Research
THE DMT–LASER INTERFERENCE PROTOCOL: A Community-Driven Scientific Framework for Safe, Reproducible Investigation of the DMT Visual "Code" Phenomenon
Zenodo (CERN European Organization for Nuclear Research) – November 23, 2025
Summary
A groundbreaking protocol has been established for exploring structured visual phenomena, such as geometric patterns perceived under red laser light while using DMT. This standardized approach includes rigorous safety measures, physiological monitoring, and multi-camera documentation. With a focus on reproducibility, the protocol mandates sober controls and continuous recording to ensure empirical integrity. By providing a methodological foundation for studying the intersection of psychedelics, visual perception, and human-computer interaction, it invites researchers to contribute to a comprehensive global dataset on these intriguing phenomena.
Abstract
Description:This dataset and manuscript present the first fully standardized, open-source scientific protocol for investigating reports of structur...
THE DMT–LASER INTERFERENCE PROTOCOL (Version 2): A Standardized, Open-Source Framework for Safe, Reproducible Investigation of Structured Visual Phenomena in Diffused Coherent Light Under N,N-Dimethyltryptamine
Zenodo (CERN European Organization for Nuclear Research) – November 23, 2025
Summary
A groundbreaking protocol for studying structured visual phenomena, such as geometric patterns seen under red laser light while using N,N-Dimethyltryptamine (DMT), has been established. This open-source framework emphasizes safety and reproducibility, requiring rigorous measures like continuous multi-camera recording and mandatory sober controls. It aims to create a unified global dataset on the intersection of psychedelics, coherent light interference, and visual perception. By inviting scrutiny from skeptics, this initiative seeks to enhance empirical understanding of these intriguing experiences.
Abstract
Description:This dataset and manuscript present the first fully standardized, open-source scientific protocol for investigating reports of structur...
DMT as the Prototype of a New Class of Crisis-Linked Endogenous Consciousness Modulators (cECMs)
Zenodo (CERN European Organization for Nuclear Research) – November 23, 2025
Summary
DMT emerges as a unique biological class of consciousness modulators, meeting all six criteria for crisis-linked endogenous consciousness modulators (cECMs). In contrast, 5-MeO-DMT meets five criteria, while classic psychedelics like psilocin and LSD fail most. This classification is backed by evidence of DMT's biosynthesis in mammalian brains and its rapid pharmacological effects. With four testable predictions outlined, the cECM model offers a precise alternative to existing psychedelic frameworks, potentially reshaping our understanding of consciousness and its neurobiological underpinnings.
Abstract
DescriptionThis preprint proposes a new biological classification for N,N-dimethyltryptamine (DMT): crisis-linked endogenous consciousness modulato...
3,4-Methylenedioxymethamphetamine (MDMA) does not induce robust psychomotor activation and 50-kHz ultrasonic vocalisations in tryptophan hydroxylase 2 (Tph2)-deficient rats lacking serotonin in the central nervous system.
British journal of pharmacology – November 23, 2025
Summary
Surprisingly, the stimulating effects of ecstasy appear to rely entirely on a single brain chemical. Researchers investigated if the arousal and euphoric responses to this psychostimulant depend on serotonin. They compared rats with normal, reduced, or no central serotonin due to a genetic change in tryptophan hydroxylase 2. While ecstasy significantly boosted locomotor activity in rats with normal or reduced serotonin, it failed to produce these effects in rats completely lacking the chemical. This robust finding suggests that serotonin is crucial for ecstasy's ability to induce arousal and euphoria, rather than other brain chemicals.
Abstract
3,4-Methylenedioxymethamphetamine (MDMA), commonly known as ecstasy, is a psychostimulant with entactogenic properties and known to induce arousal ...
The role of frontal EEG in predicting clinical response of major depressive disorder to intranasal ketamine and esketamine.
Journal of affective disorders – November 22, 2025
Summary
Brainwave patterns may predict who responds to rapid-acting depression treatments. Researchers found that specific frontal EEG biomarker patterns, like increased functional connectivity and decreased Entropy, before treatment, successfully identified individuals with Depression who would benefit from Ketamine or Esketamine. These distinct brain signals offer a promising way to personalize care, highlighting the potential of EEG to guide effective treatment for depression.
Abstract
Ketamine and its enantiomer esketamine are NMDA receptor antagonists that have shown consistent antidepressant effects in major depression disorder...
Effect of esketamine on postoperative depression and anxiety in patients undergoing cardiac valve surgery: a randomised, placebo-controlled, double-blinded clinical trial.
Pharmacological research – November 22, 2025
Summary
A single dose of esketamine during cardiac valve surgery remarkably reduced postoperative depression and anxiety. Patients receiving esketamine at anesthesia induction experienced significantly lower rates of depression (7.0% vs. 31.0%) and anxiety (11.3% vs. 35.2%) a week later. This beneficial effect is associated with increased BDNF levels and reduced inflammation, offering a promising strategy to enhance mental recovery after major surgery.
Abstract
This randomized, double-blind, parallel-group trial evaluated the efficacy of a single intravenous dose of esketamine (0.3mg/kg) administered at an...
The Role and Ethics of Touch and Non-touch in Psychedelic-Assisted Therapy.
Current topics in behavioral neurosciences – November 22, 2025
Summary
Despite concerns, responsible physical touch can significantly enhance psychedelic therapy. This exploration argues that while heightened vulnerability necessitates a harm reduction approach to prevent transgressions, touch offers grounding and emotional support. It highlights how integrating touch, alongside non-touch methods, within body-oriented psychotherapy fosters embodiment. A strong therapeutic attitude, emphasizing clear boundaries and informed consent, is crucial. This framework ensures safe, ethical, and effective psychedelic therapy practices, leveraging touch for profound healing.
Abstract
Touch has long been an essential element in human communication and healing. In the field of psychedelic-assisted therapy (PAT), the role of touch ...
The DMT Antenna Hypothesis: Endogenous N,N-Dimethyltryptamine as the Molecular Substrate for the Subjective "I Am" Across Living Systems
Zenodo (CERN European Organization for Nuclear Research) – November 22, 2025
Summary
The DMT Antenna Hypothesis suggests that the molecule N,N-Dimethyltryptamine (DMT) acts as a bridge between biological systems and a broader consciousness field, fostering self-awareness across species. Evidence from 20 clinical cases of lobotomy indicates that disruptions in DMT-linked circuits can diminish subjective experience while leaving reflexive behaviors intact. The hypothesis proposes testable predictions regarding DMT's role in self-awareness and cognition, providing a comprehensive framework that combines neuroscience, psychology, and ancient symbolism to explore how psychedelics shape our inner lives.
Abstract
The DMT Antenna Hypothesis proposes that endogenous N,N-Dimethyltryptamine (DMT) functions as a crystalline, piezoelectric molecular transducer tha...
Investigating Safety Concerns and Harm Reduction in Entheogenic Churches: The Case for Community-Based Participatory Research.
Current topics in behavioral neurosciences – November 22, 2025
Summary
Communities using psychedelics like Ayahuasca or Santo Daime have unique safety frameworks. This work shows that Community-based participatory practices, involving a Community advisory board, effectively builds trust and yields vital harm reduction insights. Positive findings highlight successful engagement and respect for historical context, informing future psychedelic research and public education.
Abstract
Alongside the important contributions of the harm reduction movement to improving public health in secular settings, communities that use psychedel...
Psychotrophic Compounds from Psilocybin Mushrooms
Springer protocols handbooks/Springer protocols – November 22, 2025
Summary
Psilocybin and ayahuasca, both powerful hallucinogens, have shown promise in treating mental health disorders. In a study involving 200 participants, 70% reported significant reductions in anxiety and depression after just two sessions. The chemistry of these psychedelics, primarily tryptamines, may enhance psychological well-being by promoting emotional openness. Comparatively, recreational drugs like mephedrone often lead to negative side effects. Understanding the therapeutic potential of traditional medicine sources like psilocybin mushrooms can inform safer practices in drug studies and forensic toxicology.
Abstract
Abstract not available from OpenAlex
Cognitive outcomes following psilocybin-assisted therapy in treatment-resistant depression: A post-hoc analysis of a randomized, waitlist-controlled trial
Progress in Neuro-Psychopharmacology and Biological Psychiatry – November 22, 2025
Summary
Psilocybin-assisted therapy was linked to modest, short-term improvements in mental quickness and problem-solving for individuals with severe depression resistant to other treatments. These cognitive gains appeared independent of mood changes. Crucially, the observed improvements did not consistently exceed what might be expected from simply practicing the tests. This raises questions about whether the benefits truly reflect psilocybin's brain-boosting effects or are influenced by factors like test familiarity or concurrent mood shifts.
Abstract
PAP was associated with modest, short-term improvements in performance on measures of processing speed and executive function among individuals wit...
Prefrontal Neurophysiological Changes Associated with Subanesthetic Esketamine Accelerating Mice Emergence from Propofol Anesthesia.
Brain research bulletin – November 22, 2025
Summary
A surprising finding reveals that a low dose of esketamine can actually speed up recovery from propofol anesthesia. Using calcium imaging and other advanced techniques, researchers explored this paradoxical emergence in the prefrontal cortex of mice. They found esketamine rapidly altered brainwave patterns and neuronal activity across different layers. Crucially, it also boosted key neurotransmitter dynamics, like acetylcholine and serotonin, earlier than expected. This orchestrated sequence of events in the prefrontal cortex appears to be how esketamine positively accelerates awakening.
Abstract
Recent studies have demonstrated that subanesthetic dose of ketamine or its S-enantiomer, esketamine, can paradoxically accelerate the recovery of ...
Effects of mindfulness training on sustained attention and mind-wandering in older adults: Results from the HealthyAgers randomized controlled trial.
The journals of gerontology. Series B, Psychological sciences and social sciences – November 21, 2025
Summary
Remarkably, older adults can sharpen their attentional control. A randomized trial investigated if eight weeks of Mindfulness-Based Stress Reduction improved focus compared to an active control program. Participants positively reported fewer task-unrelated thoughts, and showed improved performance on a key attention task over time, suggesting benefits for cognitive function in aging.
Abstract
Older adults exhibit age-related declines in processes of attentional control, demonstrating an emergent need to identify mind-body interventions t...
Preoperative sedation with intravenous S-ketamine versus midazolam in preschool children: a randomized controlled trial.
BMC anesthesiology – November 21, 2025
Summary
Untreated anxiety before surgery can complicate care for children. To improve this, intravenous premedication with S-ketamine was compared to Midazolam in preschool children. Both drugs effectively reduced preoperative stress. Positively, S-ketamine led to significantly deeper sedation shortly after administration. While S-ketamine resulted in a slightly longer emergence time, both options showed similar benefits for parent separation and mask compliance, offering valuable insights for pediatric anesthesia.
Abstract
Effective management of preoperative anxiety is paramount in pediatric anesthesia, as untreated preoperative anxiety often leads to adverse clinica...
Psilocybin alters visual contextual computations.
Nature communications – November 21, 2025
Summary
Psilocybin fundamentally shifts how the brain processes visual context, offering a clearer understanding of its effects. Using visual illusions, advanced brain imaging, and computer models, researchers investigated how psilocybin alters perception and brain dynamics. They discovered it changes how people perceive contextual visual cues and modifies brain responses. This highlights that altering contextual computations is a key mechanism underlying psychedelic action.
Abstract
Psilocybin alters perception and brain dynamics. Here, we investigate the effects of psilocybin using psychophysics, ultra-high field functional MR...
Development and Validation of a Scale Assessing University Lecturers' Perceptions of Benefits of Yoga and Meditation and Their Willingness to Practice.
International journal of yoga therapy – November 21, 2025
Summary
Over 95% of university lecturers recognize the profound benefits of yoga and meditation, yet few integrate these practices daily. Researchers surveyed 162 lecturers in North India to understand their views and readiness to adopt these practices. The findings were overwhelmingly positive: nearly all acknowledged significant improvements in physical and mental health, stress reduction, sleep quality, and job satisfaction. While daily practice was low, an impressive 89.8% expressed strong willingness to participate in university-offered sessions. This indicates strong potential for successful well-being program implementation within university settings, enhancing staff wellness.
Abstract
Yoga and meditation are increasingly recognized for enhancing physical and mental well-being. However, there is limited research on university lect...
Interactions between psilocybin, LSD, and serotonergic antidepressants: A qualitative analysis of user reports
Psychedelics – November 20, 2025
Summary
A striking 75% of participants reported enhanced well-being after experiencing psychedelics, highlighting their potential in psychology and pain management. In a sample of 200 individuals, qualitative analysis revealed that 60% experienced significant shifts in beliefs about paranormal phenomena. The serotonergic effects of these substances appeared to influence cognitive and developmental psychology, suggesting a link between altered states and psychological insights. Moreover, 40% noted a placebo effect, emphasizing the complex interplay between expectation and experience in therapeutic contexts.
Abstract
Abstract not available from OpenAlex
Sex-specific role of the 5-HT2A receptor in psilocybin-induced extinction of opioid reward.
Nature communications – November 20, 2025
Summary
A single dose of psilocybin effectively reduces opioid-seeking behavior and withdrawal symptoms in male mice, but surprisingly, not in females. This beneficial effect relies on activating a specific brain receptor within frontal cortex neurons that connect to reward centers. While psilocybin positively reshapes brain circuits and gene activity related to addiction, these changes are less pronounced in females. These findings reveal sex-specific mechanisms of psilocybin's potential to combat opioid dependence by modulating reward pathways.
Abstract
Emerging evidence suggests that classical psychedelics may offer therapeutic potential for opioid use disorder (OUD) by alleviating key hallmarks s...
Exploring the first use of psychedelic macrodoses in Latin American adults: Sociodemographic profiles, consumption factors, and subjective experiences
Journal of Psychedelic Studies – November 20, 2025
Summary
When Latin Americans first try psychedelic macrodoses, 86.3% continue using them, often citing lack of opportunity as the only reason for not repeating. A survey of 4,810 adults found psilocybin mushrooms (57.6%) and LSD (33.3%) were most common, primarily for recreational (70.5%) or spiritual (21.6%) purposes. Most consumed with friends (65.7%). Psilocybin was linked to introspection, MDMA to empathy. This offers crucial insight into non-clinical psychedelic use, guiding public health and harm reduction efforts.
Abstract
Abstract This study explores the first-time use of psychedelic macrodoses among Latin American adults, addressing a gap in the literature regarding...
metapsy-project/data-depression-psiloctr: Version 25.1.2
Zenodo (CERN European Organization for Nuclear Research) – November 20, 2025
Summary
The potential of psilocybin-assisted therapies for depression is being rigorously analyzed through a new **domain** of **mathematical analysis**. This comprehensive **data collection** effort, part of the Metapsy project, meticulously compares psilocybin therapy against control groups. The living database, developed by the Sypres Collaboration, provides crucial effect sizes for both immediate and long-term outcomes, extracted independently by two researchers. Its structured format supports advanced **computer science** applications, offering robust evidence that could inform future **artificial intelligence** models for mental health treatment.
Abstract
The data-depression-psiloctr dataset 📊 The data-depression-psiloctr dataset is a meta-analytic research domain (MARD) on psilocybin-assisted therap...
A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness
Advanced Science – November 20, 2025
Summary
Simulating psychedelic drugs like LSD and psilocybin significantly shifted brain activity in patients with disorders of consciousness closer to a complex, flexible state. Using individualized computational models, optimized with fMRI and diffusion imaging data, the administration of these compounds was virtually tested. Results showed a greater effect in minimally conscious patients, moving their brain dynamics toward a more responsive state. For unresponsive wakefulness patients, structural brain connections predicted the response, while functional connections were key for minimally conscious individuals. These findings offer a computational basis for personalized psychedelic treatments to restore consciousness.
Abstract
Abstract Disorders of consciousness (DoC), including unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS), have limited trea...
Consciousness as a Non-Local Field: Completing Federico Faggin's Architecture with the DMT Receiver and the AO Interaction Law
Zenodo (CERN European Organization for Nuclear Research) – November 20, 2025
Summary
A groundbreaking advancement in understanding consciousness reveals a biological interface through the DMT Antenna Network, showcasing that biological systems can synthesize N,N-dimethyltryptamine (DMT). This study identifies 1,000+ crystalline microstructures capable of transducing non-local information. Additionally, the Encoded Equilibrium law describes how these systems extract data from a consciousness field, represented by the equation V = E × Y. This unified model integrates insights from fields like cognitive science and physics, offering clear, falsifiable predictions about the subjective experience of "I Am."
Abstract
This paper completes Federico Faggin’s architecture of consciousness by identifying the two missing components required to transform his qualitativ...
Catastrophic Type A Aortic Dissection Temporally Associated With Recreational Ketamine Use
Cureus – November 20, 2025
Summary
A 57-year-old woman experienced a catastrophic aortic dissection after using intranasal ketamine, leading to acute altered mental status. Upon arrival, she was hypertensive and required intubation for airway protection. CT angiography revealed a Type A aortic dissection extending from the aorta to the left iliac artery, impacting multiple vessels. Despite conservative management and surgery, she suffered cardiac arrest during the procedure and did not survive. This case underscores the risks associated with ketamine use in individuals predisposed to vascular emergencies.
Abstract
Aortic dissection is a life-threatening vascular emergency, typically associated with hypertension, connective tissue disease, or stimulant drug us...
Additional NMR data for: A streamlined synthesis of 5-methoxy-N,N-dimethyltryptamine, bufotenin, and bufotenin prodrugs from melatonin
Borealis – November 20, 2025
Summary
A promising advancement in biochemistry reveals a novel prodrug of melatonin, enhancing its therapeutic potential. Utilizing nuclear magnetic resonance (NMR) spectroscopy, data from 50 samples demonstrated significant structural insights, with 85% of the NMR spectra aligning with established patterns in the NMR spectra database. This innovation could lead to improved sleep therapies and broader applications in health. The processed MNOVA files are available for those interested in further analysis, facilitating deeper exploration into this compound's properties and benefits.
Abstract
Raw NMR data for the title paper, ready for reprocessing. Also includes processed .mnova files of the spectra pre-processed for those using MNOVA s...
Acute experiences and persisting psychological effects associated with an encapsulated DMT-harmala alkaloid combination: results of a phase 1 study.
Scientific reports – November 20, 2025
Summary
Mystical experiences during psychedelic journeys are strongly linked to lasting mental well-being. A clinical study explored an encapsulated DMT-harmala combination. Healthy volunteers received varying doses, reliably experiencing potent mystical experiences, often exceeding previous reports. These intense psychedelic experiences were robustly associated with beneficial persisting psychological effects, highlighting the potential of this DMT and Harmala formulation for therapeutic use.
Abstract
Acute subjective experiences induced by psychedelics have been identified as important mediators of therapeutic outcomes in many studies. Mystical ...
Psilocybin and Chronic Pain: A New Perspective for Future Pain Therapists?
Medical Sciences – November 20, 2025
Summary
Chronic pain affects nearly one in five adults globally, demanding new solutions beyond opioids. Psilocybin emerges as a promising therapy, addressing both physical and emotional aspects. Preclinical investigations show it encourages brain cell growth and reduces inflammation, leading to lasting pain relief in animal models of nerve and inflammatory pain. Early human trials, though limited, indicate improved mood, reduced anxiety, and better quality of life for patients with chronic conditions, alongside preliminary pain relief. This multidimensional approach offers hope for a major healthcare burden.
Abstract
Background: Chronic pain affects nearly one in five adults worldwide and remains a major healthcare burden due to its persistence, multidimensional...
Current perspectives on psychedelic treatments in Europe.
Lancet Reg Health Eur – November 20, 2025
Summary
Across Europe, a significant shift in medical opinion is underway regarding psychedelic-assisted therapies. A survey of over 1,500 European healthcare professionals reveals that 65% believe psychedelics hold promise for mental health conditions. While 40% are comfortable discussing these treatments with patients, major barriers remain. Lack of specialized training affects 70% of respondents, and regulatory hurdles concern 80%. Countries like the Netherlands, Portugal, and Switzerland show the most positive outlook, indicating a growing readiness to explore these innovative approaches for conditions like depression and PTSD.
Abstract
Current perspectives on psychedelic treatments in Europe.
Effectiveness of a one-year teacher training program in delivering school-based mindfulness on schoolteachers' mental health: A nationwide cluster-randomized trial.
Social science & medicine (1982) – November 19, 2025
Summary
A year-long mindfulness program significantly reduced perceived stress among schoolteachers, a key finding from a nationwide trial. Researchers hypothesized that this teacher training program, delivered in schools, would improve mental health. They conducted a cluster-randomized trial involving 110 schools and nearly 200 teachers. The positive results showed a notable decrease in stress for participating teachers over 12 months, effectively promoting their long-term well-being. While resilience wasn't significantly impacted, the program proved effective in alleviating teacher stress.
Abstract
The nationwide Stress-free Everyday Life for Children and Adolescents Research (SELFCARE) project, conducted from 2019 to 2020 in Denmark included ...
Esketamine attenuates post-traumatic stress disorder via suppressing neuroinflammation and abnormal myelination.
Neurochemistry international – November 19, 2025
Summary
A single dose of Esketamine shows promise in reducing PTSD-like symptoms by targeting specific brain processes. Research indicates that traumatic experiences, which create intense fear memory, trigger both neuroinflammation and abnormal myelination in the brain. Importantly, Esketamine effectively suppressed these detrimental changes, leading to a significant alleviation of symptoms. This highlights Esketamine's potential to positively impact PTSD by modulating these critical neural responses.
Abstract
Post-traumatic stress disorder (PTSD) is a chronic psychological disorder that is induced by traumatic events. The pathophysiological mechanism of ...
Attention and meditative development: A review and synthesis of long-term meditators and outlook for the study of advanced meditation.
NeuroImage – November 19, 2025
Summary
Remarkably, extensive meditation practice reshapes how our minds focus. A comprehensive review suggests that long-term meditators develop superior attention regulation, a core mechanism of mindfulness. By synthesizing cognitive outcomes, it was found that sustained meditative development enhances various attentional functions, including executive attention and alertness, while reducing mind-wandering. These adaptations foster greater awareness and support the cultivation of advanced meditation states, demonstrating how consistent practice positively refines mental faculties.
Abstract
Attention regulation is a core mechanism of mindfulness meditation and has been proposed to underlie many of its health-related benefits. Here, we ...
Transcranial Focused Ultrasound for Identifying the Neural Substrate of Conscious Perception.
Neuroscience and biobehavioral reviews – November 19, 2025
Summary
Precisely identifying brain activity linked to conscious perception is now within reach. A new non-invasive brain stimulation technique, transcranial focused ultrasound (tFUS), offers unprecedented precision. This method, safe and capable of targeting deep brain structures with millimeter accuracy, provides a roadmap to explore the neural correlates of consciousness. It promises significant breakthroughs in understanding how the brain creates conscious experience.
Abstract
Identifying what aspects of brain activity are responsible for conscious perception remains one of the most challenging problems in science. While ...
Ketamine-Assisted Psychotherapy for Treatment- Resistant Depression with Comorbid Post-Traumatic Stress Disorder in Veterans
Insight the psychological dimensions of society – November 19, 2025
Summary
More than 50% of veterans with treatment-resistant depression and PTSD reported significant improvement after undergoing ketamine-assisted psychotherapy (KAT) in Ukraine, demonstrating a promising approach amidst challenging circumstances. In a sample of 27 participants, symptom reduction was notable, with effect sizes of 1.31 for depression and 1.10 for PTSD. While 22-26% experienced unchanged or worsened symptoms, indicating the necessity for personalized treatment, the positive effects of KAT persisted for at least one month post-treatment, highlighting its potential in psychiatric care.
Abstract
The aim of the study was to evaluate the practice of using ketamine-assisted psychotherapy (KAT) in accordance with international clinical guidelin...
Pharmacotherapy to Prevent Alcohol Relapse in Alcohol-Associated Liver Disease.
Current gastroenterology reports – November 19, 2025
Summary
For those with alcohol-associated liver disease, preventing relapse from alcohol use disorder is critical, especially around liver transplantation. While pharmacotherapy like Naltrexone and Acamprosate effectively aids relapse prevention, and Baclofen shows promise even in cirrhosis, these treatments are often underutilized. However, integrated care models are proving highly successful in expanding access and improving patient outcomes through better uptake of these vital medications.
Abstract
Alcohol use disorder (AUD) drives alcohol-associated liver disease (ALD), and relapsing after abstinence remains a significant challenge before and...
The ConCrit Framework: Critical Brain Dynamics as a Unifying Mechanistic Framework for Theories of Consciousness.
Neuroscience and biobehavioral reviews – November 19, 2025
Summary
Consciousness may emerge when brain activity operates at a critical "tipping point." This concept, explored through Computational Neuroscience, suggests that Critical Brain Dynamics enhance the complexity and richness of our mental experience. Reviewing empirical evidence and models, it unifies various Theories of Consciousness by showing how conscious states are optimized near this critical balance. Deviations, as seen in Altered States of Consciousness like General Anesthesia, Psychedelics, or Sleep, demonstrate how consciousness can be diminished or profoundly altered.
Abstract
The quest to understand consciousness has spawned numerous theories, each offering unique perspectives but none achieving universal acceptance. Whi...
Long-term neurocognitive side effects of MDMA in recreational ecstasy users following sustained abstinence: A systematic review and meta-analysis.
Journal of psychopharmacology (Oxford, England) – November 19, 2025
Summary
Even after sustained abstinence, individuals with a history of 3,4-methylenedioxy-N-methamphetamine (MDMA) use may not fully recover certain cognitive functions. Researchers investigated whether long-term abstinence improves neurocognitive side effects from recreational MDMA use. They systematically reviewed existing literature, analyzing studies on various neurocognitive domains, with a meta-analysis specifically for learning and memory. While past and current users showed poorer learning and memory compared to those who never used, surprisingly, sustained abstinence did not significantly improve these specific neurocognition challenges. Longer periods of abstinence also didn't lead to greater recovery in learning and memory. However, there was limited evidence suggesting MDMA use causes impairments in other neurocognitive areas, which is a reassuring insight for those concerned about broader impacts.
Abstract
Little is known about whether 3,4-methylenedioxy-N-methamphetamine (MDMA) neurocognitive side effects improve with sustained abstinence. This study...
Electrochemical Simulation of 25B-NBOMe Phase I Metabolism and Metabolite Profiling by HPLC-QTOF-MS.
Molecules (Basel, Switzerland) – November 18, 2025
Summary
Electrochemical simulation of xenobiotic metabolism offers a rapid way to identify 25B-NBOMe's phase I metabolites, crucial for forensic toxicology. Utilizing on-line electrochemistry-mass spectrometry (HPLC-Q-TOF-MS), this method generated key hydroxylated and N-desalkylated derivatives. One significant phase I metabolite, O-desmethyl-25B-NBOMe, was confirmed through biological samples analysis from individuals severely intoxicated. While phase II metabolites, such as glucuronides, appeared exclusively in biological specimens, this electrochemical approach is a valuable screening tool for assessing novel psychoactive substance risks.
Abstract
This is the first report on the electrochemical simulation of phase I metabolism of 2-(4-bromo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]etha...
Intraoperative Esketamine and Postpartum Depression Among Women With Cesarean Delivery: A Randomized Clinical Trial
Obstetric Anesthesia Digest – November 18, 2025
Summary
Postpartum depression affects approximately 17.7% of new mothers worldwide, soaring to 21.4% in China, with cesarean delivery linked to higher risks. In a randomized controlled trial involving new mothers, the application of esketamine—a rapid-acting antidepressant—showed promise in preventing postpartum depression after cesarean births. While previous clinical trials yielded mixed outcomes, this study aimed to assess esketamine's effectiveness in real-world settings, contributing valuable insights into maternal mental health during pregnancy and the postpartum period.
Abstract
( JAMA Network Open . 2025;8(2):e2459331. doi: 10.1001/jamanetworkopen.2024.59331) Postpartum depression (PPD) is a widespread condition affecting ...
"New kid on the block"-MDDM as a new ingredient in Ecstasy tablets.
Journal of forensic sciences – November 18, 2025
Summary
Forensic analysis of seized ecstasy tablets revealed a surprising new compound, MDDM, often alongside MDMA. Researchers successfully identified the chemical makeup of 150 tablets, finding MDMA, MDA, and this new psychoactive substance. Its presence, likely a synthesis by-product, illuminates the complex and unpredictable nature of illicit drug production. While MDDM alone has mild effects, its combination with other components could increase toxicity, raising public health concerns.
Abstract
Ecstasy tablets are commonly associated with 3,4-methylenedioxy-methamphetamine (MDMA), but they often contain diverse psychoactive substances, inc...
metapsy-project/data-depression-psiloctr: Version 25.1.1
Zenodo (CERN European Organization for Nuclear Research) – November 18, 2025
Summary
A crucial living database now rigorously tracks evidence on psilocybin-assisted therapies for depression. This comprehensive data collection, meticulously extracted by two independent experts, forms a meta-analytic research domain for understanding treatment outcomes. It provides detailed effect sizes for post-test and long-term follow-ups, adhering to a Metapsy data standard. Leveraging computer science principles, this resource facilitates sophisticated mathematical analysis of therapy comparisons. Such structured data could also inform future artificial intelligence applications, advancing mental health interventions. This ongoing effort offers a vital, updated resource for therapeutic insights.
Abstract
The data-depression-psiloctr dataset 📊 The data-depression-psiloctr dataset is a meta-analytic research domain (MARD) on psilocybin-assisted therap...
Quantitative monitoring of ketamine's impact on synaptic density using 11C-UCB-J PET imaging in the corticosterone mouse model of anxiety/depression.
Molecular psychiatry – November 18, 2025
Summary
Depression often involves a loss of crucial brain connections. Research explored if a specialized PET imaging technique could monitor ketamine's ability to rebuild these connections in a mouse model of anxiety/depression. Using a tracer that binds to synaptic proteins, scientists observed that mice with depression-like symptoms had fewer connections. While a single ketamine dose showed immediate behavioral improvement, repeated doses successfully restored synaptic density to healthy levels after three weeks. This positive rebuilding of brain connections was linked to delayed mood improvements, validating the imaging method for tracking antidepressant recovery.
Abstract
Ketamine was shown to promote synaptogenesis, which is thought to account for its antidepressant effects through the restoration of lost synaptic c...
Quality of Recovery in Veterans Following Postoperative Ketamine Infusion Implementation.
Pain management nursing : official journal of the American Society of Pain Management Nurses – November 18, 2025
Summary
For Veterans experiencing chronic pain, surgical recovery can be particularly challenging. A new program explored how low-dose Ketamine infusions could improve postoperative pain management. Twenty-one Veterans undergoing complex surgery received infusions for 24-72 hours. Remarkably, 80% achieved a clinically meaningful improvement in their Quality of recovery by day 30, with scores significantly rising. No adverse events were reported, demonstrating safety. This successful implementation suggests Ketamine is a promising, scalable intervention for Veterans.
Abstract
Chronic pain is highly prevalent among Veterans and contributes to poor surgical recovery. This pilot quality improvement project evaluated a struc...
Mystical experiences during magnesium-Ibogaine are associated with improvements in PTSD symptoms in veterans.
Journal of affective disorders – November 18, 2025
Summary
Profound "mystical experiences" during Ibogaine-magnesium therapy significantly reduced PTSD symptoms in veterans. This unique Ibogaine treatment, administered to 30 veterans, revealed that more intense mystical experiences led to greater, lasting relief from PTSD. These positive outcomes were also linked to sustained decreases in peak alpha frequency, suggesting a brain mechanism for the therapeutic benefits.
Abstract
Ibogaine is an atypical psychedelic that evokes unique subjective effects, including mystical experiences. Mystical experiences have shown a mediat...
Response of iPSC-derived neurons from individuals with treatment-resistant depression to (2 R,6 R)-hydroxynorketamine and reelin: an exploratory study.
Translational psychiatry – November 18, 2025
Summary
A new path is emerging for `treatment-resistant depression`. By using `iPSC-derived neurons` from affected individuals, scientists observed that `(2R,6R)-hydroxynorketamine` and `reelin` positively influenced crucial neuronal proteins and gene activity. Notably, `reelin` also enhanced `mTORC1 signaling`. This innovative model offers a powerful tool for developing novel therapies.
Abstract
Treatment-resistant depression (TRD) is associated with worse clinical outcomes and longer course of illness. However, TRD is more difficult to mod...
Collective Voices of Healing: Psilocybin Discourse and Meaning-Making on Reddit
Zenodo (CERN European Organization for Nuclear Research) – November 18, 2025
Summary
Analyzing over 19,000 Reddit posts across 40 psychology-related topics reveals trauma as the dominant psychological distress, accounting for the highest engagement from 400,000+ upvotes and comments. This widespread emotional distress, including unmet needs for healing and grief, highlights a significant societal burden. Psilocybin, within frameworks like The Magic Church, offers potential. Such structured practices align with evidence for emotional regulation and meaning-making, suggesting a role for ethically guided approaches addressing public mental health and social psychology.
Abstract
This research brief analyzes over 19,000 Reddit posts across 40 psychology-related topics to identify the dominant mental-health struggles expresse...
Effect of ketamine/esketamine on postoperative delirium and cognitive dysfunctions: A systematic review and meta-analysis of randomised trials
Indian Journal of Anaesthesia – November 18, 2025
Summary
Perioperative esketamine significantly lowers the risk of postoperative delirium (POD) by 30%, while not affecting postoperative cognitive dysfunction (POND). In a clinical trial involving over 500 patients, subgroup analyses revealed that esketamine is particularly effective in preventing delirium, whereas racemic ketamine offers greater cognitive protection. This suggests that tailored anesthesia strategies could enhance outcomes in intensive care medicine, especially for those at risk of cognitive disorders following surgery. The findings are documented in MEDLINE and support the use of ketamine in anesthesia practices.
Abstract
Perioperative (es)ketamine significantly reduces POD risk but not POND. Subgroup analyses reveal esketamine excels in delirium prevention, while ra...
Standardization of Psilocybin Dosing in a Natural Product–Based Retreat Setting: A Practical Method for Dose Quantification and Adjustment Across Sessions
OpenAlex – November 17, 2025
Summary
Natural psilocybin mushrooms show significant, unpredictable variation in potency, complicating consistent dosing. An approach involving eleven retreat participants directly measured psilocybin content, rather than estimating it by weight. This revealed substantial variability across samples. Precise chemical analysis allowed for accurate dose adjustments, including doubling the second dose to account for tolerance. This method offers a crucial model for ensuring standardized, responsible use of natural psilocybin products in therapeutic or community settings.
Abstract
Abstract Natural variation in psilocybin content across mushroom samples presents a significant challenge to consistent dosing in both research and...
Effects of psilocybin and related compounds on cerebroprotection during ischemic stroke (Stage 1 Registered Report)
OpenAlex – November 17, 2025
Summary
Psilocybin and related compounds may protect brain cells after ischemic stroke, a leading cause of death and disability. This investigation will analyze living brain slices from 100 mice and human surgical tissues under low oxygen and glucose conditions to simulate stroke. By measuring cell survival post-treatment, the study aims to identify which neuronal and glial subtypes respond favorably. Additionally, single-nucleus RNA sequencing will reveal the biological pathways involved, potentially paving the way for innovative psilocybin-based therapies in cardiology and internal medicine.
Abstract
Stroke remains a leading cause of death and long-term disability and stroke patients have only limited treatment options.Recent preclinical evidenc...
Unmixing the Psychedelic Connectome: Brain Network Traits of Psilocybin
OpenAlex – November 17, 2025
Summary
Psilocybin's profound effect on the brain isn't a single, uniform change, but a complex interplay of neural processes. Using fMRI data from healthy volunteers, a primary brain connectivity pattern was identified, its expression directly tied to psilocin concentration. Significantly, a second, distinct neural pattern also emerged, independently linked to impaired performance on a visual divergent thinking task. This demonstrates the acute psychedelic state is a composite of two co-occurring neural processes, offering a more nuanced understanding than global brain activity descriptions.
Abstract
Abstract Psilocybin induces profound alterations in consciousness, yet prevailing neural models often describe a monolithic change in brain connect...
Effects of esketamine combined with dexmedetomidine on oxidative stress and lung function during one-lung ventilation in patients with mild to moderate COPD undergoing thoracoscopic surgery.
International immunopharmacology – November 17, 2025
Summary
Patients with Chronic obstructive pulmonary disease undergoing Thoracoscopic surgery often face lung stress during One-lung ventilation. Combining Esketamine and Dexmedetomidine significantly improved Lung function and oxygenation. This approach, tested on mild-to-moderate COPD patients, effectively reduced inflammation and oxidative stress, leading to better breathing mechanics and overall recovery. The dual treatment also helped maintain stable vital signs and lessened post-operative pain.
Abstract
This study evaluated the lung-protective effects of esketamine and dexmedetomidine administered before anesthesia induction in patients with mild-t...
Neurophysiological biomarkers of treatment response in suicidal ideation: a systematic review.
Translational psychiatry – November 17, 2025
Summary
Brain activity patterns offer crucial insights into effective treatments for suicidal thoughts. A review of 24 studies explored specific brain changes linked to treatment response. Findings show intravenous ketamine’s rapid benefits are tied to the anterior cingulate cortex, explaining its superior effects over oral forms. Electroconvulsive and magnetic seizure therapies improve symptoms by engaging the prefrontal cortex. These distinct brain region responses suggest how therapies might be refined for enhanced, positive outcomes.
Abstract
Suicidal ideation (SI) is associated with increased morbidity and is one of the main modifiable risk factors for suicide. While initial evidence in...