Drug Testing and Analysis
June 22, 2017
Sarah M.r. Wille, Camille Richeval, M. Nachon‐phanithavong et al.
68 citations
Among drivers stopped in Belgium in 2015, 7% of blood samples and 11% of oral fluid samples contained new psychoactive substances (NPS), including diphenidine, ketamine, mephedrone, and synthetic cannabinoids. Additionally, 17% of blood samples contained an analgesic drug, 10% a benzodiazepine or hypnotic, and smaller proportions antidepressants, antipsychotics, antiepileptics, or methylphenidate. Poly-drug use combining NPS with licit drugs and drugs of abuse was common. The findings demonstrate that NPS are present in the predominantly young male driving-under-the-influence population and highlight the need for on-site detection methods and further research on combined drug effects on driving ability.
Forensic science international
July 1, 2021
Thomas Gicquel, Camille Richeval, Vadim Mesli et al.
45 citations
A 42-year-old man was found dead at home with bags of 'research chemicals' powders. Toxicological analysis identified three new psychoactive substances (NPS) in his system: 2-fluoro-deschloroketamine (2F-DCK), 3-methoxyeticyclidine (3-MeO-PCE), and 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), each with purity above 95%. Peripheral blood concentrations were 1780 µg/L for 2F-DCK, 90 µg/L for 3-MeO-PCE, and 52 µg/L for 5-MeO-DMT. The death was attributed to respiratory depression from a 'cocktail effect' of these substances combined with amphetamine and cocaine. Hair analysis showed a pattern of addiction over several months. This case provides analytical data to aid interpretation in future forensic cases involving arylcyclohexylamine derivatives.
Drug testing and analysis
January 1, 2022
Thomas Gicquel, Romain Pelletier, Camille Richeval et al.
32 citations
Thirteen metabolites of the dissociative drug 2-fluoro-deschloroketamine (2F-DCK) were produced in vitro using human liver microsomes and HepaRG liver cells. Seven additional metabolites, including three Phase II conjugates, were identified in post-mortem bile and urine from a fatal case. Molecular networking helped compare the two in vitro models, which proved complementary. The authors propose that nor-2F-DCK (mass-to-charge 208.1137) and a hydrogenated metabolite (224.1443) are reliable markers for detecting 2F-DCK use in high-resolution mass spectrometry libraries.
Current Pharmaceutical Design
January 30, 2018
Camille Richeval, Delphine Allorge, Xavier Vanhoye et al.
6 citations
Lysergic acid diethylamide (LSD) is a potent hallucinogen active at very low doses, making its detection and quantification difficult in body fluids and especially in hair. This review examines the challenges of LSD hair analysis, noting that only ten published cases provide data on LSD concentrations in hair. Interpretation of results is complicated by possible pubic hair contamination from urine and limited understanding of how LSD incorporates into and remains stable in head and pubic hair. The absence of LSD in head hair does not rule out consumption, and positive results cannot reliably distinguish single from repeated use. Even a positive pubic hair result does not formally prove repeated LSD use.
Clinical Toxicology
November 2, 2023
Alexandr Gish, Florian Hakim, Camille Richeval et al.
4 citations
Ayahuasca, a traditional Amazonian psychoactive brew, is the subject of a letter to the editor. The letter likely discusses aspects of ayahuasca's composition, effects, or research context, though the abstract is truncated and does not provide a complete finding or argument. The available text only identifies the substance and its traditional use, without presenting a specific result, claim, or analysis.