Frontiers in medicine
January 1, 2024
Débora Silva Teixeira, Sandra Fortes, Celia Kestenberg et al.
8 citations
A mindfulness-based health promotion program adapted for Brazil's public health system was tested in nine groups in Rio de Janeiro primary care units. Of 62 mostly low-income women participants, 80% had chronic conditions, including anxiety (42%) and depression (35%). After eight weeks, anxiety and depression improved significantly, and quality of life improved in psychological, physical, and social domains. Participants reported using mindfulness practices for insomnia and emotional distress, and involving family members helped create space for meditation at home. Mindfulness was seen as a complement to medication and therapy. The intervention proved feasible and effective for psychosocial support in low-resource primary care settings.
Frontiers in medicine
January 1, 2024
Xiaoming Zhao, Zhendong Zhou, Zhenhua Li et al.
3 citations
In elderly patients undergoing bronchoscopy and lavage under general anesthesia, esketamine maintains more stable intraoperative blood pressure and shortens recovery time compared to sufentanil. A randomized controlled trial of 100 patients aged 60 years or older compared esketamine (0.3 mg/kg) with sufentanil (0.2 μg/kg) during anesthesia induction. The esketamine group had higher blood pressure at multiple time points during the operation and more stable blood pressure overall, though heart rate and oxygen saturation did not differ between groups. Blood pressure and heart rate fluctuated significantly after laryngeal mask insertion in the esketamine group but not in the sufentanil group. Esketamine may enhance hemodynamic stability and reduce hypotension in this population.
Frontiers in medicine
January 1, 2024
Jiangning Xu, Jin Jian, Yunyun Zhang et al.
1 citation
Nasal administration of esketamine effectively relieves acute pain after CT-guided needle localization before lung surgery. In a double-blind, placebo-controlled trial, 90 patients with pain scores above 3 on a 10-point scale received either a low or high dose of esketamine or saline. Satisfactory pain relief—a score of 3 or lower 15 minutes after treatment—occurred in 56.7% of patients given 0.3 mg/kg esketamine, 53.3% given 0.5 mg/kg, but only 16.7% given saline. Those receiving esketamine also required less rescue pain medication and had similar rates of side effects. The results indicate that intranasal esketamine is a safe and effective option for managing acute pain in this setting.
Frontiers in medicine
January 1, 2026
Hui Zhang, Yan An Jiang, Huajun Fu et al.
Postpartum depression affects 10-20% of women after childbirth, with rates up to 30-50% in high-risk groups. A multimodal analgesic protocol combining dexmedetomidine and esketamine, given during and after cesarean delivery, was associated with a lower incidence of postpartum depression at six weeks (14.6% vs. 29.1% in controls), better sleep quality, and reduced opioid use in 82 high-risk parturients. The intervention group showed a greater decrease in depression scores and improved sleep scores. Transient psychotomimetic effects occurred in 8.5% of patients. These findings suggest the protocol may reduce postpartum depression risk, though randomized trials are needed to confirm causality.
Frontiers in medicine
January 1, 2024
Aruzhan Zhaksylyk, Yerkin G Abdildin, Suienish Sultangazin et al.
Adding ketamine to morphine after thoracotomy reduces acute pain and lowers opioid use. A meta-analysis of nine randomized controlled trials with 556 patients found that patients receiving ketamine plus morphine had significantly less pain at rest and when moving or coughing during the first few days after surgery, and they consumed less morphine overall. The analysis found no data on whether ketamine prevents chronic pain after thoracotomy. The authors call for larger, standardized trials to assess both short- and long-term effects.