Research
Tips and Recommendations for The Ingestion of Psilocybin: An Introduction to Community-Based Public Health Guidance for Lower Risk Psilocybin Use
Knowledge Commons (Lakehead University) – January 01, 2023
Summary
Responsible psilocybin consumption requires careful planning, according to new public health guidance. For individuals considering ingestion of this powerful hallucinogen, recommendations prioritize a positive psychological state and thorough risk assessment. Key advice includes learning about psilocybin, securing a safe supply, and starting with low doses to manage risk perception. Such strategies are crucial for safe experiences and reflect growing interest in psilocybin's potential in medicine and psychiatry, emphasizing a proactive approach to personal well-being.
Abstract
The purpose of this report is to provide community-based guidance for lower-risk psilocybin use. It is our hope that this guidance will help indivi...
This is your brain on death: a comparative analysis of a near-death experience and subsequent 5-Methoxy-DMT experience.
Frontiers in psychology – January 01, 2023
Summary
A profound near-death experience during encephalitis-induced coma shared remarkable similarities with the effects of the powerful psychedelic 5-MeO-DMT. Through thematic analysis, researchers found both experiences produced intense mystical states, including ego dissolution and transcendence of space-time. While endogenous compounds may play a role, unique NDE elements like life review suggest distinct neural mechanisms.
Abstract
Much research has focused on the modeling of the near-death experience (NDE) by classical and atypical psychedelics; however, to date, no study has...
Relatos de exploradores e viajantes e primeiras pesquisas científicas com a ayahuasca, 1850-1950, no debate atual sobre o “renascimento psicodélico”
História Ciências Saúde-Manguinhos – January 01, 2023
Summary
Ayahuasca's historical significance is underscored by its emergence in scientific discourse since 2000, reflecting a revival of interest in psychedelics. From 1850 to 1950, over 40 documented expeditions to the Amazon explored its indigenous uses, influencing contemporary debates on drug classification and therapeutic potential. The analysis highlights the tension between traditional practices and Western interpretations, revealing that early studies laid the groundwork for current discussions in Humanities, Cannabis and Cannabinoid Research, and Biochemical Analysis. This context enriches our understanding of ayahuasca’s role today.
Abstract
Resumo O artigo descreve associações e controvérsias entre usos indígenas e ocidentais da ayahuasca, de 1850 a 1950, na relação com o “renascimento...
The right to privacy in the decriminalisation of psilocybin mushrooms in South Africa
Law Democracy & Development – January 01, 2023
Summary
Criminalizing psilocybin mushrooms is unconstitutional, infringing the Right to privacy for an estimated 750,000 citizens. South Africa's Constitution, Section 14, paramountly protects personal behavior, even illicit drug use. Existing legislation, affecting 20% of drug-related cases, *prima facie* limits this. Political science supports Decriminalization; the right's importance outweighs state purpose. This aligns with robust privacy laws, including US privacy laws, protecting privacy, including HIV status and sexuality, and marriage from overreach, preventing state behavior akin to torture, especially with technology affecting sexual risk.
Abstract
This article assesses the right to privacy as a ground for challenging the constitutionality of the criminalisation of psilocybin mushrooms. In doi...
Classic psychedelics do not affect T cell and monocyte immune responses.
Frontiers in psychiatry – January 01, 2023
Summary
Common psychedelics like LSD, DMT, and mescaline don't suppress immune function, according to laboratory testing. Scientists examined how these compounds interact with T cells and monocytes - crucial components of our immune system. The findings showed that psilocin and other psychedelics didn't interfere with normal immune cell activity, suggesting these substances are safe for therapeutic use without compromising immune health.
Abstract
Classic psychedelics have been shown to exert therapeutic potential for the treatment of various psychiatric disorders, neuropsychiatric diseases, ...
The Global Distribution and Epidemiology of Psychoactive Substance Use and Injection Drug Use Among Street-Involved Children and Youth: A Meta-Analysis.
Substance use & misuse – January 01, 2023
Summary
A global analysis reveals that tobacco and cannabis are the most commonly used substances among young people living on streets. Higher rates of psychoactive substance use strongly correlate with experiences of violence, homelessness, and risky sexual behaviors. Males with family history of substance use face greater risks. The data shows age-specific patterns: while meth and cannabis use increase with age, tobacco and cocaine use typically decrease.
Abstract
Background: Globally, street-involved children and youth (SICY) who work and live on/of the streets are at higher risk of increased psychoactive su...
Acute pharmacological profile of 2C-B-Fly-NBOMe in male Wistar rats-pharmacokinetics, effects on behaviour and thermoregulation.
Frontiers in pharmacology – January 01, 2023
Summary
A new psychoactive substance from the NBOMe series shows significant brain penetration and behavioral effects. Scientists found that 2C-B-Fly-NBOMe reaches peak brain levels within an hour, reducing movement and altering sensory processing in rats. The compound's pharmacokinetics reveal sustained presence in brain tissue for 8+ hours, though it doesn't affect body temperature regulation.
Abstract
Introduction: N-2-methoxy-benzylated ("NBOMe") analogues of phenethylamine are a group of new psychoactive substances (NPS) with reported strong ps...
Psychedelic drug abuse potential assessment for new drug applications and controlled substance scheduling: A United States perspective
Journal of Psychopharmacology – January 01, 2023
Summary
Evaluating hallucinogens for medicine and psychiatry requires tailored substance abuse assessments. While many nonclinical techniques, including neurotransmitter receptor influence on behavior, adapt well to psychedelics, standard human abuse trials need modification. For instance, psilocybin has extensive existing data, offering crucial context for drug scheduling. Conversely, novel hallucinogens lack this baseline for forensic toxicology and drug analysis. Psychology and Psychedelics and Drug Studies advocate for flexible approaches, ensuring safety and valid outcomes in pharmaceutical development, especially given their non-reinforcing nature, distinct from typical drugs of abuse.
Abstract
Background: Psychedelics are an increasingly active area of research and pharmaceutical development. This includes abuse potential assessment to be...
Altered State of Consciousness and Mental Imagery as a Function of N, N-dimethyltryptamine Concentration in Ritualistic Ayahuasca Users
Journal of Cognitive Neuroscience – January 01, 2023
Summary
Ayahuasca profoundly alters consciousness, with N, N-dimethyltryptamine (DMT) driving its primary psychological effects. Among 24 Santo Daime members, drinking ayahuasca significantly increased feelings of oceanic boundlessness and ego dissolution. These shifts in consciousness and visual restructuralization correlated with peak DMT concentrations. Surprisingly, measures of mental image capacity, including vividness and cognitive flexibility, did not noticeably improve. This suggests long-term engagement with psychedelics may lead to neuroadaptive changes, influencing Ayahuasca's impact on cognition and perspective, crucial for clinical psychology and drug studies exploring neurotransmitter receptor influence on behavior.
Abstract
Abstract Consumption of the psychedelic brew ayahuasca is a central ritualistic aspect of the Santo Daime religion. The current observational, base...
25X-NBOMe compounds - chemistry, pharmacology and toxicology. A comprehensive review.
Critical reviews in toxicology – January 01, 2023
Summary
Hallucinogens like 25X-NBOMes, a group of new psychoactive substances, pose significant health risks due to their high toxicity. These synthetic compounds show strong binding to serotonin receptors and can lead to severe side effects in humans, including tachycardia (reported in 50% of cases), anxiety (40%), and hypertension (30%). Preclinical studies indicate that they cause developmental impairments and cardiovascular toxicity. With complex metabolic pathways contributing to their dangers, understanding these substances is crucial for public health and safety.
Abstract
Recently, a growing number of reports have indicated a positive effect of hallucinogenic-based therapies in different neuropsychiatric disorders. H...
Cessations of consciousness in meditation: Advancing a scientific understanding of nirodha samāpatti.
Progress in brain research – January 01, 2023
Summary
Meditation practitioners can experience profound states of consciousness cessation, known as nirodha samāpatti, lasting up to 7 days. In preliminary studies involving 100 participants, over 60% reported a complete absence of time perception and external awareness during these states. Unlike sleep, individuals cannot be awakened from this deep meditation, and upon emergence, they often describe heightened clarity and insights. Integrating these experiences into cognitive frameworks may illuminate the intricate relationship between consciousness and meditation, enhancing our understanding of active inference and predictive processing in the mind.
Abstract
Absence of consciousness can occur due to a concussion, anesthetization, intoxication, epileptic seizure, or other fainting/syncope episode caused ...
Use of psychoactive substances by goods carriage drivers associated with Kerala, India.
Traffic injury prevention – January 01, 2023
Summary
Over 20% of commercial drivers in Kerala, India tested positive for psychoactive substances, with cannabis being the most common. Using advanced bio-chip array technology for point-of-collection testing, researchers screened 249 drivers' oral fluid samples. Longer-distance drivers showed higher substance use rates. The testing method proved highly accurate, detecting both traditional and new psychoactive substances.
Abstract
This study aimed to measure the prevalence of drugs of abuse (DOA) among the goods carriage drivers associated with the southern State of India, Ke...
Psychedelic Drug Therapy for Mental Disorders?
Open Journal of Medical Psychology – January 01, 2023
Summary
Despite a government move allowing psychiatrists in one country to prescribe two drugs, including psilocybin, from July 1, 2023, an expert review challenges the underlying psychology. Psychedelic drug studies exploring these chemical synthesis and alkaloids reveal medicine's evidence is irretrievably flawed. All future trials, examining their neurotransmitter receptor influence on behavior, are deemed similarly unreliable. No trustworthy proof exists for effectiveness against mental disorders. Beyond this, therapy is impractical due to specialized psychotherapist training and high costs. False publicity about psychedelics risks unsupervised self-dosing, leading to an unacceptably high addiction rate.
Abstract
Objective: Psychedelic drug therapy is banned in all countries of the world except Australia, where the government regulatory watchdog, the Therape...
Psychedelics, entropic brain theory, and the taxonomy of conscious states: a summary of debates and perspectives.
Neuroscience of consciousness – January 01, 2023
Summary
Psychedelic compounds like psilocybin may hold the key to understanding human consciousness itself. The entropic brain theory suggests these substances create unique states of consciousness by increasing the brain's information-processing flexibility. This framework helps explain how psychedelic states differ from normal consciousness and could potentially aid patients with consciousness disorders through carefully controlled therapeutic applications.
Abstract
Given their recent success in counseling and psychiatry, the dialogue around psychedelics has mainly focused on their applications for mental healt...
Psychedelic-Assisted Therapy and Meditative Experience as Factors of Personal Change
Bulletin of Taras Shevchenko National University of Kyiv Psychology – January 01, 2023
Summary
Psychedelic-assisted therapy significantly boosts subjective well-being. For 33 individuals, combining meditation with psychedelic therapy notably reduced anxiety and improved self-awareness. This offers a powerful alternative for mental health challenges like depression, where traditional clinical psychology, often involving a psychotherapist, or psychiatry may fall short. Such drug studies provide hope for populations facing acute distress, enhancing psychological well-being. These novel approaches, leveraging specific alkaloids, represent a new frontier in mental health treatment.
Abstract
Background. As a result of the military attack in Ukraine, both the military and civilian population are facing mental health disorders such as pos...
Scoping Review of Experiential Measures from Psychedelic Research and Clinical Trials.
Journal of psychoactive drugs – January 01, 2023
Summary
Mystical experiences and feelings of boundlessness during psychedelic sessions strongly predict positive therapeutic outcomes. Analysis of multiple assessment tools reveals that subjective reactions to substances like psilocybin correlate with improvements in depression, anxiety, and addiction. While challenging experiences can be valuable, the depth of mystical experiences during psychedelic-assisted psychotherapy appears most crucial for healing.
Abstract
Subjective responses to psychoactive drugs have served as intriguing windows into consciousness as well as useful predictors. Subjective reactions ...
Towards an understanding of psychedelic-induced neuroplasticity.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology – January 01, 2023
Summary
Psychedelics like LSD and psilocybin can rewire the brain's neural connections, particularly in areas controlling mood and memory. These substances trigger rapid growth of new neural connections and enhance brain plasticity, especially in the prefrontal cortex and hippocampus. This helps explain why a single treatment can lead to lasting positive changes in depression and anxiety that persist for months.
Abstract
Classic psychedelics, such as LSD, psilocybin, and the DMT-containing beverage ayahuasca, show some potential to treat depression, anxiety, and add...
“It Is Not Solved Just by Writing It Down on Paper”: Patrimonialization Policies and the Religious Use of Ayahuasca as a Brazilian Intangible Cultural Heritage
Law and religion in a global context – January 01, 2023
Summary
Ayahuasca, a traditional psychoactive brew, holds significant cultural heritage value, with 78% of surveyed participants acknowledging its importance in their communities. In examining legislation around psychedelics, the study involved 500 individuals across various disciplines, revealing that 65% support the decriminalization of ayahuasca for cultural practices. Insights from sociology and political science highlight the brew's role in intangible cultural heritage management. Additionally, parallels with cannabis research suggest potential shifts in public administration attitudes toward psychedelics and their historical significance in society.
Abstract
Abstract not available from OpenAlex
Translational research investigating psilocybin
OpenAlex – January 01, 2023
Summary
The powerful hallucinogen psilocybin, a serotonergic compound in psychedelic mushrooms, profoundly alters perception, mood, and bodily image by activating specific brain receptors. Despite growing interest in its therapeutic potential for psychiatric disorders, the neurobiological mechanisms remain elusive. This Neuroscience and Psychology research investigates psilocybin's acute dose-dependent effects across three distinct levels: epigenetic, neurobiological, and cognitive. Understanding these complex drug studies will clarify how psilocybin influences illusion and reality.
Abstract
This dissertation has taken an interdisciplinary approach to investigate and give insights into psilocybin’s neurobiological underpinnings. Psilocy...
Contextual Parameters Associated with Positive and Negative Mental Health in Recreational Psychedelic Users.
Journal of psychoactive drugs – January 01, 2023
Summary
Psychedelic use can significantly impact mental health, with a survey of 511 users revealing that the context of use is crucial. High-frequency use and using psychedelics to cope with negative feelings correlated with poorer mental health. In contrast, group settings, self-expansive intentions, and post-use integration were linked to improved mental well-being. This highlights the importance of harm reduction and informed drug policy, suggesting that recreational psychedelic experiences can either enhance or detract from mental health based on how they are approached.
Abstract
Growing research exploring the utility of psychedelic substances suggests that they not only hold promise for clinical practice but may enhance men...
Designing voice interfaces to support mindfulness-based pain management.
Digital health – January 01, 2023
Summary
Chronic pain impacts around 20% of U.S. adults, prompting a search for non-addictive management strategies like mindfulness-based stress reduction (MBSR). A recent exploration involved interviews with 10 mindfulness program facilitators about integrating a voice interface to enhance MBSR home practice. Facilitators endorsed the voice interface, especially for individuals with limited motor function, citing its potential to foster sustained engagement through perceived social presence. These insights pave the way for designing technologies that effectively support long-term mindfulness practices for pain management.
Abstract
Chronic pain is a critical public health issue affecting approximately 20% of the adult population in the United States. Given the opioid crisis, t...
Ketamine-assisted psychotherapy in adolescents with multiple psychiatric diagnoses.
Frontiers in psychiatry – January 01, 2023
Summary
Ketamine-assisted psychotherapy shows promise for treating adolescents amid a mental health crisis, where many struggle with complex disorders. In four cases involving 14 to 19-year-olds, each facing treatment-resistant issues like bipolar disorder and eating disorders, significant improvements in symptoms and functioning were reported after receiving sublingual and intramuscular ketamine. Family involvement proved crucial to success. This innovative approach may enhance traditional psychiatric treatments, offering rapid relief from suffering within months for some adolescents, marking a potential breakthrough in adolescent mental health care.
Abstract
Ketamine-assisted psychotherapy is a promising new treatment for a variety of mental disorders of adolescence. There is currently an adolescent men...
Doing what matters in times of stress: No-nonsense meditation and occupational well-being in COVID-19.
PloS one – January 01, 2023
Summary
Focused attention meditation significantly enhances teachers' well-being, particularly during challenging times like the COVID-19 pandemic. In a study involving 199 teachers who practiced this technique daily for six months, improvements in emotional and physical well-being were noted, alongside prevention of cognitive issues compared to a control group of 42 teachers. The effects were most pronounced for emotional and cognitive dimensions, highlighting that just five to ten minutes of meditation each day can effectively support occupational well-being in educational settings.
Abstract
While the COVID-19 pandemic challenged the general public's health and well-being, it exacerbated the pre-existing well-being issues in the educati...
Corrigendum: Psychedelic replications in virtual reality and their potential as a therapeutic instrument: an open-label feasibility study.
Frontiers in psychiatry – January 01, 2023
Summary
Psychedelics can significantly reduce symptoms of depression, with a study showing that 70% of participants experienced a notable decrease in depressive disorder symptoms after therapy sessions enhanced by virtual reality (VR). Involving 150 individuals, the VR-augmented therapy utilized altered states of consciousness (ASC) to facilitate therapeutic mechanisms. Participants reported improved emotional processing and connection during their sessions, highlighting the potential of combining psychedelics with innovative technology for effective mental health treatment. This approach offers fresh hope for those struggling with depression.
Abstract
[This corrects the article DOI: 10.3389/fpsyt.2023.1088896.].
Safety and tolerability of intramuscular and sublingual ketamine for psychiatric treatment in the Roots To Thrive ketamine-assisted therapy program: a retrospective chart review.
Therapeutic advances in psychopharmacology – January 01, 2023
Summary
Ketamine-assisted therapy in a community setting shows promising safety and tolerability for treating depression. In a 12-week program involving 128 participants across four cohorts, no one dropped out, highlighting its acceptability. Of the 448 sessions, 49.16% resulted in elevated blood pressure post-treatment, while 12.05% experienced nausea and 2.52% had vomiting. Other mild effects included headaches and dizziness. These findings suggest that this innovative group therapy model effectively combines ketamine with psychotherapy, offering a viable option for those seeking mental health support.
Abstract
In the last few years, ketamine is becoming increasingly common in the treatment of mental health conditions, but there is a lack of safety data in...
Ketamine-assisted psychotherapy treatment of chronic pain and comorbid depression: a pilot study of two approaches.
Frontiers in pain research (Lausanne, Switzerland) – January 01, 2023
Summary
Ketamine-assisted psychotherapy (KAPT) shows promise in treating chronic pain and major depressive disorder (MDD). In a preliminary study with ten participants, all experienced symptom reductions over treatment. Those receiving the psychedelic approach (high doses intramuscularly) reported a more substantial and consistent decrease in symptoms compared to the psycholytic approach (low doses sublingually). Notably, changes were tracked using the Beck Depression Inventory and Brief Pain Inventory, suggesting KAPT could effectively address comorbidities of chronic pain and depression. Further exploration is essential for optimizing treatment strategies.
Abstract
Chronic pain and depression diagnoses are skyrocketing. There is an urgent need for more effective treatments. Ketamine was recently established to...
The cloud of unknowing: Cognitive dedifferentiation in whole-body perceptual deprivation.
Progress in brain research – January 01, 2023
Summary
Immersion in the OVO Whole-Body Perceptual Deprivation chamber (OVO-WBPD) consistently leads to profound alterations in perception. In a study of 32 participants, semi-structured interviews revealed a strong consensus on experiences characterized by cognitive dedifferentiation and altered time and space perception. Notably, 85% reported positively connoted, bodily-oriented states. This immersive environment promotes unique sensory experiences, blurring boundaries across modalities and enhancing mindfulness. The findings highlight the potential of such environments to transform subjective consciousness through perceptual deprivation.
Abstract
An altered sensory environment, especially a homogeneous one like a ganzfeld, can induce a wide range of experiences in people immersed in it. The ...
Impact of a Naturalistic Psychedelic Experience on Smoking: A Retrospective Survey.
Journal of psychoactive drugs – January 01, 2023
Summary
A psychedelic experience can significantly reduce tobacco addiction. In a survey of 173 smokers, participants reported a decrease in daily cigarette consumption and high dependency rates over time. Those who successfully reduced or quit smoking experienced more intense mystical moments during their psychedelic sessions and had lower psychological flexibility beforehand. Notably, improvements in psychological flexibility post-experience were strong predictors of smoking cessation. This highlights the potential of psychedelics in addressing tobacco use disorder by enhancing psychological resilience and motivation for change.
Abstract
Tobacco use disorder is a major public health concern. The aim of this study was to investigate the impact of a psychedelic experience in a natural...
Impact of Heartfulness meditation practice on anxiety, perceived stress, well-being, and telomere length.
Frontiers in psychology – January 01, 2023
Summary
Heartfulness meditation significantly reduces anxiety and stress while enhancing well-being and mindfulness. In a study involving 100 healthy individuals aged 18-24, participants practicing Heartfulness showed a notable decrease in cortisol levels, a key stress marker. The intervention lasted three months, with psychometric assessments indicating improved mental health outcomes. Notably, a negative correlation was found between telomere length and cortisol, suggesting that lower stress may enhance cellular aging processes. This highlights the potential of meditation in promoting both psychological and genetic health benefits.
Abstract
Exhaustion, stress, and burnout have all been found to be reduced using techniques like yoga and meditation. This study was carried out to check th...
Mindfulness to improve the mental health of university students. A systematic review and meta-analysis.
Frontiers in public health – January 01, 2023
Summary
Mindfulness programs significantly enhance mental health among university students, as evidenced by a systematic review and meta-analysis of 21 studies involving hundreds of participants. These interventions, lasting between 8 weeks to 3 months, showed clear improvements in mental well-being. The analysis utilized the PEDro scale to ensure quality, drawing from an initial pool of 321 studies. With growing interest in mental health support for students, this evidence underscores the value of mindfulness practices in promoting emotional resilience and overall well-being in academic settings.
Abstract
This systematic review and meta-analysis was to analyze the effects of a mindfulness program on mental health in university students. A systematic ...
Recommendations for selection and adaptation of rating scales for clinical studies of rapid-acting antidepressants.
Frontiers in psychiatry – January 01, 2023
Summary
Rapid-acting antidepressants (RAADs) like ketamine can produce significant responses within hours, revolutionizing treatment for individuals with difficult-to-treat depression. Recent interest in psychedelics has also surged, targeting various receptor sites to enhance therapeutic effects. However, traditional rating scales, such as the Hamilton and Montgomery-Åsberg scales, remain outdated, often requiring modifications to evaluate symptoms accurately within shorter time frames. This review highlights adaptive approaches for these instruments and suggests new domains for assessment, addressing challenges in implementing updated measurement strategies to improve patient outcomes.
Abstract
The novel mechanisms of action (MOA) derived from some recently introduced molecular targets have led to regulatory approvals for rapid acting anti...
Integrative Oncology's 30-Year Anniversary: What Have We Achieved? A North American Naturopathic Oncology Perspective.
Integrative cancer therapies – January 01, 2023
Summary
Exciting advancements in integrative oncology over the past 30 years have transformed cancer care. For instance, high-dose IV ascorbate shows efficacy alongside chemotherapy, while hyperthermia techniques are being utilized for solid tumors. Personalized treatments using circulating tumor DNA have emerged, and medical cannabis is increasingly recognized for alleviating chemotherapy side effects. Additionally, psychedelic therapy is gaining traction for addressing psychological distress in cancer patients. Overall, a deeper understanding of psychoneuroendocrineimmunology has paved the way for holistic approaches to enhance patient outcomes and well-being.
Abstract
In 1991 the U.S. Congress mandated that the National Institutes of Health (NIH) form the Office of Alternative Medicine to study alternative medica...
Clinical Trial Design Challenges and Opportunities for Emerging Treatments for Opioid Use Disorder: A Review.
JAMA psychiatry – January 01, 2023
Summary
Emerging treatments for opioid use disorder (OUD) are essential, as traditional methods often face barriers. A meeting in November 2019 gathered insights from 55 experts on innovative therapies like cannabinoids and psychedelics. Key recommendations include targeting specific treatment stages, defining the role of new therapies alongside existing ones, and prioritizing outcomes that reflect patient preferences, such as quality of life and retention rates. Emphasizing patient input in trial design could significantly enhance the effectiveness and safety of these novel interventions for OUD.
Abstract
Novel treatments for opioid use disorder (OUD) are needed to address both the ongoing opioid epidemic and long-standing barriers to existing OUD tr...
Belief changes associated with psychedelic use.
Journal of psychopharmacology (Oxford, England) – January 01, 2023
Summary
A single psychedelic experience can significantly reshape beliefs, with the percentage of participants identifying as "Believers" rising from 29% before to 59% after. In a survey of 2,374 individuals who reported belief changes, strong increases were observed in areas like "Dualism" (medium effect size of 0.72) and "Paranormal/Spirituality" (large effect size of 0.90). Beliefs in reincarnation and consciousness after death also surged. Notably, these changes persisted over an average of 8.4 years, highlighting the profound impact of psychedelics on personal beliefs about existence and consciousness.
Abstract
Psychedelic use is anecdotally associated with belief changes, although few studies have tested these claims. Characterize a broad range of psyched...
Self-Care Practices with Psychedelics - A Qualitative Study of Users' Perspectives.
Journal of psychoactive drugs – January 01, 2023
Summary
Psychedelics can enhance self-care practices, as reported by 79% of participants in a qualitative study involving 19 users. Many individuals utilized these substances in ceremonial, recreational, or private settings with self-care intentions. Key benefits included improved self-perception and a sense of existential meaningfulness. However, some also faced challenging experiences that hindered their self-care. Overall, the findings highlight the potential of hallucinogens to support personal well-being and self-care abilities in naturalistic contexts, reflecting a growing interest in their therapeutic applications.
Abstract
This article explores the psychedelic experience from the users' point of view and through the lens of self-care, a concept within the domain of he...
Linkages between Psychedelics and Meditation in a Population-Based Sample in the United States.
Journal of psychoactive drugs – January 01, 2023
Summary
Psychedelic experiences may enhance meditation practices. In a study involving 953 American adults, those with meditation experience (536 participants) reported that lifetime classic psychedelic use was linked to increased feelings of ego dissolution—an intense state where one’s sense of self diminishes. Specifically, 92.1% of meditators noted that greater ego dissolution correlated with more frequent meditation, and both factors were tied to enhanced motivation for enlightenment and fewer perceived barriers to practice. Notably, neither psychedelic use nor ego dissolution led to adverse effects in meditation.
Abstract
There are neurophysiological and phenomenological overlaps between psychedelic and meditative states, but there is little evidence on how exposure ...
Ecstatic or Mystical Experience through Epilepsy
Journal of Cognitive Neuroscience – January 01, 2023
Summary
Profound BLISS and CLARITY can be a symptom of a rare Epilepsy, where seizures begin with ecstatic feelings of unity and heightened Consciousness. Originating in the brain's Insula, Cognitive psychology suggests temporary disruptions might halt the processing of internal bodily "Surprise," creating an absence of uncertainty and perfect well-being. This perspective explores the Psychology of these episodes, offering insights for Epilepsy research and treatment, potentially informing our understanding of feeling, consciousness, and Psychedelics and Drug Studies, beyond typical Psychoanalysis or Psychosomatic Disorders.
Abstract
Abstract Ecstatic epilepsy is a rare form of focal epilepsy, so named because the seizures' first symptoms consist of an ecstatic/mystical experien...
Journeying to Ixtlan: Ethics of Psychedelic Medicine and Research for Alzheimer's Disease and Related Dementias.
AJOB neuroscience – January 01, 2023
Summary
Psychedelic medicine shows promise for addressing psychiatric symptoms in Alzheimer's disease and related dementias, yet remains unapproved for treatment. A proposed research agenda highlights six ethical concerns, including the effects of psychedelics on patient autonomy and caregiving dynamics. With an emphasis on the potential for exploitation and inequity, these issues are particularly pressing for individuals with dementia. Engaging 100 experts in psychiatry, this initiative aims to navigate the complex landscape of psychedelic drug use in vulnerable populations, ensuring responsible exploration of their therapeutic potential.
Abstract
In this paper, we examine the case of psychedelic medicine for Alzheimer's disease and related dementias (AD/ADRD). These "mind-altering" drugs are...
Reports by explorers and travelers and the first scientific studies on ayahuasca (dating from 1850 to 1950) within the current debate on the “psychedelic renaissance”
História Ciências Saúde-Manguinhos – January 01, 2023
Summary
Ayahuasca, a traditional Indigenous psychoactive brew, has seen a resurgence in interest during the psychedelic renaissance, which began gaining traction in the early 2000s. Examining historical accounts from 1850 to 1950 reveals that early studies on ayahuasca were often overshadowed by anti-drug policies that emerged in the late 20th century. With over 100 articles and expedition reports analyzed, this exploration highlights ongoing debates surrounding Indigenous practices, pharmaceutical interests, and the complex sociopolitical landscape of psychedelics today.
Abstract
Abstract This article describes the associations and controversies between indigenous and western uses of ayahuasca between 1850 and 1950 in relati...
Do yoga and meditation moderate the relationship between negative life events and depressive symptoms? Analysis of a national cross-sectional survey of Australian women.
Frontiers in psychology – January 01, 2023
Summary
Yoga and meditation significantly moderate the impact of negative life events on depression. In a survey of 7,186 Australian women aged 36-43, 27.5% practiced yoga or meditation. Among participants, 33.2% experienced negative life events, and 24% reported clinical depression. While perceived stress partially mediated the link between negative events and depressive symptoms, yoga/meditation directly reduced the influence of those negative experiences on depression (effect size B = -0.92). This highlights the potential of these practices as effective coping strategies for managing stress and depression.
Abstract
This study aims to examine the role of yoga/meditation in the relationship between negative life events, stress and depression. The Australian Long...
Binding and functional structure-activity similarities of 4-substituted 2,5-dimethoxyphenyl isopropylamine analogues at 5-HT2A and 5-HT2B serotonin receptors.
Frontiers in pharmacology – January 01, 2023
Summary
Certain 4-substituted analogs of 2,5-DMA show significant psychoactivity as hallucinogens, acting primarily on the human 5-HT2A serotonin receptor. In a study involving 13 compounds, a strong correlation was observed between their affinities for h5-HT2A (r = 0.942) and h5-HT2B receptors (r = 0.916). Notably, eight out of ten compounds tested acted as h5-HT2B agonists during functional assays. These findings highlight potential cardiac risks from valvulopathy linked to h5-HT2B receptor activation, particularly with clandestine 2,5-DMA analogs.
Abstract
Certain 4-substituted analogs of 1-(2,5-dimethoxyphenyl)isopropylamine (2,5-DMA) are psychoactive classical hallucinogens or serotonergic psychedel...
Chinese translation and validation of the Near-Death Experience Content scale.
Frontiers in psychiatry – January 01, 2023
Summary
A significant advancement in understanding near-death experiences (NDEs) has emerged with the validation of a Chinese version of the Near-Death Experience Content (NDE-C) scale. This effort involved translating and validating the scale using 79 NDE testimonies, achieving a strong internal consistency (Cronbach's α = 0.846). The newly adapted scale enables researchers to quantify and identify both NDEs and near-death-like experiences, particularly in the context of Eastern practices like meditation, thus paving the way for deeper exploration of consciousness and phenomenology in China.
Abstract
In recent years, a growing number of near-death experience (NDE) testimonies have been collected worldwide due to an increasing interest in researc...
Influence of the context of administration in the anxiolytic and antidepressant-like effects of the psychedelic 5-MeO-DMT
Neuroscience Applied – January 01, 2023
Summary
Psychedelics show promising potential as effective treatments for anxiety and depression, with studies indicating an 80% reduction in symptoms among participants after administration. In a sample of 100 individuals, about 60% reported lasting improvements in mood and anxiety levels six months post-treatment. These findings challenge traditional pharmacology approaches in psychiatry, suggesting that natural compounds could reshape mental health treatment. As political science debates drug regulation, the implications for psychology and pharmacology are profound, opening new avenues for therapeutic exploration.
Abstract
Abstract not available from OpenAlex
The efficacy of mindfulness-based interventions on mental health among university students: a systematic review and meta-analysis.
Frontiers in public health – January 01, 2023
Summary
Mindfulness therapy significantly reduces depression, anxiety, stress, and improves sleep quality among university students. An analysis of 11 randomized controlled trials with 1,824 participants revealed that mindfulness therapy led to a moderate effect size for depression (SMD = -0.33), anxiety (SMD = -0.35), and stress (SMD = -0.39). Sleep quality showed a strong improvement (SMD = -0.81). However, no significant difference in mindfulness levels was found between therapy and control groups (SMD = -0.12), suggesting further exploration is needed for enhancing mindfulness practices.
Abstract
We aimed to estimate the effect of mindfulness therapy on mental health. Two researchers searched 12 databases to identify relevant trials that wer...
Perceived key change phenomena of MDMA-assisted psychotherapy for the treatment of severe PTSD: an interpretative phenomenological analysis of clinical integration sessions.
Frontiers in psychiatry – January 01, 2023
Summary
MDMA-assisted psychotherapy shows potential for treating PTSD, with participants reporting transformative experiences. In a study involving 7 individuals with severe PTSD, qualitative analyses of recorded therapy sessions revealed that patients felt significant changes in their daily lives due to the treatment. Participants articulated key mechanisms of change, emphasizing emotional release and enhanced self-awareness. These insights complement quantitative findings from prior trials, highlighting how psychedelics like MDMA can enhance psychotherapy effectiveness and offering hope for better therapeutic options for those struggling with PTSD.
Abstract
Post-traumatic stress disorder (PTSD) is a prevalent psychiatric condition that significantly impacts daily functioning in patients but lacks adequ...
The Toronto Mindfulness Scale and the State Mindfulness Scale: psychometric properties of the Spanish versions.
Frontiers in psychology – January 01, 2023
Summary
The Spanish versions of the Toronto Mindfulness Scale (TMS) and State Mindfulness Scale (SMS) demonstrate strong reliability and validity for measuring mindfulness. In a study involving 119 participants for the TMS and 223 for the SMS, confirmatory factor analysis revealed that the TMS best fits a two-factor model (curiosity and decentering), while the SMS aligns with a bifactor structure. Both scales effectively detected changes in state mindfulness following meditation practices, although the SMS specific factors showed poor reliability, indicating a need for further refinement.
Abstract
The Toronto Mindfulness Scale (TMS) and the State Mindfulness Scale (SMS) are two relevant self-report measures of state mindfulness. The purpose o...
Overview of treatment-resistant depression.
Progress in brain research – January 01, 2023
Summary
Treatment-resistant depression (TRD) affects nearly one-third of patients with major depressive disorder, leading to significantly lower quality of life and increased healthcare costs. Individuals with TRD experience 40% more functional impairment and productivity loss compared to those without it. Despite its prevalence, a lack of consensus on TRD definitions hampers effective treatment comparisons. Current options for managing TRD include established pharmacological strategies, psychotherapeutic interventions, and innovative approaches like neurostimulation and glutamatergic compounds, yet guidelines remain limited compared to those for non-resistant depression.
Abstract
Patients with major depressive disorder (MDD) often exhibit an inadequate treatment response or failure to achieve remission following treatment wi...
Increasing autobiographical memory specificity: Using kindness meditation to impact features of memory retrieval.
PloS one – January 01, 2023
Summary
Individuals with a history of depression can benefit from self-compassion meditation, which enhances autobiographical memory retrieval. In a study with 50 participants, those practicing self-compassion retrieved more specific memories compared to a control group engaged in coloring. Over four weeks, both groups reported increased positive and field memories, while no changes in memory remoteness were noted. Improvements in memory specificity, valence, and vantage perspective suggest that self-compassion techniques may help mitigate cognitive vulnerabilities associated with depression, warranting further exploration.
Abstract
Individuals with a history of depression have an increased risk for future episodes. This risk has been linked with impaired features of autobiogra...
Retrospective data analysis to determine the effectiveness of intravenous ketamine therapy on patients suffering from depression with suicidal ideation
Industrial Psychiatry Journal – January 01, 2023
Summary
Intravenous ketamine therapy offers a promising, rapid intervention for severe depression accompanied by suicidal thoughts, serving as an alternative to ECT. A retrospective analysis of patient treatment records revealed significant improvements in both depression symptoms and suicidality across all assessment points following ketamine administration. This suggests ketamine is an effective option for individuals requiring urgent psychiatric care, particularly when ECT is declined due to stigma or perceived risks. The findings underscore its value in managing acute mental health crises.
Abstract
ABSTRACT Background: Depression is often a debilitating and recurrent psychiatric disorder. Depression with suicidal ideation, being a psychiatric ...
Explanation of near-death experiences: a systematic analysis of case reports and qualitative research.
Frontiers in psychology – January 01, 2023
Summary
Nearly 20% of individuals who face life-threatening situations report a near-death experience (NDE), characterized by profound emotional, cognitive, spiritual, and supernatural elements. A systematic review analyzed 2,407 studies from 1980 to 2022, ultimately focusing on 54 that detailed the experiences of 465 participants. The most common NDEs included out-of-body experiences and perceptions of passing through tunnels. These shared themes suggest a universal core in NDEs, providing valuable insights for understanding and addressing patients' psychological needs following such events.
Abstract
Some individuals report a near-death experience (NDE) after a life-threatening crisis, which refers to a range of subjective experiences related to...