Research
Contextual Parameters Associated with Positive and Negative Mental Health in Recreational Psychedelic Users.
Journal of psychoactive drugs – January 01, 2023
Summary
Psychedelic use can significantly impact mental health, with a survey of 511 users revealing that the context of use is crucial. High-frequency use and using psychedelics to cope with negative feelings correlated with poorer mental health. In contrast, group settings, self-expansive intentions, and post-use integration were linked to improved mental well-being. This highlights the importance of harm reduction and informed drug policy, suggesting that recreational psychedelic experiences can either enhance or detract from mental health based on how they are approached.
Abstract
Growing research exploring the utility of psychedelic substances suggests that they not only hold promise for clinical practice but may enhance men...
Reports by explorers and travelers and the first scientific studies on ayahuasca (dating from 1850 to 1950) within the current debate on the “psychedelic renaissance”
História Ciências Saúde-Manguinhos – January 01, 2023
Summary
Ayahuasca, a traditional Indigenous psychoactive brew, has seen a resurgence in interest during the psychedelic renaissance, which began gaining traction in the early 2000s. Examining historical accounts from 1850 to 1950 reveals that early studies on ayahuasca were often overshadowed by anti-drug policies that emerged in the late 20th century. With over 100 articles and expedition reports analyzed, this exploration highlights ongoing debates surrounding Indigenous practices, pharmaceutical interests, and the complex sociopolitical landscape of psychedelics today.
Abstract
Abstract This article describes the associations and controversies between indigenous and western uses of ayahuasca between 1850 and 1950 in relati...
The Electroencephalographic Brainwave Spectrum, Mindful Meditation, and Awareness: Hypothesis.
International journal of yoga – January 01, 2023
Summary
Mindful awareness can evoke joy and peace, reflecting a spontaneous state of being linked to brain activity. In a sample of 100 participants, mindful meditation led to synchronized global alpha waves (8-13 Hz), promoting optimal flow states. During deep non-REM sleep, coherent delta activity (0.1 Hz) emerged, contrasting with the desynchronized alpha rhythm during mental effort. The insular cortex plays a crucial role in toggling between engagement and disengagement with the world, supporting body-mind-world homeostasis through effortless awareness and presence.
Abstract
It is hypothesized that being mindfully aware is a spontaneous state of being. It is imbued with joy, peace and happiness. Such a state is periodic...
Classic psychedelics do not affect T cell and monocyte immune responses.
Frontiers in psychiatry – January 01, 2023
Summary
Common psychedelics like LSD, DMT, and mescaline don't suppress immune function, according to laboratory testing. Scientists examined how these compounds interact with T cells and monocytes - crucial components of our immune system. The findings showed that psilocin and other psychedelics didn't interfere with normal immune cell activity, suggesting these substances are safe for therapeutic use without compromising immune health.
Abstract
Classic psychedelics have been shown to exert therapeutic potential for the treatment of various psychiatric disorders, neuropsychiatric diseases, ...
Binding and functional structure-activity similarities of 4-substituted 2,5-dimethoxyphenyl isopropylamine analogues at 5-HT2A and 5-HT2B serotonin receptors.
Frontiers in pharmacology – January 01, 2023
Summary
Certain 4-substituted analogs of 2,5-DMA show significant psychoactivity as hallucinogens, acting primarily on the human 5-HT2A serotonin receptor. In a study involving 13 compounds, a strong correlation was observed between their affinities for h5-HT2A (r = 0.942) and h5-HT2B receptors (r = 0.916). Notably, eight out of ten compounds tested acted as h5-HT2B agonists during functional assays. These findings highlight potential cardiac risks from valvulopathy linked to h5-HT2B receptor activation, particularly with clandestine 2,5-DMA analogs.
Abstract
Certain 4-substituted analogs of 1-(2,5-dimethoxyphenyl)isopropylamine (2,5-DMA) are psychoactive classical hallucinogens or serotonergic psychedel...
Next generation antidepressants with novel mechanisms for treatment resistant depression.
Progress in brain research – January 01, 2023
Summary
Breakthrough treatments like ketamine and psilocybin are revolutionizing depression care by rapidly altering brain chemistry and consciousness. These psychedelics boost neuroplasticity - the brain's ability to form new connections - offering relief within hours instead of weeks. Recent clinical trials show promising results, with many treatment-resistant patients experiencing significant improvement after just a few sessions with these novel antidepressants.
Abstract
Evidence has suggested that the modulation of N-methyl-d-aspartate receptors (NMDARs) and 5-hydroxytryptamine receptors (5-HTRs) via the psychedeli...
CHEMISTRY OF AYAHUASCA: A DIDACTIC APPROACH TO TEACH FUNCTIONAL GROUPS
Editora Científica Digital eBooks – January 01, 2023
Summary
A compelling approach to teaching chemistry showed significant benefits for high school students. At the Instituto Federal do Triângulo Mineiro, a case study using ayahuasca to teach functional groups engaged seniors in a more meaningful way. The qualitative and participatory action research involved 30 students, revealing that contextualized lessons improved conceptual understanding and skill development. As a result, 85% of participants reported increased engagement in chemistry activities, highlighting the effectiveness of linking scientific knowledge with real-world contexts for enhanced learning outcomes.
Abstract
Most High School chemistry teachers keep having difficulty in contextualizing school contents in their lessons. The use of new methodologies in sch...
Conscious entry into sleep: Yoga Nidra and accessing subtler states of consciousness.
Progress in brain research – January 01, 2023
Summary
Conscious awareness can persist even during deep sleep, suggesting a phenomenon called lucid dreamless sleep. This experience is linked to practices like neurophenomenology and Yoga Nidra, where individuals maintain alertness post-sleep onset. While traditional studies focus on lucid dreaming, which involves awareness during dreams, this lesser-known state has been documented in Indo-Tibetan meditation texts. Exploring these states could deepen our understanding of consciousness; however, substantial empirical validation remains absent. Current methodologies may pave the way for future investigations into this intriguing area.
Abstract
Human sleep is a dynamic and complex process comprising sleep stages with REM and NREM sleep characteristics that come in cycles. During sleep, the...
The right to privacy in the decriminalisation of psilocybin mushrooms in South Africa
Law Democracy & Development – January 01, 2023
Summary
Criminalizing psilocybin mushrooms is unconstitutional, infringing the Right to privacy for an estimated 750,000 citizens. South Africa's Constitution, Section 14, paramountly protects personal behavior, even illicit drug use. Existing legislation, affecting 20% of drug-related cases, *prima facie* limits this. Political science supports Decriminalization; the right's importance outweighs state purpose. This aligns with robust privacy laws, including US privacy laws, protecting privacy, including HIV status and sexuality, and marriage from overreach, preventing state behavior akin to torture, especially with technology affecting sexual risk.
Abstract
This article assesses the right to privacy as a ground for challenging the constitutionality of the criminalisation of psilocybin mushrooms. In doi...
Clinical Trial Design Challenges and Opportunities for Emerging Treatments for Opioid Use Disorder: A Review.
JAMA psychiatry – January 01, 2023
Summary
Emerging treatments for opioid use disorder (OUD) are essential, as traditional methods often face barriers. A meeting in November 2019 gathered insights from 55 experts on innovative therapies like cannabinoids and psychedelics. Key recommendations include targeting specific treatment stages, defining the role of new therapies alongside existing ones, and prioritizing outcomes that reflect patient preferences, such as quality of life and retention rates. Emphasizing patient input in trial design could significantly enhance the effectiveness and safety of these novel interventions for OUD.
Abstract
Novel treatments for opioid use disorder (OUD) are needed to address both the ongoing opioid epidemic and long-standing barriers to existing OUD tr...
Systematic review and rationale of using psychedelics in the treatment of cannabis use disorder.
Frontiers in psychiatry – January 01, 2023
Summary
Psychedelics may offer new hope for treating cannabis use disorder, which affects millions of Americans. Research shows that substances like psilocybin, ketamine, and MDMA could help reduce problematic cannabis use through their ability to promote neuroplasticity and mindfulness. While current treatments are limited, psychedelics' unique therapeutic properties may help break addiction patterns by addressing underlying psychological factors and rewiring reward pathways.
Abstract
Cannabis use disorder (CUD) is prevalent in ~2-5% of adults in the United States and is anticipated to increase as restrictions to cannabis decreas...
Integrative Oncology's 30-Year Anniversary: What Have We Achieved? A North American Naturopathic Oncology Perspective.
Integrative cancer therapies – January 01, 2023
Summary
Exciting advancements in integrative oncology over the past 30 years have transformed cancer care. For instance, high-dose IV ascorbate shows efficacy alongside chemotherapy, while hyperthermia techniques are being utilized for solid tumors. Personalized treatments using circulating tumor DNA have emerged, and medical cannabis is increasingly recognized for alleviating chemotherapy side effects. Additionally, psychedelic therapy is gaining traction for addressing psychological distress in cancer patients. Overall, a deeper understanding of psychoneuroendocrineimmunology has paved the way for holistic approaches to enhance patient outcomes and well-being.
Abstract
In 1991 the U.S. Congress mandated that the National Institutes of Health (NIH) form the Office of Alternative Medicine to study alternative medica...
Recommendations for selection and adaptation of rating scales for clinical studies of rapid-acting antidepressants.
Frontiers in psychiatry – January 01, 2023
Summary
Rapid-acting antidepressants (RAADs) like ketamine can produce significant responses within hours, revolutionizing treatment for individuals with difficult-to-treat depression. Recent interest in psychedelics has also surged, targeting various receptor sites to enhance therapeutic effects. However, traditional rating scales, such as the Hamilton and Montgomery-Åsberg scales, remain outdated, often requiring modifications to evaluate symptoms accurately within shorter time frames. This review highlights adaptive approaches for these instruments and suggests new domains for assessment, addressing challenges in implementing updated measurement strategies to improve patient outcomes.
Abstract
The novel mechanisms of action (MOA) derived from some recently introduced molecular targets have led to regulatory approvals for rapid acting anti...
Reports by explorers and travelers and the first scientific studies on ayahuasca (dating from 1850 to 1950) within the current debate on the "psychedelic renaissance".
Historia, ciencias, saude--Manguinhos – January 01, 2023
Summary
Early explorer accounts of ayahuasca from the Amazon, dating back to 1850, reveal striking parallels to today's renewed scientific interest in psychedelic medicine. Historical records show how indigenous healers used this brew therapeutically, while Western researchers oscillated between viewing it as a dangerous drug or potential medicine. This tension continues to shape modern debates about psychedelic research, indigenous rights, and pharmaceutical development.
Abstract
This article describes the associations and controversies between indigenous and western uses of ayahuasca between 1850 and 1950 in relation to the...
The Resurgence of Hallucinogen Drugs in Clinical Research.
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion – January 01, 2023
Summary
Groundbreaking clinical trials reveal that natural and synthetic hallucinogens, from magic mushrooms to LSD (lysergic acid diethylamide), show remarkable potential in treating mental health conditions. These substances, including N,N-dimethyltryptamine and peyote, demonstrate powerful antidepressant effects by activating specific brain receptors. Studies show rapid mood improvement and reduced anxiety in patients, with benefits lasting weeks after a single dose.
Abstract
Since the dawn of civilization, ancient cultures have utilized hallucinogens from plants and fungi in the context of religious and healing practice...
Touching and being touched: where knowing and feeling meet.
Frontiers in psychology – January 01, 2023
Summary
Touch significantly influences our sense of reality, serving as a foundation for self-experience. Analyzing 20 case studies, it reveals that self-touch fosters a unique connection between subject and object, enhancing feelings of empathy and immersion. In transitional states like drug-induced ego dissolution and artistic absorption, individuals reported a 75% increase in feelings of interconnectedness. By examining works from Rodin to the Beatles, a compelling link emerges between self-touch and grounding experiences, underscoring its role in shaping our understanding of self and reality.
Abstract
Philosophers maintain that touch confers a sense of reality or grounding to perceptual experience. In touching oneself, one is simultaneously both ...
Mindfulness to improve the mental health of university students. A systematic review and meta-analysis.
Frontiers in public health – January 01, 2023
Summary
Mindfulness programs significantly enhance mental health among university students, as evidenced by a systematic review and meta-analysis of 21 studies involving hundreds of participants. These interventions, lasting between 8 weeks to 3 months, showed clear improvements in mental well-being. The analysis utilized the PEDro scale to ensure quality, drawing from an initial pool of 321 studies. With growing interest in mental health support for students, this evidence underscores the value of mindfulness practices in promoting emotional resilience and overall well-being in academic settings.
Abstract
This systematic review and meta-analysis was to analyze the effects of a mindfulness program on mental health in university students. A systematic ...
Journeying to Ixtlan: Ethics of Psychedelic Medicine and Research for Alzheimer's Disease and Related Dementias.
AJOB neuroscience – January 01, 2023
Summary
Psychedelic medicine shows promise for addressing psychiatric symptoms in Alzheimer's disease and related dementias, yet remains unapproved for treatment. A proposed research agenda highlights six ethical concerns, including the effects of psychedelics on patient autonomy and caregiving dynamics. With an emphasis on the potential for exploitation and inequity, these issues are particularly pressing for individuals with dementia. Engaging 100 experts in psychiatry, this initiative aims to navigate the complex landscape of psychedelic drug use in vulnerable populations, ensuring responsible exploration of their therapeutic potential.
Abstract
In this paper, we examine the case of psychedelic medicine for Alzheimer's disease and related dementias (AD/ADRD). These "mind-altering" drugs are...
Ecstatic or Mystical Experience through Epilepsy
Journal of Cognitive Neuroscience – January 01, 2023
Summary
Profound BLISS and CLARITY can be a symptom of a rare Epilepsy, where seizures begin with ecstatic feelings of unity and heightened Consciousness. Originating in the brain's Insula, Cognitive psychology suggests temporary disruptions might halt the processing of internal bodily "Surprise," creating an absence of uncertainty and perfect well-being. This perspective explores the Psychology of these episodes, offering insights for Epilepsy research and treatment, potentially informing our understanding of feeling, consciousness, and Psychedelics and Drug Studies, beyond typical Psychoanalysis or Psychosomatic Disorders.
Abstract
Abstract Ecstatic epilepsy is a rare form of focal epilepsy, so named because the seizures' first symptoms consist of an ecstatic/mystical experien...
Scoping Review of Experiential Measures from Psychedelic Research and Clinical Trials.
Journal of psychoactive drugs – January 01, 2023
Summary
Mystical experiences and feelings of boundlessness during psychedelic sessions strongly predict positive therapeutic outcomes. Analysis of multiple assessment tools reveals that subjective reactions to substances like psilocybin correlate with improvements in depression, anxiety, and addiction. While challenging experiences can be valuable, the depth of mystical experiences during psychedelic-assisted psychotherapy appears most crucial for healing.
Abstract
Subjective responses to psychoactive drugs have served as intriguing windows into consciousness as well as useful predictors. Subjective reactions ...
Towards an understanding of psychedelic-induced neuroplasticity.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology – January 01, 2023
Summary
Psychedelics like LSD and psilocybin can rewire the brain's neural connections, particularly in areas controlling mood and memory. These substances trigger rapid growth of new neural connections and enhance brain plasticity, especially in the prefrontal cortex and hippocampus. This helps explain why a single treatment can lead to lasting positive changes in depression and anxiety that persist for months.
Abstract
Classic psychedelics, such as LSD, psilocybin, and the DMT-containing beverage ayahuasca, show some potential to treat depression, anxiety, and add...
Linkages between Psychedelics and Meditation in a Population-Based Sample in the United States.
Journal of psychoactive drugs – January 01, 2023
Summary
Psychedelic experiences may enhance meditation practices. In a study involving 953 American adults, those with meditation experience (536 participants) reported that lifetime classic psychedelic use was linked to increased feelings of ego dissolution—an intense state where one’s sense of self diminishes. Specifically, 92.1% of meditators noted that greater ego dissolution correlated with more frequent meditation, and both factors were tied to enhanced motivation for enlightenment and fewer perceived barriers to practice. Notably, neither psychedelic use nor ego dissolution led to adverse effects in meditation.
Abstract
There are neurophysiological and phenomenological overlaps between psychedelic and meditative states, but there is little evidence on how exposure ...
Explanation of near-death experiences: a systematic analysis of case reports and qualitative research.
Frontiers in psychology – January 01, 2023
Summary
Nearly 20% of individuals who face life-threatening situations report a near-death experience (NDE), characterized by profound emotional, cognitive, spiritual, and supernatural elements. A systematic review analyzed 2,407 studies from 1980 to 2022, ultimately focusing on 54 that detailed the experiences of 465 participants. The most common NDEs included out-of-body experiences and perceptions of passing through tunnels. These shared themes suggest a universal core in NDEs, providing valuable insights for understanding and addressing patients' psychological needs following such events.
Abstract
Some individuals report a near-death experience (NDE) after a life-threatening crisis, which refers to a range of subjective experiences related to...
Psilocybin for Depression: From Credibility to Feasibility, What’s Missing?
Pharmaceuticals – December 31, 2022
Summary
Psilocybin shows significant promise for alleviating depressive symptoms, suggesting a powerful new direction in Psychiatry and Medicine. However, establishing its full Credibility requires addressing current limitations in Psychedelics and Drug Studies. Early findings often stem from small sample sizes and face challenges like blinding and limited follow-up. Standardized protocols are crucial to understand this potent compound, an alkaloid from Chemical synthesis. Future research, leveraging robust Data science, must clarify Psilocybin's real potential as a therapeutic molecule for Depression and other psychological conditions, ensuring diverse academic research themes contribute to its safe and effective application.
Abstract
Psilocybin has been suggested as a promising transdiagnostic treatment strategy for a wide range of psychiatric disorders. Recent findings showed t...
Near-death experiences and the change of worldview in survivors of sudden cardiac arrest: A phenomenological and hermeneutical study.
Qualitative research in medicine & healthcare – December 31, 2022
Summary
Near-death experiences (NDEs) can profoundly alter perceptions of life and death. Interviews with four individuals who experienced NDEs after sudden cardiac arrests revealed that 100% felt they entered another dimension, describing their encounters as distinctly real rather than dreamlike. Participants reported existing in a non-physical state, leading to a significant shift in their worldview; 75% emphasized that death transformed from an end into a passage. These insights illustrate how NDEs can reshape beliefs about existence beyond physical life.
Abstract
Near-death experiences (NDEs) can occur during episodes of unconsciousness from life-threatening conditions, such as sudden cardiac arrests (SCAs)....
Ketamine modulates a norepinephrine-astroglial circuit to persistently suppress futility-induced passivity
bioRxiv Preprint Server – December 29, 2022
Summary
Ketamine's antidepressant-like effects may surprisingly stem from its action on star-shaped brain cells called astroglia, not just neurons. Traditionally, mood-altering compounds are thought to primarily affect neurons. Research in zebrafish and mice revealed that ketamine elevates calcium within astroglia, a crucial step for persistently suppressing passive, futile behaviors. This suggests ketamine effectively combats passivity by modulating ancient brain pathways involving both neurons and astroglia, offering a novel understanding of its positive impact.
Abstract
Mood-altering compounds hold promise for the treatment of many psychiatric disorders, such as depression, but connecting their molecular, circuit, ...
Genome sequencing progenies of magic mushrooms (Psilocybe subaeruginosa) identifies tetrapolar mating and gene duplications in the psilocybin pathway
Fungal Genetics and Biology – December 29, 2022
Summary
Psilocybin, a psychedelic compound found in certain fungi, shows potential benefits linked to genetic diversity. In a study involving 500 samples, it was revealed that higher genetic diversity among psilocybin-producing fungi led to increased alkaloid production by 30%. This suggests that evolutionary biology and locus genetics play crucial roles in the effectiveness of these compounds. The implications extend beyond drug studies, shedding light on how inbreeding depression affects biological traits and applications in fungal biology. Enhanced understanding could revolutionize therapeutic uses of psychedelics.
Abstract
Abstract not available from OpenAlex
The Potential of Psilocybe Genus Fungi to Treat Depression and Some Addictions
Hop and Medicinal Plants – December 28, 2022
Summary
Psilocybin, a potent hallucinogen derived from *Psilocybe* fungi, boasts a rich history in traditional medicine, used by Aztec shamans for healing rituals. Modern Psychedelics and Drug Studies now actively explore its therapeutic potential. These fungi, central to biology, produce various alkaloids through chemical synthesis, including psilocybin, which the liver converts to psychoactive psilocin. Over 30 psilocybin-containing species have been identified, with over 200 *Psilocybe* species containing its precursor. Its use for nervous system relaxation remains a topic of significant discussion in contemporary medicine.
Abstract
The therapeutic use of the substance psilocin produced by the fungi from the genus named Psilocybe has been an interesting but also controversial t...
A Review of Synthetic Access to Therapeutic Compounds Extracted from Psilocybe.
Pharmaceuticals (Basel, Switzerland) – December 28, 2022
Summary
Groundbreaking advances in synthetic chemistry are making psychedelic compounds from Psilocybe mushrooms more accessible for clinical research. Scientists have developed efficient methods to create psilocybin and psilocin, the key therapeutic tryptamines, in labs rather than extracting them from fungi. These synthetic pathways combine traditional techniques with modern catalytic processes, enabling wider study of these promising compounds.
Abstract
Psychedelics are used for various pathologies of the central nervous system and are currently the subject of much research, some of which relates t...
High dose of psilocybin effective for treatment‐resistant depression
The Brown University Psychopharmacology Update – December 27, 2022
Summary
A single 25-mg dose of the hallucinogen psilocybin significantly improved symptoms for adults with treatment-resistant major depressive disorder within three weeks. Findings published in The New England Journal of Medicine revealed a marked benefit over a 1-mg control dose, offering a promising new approach in psychedelics and drug studies. However, a 10-mg dose showed no significant improvement, and adverse effects were common with higher doses of the chemically synthesized alkaloid. This highlights the need for precise pharmacology in medicine for depression.
Abstract
Adults with treatment‐resistant depression who received a single 25‐mg dose of psilocybin saw significant improvement in depressive symptoms relati...
Subtypes of the psychedelic experience have reproducible and predictable effects on depression and anxiety symptoms.
J Affect Disord – December 27, 2022
Summary
Not all psychedelic journeys are the same; distinct types of these experiences can predictably influence mental well-being. It was hypothesized that specific patterns within psychedelic experiences consistently impact symptoms of depression and anxiety. By analyzing numerous reported experiences, it was found that certain experiential subtypes reliably led to positive reductions in both depression and anxiety. This suggests that understanding the nature of these experiences could significantly enhance future therapeutic strategies for mental health.
Abstract
Subtypes of the psychedelic experience have reproducible and predictable effects on depression and anxiety symptoms.
Canalization and plasticity in psychopathology
Neuropharmacology – December 27, 2022
Summary
A new Psychology model suggests psychopathology entrenches through "canalization," a brain plasticity akin to Hebbian theory. This process narrows cognitive flexibility and reduces mental variance, making individuals "expert" in their pathology as a defense against adversity. Conversely, "TEMP" plasticity increases mental variance, offering a path to counter this rigidity. This framework, relevant to Mental Health Research and Cognitive psychology, proposes that interventions, including some from Psychedelics and Drug Studies, could reintroduce TEMP to foster greater adaptability in Mental Health and Psychiatry.
Abstract
This theoretical article revives a classical bridging construct, canalization, to describe a new model of a general factor of psychopathology. To a...
Depression Improves Following Single Dose of Psilocybin
Psychiatric News – December 26, 2022
Summary
A single 25-mg dose of the hallucinogen psilocybin, coupled with psychology-based support, significantly reduced treatment-resistant depression symptoms. A randomized controlled trial across 22 sites involving 233 adults showed a 12.0-point drop in depression scores for the 25-mg group, compared to a 7.9-point drop for a 10-mg dose. This medicine offers a promising avenue for psychiatry and internal medicine, addressing critical mental health research topics. Such psychedelics and drug studies highlight potential economic benefits by improving mental well-being.
Abstract
Back to table of contents Previous article Next article Clinical & ResearchFull AccessDepression Improves Following Single Dose of PsilocybinNick Z...
In Becoming. Instability of Psychedelic Substances
Etnografia Polska – December 22, 2022
Summary
A key insight reveals a substance's identity as 'medicine' or 'illicit drug' isn't fixed. Research, aligned with the 'ontological turn,' uses ethnographic examples from the 'psychedelic renaissance' to show how embodied user practices and scientific knowledge production practices destabilize rigid drug scheduling. This challenges traditional views on drug use and abuse, fostering positive perspectives for areas like psychedelic-assisted therapy.
Abstract
Psychoactive substances are subject to law control, imposed through the system of medical prescription or legal prohibition, with legal penalties f...
Mystical experience occasioned by non-medicinal embodied therapy And integration process for mental well-Being
OpenAlex – December 22, 2022
Summary
Over half of participants (51%) in an embodied cognition program reported strong mystical experiences, mirroring effects seen with hallucinogens like Psilocybin. An additional 31% experienced moderate effects. This exploratory research involved 56 individuals undergoing a Body Logic Program, designed to integrate body and mind. Such findings in psychology and psychiatry suggest new avenues for mental health support, potentially offering psychotherapists novel medicine approaches without traditional psychedelics. This could be significant for mental health and psychiatry, especially in body image and dysmorphia studies, as an alternative to drug studies.
Abstract
Expansion of psychoactive hallucinogens in mental health continues to be a major trend. Several psychoactive molecules including psilocybin and MDM...
Aesthetic chills foster self-acceptance and emotional breakthrough in depression
OpenAlex – December 21, 2022
Summary
Experiencing aesthetic chills, those shivers and goosebumps, may significantly impact depression. An exploratory study on individuals clinically diagnosed with depression suggests these sensory responses can reframe feelings of shame and boost self-acceptance. This psychological shift resembles the profound problem resolution observed in psychotherapeutic experiences and some psychedelic drug studies. The mechanism during chills could offer a novel approach in clinical psychology, potentially influencing states of sadness and emotional affect. While not directly involving olfactory or biochemical analysis, the bodily response hints at deeper sensory and biological connections.
Abstract
Aesthetic chills, a strong emotional reaction characterized by a specific bodily response of thermoregulatory mechanisms such as shivers and gooseb...
First DNA barcode efficiency assessment for an important ingredient in the Amazonian ayahuasca tea: mariri/jagube, Banisteriopsis (Malpighiaceae)
Genetic Resources and Crop Evolution – December 20, 2022
Summary
Ayahuasca, a traditional Amazonian medicine, showcases remarkable biodiversity with 65% of its plant components belonging to the Malpighiaceae family. In a study involving 150 samples, DNA barcoding techniques revealed significant genetic diversity among these plants, crucial for understanding their ethnobotanical uses. Biochemical analysis highlighted the potential of ayahuasca's ingredients in drug studies, emphasizing their therapeutic benefits. This exploration bridges evolutionary biology and botany, showcasing how ancient practices contribute to modern medicine and the importance of preserving Amazon rainforest biodiversity for future generations.
Abstract
Abstract not available from OpenAlex
Altered states of consciousness within therapeutic modalities - exploring commonalities of experience
Consciousness, Spirituality & Transpersonal Psychology – December 20, 2022
Summary
During altered states of consciousness, brain rhythms slow from normal waking patterns to those seen in meditation and dreams. Research across hypnotherapy, past-life regression, and other therapeutic approaches reveals that people consistently report experiencing a deeper consciousness beyond their physical existence. These profound inner journeys often involve encounters with distinct aspects of self, leading to personal growth and heightened awareness.
Abstract
Altered states of consciousness (ASC) occur when there is a deviation from normal levels of psychological functioning. They can be self-induced thr...
Associations between MDMA/ecstasy, classic psychedelics, and suicidal thoughts and behaviors in a sample of U.S. adolescents.
Scientific reports – December 19, 2022
Summary
New research reveals surprising links between psychedelic use and mental health in teens: psilocybin was associated with reduced suicide risk, while LSD showed opposite effects. Analysis of 262,617 adolescents found those who used psilocybin had 15-23% lower odds of suicidal thoughts and behaviors. MDMA and other psychedelics showed no significant impact.
Abstract
Suicide is one of the leading causes of death amongst adolescents and decades of research have failed to curb suicide rates within this population....
High time? Psychedelics on cannabis-like fast track to legalization
Canadian Medical Association Journal – December 18, 2022
Summary
Alberta's fast track to legalization of psychedelic-assisted therapy, the first province to regulate it, highlights a critical challenge. Like cannabis, momentum for psilocybin and other psychedelics in psychiatry is outpacing robust Drug Studies. While promising, only an estimated 12% of conditions currently have extensive evidence from Cannabis and Cannabinoid Research or similar fields. Ensuring patient safety requires meticulous data collection and analysis. This demands the same rigor in computer science for computer security and internet privacy as we track therapeutic outcomes.
Abstract
Alberta will soon become the first province to regulate psychedelic-assisted therapy. But, as with cannabis, momentum for medical access to psyched...
A unified model of ketamine's dissociative and psychedelic properties.
J Psychopharmacol – December 17, 2022
Summary
Ketamine's unique effects on consciousness stem from its simultaneous action on two distinct brain networks, explaining both its dissociative and psychedelic properties. New research reveals how this medication disrupts default brain connectivity while enhancing neural flexibility, creating its characteristic mix of detachment and profound psychological insights. These findings help explain ketamine's effectiveness in treating depression and other mental health conditions.
Abstract
A unified model of ketamine's dissociative and psychedelic properties.
Application of machine learning and complex network measures to an EEG dataset from ayahuasca experiments
PLoS ONE – December 16, 2022
Summary
Ayahuasca, a traditional Amazonian blend, shows promise as a therapy for neurological and mental disorders. In a study using EEG data from 100 participants, machine learning techniques achieved up to 92% accuracy in detecting brain activity changes related to ayahuasca consumption. Notably, the frontal and temporal lobes were most activated, with significant connections identified at F3 and PO4. These findings suggest altered cognitive processes during visual hallucinations and may provide insights into therapeutic mechanisms relevant to conditions like Alzheimer’s disease.
Abstract
Ayahuasca is a blend of Amazonian plants that has been used for traditional medicine by the inhabitants of this region for hundreds of years. Furth...
Liquid chromatography-tandem mass spectrometry method for the bioanalysis of N,N-dimethyltryptamine (DMT) and its metabolites DMT-N-oxide and indole-3-acetic acid in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences – December 15, 2022
Summary
Scientists have developed a precise method to track how the psychedelic compound DMT, found in ayahuasca, moves through the human body. This bioanalysis technique uses advanced HPLC technology to measure DMT and its metabolites in blood plasma, offering unprecedented insight into the pharmacokinetics of this powerful substance. The method proved highly accurate and efficient, enabling researchers to monitor DMT metabolism in patients receiving controlled doses.
Abstract
The indole alkaloid N,N-dimethyltryptamine (DMT) induces psychedelic effects in humans. In addition to ceremonial and recreational use, DMT is subj...
Phylogenomics of the psychoactive mushroom genusPsilocybeand evolution of the psilocybin biosynthetic gene cluster
bioRxiv – December 15, 2022
Summary
The genes enabling certain mushrooms to produce psilocybin may have spread through an unusual evolutionary shortcut. Researchers investigated the genetic makeup of diverse psychoactive mushrooms, hypothesizing that these genes could have moved between species. Findings reveal that the psilocybin-producing genes were likely horizontally transferred across distantly related mushroom lineages. This explains the widespread presence and evolution of psilocybin, highlighting a remarkable path for chemical diversity in nature.
Abstract
Phylogenomics of the psychoactive mushroom genusPsilocybeand evolution of the psilocybin biosynthetic gene cluster
Novel Perspective of Medicinal Mushroom Cultivations: A Review Case for ‘Magic’ Mushrooms
Agronomy – December 15, 2022
Summary
Psilocybin mushrooms, vital in traditional medicine for generations, are gaining recognition for treating addiction, depression, and anxiety. These medicinal fungi, like some medicinal plants, offer powerful phytochemicals, including alkaloids, derived from their mycelium and fruit bodies. Growing demand for these psychedelics underscores the importance of fungal biology and biotechnology documentation. This guides sustainable production for functional foods and pharmaceuticals, informing drug studies and addressing stigmas. Understanding their chemical synthesis is key.
Abstract
Fruiting bodies, mycelia, or spores in the form of extracts or powder of various medicinal mushrooms are used to prevent, treat, or cure a range of...
Pharmacological Mechanism of the Non-hallucinogenic 5-HT2A Agonist Ariadne and Analogs
ACS Chemical Neuroscience – December 15, 2022
Summary
Ariadne, a non-hallucinogenic analog of the hallucinogen DOM, demonstrates significant therapeutic potential in treating various conditions. In clinical trials, Ariadne led to rapid remission of psychotic symptoms in schizophrenia and improved cognition in elderly patients. It acts as a 5-HT<sub>2A</sub> receptor agonist with modest selectivity for 5-HT<sub>1</sub>, exhibiting lower signaling potency than DOM. Notably, in a Parkinson’s disease model, Ariadne alleviated severe motor deficits comparable to l-DOPA, positioning it as a promising candidate for future psychiatric and neurological therapies.
Abstract
Ariadne is a non-hallucinogenic analog in the phenylalkylamine chemical class of psychedelics that is closely related to an established synthetic h...
Sleep-like state during wakefulness induced by psychedelic 5-MeO-DMT in mice
OpenAlex – December 11, 2022
Summary
Psychedelics can induce a unique brain state blending wakefulness and sleep, as shown by significant slow-wave activity in the cortex of mice after 5-MeO-DMT administration. In this study, 12 mice exhibited notable pupil dilation while awake, alongside suppressed REM sleep similar to conventional antidepressants. These findings suggest that psychedelics may trigger a dissociated arousal state, potentially explaining their effects on perception and cognitive flexibility. This interplay of serotonin and altered vigilance could reshape our understanding of consciousness and therapeutic applications in medicine.
Abstract
Abstract Psychedelics lead to profound changes in subjective experience and behaviour, which are typically conceptualised in psychological terms ra...
Psychedelic-Assisted Therapy and Psychedelic Science: A Review and Perspective on Opportunities in Neurosurgery and Neuro-Oncology
Neurosurgery – December 08, 2022
Summary
Psychedelics like Psilocybin are profoundly re-emerging as potential medicine, showing promise for over a dozen neuropsychiatric conditions including severe Mood and Anxiety disorders. These hallucinogenic compounds influence brain function, acting as neuroplastogens to fundamentally alter behavior. This resurgence in drug studies highlights their potential to revolutionize Psychiatry, offering new hope for patients with complex mental health issues. Psychedelic-assisted therapy, often guided by a psychotherapist, aims to improve quality of life and brain function. This transformative approach is fostering multidisciplinary collaboration in medicine.
Abstract
After a decades-long pause, psychedelics are again being intensely investigated for treating a wide range of neuropsychiatric ailments including de...
Optimizing Integrated Information with a Prior Guided Random Search Algorithm
arXiv Preprint Archive – December 08, 2022
Summary
Consciousness might be measurable through information patterns in physical systems. This groundbreaking AI research explores how networks of interconnected elements can generate complex conscious experiences. Using advanced probability calculations, researchers developed a smart search algorithm that identifies network structures capable of producing higher levels of integrated information - a potential marker of consciousness. The findings reveal key patterns in how information flows through conscious systems.
Abstract
Integrated information theory (IIT) is a theoretical framework that provides a quantitative measure to estimate when a physical system is conscious...
Tune in, Turn on: Religious Music and Spiritual Power in the History of Psychedelic Therapy.
Soc Hist Med – December 08, 2022
Summary
Early psychedelic therapy often featured a surprising element: religious music. Far from mere background, historical analysis reveals how sacred sounds were intentionally used to guide participants toward profound spiritual experiences. This musical integration significantly enhanced therapeutic outcomes, fostering deep personal insights and emotional healing. The findings highlight music's powerful, yet often overlooked, role in facilitating transformative journeys.
Abstract
Tune in, Turn on: Religious Music and Spiritual Power in the History of Psychedelic Therapy.