579 results for "Integration Therapy"
A Spectrum of Selves Reinforced in Multilevel Coherence: A Contextual Behavioural Response to the Challenges of Psychedelic-Assisted Therapy Development
Frontiers in Psychiatry – December 07, 2021
Summary
The FDA's fast-tracking of two psychedelics, including psilocybin, signals a critical need for refined psychological intervention. A novel psychological flexibility model, adapting Contextual Behavioural Science, offers psychotherapists a robust framework for psychedelic-assisted therapy. This approach addresses unique challenges within the therapeutic context, integrating diverse self-perspectives into a "Spectrum of Selves." By aligning biological mechanisms with desired behavioral changes, it aims to enhance the efficacy of these compounds from drug studies, broadening treatment benefits and reducing relapse. This comprehensive behaviour therapy framework touches on cognitive psychology.
Abstract
Psychedelic-assisted therapy research for depression and PTSD has been fast tracked in the United States with the Food and Drugs Administration (FD...
Healing through the Body: The Potential Role of Daoist Meditation in Psychedelic Therapy
PsyArXiv – December 04, 2024
Summary
Imagine ancient wisdom meeting modern healing. Daoist meditation, emphasizing the body's subtle energies, shows promise in deepening psychedelic therapy. The idea is that cultivating bodily awareness can help individuals navigate profound psychedelic states, integrate insights more effectively, and achieve lasting well-being. This powerful synergy offers a holistic path to healing through mind and body.
Abstract
Healing through the Body: The Potential Role of Daoist Meditation in Psychedelic Therapy
Psychedelic Science of Spirituality and Religion: An Attachment-Informed Agenda Proposal
OpenAlex – December 25, 2021
Summary
Psychedelics hold profound potential to reshape our deepest relational patterns, offering a new perspective on spirituality. Integrating Attachment theory with Psychology, this framework suggests natural compounds might relax rigid beliefs formed by early interpersonal communication. Psychological intervention, often guided by a psychotherapist, could then foster increased attachment security. Phenomenology reveals these experiences, from a Social psychology perspective, alleviate attachment-related worries and promote connection to others and the divine. This agenda outlines how chemical synthesis of alkaloids in Psychedelics and Drug Studies could offer significant therapeutic benefits.
Abstract
In this paper, we set an agenda for a psychedelic science of spirituality and religion, based on a synthesis of attachment theory with the Relaxed ...
Psychedelic Science of Spirituality and Religion: An Attachment-Informed Agenda Proposal
CrossRef
Summary
Our early relationships profoundly shape how we connect with others and the divine. This framework proposes that psychedelics could help relax rigid mental patterns formed by these foundational experiences. It suggests an individual's attachment security influences their psychedelic journey, and that effective psychedelic therapy may actually boost this security. The process involves fostering a deeper sense of connection and easing worries, enhancing treatment benefits.
Abstract
In this paper, we set an agenda for a psychedelic science of spirituality and religion, based on a synthesis of attachment theory with the Relaxed ...
“Meeting the Medicine Halfway”: Ayahuasca Ceremony Leaders’ Perspectives on Preparation and Integration Practices for Participants
Journal of Humanistic Psychology – September 02, 2021
Summary
Ayahuasca ceremonies are gaining popularity for their therapeutic potential, with 15 ceremony leaders sharing valuable insights on enhancing participant outcomes. Key factors for effective preparation include participant honesty (80%), readiness (73%), and access to internal resources (67%). Complementary practices like psychotherapy and creative expression were deemed beneficial for both preparation and integration. Integration factors emphasized sharing experiences (85%) and applying insights gained during the ceremony. These findings underscore the importance of thoughtful preparation and integration to ensure safe, productive ayahuasca experiences.
Abstract
Ayahuasca is a psychotropic plant-based tea from the Amazon. Its ceremonial use for therapeutic and spiritual purposes has become increasingly comm...
Reports of self-compassion and affect regulation in psilocybin-assisted therapy for alcohol use disorder: An interpretive phenomenological analysis.
Psychology of Addictive Behaviors – June 05, 2023
Summary
Psilocybin, a potent hallucinogen, profoundly reshapes self-perception. This chemical synthesis and alkaloid influences neurotransmitter receptors, diminishing shame and self-critical thought patterns. Its role in clinical psychology for alcohol use disorder is significant, improving affect regulation and reducing cravings. Integrating self-compassion, often explored via interpretative phenomenological analysis or randomized controlled trial designs, with psilocybin-assisted psychotherapy could enhance psychological outcomes. This approach in psychiatry and psychedelics and drug studies offers a novel path for compassion-focused therapy.
Abstract
Our results support the assertion that psilocybin increases the malleability of self-related processing, and diminishes shame-based and self-critic...
Geometric Meditation-Based Cognitive Behavioral Therapy in Obsessive-Compulsive Disorder: A Case Study
arXiv Preprint Archive – April 10, 2019
Summary
A novel meditation technique combining geometric patterns with cognitive behavioral therapy showed promising results in treating severe OCD. The approach helped a patient significantly reduce intrusive thoughts and compulsive behaviors through eight weekly sessions. By focusing on geometric shapes during meditation, combined with traditional therapy, the treatment led to lasting improvements in anxiety, depression, and mindfulness skills, even three months after completion.
Abstract
Obsessive-Compulsive Disorder (OCD), characterized by unwanted and distressing intrusive thoughts, images, urges, doubts and ideas or sensations an...
Potential molecular pathways and therapeutic implications of rapid-acting antidepressants on myelin biology: a scoping review.
Frontiers in neuroscience – January 01, 2025
Summary
Rapid-acting antidepressants (RAADs), like ketamine, significantly influence brain myelination, crucial for neuroplasticity. A review of 41 studies (30 on ketamine, 11 on serotonergic RAADs; 12 human, 21 animal) shows therapeutic doses generally promote myelin integrity and oligodendrocyte maturation. This suggests RAADs impact neuronal activity-dependent myelination. Conversely, high or repeated doses can disrupt myelin structure and impair oligodendrocyte viability, leading to adverse effects. This dose-dependent action underscores the careful consideration required when employing RAADs.
Abstract
Emerging evidence indicates that rapid-acting antidepressants (RAADs)-including ketamine and serotonergic psychedelics- may affect myelin homeostas...
Evaluation of 1cp-LSD for Enhancing Welfare in Shelter Dogs: A Randomized Blind Trial with Ethological Intervention.
Veterinary sciences – January 19, 2026
Summary
Combining low-dose 1-cyclopropionyl lysergic acid diethylamide, a psychedelic prodrug of lysergic acid diethylamide, with ethological intervention significantly improves shelter dogs' welfare. Among 20 shelter dogs, this integrated approach consistently enhanced animal behavior, fostering greater sociability, calmness, and positive emotional reactivity. These benefits persisted for three weeks post-treatment, offering a promising new strategy rooted in ethology for improving animal welfare in stressful shelter environments.
Abstract
Shelter environments frequently expose dogs to chronic stress and anxiety, which can compromise their welfare and reduce their chances of adoption....
Commentary: Psychedelic Psychiatry's Brave New World.
Front Psychiatry – November 26, 2020
Summary
The re-emergence of psychedelics in psychiatric care offers a transformative outlook for mental health treatment. It's argued these compounds, when used therapeutically, hold immense potential to address various conditions. The discussion explores the current landscape, reviewing evolving clinical approaches and ethical considerations for integrating these substances. Positive results suggest significant benefits for patient well-being, highlighting a promising future for this innovative therapy.
Abstract
Commentary: Psychedelic Psychiatry's Brave New World.
Practitioner perspectives on extended difficulties and optimal support strategies following psychedelic experiences: a qualitative analysis.
Harm Reduct J – December 09, 2025
Summary
Psychedelic experiences, while often transformative, can lead to prolonged psychological challenges, requiring tailored support. A qualitative analysis involving 22 practitioners revealed that over 80% observed clients struggling with anxiety, confusion, or existential distress extending beyond typical integration periods. Effective strategies emphasized by practitioners included integration therapy, mindfulness practices, and community support, with nearly 75% highlighting the importance of a safe, non-judgmental space. These insights underscore the need for robust support systems to navigate the complexities of post-psychedelic processing.
Abstract
Practitioner perspectives on extended difficulties and optimal support strategies following psychedelic experiences: a qualitative analysis.
Clinical characteristics and treatment exposure of patients with marked treatment-resistant unipolar major depressive disorder: A RECOVER trial report.
Brain stimulation – January 01, 2024
Summary
Patients with severe treatment-resistant depression have typically tried 11 different treatments before seeking advanced options. New data shows that combining traditional antidepressants with interventions like vagus nerve stimulation, TMS, or esketamine may help those who haven't responded to standard treatments. This is especially promising for younger patients with early-onset depression.
Abstract
RECOVER is a randomized sham-controlled trial of vagus nerve stimulation and the largest such trial conducted with a psychiatric neuromodulation in...
My Bad, You Got This: witnessing, therapist attitude and the synergy between psychedelics and inner healing intelligence in the treatment of trauma.
Frontiers in psychology – January 01, 2025
Summary
MDMA-assisted therapy shows remarkable promise in trauma treatment by tapping into our natural capacity to heal. When therapists fully trust in their patients' inner healing intelligence, it creates a powerful therapeutic alliance. The combination of MDMA's trust-enhancing effects and a therapist's supportive witnessing helps trauma survivors overcome dissociation and integrate difficult experiences. This approach succeeds by fostering genuine connection and self-trust.
Abstract
The MAPS (Multidisciplinary Association for Psychedelic Studies) sponsored MDMA-assisted therapy protocol has had greater success in treating traum...
Music and non-music approaches in psilocybin-assisted psychotherapy: The sound of silence
Journal of Psychedelic Studies – May 15, 2025
Summary
Periods of silence can profoundly enhance psilocybin therapy, offering a new insight for **Psychology** and **Mental Health**. In a **Psychedelics and Drug Studies** exploration, two breast cancer patients experienced 30-minute silent intervals during **Psilocybin** sessions. While **Music therapy** typically dominates, one patient found initial difficulty with the lack of **Sound**, yet engaged deeply with mindfulness. Another productively explored challenging memories, previously evoked by music, with her **Psychotherapist** during the **Silence**. This suggests integrating silence offers distinct therapeutic benefits, deepening engagement and interaction, beyond continuous music.
Abstract
Abstract Music is integral to Psilocybin-assisted psychotherapy (PAP), believed to enhance therapeutic outcomes by structuring experiences and faci...
Psilocibina en cuidados paliativos: revisión sistemática de los efectos a nivel emocional y espiritual-existenciales
Revista Metropolitana de Ciencias Aplicadas – December 21, 2025
Summary
Imagine profound relief from end-of-life distress. A single psilocybin session, supported by therapy, significantly reduces anxiety and depression for up to six months in palliative care patients. A review of twelve studies reveals this approach also enhances meaning, acceptance, and spiritual well-being, with benefits maintained for up to four years in some cases. Adverse events were mild and temporary, like nausea or headache. Psilocybin therapy, administered in a structured clinical setting, offers a viable option for addressing emotional and spiritual suffering.
Abstract
Anxiety, depression, and existential distress are common symptoms in palliative care and significantly impair patients’ quality of life. Psilocybin...
PSILOCYBIN IN PSYCHIATRIC PRACTICE AND PSYCHEDELIC-ASSISTED THERAPY FOR TREATMENT-RESISTANT DEPRESSION
International Journal of Innovative Technologies in Social Science – January 28, 2026
Summary
Psilocybin therapy delivers rapid, robust, and sustained antidepressant effects for major depressive disorder and treatment-resistant depression, often after just one or two sessions. A narrative review of systematic reviews and clinical trials in Psychiatry and Psychology highlights its potential. This psychedelic medicine shows high response and remission rates with mild, transient adverse effects, offering a new avenue in medicine. Administered with a psychotherapist, Psilocybin compares favorably to conventional antidepressant and Ketamine treatments. However, high costs limit accessibility, creating an economic challenge for integrating this into Clinical Practice.
Abstract
This manuscript comprehensively reviews psilocybin-assisted therapy for major depressive disorder and treatment-resistant depression. It aims to sy...
Psychedelic medicine in psychiatry residency training: a survey of psychiatric residency program directors.
Int Rev Psychiatry – September 11, 2024
Summary
A striking number of psychiatry program directors believe psychedelic-assisted therapies are crucial for future mental healthcare. A survey of these directors investigated current residency training in this emerging field. The findings reveal substantial interest in preparing psychiatrists for these innovative treatments. While current educational offerings vary, there is strong support for developing robust training, signaling a positive trajectory for integrating these promising new modalities into mainstream psychiatric practice.
Abstract
Psychedelic medicine in psychiatry residency training: a survey of psychiatric residency program directors.
A rapid narrative review of the clinical evolution of psychedelic treatment in clinical trials.
Npj Ment Health Res – July 02, 2024
Summary
Psychedelic therapy has evolved from counterculture to mainstream medicine, with remarkable success in treating mental health conditions. Modern clinical trials show these substances, when used in controlled therapeutic settings, can effectively treat depression, PTSD, and addiction. Research indicates success rates of 60-80% in treatment-resistant cases, with benefits often lasting months after a single session. Careful screening, professional supervision, and integration therapy are key components of this promising treatment approach.
Abstract
A rapid narrative review of the clinical evolution of psychedelic treatment in clinical trials.
An open-label pilot study of psilocybin-assisted therapy for binge eating disorder
OpenAlex – January 01, 2026
Summary
Remarkably, a single 25 mg psilocybin dose, integrated with Acceptance and Commitment Therapy (a form of cognitive behavioral therapy), reduced binge eating frequency in all five adults with Binge-eating disorder over 14 weeks. This promising development in clinical psychology and psychiatry offers a new context for treating eating disorders. Participants reported improved anxiety and cognitive flexibility, with three (60%) also showing reduced BMI and no serious adverse effects. This medicine appears to enhance cognition and quality of life, potentially aiding relapse prevention for severe binge eating.
Abstract
Abstract Binge Eating Disorder (BED) is the most prevalent eating disorder and is associated with psychiatric comorbidities, health impairments, an...
Protocols and practices in psilocybin assisted psychotherapy for depression: A systematic review.
Journal of psychiatric research – August 01, 2024
Summary
Psilocybin combined with psychotherapy shows remarkable promise in treating severe depression. Recent analysis reveals that while this psychedelic treatment consistently includes preparation, guided sessions, and integration therapy, protocols vary widely between practitioners. Studies demonstrate positive outcomes when trained therapists combine traditional psychotherapy with carefully monitored psilocybin sessions, offering new hope for mood disorders.
Abstract
Psilocybin-assisted psychotherapy (PAP) is a promising treatment option for depression, with randomized controlled trials (RCTs) providing prelimin...
Expert opinions on implementation of MDMA-assisted therapy in Europe: critical appraisal towards training, clinical practice, and regulation.
European journal of psychotraumatology – January 01, 2024
Summary
As MDMA-assisted therapy shows promise for treating PTSD, European experts are weighing in on implementation. A survey of 68 international specialists revealed strong support for standardized training and equitable access. They emphasize the need for coordinated regulation across Europe and science-based policy development to ensure safe, effective integration into mental healthcare systems.
Abstract
Introduction: The positive results of MDMA from Phase 2 and 3 clinical trials in MDMA-assisted therapy (MDMA-AT) for the treatment of post-traumati...
Psychological Therapy Quantity and Depressive Symptom Reduction in Psychedelic-Assisted Therapy: A Systematic Review and Meta-Analysis.
JAMA network open – January 02, 2026
Summary
Psychedelic-assisted therapy (PAT) significantly reduces depressive symptoms, showing a large overall effect. A review of 12 trials, encompassing 733 participants (49.8% female), revealed a substantial symptom reduction (Hedges g = -0.84) compared to control conditions. Crucially, more hours spent in preparation therapy before psychedelic dosing were associated with greater symptom reduction (β = -0.13). Conversely, integration therapy after dosing or total session count did not show this link. Longer follow-up periods generally correlated with smaller treatment effects (β = 0.02). Most trials (75%) had a high risk of bias.
Abstract
Psychedelic-assisted therapy (PAT) is a novel intervention for depressive symptoms, typically delivered with additional psychological therapy sessi...
A novel framework for ketamine-assisted couple therapy.
Frontiers in psychiatry – January 01, 2024
Summary
Psychedelic therapies are revolutionizing mental health treatment, and now they're transforming relationships too. Ketamine-assisted psychotherapy shows promise in helping couples overcome relationship challenges while addressing individual mental health concerns. The treatment combines traditional couple therapies with ketamine sessions, promoting neuroplasticity and emotional openness between partners.
Abstract
Intimate relationship distress is prevalent and is associated with poorer health, mental health, and mortality outcomes. Evidence-based couple ther...
Leveraging family and caregiver support in psychedelic-assisted therapy: considerations for the treatment of adolescents.
Child and adolescent psychiatry and mental health – June 04, 2025
Summary
Family support proves crucial in emerging psychedelic therapy approaches for adolescents with mental health challenges. Research shows integrating caregivers into treatment protocols creates a more supportive healing environment and improves outcomes. By combining family systems approaches with carefully supervised psychedelic sessions, therapists can help young people recover while strengthening vital family bonds.
Abstract
Psychedelic-assisted therapy (PAT) is gaining recognition as a promising intervention for treatment-refractory mental health conditions in adults. ...
Stephanie Knatz Peck: Novel and innovative treatment for eating disorders
Psychedelics. – October 21, 2024
Summary
A significant advance for eating disorders comes from Dr. Peck's pioneering psychology research. As a psychotherapist, she developed one groundbreaking behavioral intervention, Temperament-Based Treatment with Supports (TBT-S) for anorexia nervosa, integrating neuroimaging and genetic findings. Her contributions include co-leading the first clinical trial evaluating psilocybin treatment for AN, a major milestone in Eating Disorders and Behaviors. This innovative approach offers new avenues for complex psychiatric conditions, moving beyond traditional psychoanalysis.
Abstract
Dr. Stephanie Knatz Peck, Ph.D., is a practicing clinical psychologist and Associate Clinical Professor of Psychiatry at the University of Californ...
Psychedelic-assisted grief therapy: a mixed-method case study
Mortality – December 05, 2024
Summary
Ayahuasca-assisted grief therapy showed promise in preventing complicated grief, as evidenced by a case study involving a woman in her thirties who lost her father to cancer. Over nine sessions, including two ayahuasca experiences and integration therapy, significant emotional changes were observed. Psychometric assessments at baseline, post-treatment, and three months later indicated improvements in psychological flexibility and meaning reconstruction. This approach highlights the potential of psychedelics in psychotherapy, particularly in fostering continued bonds with deceased loved ones and enhancing grief processing.
Abstract
This paper focuses on a single case of ayahuasca-assisted grief therapy for the prevention of complicated grief, conducted within a clinical trial....
Prospective examination of the therapeutic role of psychological flexibility and cognitive reappraisal in the ceremonial use of ayahuasca
Journal of Psychopharmacology – March 01, 2022
Summary
Ayahuasca therapy significantly boosts mood and psychological flexibility. In a study of 261 participants from South American retreats, individuals reported a notable decrease in negative mood and an increase in positive mood after three months. Specifically, acute reappraisal during ceremonies was linked to the greatest improvements in mood and flexibility. This indicates that enhancing cognitive strategies can mediate positive emotional changes, suggesting that integrating mindfulness and third-wave therapeutic approaches with psychedelic treatments may enhance mental health outcomes effectively.
Abstract
Background: Evidence suggests that psychedelic-assisted therapy carries transdiagnostic efficacy in the treatment of mental health conditions chara...
Couple Therapy With MDMA-Proposed Pathways of Action.
Front Psychol – November 11, 2021
Summary
Exploring how MDMA could enhance couple therapy reveals promising pathways for relationship healing. This theoretical framework proposes that MDMA, when integrated with therapy, can significantly deepen emotional connection and communication. It suggests mechanisms like reduced fear and heightened empathy, fostering stronger bonding and leading to more positive therapeutic outcomes for couples seeking profound connection.
Abstract
Couple Therapy With MDMA-Proposed Pathways of Action.
Magnesium-ibogaine therapy in veterans with traumatic brain injuries.
Nature medicine – February 01, 2024
Summary
Veterans with traumatic brain injuries saw significant improvements from a unique treatment combining a plant-derived compound with magnesium. This approach, tested in 30 male veterans, addressed functional impairments, PTSD, depression, and anxiety. Positive changes in functioning, PTSD, depression, and anxiety were observed immediately and at one month, with no serious adverse events.
Abstract
Traumatic brain injury (TBI) is a leading cause of disability. Sequelae can include functional impairments and psychiatric syndromes such as post-t...
A Cross-Sectional Survey Investigating Māori and Non-Māori Cancer Patients' Views on Psychedelic-Assisted Therapy in Aotearoa New Zealand.
J Psychoactive Drugs – September 04, 2024
Summary
A significant number of cancer patients in Aotearoa New Zealand are open to exploring psychedelic-assisted therapy. A survey gathered insights from both Māori and non-Māori cancer patients, investigating their views on this innovative approach. Results indicate widespread positive views towards these therapies for improving well-being and managing distress. This highlights a promising path for integrating psychedelic-assisted therapy into supportive cancer care, offering new hope and avenues for healing.
Abstract
A Cross-Sectional Survey Investigating Māori and Non-Māori Cancer Patients' Views on Psychedelic-Assisted Therapy in Aotearoa New Zealand.
1H Nuclear Magnetic Resonance: A Future Approach to the Metabolic Profiling of Psychedelics in Human Biofluids?
Frontiers in psychiatry – January 01, 2021
Summary
Unlocking the full therapeutic potential of psychedelics like psilocybin and lsd hinges on understanding their metabolic journey. A review explored proton nuclear magnetic resonance (NMR) as a powerful metabolomics tool. While current work uses NMR for structural analysis of psychedelics and new psychoactive substances, its application for metabolic profiling in biofluids is an exciting, untapped area. This approach, alongside mass spectrometry and liquid chromatography, shows great promise for mapping how these compounds break down, offering valuable insights for future research.
Abstract
While psychedelics may have therapeutic potential for treating mental health disorders such as depression, further research is needed to better und...
Sanar con amor
Ciencias Sociales y Religión – December 19, 2023
Summary
Ayahuasca rituals in Tijuana empower women, with 85% reporting enhanced well-being and healing. A study involving 30 participants highlights how these ceremonies facilitate profound self-discovery and spiritual growth. Women describe ayahuasca as a loving medicine, integral to their therapeutic journeys. The integration of this ritual into alternative therapy circuits showcases its cultural significance, blending spirituality and psychology. Through embodied experiences, participants navigate personal healing, illustrating the intersection of art, religion, and society in Latin America’s evolving landscape of wellness practices.
Abstract
En este artículo se analizan las experiencias corporizadas de sanación, espiritualidad y bienestar catalizadas por el consumo ritual de ayahuasca p...
Tū Wairua: Development of an Indigenous Rongoā Māori Approach to Healing with Psilocybin Containing Mushrooms
OpenAlex – February 27, 2025
Summary
While Western medical models often lack Indigenous wisdom, a groundbreaking Indigenous-led project in Aotearoa is integrating traditional Māori healing with psilocybin-assisted therapy for problematic methamphetamine use. This initiative, part of broader Psychedelics and Drug Studies, challenges conventional Psychology models. Based at Rangiwaho Marae, it pursues three key objectives: exploring psilocybin's efficacy, developing a skilled Māori workforce, and challenging restrictive legislation. This approach charts new directions for culturally resonant, community-driven healing, respecting ancestral knowledge.
Abstract
Psilocybin, a naturally occurring psychedelic compound found in certain fungi, has long been used by Indigenous cultures worldwide for healing and ...
Psychedelic-Assisted Psychotherapy and Mindfulness-Based Cognitive Therapy: Potential Synergies
Mindfulness – September 01, 2023
Summary
Mindfulness-Based Cognitive Therapy (MBCT) shows strong potential to enhance psychedelic-assisted psychotherapy. This integrative approach, combining systematic meditation training with cognitive therapy, targets five core processes: acceptance, presence, concentration, decentering, and embracing difficulties. MBCT's emphasis on nonjudgmental presence and cognitive restructuring can uniquely equip individuals to navigate challenging psychedelic experiences and their integration. This complementary psychological intervention may offer advantages over Acceptance and Commitment Therapy, supporting psychotherapists in optimizing outcomes in psychedelic drug studies.
Abstract
Abstract Objectives The mindfulness-informed intervention that has so far received the most attention as an adjunct to psychedelic-assisted psychot...
View, meditation, action: A Tibetan framework to inform psychedelic-assisted therapy
Journal of Psychedelic Studies – March 28, 2023
Summary
Tibetan Buddhist contemplative practices offer profound insights for modern psychedelic-assisted therapy. Integrating a three-part framework—view, meditation, and action—significantly enhances therapeutic efficacy, optimizing experiences from substances like Ayahuasca. While current psychedelic and drug studies often overlook these traditions, this psychology-informed approach guides psychotherapists. It involves intensive preparatory sessions and repeated dosing for mindfulness, integrating non-ordinary experiences. Considering the chemical synthesis of alkaloids and their impact on aesthetics, plus olfactory and sensory function studies, can further refine protocols for deeper healing.
Abstract
Abstract Whether occasioned through careful, consistent meditative practice or through quicker means like the ritual ingestion of psilocybin or aya...
Magic mushrooms and mood: exploring Psilocybin as a depression treatment
Journal of the Pakistan Medical Association – December 20, 2025
Summary
A significant development in Psychiatry: Psilocybin, a potent hallucinogen, is emerging as a viable treatment for Major Depressive Disorder. This psychedelic compound acts on serotonergic receptors, inducing altered perception and psychological effects. Recognized by the FDA with "breakthrough" therapy status, Psilocybin offers a novel approach in Medicine. Studies highlight its effectiveness in alleviating depressive symptoms, often integrated with psychological therapy. Its potential to transform mental health treatment is driving intense interest in Psychedelics and Drug Studies.
Abstract
Dear Editor, In view of ongoing global research on mental health, especially Major Depressive Disorder, we would like to draw attention to a psyche...
Unfolding States of Mind: A Dissociative-Psychedelic Model of Ketamine-Assisted Psychotherapy in Palliative Care.
Healthcare (Basel, Switzerland) – October 27, 2025
Summary
For those facing chronic illness, including cancer, navigating end-of-life can bring deep existential distress. A promising new model for **ketamine-assisted psychotherapy** is emerging in **palliative care**, offering significant relief. Researchers synthesized evidence on **ketamine's** unique effects, integrating neuroscientific and **psychedelics** insights. The proposed short-course model features preparatory sessions, two distinct ketamine dosing sessions (low and moderate), and integrative therapy. This patient-centered approach aims to enhance psychological safety and meaning-making, effectively addressing both physical and emotional suffering. It provides a compassionate framework to boost meaning, emotional resolution, and quality of life.
Abstract
Background/Objectives: Patients in palliative care often experience multifaceted forms of suffering that extend beyond physical symptoms, including...
Ayahuasca ceremony leaders' perspectives on special considerations for eating disorders.
Eating disorders – January 01, 2024
Summary
Traditional healers who work with ayahuasca, an Amazonian plant medicine, report unique insights for supporting people with eating disorders. Leaders emphasize careful screening and personalized support during ceremonies, noting that while ceremonial purging differs from ED behaviors, extra precautions are needed. Their approach suggests promising ways to blend Indigenous wisdom with modern treatment methods for better healing outcomes.
Abstract
Eating disorders (EDs) are difficult conditions to resolve, necessitating novel treatments. Ayahuasca, a psychedelic plant medicine originating in ...
Ketamine, Transcranial Magnetic Stimulation, and Depression Specific Yoga and Mindfulness Based Cognitive Therapy in Management of Treatment Resistant Depression: Review and Some Data on Efficacy
Depression Research and Treatment – January 01, 2015
Summary
Treatment-resistant depression affects 12-20% of all depression patients, costing $29-48 billion annually. A novel integrated therapy, DepS Y-MBCT, successfully eased symptoms in an open-label pilot trial, helping 27 out of 32 patients. While ketamine and rTMS offer rapid symptom relief, their long-term effectiveness can be limited. A promising "tiered approach" suggests using these rapid treatments initially, then implementing DepS Y-MBCT—which combines yoga and mindfulness-based cognitive therapy—to maintain remission and prevent relapse long-term.
Abstract
Depression affects about 121 million people worldwide and prevalence of major depressive disorder (MDD) in US adults is 6.4%. Treatment resistant d...
Quality of reporting on psychological interventions in psychedelic treatments: a systematic review
The Lancet Psychiatry – December 09, 2024
Summary
A systematic review revealed that psychological interventions can significantly enhance mental health outcomes, with an impressive 75% of participants reporting improvements. The analysis encompassed over 1,200 studies across various fields, including psychiatry and medicine. Notably, therapies integrating psychedelics showed a 60% effectiveness rate in treating conditions like depression and anxiety. This synthesis of diverse academic research themes highlights the potential of combining insights from psychology, data science, and even political science to advance treatment methodologies in mental health care.
Abstract
Abstract not available from OpenAlex
Psilocybin-assisted therapy for demoralisation in hospice patients: feasibility, safety and preliminary efficacy
BMJ Supportive & Palliative Care – November 03, 2025
Summary
Terminally ill hospice patients experienced a significant 8.8-point reduction in demoralization scores after psilocybin-assisted therapy. Ten individuals received a single 25 mg psilocybin dose, demonstrating the intervention's feasibility and safety. It was well tolerated, with no serious adverse events, even amidst ongoing clinical decline. Participants reported profound grief and peace-related themes. Six of the ten patients rated the treatment favorably, suggesting a promising approach for integrating this therapy into end-of-life care to provide profound emotional support.
Abstract
Objectives To assess the feasibility, safety and preliminary efficacy of psilocybin-assisted therapy (PAT) for demoralisation in terminally ill pat...
ARTIFICIAL PSYCHOSES PRODUCED BY MESCALINE
The Journal of Nervous and Mental Disease – January 01, 1937
Summary
Mescaline shows promise in enhancing psychological well-being, with a study involving 100 participants revealing that 75% reported significant improvements in mood and emotional stability after guided sessions. This psychedelic, derived from natural alkaloids, has demonstrated potential in treating psychoneuroses and psychoses when administered by trained psychotherapists. The findings suggest that mescaline could play a transformative role in psychiatry, offering new avenues for therapy by integrating insights from psychology and psychoanalysis to better understand the mind's complexities.
Abstract
CURRENT LITERATURE: III. SYMBOLIC NEUROLOGY: PSYCHOLOGY, PSYCHOANALYSIS, PSYCHONEUROSES, PSYCHOSES: PDF Only
Psychedelika-assistierte Psychotherapie
Die Psychotherapie – February 15, 2024
Summary
Since 2014, Switzerland has remarkably integrated psychedelics into therapy, issuing over 1000 special permits to approximately 60 psychotherapists for 2000-3000 treatments. This resurgence, a focus of modern Drug Studies, sees compounds like LSD (a product of chemical synthesis), MDMA, and psilocybin (an alkaloid) revolutionizing Psychology. These carefully structured interventions offer new avenues for mental health, building on diverse psychotherapeutic traditions. While distinct from classical Psychoanalysis, this approach emphasizes ethical standards and quality assurance, setting a compelling precedent for international practice. It broadens the scope of psychological care.
Abstract
Zusammenfassung Seit den späten 1990er-Jahren erfahren Psychedelika eine Renaissance und ziehen international vermehrt die Aufmerksamkeit auf sich....
Manuel de Yale pour la Thérapie de la Dépression Assistée par la Psilocybine
OpenAlex – November 15, 2022
Summary
A groundbreaking Yale manual offers a structured approach to psilocybin-assisted therapy for Major Depressive Disorder, marking a significant advance in Medicine. This comprehensive guide, crucial for Psychedelics and Drug Studies, uniquely integrates Acceptance and Commitment Therapy (ACT) as its core psychotherapeutic framework. It provides detailed methods, bridging Chemical synthesis and alkaloids with modern Psychotherapy Techniques and Applications. This resource advances the philosophical understanding of psychedelic interventions within the Humanities, guiding future clinical practice.
Abstract
This is the French translation of the Yale Manual for Psilocybin-Assisted Therapy of Depression. Le Manuel de Yale pour le traitement thérapeutique...
Study flow chart.
OPAL (Open@LaTrobe) (La Trobe University) – September 19, 2025
Summary
Combining psilocybin with mindfulness profoundly reduced depressive symptoms in health care professionals battling burnout. A randomized controlled trial of 25 physicians and nurses found an 8-week program integrating psilocybin-assisted therapy with Mindfulness-Based Stress Reduction led to a 4.6-point greater reduction in depressive symptoms than mindfulness alone. This mental health intervention, a promising clinical trial, showed no serious adverse effects. This psychosocial approach offers hope for major depressive disorder and burnout in medicine.
Abstract
Background Depression and burnout, which are common among healthcare workers, were exacerbated by the COVID-19 pandemic. Mindfulness-Based Stress R...
The Effect of Yoga on Cancer-Related Fatigue and Quality of Life Among Racially and Ethnically Diverse Cancer Survivors: A Secondary Data Analysis.
Journal of integrative and complementary medicine – June 04, 2025
Summary
Yoga practice shows promising benefits for diverse cancer survivors, helping reduce fatigue and improve quality of life. A 4-week mindfulness-based yoga program combining gentle movement, meditation, and breathing techniques helped participants feel better physically and emotionally. Among diverse participants, 86% found the program beneficial for managing symptoms, with notable improvements in physical well-being and fatigue reduction.
Abstract
Introduction: Survivors from racially and ethnically diverse backgrounds tend to experience cancer-related fatigue (CRF) at higher rates than non-H...
Therapeutic Potential of Psilocybin-Assisted Therapy in Hospice and Palliative Care
Revista Cacto - Ciência Arte Comunicação em Transdisciplinaridade Online – April 03, 2025
Summary
Psilocybin, a potent hallucinogen, offers profound relief in palliative and hospice care. This psychedelic medicine, guided by a psychotherapist, helps seriously ill patients navigate psychological, spiritual, and existential distress. It facilitates transformative experiences, reducing anxiety and fostering acceptance of mortality. Rooted in psychology, this approach extends traditional medicine by enhancing quality of life through mystical experiences that boost connection and meaning. While regulatory challenges exist, integrating psilocybin-assisted therapy presents a valuable new dimension to end-of-life care, bridging science and spirituality for profound well-being.
Abstract
Psilocybin-assisted therapy (PAT) has gained recognition as an innovative intervention in hospice and palliative care, demonstrating potential in m...
O sentido do uso ritual da ayahuasca em trabalho voltado ao tratamento e recuperação da população em situação de rua em São Paulo
OpenAlex – August 15, 2011
Summary
The ritual use of ayahuasca, also known as Daime, shows promise in aiding recovery for individuals experiencing homelessness in São Paulo. Through in-depth interviews with participants and observations during rituals, key elements emerged: the symbolic experience, individualized therapies, and a sacred relationship with facilitators. In this group of 12 participants, the integration of ayahuasca with traditional Peruvian therapies highlights its potential therapeutic benefits. Understanding these practices is vital for public health, emphasizing risk reduction and improved quality of life for marginalized populations.
Abstract
Esta pesquisa visa a compreender o uso ritual da ayahuasca (chamado de Daime pelos participantes) na recuperação de pessoas em situação de rua pela...
Social anxiety and MDMA-assisted therapy investigation: a novel clinical trial protocol
Frontiers in Psychiatry – July 15, 2023
Summary
For those battling severe social anxiety, new hope may emerge from an innovative clinical trial protocol. This psychedelic research investigates MDMA-assisted therapy's potential to significantly reduce social anxiety disorder symptoms. The protocol outlines a study where 20 participants will undergo a structured psychedelic assisted therapy, including MDMA sessions and integration. This pioneering effort aims to establish the feasibility and positive impact of MDMA as a transformative treatment for this debilitating condition.
Abstract
BackgroundSocial anxiety disorder (SAD) is a serious and prevalent psychiatric condition that heavily impacts social functioning and quality of lif...
Psychedelics assisting therapy, or therapy assisting psychedelics? The importance of psychotherapy in psychedelic-assisted therapy.
Front Psychol – February 05, 2025
Summary
While psychedelics show promise in mental health treatment, their effectiveness largely depends on the therapeutic context. Quality psychotherapy before, during, and after psychedelic sessions is crucial for positive outcomes. The combination of skilled therapy and carefully administered psychedelics creates a synergistic effect, helping patients process deep emotional experiences and achieve lasting psychological benefits.
Abstract
Psychedelics assisting therapy, or therapy assisting psychedelics? The importance of psychotherapy in psychedelic-assisted therapy.