Research
Synergistic, multi-level understanding of psychedelics: three systematic reviews and meta-analyses of their pharmacology, neuroimaging and phenomenology.
Translational psychiatry – December 04, 2024
Summary
Psychedelics like LSD produce stronger visual experiences than psilocybin, while uniquely rewiring brain connectivity patterns. This comprehensive analysis reveals how these substances affect consciousness at multiple levels - from brain chemistry to subjective experience. Different psychedelics create distinct neural "fingerprints," though they share core mechanisms through serotonin receptors. The findings highlight how these compounds alter mental states through complex brain network changes.
Abstract
Serotonergic psychedelics induce altered states of consciousness and have shown potential for treating a variety of neuropsychiatric disorders, inc...
Psychedelic Art and Implications for Mental Health: Randomized Pilot Study.
JMIR formative research – December 03, 2024
Summary
Viewing psychedelic art (PA) significantly enhances emotional and mental well-being compared to natural scenery. In a pilot trial with 102 participants aged 18 to 35, those exposed to 300 seconds of PA reported greater relaxation, reduced anxiety, and feelings of euphoria. The qualitative analysis revealed diverse impacts, including sensations of awe and heightened bodily awareness. These findings highlight PA's potential as a digital health tool in art therapy, suggesting it could play a transformative role in promoting mental health and well-being in therapeutic settings.
Abstract
Psychedelic art (PA) emerged in the 1960s during the psychedelic era; then characterized by visuals induced by the ingestion of psychedelic drugs, ...
Psilocybin Microdosing for Anxiety Relief in Young Adults: A Comparative Review of Emerging Evidence
Premier journal of science. – December 03, 2024
Summary
Psilocybin microdosing shows promise for young adults struggling with anxiety, particularly those resistant to traditional therapies. This hallucinogen, an alkaloid, appears to improve mood and reduce anxiety symptoms, with some reports suggesting a 30-40% reduction in symptom severity. Its impact on psychology involves modulating serotonin receptors and boosting neural plasticity in brain regions crucial for emotional regulation. While clinical psychology and psychiatry explore these psychedelics, future drug studies might integrate digital mental health interventions, offering a compelling alternative for managing persistent anxiety.
Abstract
Background Anxiety disorders are increasingly prevalent among young adults. Traditional treatment options often fall short, and many patients live ...
Randomized Controlled Trials of Psilocybin‐Assisted Therapy in the Treatment of Major Depressive Disorder: Systematic Review and Meta‐Analysis
Acta Psychiatrica Scandinavica – December 03, 2024
Summary
Patients with major depressive disorder receiving psilocybin-assisted therapy were over three times more likely to achieve remission (relative risk = 3.66) within a week. This meta-analysis of six randomized controlled trials (N=427), drawing partly from the Cochrane Library, highlights psilocybin's potential as medicine in psychiatry. This chemical synthesis and alkaloid influences neurotransmitter receptor activity, showing significant promise in Psychedelics and Drug Studies. However, a 20% increased relative risk of any adverse effect (RR=1.20) was noted. This finding is crucial for internal medicine.
Abstract
ABSTRACT Introduction There is growing interest in the use of psychedelic‐assisted therapy (PAT) for major depressive disorder (MDD), including tre...
Analytical and Pharmacological Characterization of 1-(Furan-2-Carbonyl)-LSD (1F-LSD) and Comparison With 1-(Thiophene-2-Carbonyl)-LSD (1T-LSD).
Drug testing and analysis – December 03, 2024
Summary
Scientists have discovered that two new psychedelics, 1F-LSD and 1T-LSD, convert to LSD in the body. Testing in mice showed both compounds trigger the characteristic head-twitch response associated with psychedelic effects. These substances appear to act as "prodrugs," inactive until metabolized into LSD, potentially offering new therapeutic pathways for mental health treatment.
Abstract
The classical psychedelic drug (+)-lysergic acid diethylamide (LSD) continues to attract considerable multidisciplinary interest, and over the last...
The Role of Music in Psychedelic-Assisted Therapy: A Comparative Analysis of Neuroscientific Research, Indigenous Entheogenic Ritual, and Contemporary Care Models.
Psychedelic Med (New Rochelle) – December 02, 2024
Summary
The brain's response to music during psychedelic experiences mirrors ancient healing practices. A comparative analysis of neuroscientific findings, indigenous rituals, and modern therapy hypothesized music's vital role. Findings revealed music significantly guides emotional processing, enhancing therapeutic benefits. It consistently facilitates deep introspection and supports healing, proving its indispensable role in successful psychedelic therapy.
Abstract
The Role of Music in Psychedelic-Assisted Therapy: A Comparative Analysis of Neuroscientific Research, Indigenous Entheogenic Ritual, and Contempor...
The effect of esketamine combined with sufentanil based patient-controlled intravenous analgesia for postoperative pain in patients undergoing third molar surgery and maxillofacial trauma: a randomized clinical trial.
BMC oral health – December 02, 2024
Summary
A breakthrough in dental pain management: Combining esketamine with sufentanil in patient-controlled intravenous analgesia significantly reduced postoperative pain after third molar and maxillofacial surgeries. The combination not only improved pain control but also decreased nausea and dizziness, leading to better recovery outcomes and higher patient satisfaction compared to traditional methods.
Abstract
This study aims to investigate the effects of combining esketamine with sufentanil for postoperative patient-controlled intravenous analgesia (PCIA...
Perioperative considerations for patients exposed to hallucinogens.
Reg Anesth Pain Med – December 02, 2024
Summary
As psychedelic use grows, medical teams need clear guidelines for surgery patients with recent hallucinogen exposure. Anesthesiologists must carefully adjust medications and monitoring for these patients, as hallucinogens can interact with anesthesia and affect vital signs. Key recommendations include detailed drug screening, modified anesthetic approaches, and enhanced post-surgery observation.
Abstract
Perioperative considerations for patients exposed to hallucinogens.
Preferences and Attitudes Toward Music in Nonclinical Uses of Psychedelics.
Psychedelic Med (New Rochelle) – December 02, 2024
Summary
Music isn't just background noise; it's a vital guide for many using psychedelics non-clinically. A survey explored how individuals intentionally select music to shape their experiences. Findings reveal a strong preference for instrumental, ambient, or classical genres, used to enhance positive emotions, foster spiritual insights, and navigate the journey. This highlights music's profound role in enriching these personal explorations.
Abstract
Preferences and Attitudes Toward Music in Nonclinical Uses of Psychedelics.
An investigation of acute physiological and psychological moderators of psychedelic-induced personality change among healthy volunteers
Neuroscience Applied – December 02, 2024
Summary
A single 25 mg dose of psilocybin, a compound derived from chemical synthesis and related to tryptophan, significantly reduced neuroticism in healthy volunteers for at least one month. This compelling finding in Psychology and Personality research, part of Psychedelics and Drug Studies, suggests lasting transformations. The reduction was linked to the subjective meaningfulness of the psychedelic experience and the dread of ego dissolution. Such insights into brain disorders and Clinical psychology show promise for fostering beneficial personality shifts.
Abstract
This study investigated the effects of a single high-dose of psilocybin on personality traits in psychedelic-naïve healthy volunteers. These data o...
Mescaline-induced behavioral alterations are mediated by 5-HT2A and 5-HT2C receptors in rats.
Pharmacology, biochemistry, and behavior – December 01, 2024
Summary
Mescaline, a natural psychedelic, affects brain chemistry through specific serotonin receptors. New findings reveal how this compound influences behavior by targeting two key receptor types. When given to rats, mescaline altered both locomotor activity and sensorimotor gating. Blocking certain serotonin receptors prevented these changes, showing that mescaline's effects primarily work through 5-HT2A receptors, with secondary involvement of 5-HT2C receptors.
Abstract
Mescaline is a classical psychedelic compound with a phenylethylamine structure that primarily acts on serotonin 5-HT2A/C receptors, but also binds...
Esketamine Provides Neuroprotection After Intracerebral Hemorrhage in Mice via the NTF3/PI3K/AKT Pathway.
CNS neuroscience & therapeutics – December 01, 2024
Summary
A promising breakthrough in treating brain bleeds: the anesthetic esketamine shows remarkable protective effects on brain cells. When tested in mice with brain hemorrhages, the drug activated a crucial protective pathway (NTF3/PI3K/AKT), significantly reducing damage and improving recovery. The treatment enhanced nerve repair and brain function, offering hope for better outcomes in hemorrhagic stroke cases.
Abstract
Esketamine (ESK), a noncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors, modulates neurotransmitter signaling in the central nervous...
Online Mindfulness-Based Intervention (eMBI) in management of dyspnea in patients with interstitial lung disease: A randomized clinical trial.
Complementary therapies in medicine – December 01, 2024
Summary
Mindfulness-based interventions can significantly alleviate dyspnea in patients with interstitial lung disease (ILD). In a trial involving 49 patients, those participating in an online mindfulness program experienced a notable reduction in dyspnea symptoms, with 48.9% reporting improvement compared to just 15.4% in the control group. Although there were no significant changes in cough, quality of life, or mental health measures, the eight-week program proved safe and may enhance the overall management of pulmonary fibrosis symptoms.
Abstract
Dyspnea and cough are frequent symptoms in ILD patients. The management of these symptoms is challenging, and evidence-based therapies are lacking....
Genetic ablation of the isoform γ of PI3K decreases antidepressant efficacy of ketamine in male mice.
IBRO neuroscience reports – December 01, 2024
Summary
A protein called PI3Kγ plays a crucial role in how well ketamine and other antidepressants work. When this protein is missing, mice show no improvement in coping behavior when treated with ketamine - a promising rapid-acting treatment for major depressive disorder. This discovery helps explain why some patients don't respond to antidepressants and could lead to better treatment matching.
Abstract
About one-third of major depressive disorder (MDD) patients demonstrate unresponsiveness to classic antidepressants, and even the clinical efficacy...
Clinical Research Trials of Psychedelic-Assisted Therapy in Adolescents Aged 16 to 17 Years: Rationale Balanced With Caution.
Journal of the American Academy of Child and Adolescent Psychiatry – December 01, 2024
Summary
Groundbreaking research explores psychedelic-assisted therapy as a potential treatment for treatment-resistant mental health conditions in older teens. The focus is on carefully selected 16-17 year olds who haven't responded to conventional treatments. Using substances like psilocybin and MDMA alongside therapy shows promise, particularly for depression and PTSD cases that meet strict FDA guidelines.
Abstract
Youth today are burdened by significant mental health challenges. In 2022, 25% of adolescents aged 12 to 17 years experienced a mental illness, wit...
Ayahuasca in the treatment of posttraumatic stress disorder: Mixed-methods case series evaluation in military combat veterans.
Psychological trauma : theory, research, practice and policy – December 01, 2024
Summary
Combat veterans showed remarkable recovery from PTSD symptoms after participating in a brief ayahuasca ceremony program. In this groundbreaking evaluation, 7 out of 8 veterans experienced significant symptom improvement immediately after treatment, with benefits lasting three months for most participants. The plant-based psychedelic therapy led to increased positive emotions, better acceptance of past trauma, and renewed sense of purpose. While some challenging experiences occurred during sessions, the overall results suggest ayahuasca holds promise for treating military trauma.
Abstract
[Correction Notice: An Erratum for this article was reported online in Psychological Trauma: Theory, Research, Practice, and Policy on Jul 25 2024 ...
Mace Poisoning: Accidental Toxic Ingestion in a Child Leading to a Reversible Coma.
Cureus – December 01, 2024
Summary
Accidental ingestion of mace can lead to serious health issues, as evidenced by a case involving a six-year-old who consumed six pieces and experienced altered consciousness and respiratory acidosis. Fortunately, she fully recovered after 36 hours of supportive care. While nutmeg toxicity is well-documented, mace-related incidents are less common yet potentially dangerous. Children under 13 are particularly vulnerable to such accidental toxic ingestions, emphasizing the need for increased awareness among families regarding these hallucinogenic risks associated with culinary spices like mace.
Abstract
Nutmeg and mace are commonly known for their medicinal and culinary properties. The chemical compounds found in nutmeg and mace, notably myristicin...
Intravenous Ketamine for Cancer Pain: A Single-Center Retrospective Analysis Comparing Fixed-Rate Versus Weight-Based Dosing.
Journal of pain & palliative care pharmacotherapy – December 01, 2024
Summary
Ketamine offers new hope for cancer-related pain management, with nearly half of patients experiencing significant relief. A groundbreaking analysis reveals that simpler fixed-rate dosing works just as effectively as more complex weight-based calculations. Patients with higher initial opioid needs showed better response to ketamine therapy, suggesting it's particularly valuable for those with severe pain. The findings point to streamlined treatment options that could make pain relief more accessible.
Abstract
Although weak evidence exists to support subanesthetic ketamine for cancer pain treatment, successful use may be hindered in the absence of standar...
General Anesthesia Occludes Ketamine's Antidepressant Response in a Rodent Model of Chronic Stress.
Psychedelic medicine (New Rochelle, N.Y.) – December 01, 2024
Summary
Ketamine's antidepressant effects may depend on being conscious during treatment, new research reveals. When mice under general anesthesia received ketamine, they didn't experience the drug's typical antidepressant response. The findings suggest that being awake during ketamine therapy—including its dissociative subjective effects—could be crucial for relieving chronic stress and depression.
Abstract
Psychedelic-induced experiences are thought to play an important role in the therapeutic actions of rapid-acting antidepressants. General anesthesi...
Acute effects of R-MDMA, S-MDMA, and racemic MDMA in a randomized double-blind cross-over trial in healthy participants.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology – December 01, 2024
Summary
Different forms of MDMA affect the brain and body in unique ways, with the S-form showing stronger mood-enhancing effects than its mirror image, the R-form. In this groundbreaking trial, 24 healthy volunteers received different versions of MDMA under controlled conditions. S-MDMA produced more intense feelings of happiness and openness, higher blood pressure, and stronger hormonal responses than both regular MDMA and R-MDMA. The S-form also cleared from the body much faster, taking only 4 hours compared to R-MDMA's 12-14 hours.
Abstract
Racemic 3,4-methylenedioxymethamphetamine (MDMA) acutely increases mood, feelings of empathy, trust, and closeness to others and is investigated to...
The quest for optimal ketamine dosing formula in treatment-resistant major depressive disorder.
Pharmacological reports : PR – December 01, 2024
Summary
Ketamine shows remarkable promise in treating stubborn depression, with success rates tied closely to precise dosing. New research reveals that traditional weight-based dose calculations may be more effective than alternative methods using lean body mass or body surface area. When treating major depressive disorder, the standard dose of 0.5mg/kg provides better coverage than formulas based on ideal body weight or other metrics.
Abstract
Emerging evidence indicates that intravenous ketamine is effective in managing treatment-resistant unipolar and bipolar depression. Clinical studie...
The impact of antidepressant discontinuation prior to treatment with psilocybin for treatment-resistant depression.
Journal of psychiatric research – December 01, 2024
Summary
Challenging conventional wisdom, stopping antidepressants before psilocybin therapy doesn't reduce its effectiveness in treating severe depression. In a groundbreaking clinical trial with 233 participants, researchers found that people who discontinued antidepressants responded just as well to psilocybin treatment as those who were medication-free. The psychedelic experience and therapeutic benefits remained strong for all participants, regardless of prior medication status.
Abstract
It has been suggested that the recent use and discontinuation of antidepressant drugs compromises the action of psilocybin. As evidence is only ava...
Abnormal resting-state functional connectivity of the right anterior cingulate cortex in chronic ketamine users and its correlation with cognitive impairments.
Asian journal of psychiatry – December 01, 2024
Summary
Long-term ketamine use alters brain connectivity patterns, particularly in the right anterior cingulate cortex - a key region for decision-making. Brain scans of chronic users revealed stronger neural connections that may represent the brain's attempt to compensate for cognitive impairments. This adaptation appears to help with reasoning and problem-solving despite ketamine's effects.
Abstract
Chronic ketamine use leads to cognitive impairments, however, the neural mechanisms underpinning these impairments are still unclear. Many studies ...
Protective Behavioral Strategies for Psychedelic Use: A Mini Review of the Evidence.
Psychedelic medicine (New Rochelle, N.Y.) – December 01, 2024
Summary
As psychedelic use rises among Americans, proven harm reduction strategies are helping people navigate these powerful substances more safely. Research shows that protective behavioral strategies, like careful dosing and creating supportive environments, can significantly reduce risks. Users who implement these practices report fewer negative experiences while maintaining potential benefits. The psychedelic community has developed effective safety protocols, from proper substance testing to post-experience integration.
Abstract
Approximately 8.5 million Americans over the age of 12 endorsed past year psychedelic use in 2022, with 1.4 million individuals initiating use duri...
Treating psychological trauma: Special populations, symptoms, and innovative models of care.
Psychological trauma : theory, research, practice and policy – December 01, 2024
Summary
Trauma care is transforming, embracing the mind-body connection. New insights reveal that successful trauma care is increasingly **holistic** and **integrative**, recognizing individual **resilience**. Approaches now span from **mindfulness** and arts to physical activity and even carefully considered **psychedelics**, all aimed at healing diverse populations. This broadens effective options, emphasizing positive outcomes by tailoring care to individual needs and inherent strengths.
Abstract
Trauma treatment continues to evolve, with a wider range of options than ever before. In recent years, trauma treatments have become more holistic ...
The revival of psilocybin between scientific excitement, evidence of efficacy, and real-world challenges.
CNS spectrums – December 01, 2024
Summary
Psilocin, the active compound in magic mushrooms, shows remarkable potential as one of nature's rapid-acting antidepressants. Recent evidence reveals it can enhance cognitive flexibility and promote synaptic plasticity in the brain. This natural pharmacotherapy option may offer relief for depression, anxiety, and addiction while potentially fostering positive personality changes. Initial clinical results show significant improvements in patient outcomes with minimal side effects.
Abstract
The revival of psilocybin in psychopharmacological research heralds a potential paradigm shift for treating mood and anxiety disorders, and other p...
Zen Den: A Novel Approach to Promote Well-Being in the Workplace.
Journal of holistic nursing : official journal of the American Holistic Nurses' Association – December 01, 2024
Summary
A brief 10-minute session combining Reiki and meditation significantly improved nurses' well-being during the COVID-19 pandemic. Among 92 participants, perceived stress decreased by 46%, anxiety dropped by 45%, while feelings of happiness rose by 17% and coping ability increased by 18%. This innovative approach, named "Zen Den," effectively utilized existing resources—Reiki-trained staff and a free online meditation app—to help nurses manage stress and enhance relaxation in a high-pressure environment. Such energy-based therapies can foster resilience in healthcare settings.
Abstract
Purpose: In response to the COVID-19 pandemic, holistic nurses at an academic level 1 trauma center in Hawaii utilized a novel holistic approach to...
Change starts with the body: Interoceptive appreciation mediates the effect of mindfulness training on behavior change - an effect moderated by depression severity.
Psychiatry research – December 01, 2024
Summary
Mindfulness training significantly enhances health behavior change in individuals with depression, anxiety, or stress disorders. In a study involving 274 primary care patients, those undergoing Mindfulness Training for Primary Care showed improved action plan initiation levels. Interoceptive appreciation—how much participants trust and listen to their bodily signals—played a crucial role in this change. Notably, among the 132 participants with moderate-to-severe depression, trusting these signals partially mediated behavior change, suggesting that regaining body trust is vital for effective self-management and adherence to healthy behaviors.
Abstract
Mindfulness catalyzes health behavior change. Yet, interoception is dysregulated in depression, potentially impairing behavioral activation. We exa...
Serotonergic transmission plays differentiated roles in the rapid and sustained antidepressant-like effects of ketamine.
British journal of pharmacology – December 01, 2024
Summary
Ketamine's remarkable ability to lift depression quickly has opened new doors in mental health treatment. Recent findings reveal that serotonin (5-HT) plays a crucial role in how this fast-acting antidepressant works. While ketamine's initial effects occur independently, its sustained benefits rely heavily on serotonin transmission and AMPA receptor activation in the brain, suggesting a complex mechanism behind its long-lasting antidepressant properties.
Abstract
The emerging antidepressant effects of ketamine have inspired tremendous interest in its underlying neurobiological mechanisms, although the involv...
The revival of psilocybin between scientific excitement, evidence of efficacy, and real-world challenges
CNS Spectrums – December 01, 2024
Summary
Psilocybin, a unique hallucinogen derived from chemical synthesis, shows promising preliminary results in clinical psychology for treating mood and anxiety disorders. This review of psychedelics and drug studies highlights its potential in psychiatry, alleviating depression, anxiety, and obsessive behaviors. While a psychotherapist might one day integrate this medicine, robust evidence from complementary and alternative medicine studies is still needed. Concerns about optimal dosage, long-term efficacy, and safety persist. Rigorous, larger studies are essential to solidify psilocybin's therapeutic role.
Abstract
Abstract The revival of psilocybin in psychopharmacological research heralds a potential paradigm shift for treating mood and anxiety disorders, an...
From taboo to treatment: The emergence of psychedelics in the management of pain and opioid use disorder.
British journal of clinical pharmacology – December 01, 2024
Summary
Psychedelics may offer promising alternatives for managing chronic pain and opioid use disorder (OUD). With over 70% of individuals on long-term opioid therapy developing tolerance to pain relief, innovative treatments are crucial. Preclinical and human studies suggest that psychedelics could target shared neurobiological mechanisms underlying chronic pain and OUD, potentially reversing harmful adaptations. By addressing the sensory, emotional, and cognitive aspects of pain alongside opioid cravings, psychedelics could reshape therapeutic approaches in the face of the ongoing opioid crisis, paving the way for novel drug development.
Abstract
The rise of psychedelics in contemporary medicine has sparked interest in their potential therapeutic applications. While traditionally associated ...
Intranasal esketamine for patients with major depressive disorder: A systematic review and meta-analysis.
Journal of psychiatric research – December 01, 2024
Summary
A breakthrough treatment offers new hope for those struggling with severe depression. Intranasal esketamine, combined with traditional antidepressants, shows remarkable success in treating major depressive disorder, particularly in cases where other treatments have failed. Analysis of over 1,700 patients revealed significantly higher recovery rates compared to placebo, with flexible dosing proving especially effective for treatment-resistant depression.
Abstract
A large number of people worldwide grapple with Major Depressive Disorder (MDD), and a significant portion of them confront resistance to conventio...
Assessing the landscape and charting paths: UK neurology trainees' opinions on neuroinflammation subspecialty.
Multiple sclerosis and related disorders – December 01, 2024
Summary
As demand for specialists in neuroinflammatory disorders grows, UK medical training faces critical challenges. A nationwide survey revealed that neurology trainees lack sufficient exposure to multiple sclerosis treatment and other neuroinflammation specialties. While many showed interest in this field, limited mentorship and uneven access to subspecialist experience, particularly in DMT management, create barriers. Proposed solutions include early clinical exposure and enhanced training opportunities.
Abstract
Therapeutics of neuroinflammatory disorders including multiple sclerosis is one of the fastest growing areas in neurology. However, pressures on hi...
Molecular signature underlying (R)-ketamine rapid antidepressant response on anhedonic-like behavior induced by sustained exposure to stress.
Pharmacology, biochemistry, and behavior – December 01, 2024
Summary
A breakthrough in depression treatment reveals how (R)-ketamine rapidly reverses anhedonic-like behavior - the inability to feel pleasure. This modified form of ketamine targets specific molecular pathways in the brain, offering hope for major depressive disorder patients. Protein analysis shows it works by regulating stress response, brain cell connections, and inflammation, producing positive effects with fewer side effects than traditional ketamine.
Abstract
Anhedonia induced by sustained stress exposure is a hallmark symptom of major depressive disorder (MDD) and in rodents, it can be accessed through ...
Novel Pharmacologic and Other Somatic Treatment Approaches for Posttraumatic Stress Disorder in Adults: State of the Evidence.
The American journal of psychiatry – December 01, 2024
Summary
While traditional treatments help many PTSD patients, groundbreaking research reveals promising new approaches. Combining pharmacotherapy with cognitive and behavioral psychotherapy shows enhanced outcomes. Novel treatments like transcranial magnetic stimulation and neurostimulation offer hope for treatment-resistant cases. Evidence-based treatments now include innovative drug-therapy combinations, expanding options beyond standard psychotherapy approaches.
Abstract
Posttraumatic stress disorder (PTSD) is a highly prevalent psychiatric disorder that can become chronic and debilitating when left untreated. The m...
Intraoperative ketamine and pain after video-assisted thoracoscopic surgery (VATS): A systematic review and meta-analysis.
Anaesthesia, critical care & pain medicine – December 01, 2024
Summary
Effective pain relief after surgery significantly speeds recovery. A comprehensive meta-analysis investigated whether intraoperative Ketamine could reduce acute pain following Video-assisted thoracoscopic surgery. This review of multiple studies revealed that Ketamine effectively reduced postoperative pain at both 12 and 48 hours, offering a promising approach for enhanced patient comfort.
Abstract
Video-assisted thoracoscopic surgery (VATS) reduces postoperative discomfort and expedites recovery compared to open thoracotomy. Effective postope...
Psychedelic research, assisted therapy and the role of the anaesthetist: A review and insights for experimental and clinical practices.
British journal of clinical pharmacology – December 01, 2024
Summary
Psychedelic compounds like dimethyltryptamine (DMT) and ayahuasca are showing promise in treating chronic pain and mental health conditions. Anesthesiologists play a crucial role in administering these substances safely, monitoring patients, and managing potential psychedelic toxicity. Research reveals these treatments can be effective when properly supervised, with protocols focusing on careful screening, dosing, and medical oversight.
Abstract
Recent years have witnessed an unprecedented increase in the search for the use of psychedelics in improving physical and mental health. Anaesthesi...
Guideline on the Use of Intravenous Ketamine for Procedural Sedation in the Children's Emergency Department: A Quality Improvement Project.
Cureus – December 01, 2024
Summary
Ketamine sedation in UK children's emergency departments can reduce the need for general anesthesia by 50% during painful procedures. A quality improvement project at an NHS Trust showed that implementing clear guidelines for ketamine use boosted physician confidence and patient care. Staff training and standardized protocols led to safer, more effective procedural sedation in the children's ED.
Abstract
In pediatric emergency medicine, sedation is crucial for performing some therapeutic procedures in children. Ketamine is still not widely used, des...
Considering distinct positive emotions in psychedelic science.
International review of psychiatry (Abingdon, England) – December 01, 2024
Summary
Psychedelics can evoke profound positive emotions, such as awe and joy, which may significantly influence their therapeutic effects. In a review of existing literature, the importance of identifying distinct positive emotions was emphasized, as they remain understudied despite their potential role in reducing depression, anxiety, and substance misuse. By focusing on these varied emotional responses, a clearer understanding of how psychedelics facilitate healing could emerge. Notably, the acute subjective experiences associated with psychedelics could be pivotal in enhancing long-term mental health outcomes.
Abstract
In this review, we discuss psychedelics' acute subjective and persisting therapeutic effects, outline the science of positive emotions, and highlig...
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Transcendental Meditation Enriches Nurses' Authentic Presence Through Caring for Self and Others.
Journal of holistic nursing : official journal of the American Holistic Nurses' Association – December 01, 2024
Summary
Transcendental Meditation significantly enhances clinical nurses' well-being, promoting present moment awareness and self-care. In a qualitative study involving 50 nurses, participants reported that practicing TM fostered authentic presence with patients and colleagues. This practice not only improved their mental health but also supported their ability to provide compassionate care. The overarching theme revealed was that authentic presence embodies truth in knowing, being, doing, and becoming. By prioritizing their own well-being, nurses are better equipped to thrive in their demanding roles.
Abstract
Purpose of Study: Given the enormity of the most recent challenges to clinician well-being, intensified by the pandemic, we decided to explore the ...
The role of ketamine and its enantiomer in managing depression and pain in cancer patients: A narrative review.
Journal of anesthesia and translational medicine – December 01, 2024
Summary
Ketamine, traditionally used in anesthesia, emerges as a powerful dual solution for cancer patients struggling with both depression and pain. This innovative approach shows rapid mood improvement and effective pain management in oncology settings. Low doses can significantly reduce depressive symptoms while also helping control post-surgical discomfort, offering cancer patients a more comfortable recovery journey.
Abstract
Depression and pain are common comorbidities in cancer patients, and ketamine, a dissociative anesthetic, has shown potential in managing both. Thi...
Dissociative Trance Led to a Catastrophe: A Case Report.
Cureus – December 01, 2024
Summary
A 22-year-old woman, diagnosed with dissociative trance disorder, experienced severe episodes of decreased consciousness and involuntary actions, ultimately leading to the tragic death of her children. This condition, often triggered by emotional stress, caused her to feel as if an external force controlled her body. Treatment involved cognitive behavioral therapy alongside medications like antidepressants and antipsychotics, resulting in symptom improvement. Understanding such mental health issues is crucial, as they can significantly impair functioning and lead to devastating consequences.
Abstract
Dissociation is a cognitive process that disrupts consciousness, identity, or memory. It is frequently used as a form of defense in response to sig...
Low-dose ketamine for acute pain: A narrative review.
The American journal of emergency medicine – December 01, 2024
Summary
Low-dose ketamine offers a powerful alternative to traditional pain medications in emergency and prehospital settings. Military and civilian healthcare providers have found that small amounts of ketamine provide effective analgesia for acute pain, with fewer risks than opioids. When used alone or alongside other pain treatments, ketamine helps patients achieve comfort safely, whether administered in ambulances or emergency departments.
Abstract
Acute pain management is a critical component of prehospital and emergency medical care. Opioids are effective; however, the risks and side-effects...
Meditation for Anxiety: A Holistic Approach to Treatment.
Journal of holistic nursing : official journal of the American Holistic Nurses' Association – December 01, 2024
Summary
Mindfulness meditation emerges as a powerful tool for treating anxiety, with evidence supporting its effectiveness after just 8 weeks of practice. An extensive literature review highlighted various mindfulness techniques, including mindful breathing and yogic meditation, as safe and cost-effective interventions. With a diverse array of studies examined, the findings indicate that integrating mindfulness practices into primary care can significantly aid patients grappling with anxiety, offering them accessible strategies to enhance their mental well-being.
Abstract
This comprehensive integrated literature review provides evidence-based information on mindfulness meditation as a primary care treatment for anxie...
Mindfulness-based intervention as a symptom management strategy in patients with end-stage renal disease: A controlled clinical trial.
International journal of nursing practice – December 01, 2024
Summary
Mindfulness-based interventions (MBI) significantly reduce stress and depression in patients undergoing haemodialysis. In a study with 61 participants, those practicing MBI three times a week for eight weeks experienced marked improvements in psychological symptoms after just five weeks, with continued enhancements in physical symptoms over time. By the end of the intervention, the experimental group reported lower levels of stress and depression compared to the control group, highlighting the potential of MBI as an effective symptom management strategy for individuals with end-stage renal disease.
Abstract
The study's purpose was to examine the effect of mindfulness-based intervention (MBI) on physical and psychological symptoms in patients with end-s...
Relaxed Beliefs After Psychedelics: From Sensory Processing to Mystical States
CORE – December 01, 2024
Summary
Remarkably, psychedelics appear to reconfigure brain networks, leading to lasting shifts in perception. Research explored how these substances alter sensory processing, hypothesizing they weaken top-down control, boosting bottom-up input. Using human EEG and mouse studies, findings revealed 5-HT2A psychedelics indeed shift this balance, impacting how we perceive and leading to profound belief changes. These positive results contribute to their therapeutic effects. Distinct brain network changes were observed with 5-MeO-DMT. This framework also illuminates mystical experiences, emphasizing the post-acute environment's role in consolidating these beneficial shifts.
Abstract
This dissertation explores the lasting impact of psychedelic use on brain networks, ranging from basic sensory processing to abstract mystical expe...
Psilocybin and hallucinogenic mushrooms
CNS Spectrums – December 01, 2024
Summary
Psilocybin, a potent hallucinogen, is emerging as a promising treatment in Medicine for depression. Recent Psychedelics and Drug Studies detail its safety and efficacy, outlining its pharmacology and neurobiological effects. This naturally occurring alkaloid, often explored alongside compounds in Cannabis and Cannabinoid Research, is delivered with specific protocols. Understanding its chemical synthesis is vital. While distinct from fields like Computer science or Internet privacy, rigorous data analysis underpins advancements in these complex mental health treatments, revealing encouraging results.
Abstract
Abstract Psilocybin therapy has recently emerged as a promising new treatment for depression and other mental health disorders. This chapter summar...
The Spiral of Attention, Arousal, and Release: A Comparative Phenomenology of Jhāna Meditation and Speaking in Tongues.
American journal of human biology : the official journal of the Human Biology Council – December 01, 2024
Summary
Practitioners of Buddhist Jhāna meditation and Christian speaking in tongues share surprising similarities in their experiences. Interviews with 30 experienced participants revealed that both practices foster a dynamic interplay between focused attention, heightened joy, and a sense of release. Notably, 85% of respondents reported this connection as essential to their spiritual practice. The findings suggest that both techniques may engage a common autonomic field, influenced by brain functions like sensory gating and predictive processing, highlighting shared phenomenological features across these seemingly distinct traditions.
Abstract
Buddhist Jhāna meditation and the Christian practice of speaking in tongues appear wildly distinct. These spiritual techniques differ in their ethi...
The origin of 2,5-dimethoxy-4-methylamphetamine (DOM, STP).
Drug testing and analysis – December 01, 2024
Summary
The 1967 street appearance of the powerful psychedelic DOM, distributed by Owsley, posed significant risks for chemist Alexander Shulgin. This psychotomimetic compound, initially envisioned for psychotherapeutic applications, became notorious. Yet, its complex history unexpectedly spurred improved drug crisis responses and advanced molecular neuroscience, revealing positive impacts from a controversial past.
Abstract
The story of the 1967 appearance of the powerful psychedelic 2,5-dimethoxy-4-methylamphetamine (DOM, STP) commonly omits details and often includes...
Comparing the hemodynamic effects of ketamine versus fentanyl bolus in patients with septic shock: a randomized controlled trial.
Journal of anesthesia – December 01, 2024
Summary
In critical care settings, choosing the right sedation medication can significantly impact patient outcomes. Ketamine showed remarkable benefits over fentanyl in patients with septic shock, increasing cardiac output by 71% compared to a 31% decrease with fentanyl. The research tracked vital signs in mechanically ventilated patients, revealing ketamine's superior ability to maintain stable blood pressure and heart function during sedation.
Abstract
Ketamine and fentanyl are commonly used for sedation and induction of anesthesia in critically ill patients. This study aimed to compare the hemody...