Journal of Forensic Sciences
September 1, 1993
Tibor Veress
23 citations
The efficiency of extracting LSD from impregnated papers depends on the extraction method, temperature, time, and solvent. Using the Plackett-Burman design, the optimal conditions for maximal LSD recovery were determined. Quantitative analysis was performed with reversed-phase ion-pair chromatography and UV detection. The extraction procedure's constant and proportional bias were also characterized.
Journal of Chromatographic Science
November 15, 2018
Norbert Rácz, Júlia Nagy, Wen Jiang et al.
12 citations
Three hydrophilic interaction liquid chromatography (HILIC) charge modulated amide columns—iHILIC®-Fusion, iHILIC®-Fusion(+), and iHILIC®-Fusion(P)—were compared for separating hallucinogenic alkaloids (psilocin, psilocybin, and baeocystin) from an extract of a truffle-like fungus. Three modeling methods predicted retention times in isocratic separation as a function of mobile phase composition, pH, and temperature. All columns separated the two hallucinogenic alkaloids from each other and from matrix components, with most compounds achieving satisfactory resolution. The quadratic modeling approach best predicted chromatograms under predefined conditions, the exponential model performed worst, and multivariate data analysis fell between the two.
Journal of Forensic Research
January 1, 2016
Julia Nagy, Tibor Veress
12 citations
A new method using hydrophilic interaction chromatography (HILIC) with UV-photometric and mass spectrometric detection reliably quantifies psilocin and psilocybin in hallucinogenic mushrooms. The HILIC phase system, employing a zwitterionic stationary phase and acetonitrile-formate buffer mobile phase, provides sufficient retention for both compounds and baseline separation from each other and matrix components. A novel finding is that psilocybin elutes with a retention factor about twice that of psilocin. The procedure was demonstrated on police-seized mushrooms, offering a forensic tool for accurate quantification, which is critical for court judgments.
Journal of chromatographic science
October 26, 2020
Júlia Nagy, Tibor Veress
1 citation
A mathematical model originally developed for supercritical fluid extraction of cannabinoids was tested for liquid extraction of other psychoactive compounds. The model successfully predicted extraction times and recoveries for quasi-counter current liquid-solid extractions of psilocin from hallucinogenic mushrooms, mescaline from cactus, harmine from a tropical liana, and salvinorin A from sage. Calculated component transport constants indicated extraction velocity: higher constants correspond to faster extraction. For mushrooms, pretreatment with liquid nitrogen markedly improved psilocin extractability.