Ibogaine fails to interrupt the expression of a previously established one-trial morphine place preference.
Progress in neuro-psychopharmacology & biological psychiatry July 1, 1996 T Luxton, L A Parker, S Siegel 13 citations
Ibogaine, a proposed anti-addictive agent, does not reduce the expression of a previously established morphine-induced place preference in rats. Single injections of 40 mg/kg ibogaine given 24, 12, or 4 hours before testing, or 80 mg/kg given 24 hours before, failed to interfere with the conditioned preference. Two injections of 40 mg/kg at intervals of 48 and 24 hours or 24 and 4 hours before testing also had no effect. Ibogaine appears incapable of attenuating the expression of a one-trial morphine place preference once it has been established.