionality, and consistency of these experiences. The analysis argues that their enduring significance lies in their reproducible structure, communicability, and epistemic impact, challenging conventional models of consciousness and warranting continued interdisciplinary study.
Zenodo (CERN European Organization for Nuclear Research)
December 14, 2025
Bucurenciu, Mihai Alexandru
A single measured primordial current density of 1.000 × 10¹⁸ A/m² is claimed to generate, without free parameters, a complete description of cosmology, consciousness, quantum biology, and the neurophysiology of enlightenment at exactly 43 Hz and a switch at 41 seconds. The work asserts that cosmology can proceed without dark matter, dark energy, or inflation; consciousness is a physical field at 43 Hz; ego dissolution occurs at 41 seconds; and an immortality switch has been measured. The archive includes 486 reproducible Python proofs, 586 plots, raw EEG data from subjects under 5-MeO-DMT, DMT, and sustained meditation, and cosmic datasets.
Zenodo (CERN European Organization for Nuclear Research)
December 14, 2025
Mardonova, Madina
Rumi's Masnavi reinterprets existence and non-existence not as static opposites but as dynamic dimensions of spiritual experience. Existence means participation in divine reality, while non-existence signifies self-effacement (fanā'), potentiality, and openness to the Divine, not absolute nothingness. Through allegory and metaphor, Rumi transforms philosophical abstractions into ethical principles guiding spiritual perfection. A qualitative, hermeneutical, and comparative analysis of key Masnavi passages, in dialogue with Avicennan metaphysics and Sufi thought, shows that Rumi's ontology bridges philosophy and mysticism, integrating ontological reflection with spiritual transformation.
Zenodo (CERN European Organization for Nuclear Research)
December 13, 2025
Gregus, David, Hlinka, Jaroslav, Tylš, Filip et al.
Cingulate cortex thickness patterns, not just a single region, predict how intensely people experience altered states of consciousness under psilocybin. In 25 healthy adults given psilocybin or placebo in a double-blind crossover design, an anterior-to-posterior gradient of cingulate thickness strongly correlated with psychedelic experience intensity. The previously reported link between rostral anterior cingulate thickness and emotional response showed a similar effect size but was not statistically significant, likely due to the smaller sample. The spatial organization across the cingulate cortex, rather than thickness in one area, appears to be a neuroanatomical marker of variability in psychedelic response.
Zenodo (CERN European Organization for Nuclear Research)
December 10, 2025
Paduano, Ivan
Aleister Crowley radically reformulated astrology from a fatalistic predictive system into a structural language of the 'True Will' and Thelemic cosmology. This research report traces the evolution of his astrological thought from his training in the Hermetic Order of the Golden Dawn through the 1904 revelation of Liber AL vel Legis to the systemic maturity of the Book of Thoth and his collaboration with Evangeline Adams. For Crowley, astrology was not an auxiliary discipline but the fundamental grammar through which the initiate codifies and navigates the magical universe. The analysis extends to geopolitical implications of worldly astrology during world wars and topological revisions of the Zodiac that redefined twentieth-century Tarot iconography.
Zenodo (CERN European Organization for Nuclear Research)
December 8, 2025
Farias, Gabriela, Ventura, Wanessa, Cardoso Filho, José
Pharmaceutical care plays a key role in the therapeutic use of ketamine, an anesthetic with clinical applications that also carries risks of adverse effects and recreational misuse. A review of literature from PubMed, Scielo, and health sector books indicates that pharmacists can assist in monitoring patients undergoing ketamine therapies by ensuring safe use, tracking side effects, providing dosage guidance, and promoting treatment adherence. The work underscores the importance of the pharmacist's involvement in managing ketamine's benefits and risks, particularly in contexts such as treatment of major depression and healthcare during the COVID-19 pandemic.
Zenodo (CERN European Organization for Nuclear Research)
December 6, 2025
Bucurenciu, Mihai Alexandru
A single measured current density of 1.000 × 10¹⁸ A/m² is claimed to derive the entire observable universe with zero free parameters, replacing dark matter, dark energy, and inflation. Experimental evidence from three human brains under 5-MeO-DMT, DMT, and meditation, along with 127 X-class solar flares, is reported to lock to exactly 43.000000000 Hz—a universal frequency said to govern the cosmic microwave background, black hole ringdowns, and ITER plasma stability. The work includes a 180+ page theory, Python proofs, raw EEG data, and a visualization titled 'Nirvana Maria' showing ego dissolution at t = 41.000 s.
Zenodo (CERN European Organization for Nuclear Research)
December 5, 2025
Bucurenciu, Mihai Alexandru
A 256-channel geodesic EEG recording of 35 breakthrough states (10–5 system) demonstrates that electrode AFz corresponds to a physical, piezoelectric organ at exactly 43 Hz, with a signal gain of +34.2 dB at that frequency. Only 1024 Hz sampling combined with a Hamming window and 8th-order Butterworth filter reveals the spike. Every DMT, 5-MeO-DMT, and deep meditation breakthrough locks to precisely 43.000000000 Hz. The finding is supported by a p-value less than 10⁻¹⁸. The authors conclude the Third Eye is not mystical but a physical 43 Hz organ, and present all raw data, code, and high-resolution plots.
Zenodo (CERN European Organization for Nuclear Research)
December 1, 2025
Barikani, Hannaneh
The number 33 holds symbolic and mystical significance across Persian Sufism, Kabbalah, and other esoteric traditions, and this significance is embodied in the architecture of Si-o-se-pol (33 Bridges) in Isfahan. The bridge functions as a metaphysical structure linking the material and spiritual realms, with its design reflecting sacred geometry and numerological principles. The analysis draws on comparative mysticism and iconographic study to show how architectural forms can encode spiritual meanings.
Zenodo (CERN European Organization for Nuclear Research)
November 25, 2025
Swygert, John
A new quantitative model proposes that the body's own DMT, acting through sigma-1 receptors, can increase coherence between neural activity and an underlying substrate. The model integrates neuropharmacology and quantum biology to explain how sigma-1 receptor chaperone activity stabilizes microtubule coherence and improves phase alignment between brain oscillations and substrate eigenmodes. The paper provides a kinetic derivation, an experimental protocol, and five falsifiable predictions, all compatible with established biophysics. It suggests DMT is a biologically regulated modulator of neural-substrate phase coupling, offering a unified mechanism for altered-state phenomena.
Zenodo (CERN European Organization for Nuclear Research)
November 23, 2025
Swygert, John
A new biological classification for DMT is proposed: crisis-linked endogenous consciousness modulators (cECMs). DMT uniquely satisfies six falsifiable criteria: endogenous neural biosynthesis, deep evolutionary conservation, ultra-rapid pharmacokinetics, multi-receptor promiscuity, crisis-linked release, and induction of information-rich structured internal states. 5-MeO-DMT meets five criteria and is designated borderline; classic psychedelics (psilocin, LSD, mescaline) and conventional neuromodulators fail most criteria. Published evidence of mammalian brain biosynthesis, sigma-1 receptor regulation, TAAR signaling, and ischemia-linked surges supports the framework. Four concrete, testable predictions are presented. The cECM model offers a precise, predictive alternative to the current "classic psychedelic" taxonomy.
Zenodo (CERN European Organization for Nuclear Research)
November 23, 2025
Swygert, John
A standardized, open-source scientific protocol enables rigorous investigation of structured visual patterns reported by people under the influence of DMT when viewing diffused coherent red laser light. The protocol specifies safety, legal, optical, camera, dosing, physiological monitoring, blinding, and phenomenology requirements. It mandates sober negative controls, lens inspection, continuous multi-camera recording, and a standardized data format for academic review. The protocol aims to allow researchers, including skeptics, to generate reproducible, falsifiable evidence about the interaction between psychedelics, coherent light interference, visual neuroscience, and altered sensory gating.
Zenodo (CERN European Organization for Nuclear Research)
November 23, 2025
Swygert, John
A standardized, open-source scientific protocol has been developed for investigating reports of structured visual patterns seen within diffused red laser light under the influence of DMT. The protocol specifies safety, legal, optical, dosing, monitoring, blinding, and documentation requirements to ensure reproducibility and falsifiability. It mandates sober negative controls, lens inspection, continuous multi-camera recording, and a standardized data format for academic review. The protocol aims to generate confirming or falsifying evidence about the DMT–laser visual phenomenon and serves as a foundation for a global dataset on psychedelics, coherent light interference, visual neuroscience, and altered sensory gating.
Zenodo (CERN European Organization for Nuclear Research)
November 22, 2025
Swygert, John
A new hypothesis proposes that the brain's own DMT acts as a piezoelectric molecular antenna, coupling living systems to a non-local field that generates the sense of self. Drawing on biochemistry, clinical lobotomy data, and cross-species comparisons, the paper argues DMT-linked circuits enable self-modeling; severing them, as in lobotomy, collapses inner experience despite preserved behavior. The model yields testable predictions about self-awareness, DMT synthesis, and crystalline structure disruption, offering a falsifiable framework for consciousness research.
Zenodo (CERN European Organization for Nuclear Research)
November 20, 2025
Nagatsu, Kazutoshi
Amrita Field Theory (AFT) v1.4 proposes a unified framework in which consciousness, life, and causality arise from a low-entropy, ultra-fine information carrier called Amrita. The theory describes a tri-layer structure: a maximally coherent light-like domain (0L), an Amrita information field where interference patterns encode souls and memories (1L), and the phenomenal domain of spacetime and matter (2L). Conscious experience is a compressed projection of higher-dimensional field structure into neural dynamics; the brain acts as a receiver, and the subjective 'I' corresponds to a localized interference node in the 1L field. Version 1.
Zenodo (CERN European Organization for Nuclear Research)
November 20, 2025
Parker Singleton, Mathias Harrer, Brooke Sevchik
A meta-analytic dataset on psilocybin-assisted therapies for adults with depressive symptoms, part of the Metapsy project, compares psilocybin therapy against control conditions. Effect sizes are reported for post-test and long-term follow-up outcomes. Data were independently extracted by two researchers, and risk of bias was assessed using the Cochrane Risk of Bias Tool (Version 2). The dataset is maintained by the Sypres Collaboration and follows the Metapsy data standard.
Zenodo (CERN European Organization for Nuclear Research)
November 20, 2025
Swygert, John
This paper completes Federico Faggin's architecture of consciousness by identifying two missing components: a biological receiver (the DMT antenna network) and an interaction law (encoded equilibrium, expressed as V = E × Y). The DMT antenna hypothesis proposes that endogenous DMT synthesis in biological systems creates crystalline and piezoelectric microstructures capable of transducing non-local information. The encoded equilibrium equation defines how biological systems extract information from a consciousness field, governing coherence, self-modeling, and the emergence of subjective experience. The work synthesizes quantum information theory, neurochemistry, plant electrophysiology, clinical lobotomy data, and near-death experience phenomenology, offering falsifiable predictions.