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S Siegel

2 papers in the library · 24 citations · publishing 1996-1997

Papers

Ibogaine fails to interrupt the expression of a previously established one-trial morphine place preference.

Progress in neuro-psychopharmacology & biological psychiatry July 1, 1996 T Luxton, L A Parker, S Siegel 13 citations

Ibogaine, a proposed anti-addictive agent, does not reduce the expression of a previously established morphine-induced place preference in rats. Single injections of 40 mg/kg ibogaine given 24, 12, or 4 hours before testing, or 80 mg/kg given 24 hours before, failed to interfere with the conditioned preference. Two injections of 40 mg/kg at intervals of 48 and 24 hours or 24 and 4 hours before testing also had no effect. Ibogaine appears incapable of attenuating the expression of a one-trial morphine place preference once it has been established.

DOI: 10.1016/0278-5846(96)00064-4 Full text

Ibogaine interferes with the establishment of amphetamine place preference learning.

Experimental and clinical psychopharmacology May 1, 1997 I Moroz, L A Parker, S Siegel 11 citations

A single injection of ibogaine given 24 hours before amphetamine prevented the formation of a conditioned place preference for amphetamine after one or two conditioning trials, but was less effective after four trials. The reduced effectiveness with more trials appears due to tolerance developing to ibogaine.

DOI: 10.1037//1064-1297.5.2.119 Full text