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David R. Vago

7 papers in the library · 6,720 citations · publishing 2011-2024

Papers

How Does Mindfulness Meditation Work? Proposing Mechanisms of Action From a Conceptual and Neural Perspective

Perspectives on Psychological Science October 14, 2011 Britta K. Hölzel, Sara W. Lazar, Tim Gard et al. 2,997 citations

Mindfulness meditation, the nonjudgmental awareness of present-moment experiences, improves well-being and reduces psychiatric and stress-related symptoms, leading to its integration into psychotherapeutic interventions. Despite a surge in publications, few theoretical reviews synthesize the literature into a comprehensive framework. This article explores four components through which mindfulness exerts its effects: attention regulation, body awareness, emotion regulation (including reappraisal, exposure, extinction, and reconsolidation), and a change in perspective on the self. Empirical research, including self-reports and experimental data, supports these mechanisms. Neuroimaging studies show mindfulness practice is associated with neuroplastic changes in the anterior cingulate cortex, insula, temporo-parietal junction, fronto-limbic network, and default mode network. The authors suggest these components work synergistically to enhance self-regulation, guiding future research and treatment development.

Mind the Hype: A Critical Evaluation and Prescriptive Agenda for Research on Mindfulness and Meditation

Perspectives on Psychological Science October 10, 2017 Nicholas T. Van Dam, Marieke K. Van Vugt, David R. Vago et al. 1,500 citations

Mindfulness meditation has become widely used in therapy, corporate wellness, education, and the military, but the research backing it has faced criticism for poor methodology and misinformation. This article reviews the current state of mindfulness research, discussing difficulties in defining mindfulness, the proper scope of studies, and key methodological issues. The authors summarize what is known and unknown, offering a prescriptive agenda for contemplative science that focuses on assessment, training, possible adverse effects, and brain imaging. The goal is to inform scientists, media, and the public, minimize harm, curb poor research practices, and stop the spread of misinformation about mindfulness's benefits, costs, and future.

Self-awareness, self-regulation, and self-transcendence (S-ART): a framework for understanding the neurobiological mechanisms of mindfulness

Frontiers in Human Neuroscience January 1, 2012 David R. Vago, David A. Silbersweig 1,324 citations

Mindfulness—whether as a state, trait, process, meditation type, or intervention—benefits a range of psychological disorders and reduces stress. However, how it works and how it is defined remain unclear. This paper presents an integrative theoretical framework and neurobiological model called S-ART (self-awareness, self-regulation, self-transcendence). It explains that systematic mental training develops meta-awareness, behavioral self-modulation, and prosocial characteristics that transcend self-focused needs. The model proposes that meditation modulates self-specifying and narrative self-networks via a fronto-parietal control network, supported by processes like attention regulation, emotion regulation, and decentering. The framework aims to guide future research in contemplative sciences and treatments for psychological disorders.

The Varieties of Self-Transcendent Experience

Review of General Psychology May 1, 2017 David Bryce Yaden, Jonathan Haidt, Ralph W. Hood et al. 682 citations

Self-loss is often linked to mental illness, but this review proposes that temporary states of reduced self-focus and heightened connectedness—called self-transcendent experiences (STEs)—may also promote mental health. The authors identify common psychological constructs with a self-transcendent aspect, such as mindfulness, flow, peak experiences, mystical-type experiences, and positive emotions like love and awe. Drawing on literature from social psychology, clinical psychology, and affective neuroscience, they propose psychological and neurobiological mechanisms that might underlie STEs' effects. The review concludes with suggestions for future empirical research to further explore these experiences.

The Effect of Mindfulness-based Programs on Cognitive Function in Adults: A Systematic Review and Meta-analysis

Neuropsychology Review August 4, 2021 Tim Whitfield, Thorsten Barnhofer, Rebecca L. Acabchuk et al. 193 citations

Mindfulness-based programs (MBPs) show a small but significant benefit for cognitive performance, particularly for executive function and working memory, according to a meta-analysis of 56 randomized controlled trials involving 2,931 adults. The overall effect favoring MBPs over comparators was small (g = 0.15). Benefits were strongest for non-clinical samples and adults over 60, and when MBPs were compared to inactive controls rather than active ones. No significant effects were found for other cognitive domains. Most studies had unclear risk of bias, and some statistical results were unreliable. The findings partially support the idea that mindfulness practice can enhance certain cognitive abilities.

Pattern Theory of Selflessness: How Meditation May Transform the Self-Pattern

Mindfulness August 1, 2024 Aviva Berkovich‐ohana, Kirk Warren Brown, Shaun Gallagher et al. 22 citations

A selfless state of consciousness, reported for centuries in wisdom traditions, involves both temporary and lasting conditions. In psychology, the healthy self is typically emphasized, and the idea of selfless modes is sometimes dismissed, hindering empirical progress. This paper offers an interdisciplinary conceptual discussion grounded in the pattern theory of self (PTS), which views the self as a complex pattern of dynamically related processes. It proposes that meditative practices induce a reorganization of the self-pattern, enabling temporary or persistent selfless experience. The authors present a heuristic model, the pattern theory of selflessness (PTSL), with six nonlinear transformations: consolidating and integrating the self-pattern; cultivating concentration and present-moment awareness; cultivating mindful awareness; self-deconstruction states; self-flexibility; and self-liberation as a trait. This integrative view advances understanding of non-self experience and guides empirical research.

ENIGMA-Meditation: Worldwide consortium for neuroscientific investigations of meditation practices

April 8, 2024 Saampras Ganesan, Aki Tsuchiyagaito, Greg J. Siegle et al. 2 citations preprint

Meditation practices, which have been adapted into manualized interventions for conditions like depression, pain, addiction, and anxiety, show therapeutic promise, but their neuroscientific basis remains unclear. Current neuroimaging studies rely on small, heterogeneous datasets that vary in practice types, participant experience, clinical targets, and imaging methods, limiting generalizability and replicability. To address this, the ENIGMA-Meditation consortium was formed as a global collaboration to conduct systematic meta- and mega-analyses of distributed neuroimaging data using standardized methods. This framework aims to improve statistical power and rigorously characterize the neural mechanisms underlying meditation's effects on psychological and cognitive attributes, advancing the field of contemplative neuroscience.