The Fate of Lysergic Acid Di[14C]ethylamide ([14C]LSD) in the Rat

In rats, radiolabeled LSD was administered and its distribution and elimination were tracked. The compound was rapidly cleared from the blood and taken up by tissues, with the highest concentrations found in the liver, kidney, and lung. Most of the radioactivity was excreted in the bile and urine within 24 hours, indicating that LSD is quickly metabolized and eliminated from the body.

Study at a glance

Abstract

Conference Article| April 01 1975 The Fate of Lysergic Acid Di[14C]ethylamide ([14C]LSD) in the Rat ZAHID H. SIDDIK; ZAHID H. SIDDIK 1Department of Biochemistry, St. Mary's Hospital Medical School, London W2 1PG, U.K. Search for other works by this author on: This Site PubMed Google Scholar ROGER D. BARNES; ROGER D. BARNES 1Department of Biochemistry, St. Mary's Hospital Medical School, London W2 1PG, U.K. Search for other works by this author on: This Site PubMed Google Scholar L. GRAHAM DRING; L. GRAHAM DRING 1Department of Biochemistry, St. Mary's Hospital Medical School, London W2 1PG, U.K. Search for other works by this author on: This Site PubMed Google Scholar ROBERT L. SMITH; ROBERT L. SMITH 1Department of Biochemistry, St. Mary's Hospital Medical School, London W2 1PG, U.K. Search for other works by this author on: This Site PubMed Google Scholar R. TECWYN WILLIAMS R. TECWYN WILLIAMS 1Department of Biochemistry, St. Mary's Hospital Medical School, London W2 1PG, U.K. Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1975 Biochemical Society1975 Biochem Soc Trans (1975) 3 (2): 290–292. https://doi.org/10.1042/bst0030290 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation ZAHID H. SIDDIK, ROGER D. BARNES, L. GRAHAM DRING, ROBERT L. SMITH, R. TECWYN WILLIAMS; The Fate of Lysergic Acid Di[14C]ethylamide ([14C]LSD) in the Rat. Biochem Soc Trans 1 April 1975; 3 (2): 290–292. doi: https://doi.org/10.1042/bst0030290 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1975 Biochemical Society1975 Article PDF first page preview Close Modal You do not currently have access to this content.