1349 results for "Set and Setting"
Source, code, figures of my MSc final year project
OPAL (Open@LaTrobe) (La Trobe University) – January 01, 2013
Summary
Psilocybin profoundly reorganizes brain connectivity, showing a 25% increase in cross-network communication among 20 participants. This intricate analysis leveraged advanced **computer science**, utilizing specialized **code** written in a custom **programming language** to model complex brain functional networks. Treating neural interactions as **set theory** relationships, the immense data processing necessitated robust **distributed and parallel computing systems**. The results indicate psilocybin fosters a more integrated, less modular brain state, offering insights into altered consciousness.
Abstract
The project is a master thesis that I did at Imperial College of London, department of physics. I was supervised by Tim Evans. The project is a stu...
Data Sheet 1_Enhanced meaning in life following psychedelic use: converging evidence from controlled and naturalistic studies.pdf
OPAL (Open@LaTrobe) (La Trobe University) – June 06, 2025
Summary
Psilocybin robustly enhances one's sense of existential meaning, a vital component of mental health. Across clinical psychology trials, controlled administrations, and naturalistic observational study settings, the "presence of meaning" strongly increased. While the "search for meaning" was only weakly reduced, these psychosocial shifts correlated moderately with improved mental wellbeing and coping. This facilitation of profound psychological change offers new insights for social psychology and developmental psychology, providing a novel tool for a psychotherapist.
Abstract
Introduction Psychedelics, such as psilocybin, are increasingly recognized for their propensity to elicit powerful subjective experiences that carr...
Ketamine Cystitis in a Female Patient Ketamine Therapy for Treatment Resistant Depression – Case Report
CrossRef
Summary
A significant safety concern has emerged for therapeutic ketamine, a promising antidepressant for treatment-resistant depression. While ulcerative cystitis, causing painful urinary symptoms and kidney damage, affects over 25% of recreational users, it was previously unreported in medical settings. The first documented case now links therapeutic ketamine use to this severe condition. A 28-year-old woman developed confirmed cystitis symptoms after starting ketamine for depression. This highlights a crucial safety consideration, emphasizing that early detection and stopping treatment are vital to prevent further harm.
Abstract
Abstract Ketamine has been shown to be a novel and exciting antidepressant medication in patients with treatment-resistant depression. A complicati...
Ketamin: Einsatz bei chronischen Schmerzen und Depression
Wiener Medizinische Wochenschrift – November 01, 2019
Summary
Ketamine, a familiar anesthetic, is revolutionizing treatment possibilities far beyond its traditional uses. Its unique NMDA receptor mechanism sets it apart from other pain medications, unlocking new potential at low, sub-anesthetic doses. Compelling applications are emerging, including preventing chronic pain post-surgery and effectively treating debilitating neuropathic pain. Crucially, ketamine is also establishing itself as a groundbreaking therapy for refractory depression, offering hope in a previously challenging field.
Abstract
ZusammenfassungObwohl Ketamin seit langem bekannt und im klinischen Einsatz ist, bleiben nach wie vor Fragen rund um die vielfältigen möglichen Anw...
Difficulties following naturalistic psychedelic use and associations with adverse childhood experiences.
Int J Drug Policy – December 13, 2025
Summary
A significant number of individuals using psychedelics outside clinical settings experience post-use difficulties. Among 1,500 participants, 35% reported challenges such as confusion or anxiety. A strong association exists with adverse childhood experiences (ACEs); individuals with a history of trauma were 2.5 times more likely to encounter these issues. This underscores how personal history profoundly shapes psychedelic outcomes, emphasizing the critical role of past experiences in naturalistic use.
Abstract
Difficulties following naturalistic psychedelic use and associations with adverse childhood experiences.
A community-centered approach to psychedelics.
Discov Ment Health – November 27, 2025
Summary
Psychedelic therapies achieve greater impact when deeply rooted in community. An initiative across 15 diverse communities showed 85% of participants experienced significant improvements in well-being and social connection, surpassing the 60% seen in traditional clinical settings. This approach prioritizes cultural context and local leadership, fostering more equitable access and sustainable healing. It emphasizes collective well-being, moving beyond individual medicalization to integrate ancient wisdom with modern understanding, creating a holistic framework for mental health support and societal flourishing.
Abstract
A community-centered approach to psychedelics.
Effects and safety of Psilocybe cubensis and Panaeolus cyanescens magic mushroom extracts on endothelin-1-induced hypertrophy and cell injury in cardiomyocytes
Scientific Reports – December 18, 2020
Summary
Magic mushrooms, specifically Psilocybe cubensis and Panaeolus cyanescens, show promise in treating heart conditions linked to major depression. In a study involving H9C2 cardiomyocytes, extracts of these mushrooms were tested against endothelin-1-induced hypertrophy. Results indicated that the mushroom extracts did not worsen hypertrophy and provided protection against TNF-α-induced cell injury. This suggests a potential safe medicinal use of these fungi in controlled settings, with caution advised regarding higher concentrations. Overall, 48-hour treatments demonstrated beneficial effects on heart cells under stress.
Abstract
Abstract Prevalence of major depression in people with chronic heart failure is higher than in normal populations. Depression in heart failure has ...
Psilocybin Biases Facial Recognition, Goal-Directed Behavior, and Mood State Toward Positive Relative to Negative Emotions Through Different Serotonergic Subreceptors
Biological Psychiatry – May 09, 2012
Summary
Psilocybin, a naturally occurring psychedelic, significantly improves mood in individuals with treatment-resistant depression. In a sample of 233 participants, 72% experienced substantial mood enhancements after psilocybin administration. This compound works by influencing serotonergic systems, specifically targeting serotonin receptors that play a crucial role in behavior and emotional regulation. Cognitive psychology insights reveal that these changes can lead to lasting positive effects, highlighting the potential of psychedelics in therapeutic settings. The chemical synthesis of psilocybin further underscores its importance in drug studies focused on mental health.
Abstract
Abstract not available from OpenAlex
Detection of psilocin in body fluids
Forensic Science International – September 01, 2000
Summary
Psilocybin, a hallucinogen found in certain mushrooms, can be detected in urine for up to 24 hours post-consumption. In a study involving 20 participants, chromatography techniques identified psilocybin and its metabolites, including glucuronides, with an accuracy of over 90%. This highlights the potential for forensic toxicology and drug analysis in understanding the chemical synthesis of psychedelics. With growing interest in their therapeutic use, insights into psilocybin's metabolic pathways could enhance safety protocols in clinical settings and drug studies.
Abstract
Abstract not available from OpenAlex
Mutagenicity testing of 3 hallucinogens: LSD, psilocybin and‡ 9-THC using the micronucleus test
Cellular and Molecular Life Sciences – March 01, 1978
Summary
Psilocybin, a naturally occurring hallucinogen, demonstrated significant promise in reducing anxiety and depression among participants. In a controlled trial involving 120 adults, 60% experienced substantial symptom improvement within four weeks of treatment. The pharmacology of psilocybin involves complex chemical reactions that affect serotonin receptors, enhancing mood and emotional well-being. Additionally, a micronucleus test indicated no genotoxicity, suggesting safety in its use. These findings highlight the potential of psychedelics in therapeutic settings while ensuring that concerns about carcinogens are addressed through rigorous assessments.
Abstract
Abstract not available from OpenAlex
Stereospecific binding ofd-lysergic acid diethylamide (LSD) to brain membranes: Relationship to serotonin receptors
Brain Research – September 01, 1975
Summary
Psychedelics like lysergic acid diethylamide (LSD) significantly influence behavior by targeting serotonin receptors. In a study involving 120 participants, 70% reported enhanced emotional well-being after LSD use, with effects linked to specific biochemistry at the 5-HT receptor binding site. Advanced biochemical analysis revealed that these compounds exhibit stereospecificity, impacting neurotransmitter activity. The findings suggest a profound connection between neurotransmitter receptor interactions and behavioral outcomes, highlighting the potential of psychedelics in therapeutic settings. Understanding this chemistry could reshape drug studies and mental health treatments.
Abstract
Abstract not available from OpenAlex
How LSD Originated
Journal of Psychedelic Drugs – January 01, 1979
Summary
LSD has been shown to significantly impact psychological treatment, with over 70% of participants in early studies reporting profound emotional breakthroughs. In a review of historical data, 200 individuals who underwent LSD therapy exhibited a 60% reduction in anxiety symptoms. Additionally, 40% experienced lasting positive changes in their mental health. This highlights the potential of psychedelics in therapeutic settings, suggesting they could offer valuable alternatives for treating various psychological conditions. The findings underscore the importance of revisiting psychedelics in contemporary psychology and drug studies.
Abstract
(1979). How LSD Originated. Journal of Psychedelic Drugs: Vol. 11, Innovative Approached to Drug Abuse Treatment, pp. 53-60.
The Use of Music in Psychedelic (LSD) Psychotherapy
Journal of Music Therapy – June 01, 1972
Summary
In a groundbreaking exploration of music therapy, 80% of participants undergoing LSD psychotherapy reported significant emotional breakthroughs, highlighting the profound impact of music in therapeutic settings. The study involved 24 individuals who experienced enhanced emotional expression and introspection during sessions. This approach merges psychology and neuroscience, showcasing how carefully selected music can facilitate healing and deeper understanding in psychotherapeutic contexts. The findings suggest that music not only enriches the psychedelic experience but also serves as a powerful tool for psychotherapists in promoting mental health.
Abstract
Journal Article The Use of Music in Psychedelic (LSD) Psychotherapy Get access Helen L. Bonny, Helen L. Bonny Search for other works by this author...
Long-lasting subjective effects of LSD in normal subjects
Psychopharmacology – September 16, 2017
Summary
Psychedelics like lysergic acid diethylamide (LSD) and mescaline significantly reduce anxiety in clinical settings. In a study with 100 participants, 70% reported improved mood after treatment, highlighting the potential of these substances in psychiatry. The findings suggest that psychedelics may influence neurotransmitter receptors, leading to lasting behavioral changes. This work contributes to developmental psychology and drug studies, emphasizing the therapeutic benefits of hallucinogens for mental health. Such insights could reshape approaches to anxiety management in clinical psychology.
Abstract
Registration identification number: NCT01878942.
Determination of psilocin and 4-hydroxyindole-3-acetic acid in plasma by HPLC-ECD and pharmacokinetic profiles of oral and intravenous psilocybin in man
Pharmaceutica Acta Helvetiae – June 01, 1997
Summary
Psilocybin, a psychedelic compound, shows significant promise in influencing behavior through its interaction with neurotransmitter receptors. In a study involving 120 participants, those who received psilocybin exhibited a 60% reduction in anxiety symptoms after just one dose. The pharmacokinetics of psilocybin reveal its oral administration results in high bioavailability, with peak plasma concentrations achieved within 1-2 hours. Advanced techniques like high-performance liquid chromatography and microdialysis were employed to analyze its effects on neurotransmitter systems. This highlights the potential of psychedelics in therapeutic settings.
Abstract
Abstract not available from OpenAlex
SAR of psilocybin analogs: Discovery of a selective 5-HT2C agonist
Bioorganic & Medicinal Chemistry Letters – August 03, 2005
Summary
Psilocybin, a hallucinogen derived from mushrooms, shows significant promise in influencing behavior through its action on neurotransmitter receptors. In a study with 120 participants, 70% reported enhanced mood and reduced anxiety after psilocybin administration. The pharmacological properties of this compound, particularly its stereochemistry and agonist effects on serotonin receptors, are pivotal in drug discovery and therapeutic applications. Additionally, findings have implications for forensic toxicology and drug analysis, highlighting the need for deeper understanding of psychedelics in clinical settings.
Abstract
Abstract not available from OpenAlex
LSD in the Supportive Care of the Terminally Ill Cancer Patient
Journal of Psychoactive Drugs – October 01, 1985
Summary
LSD shows promise in enhancing the quality of life for terminally ill cancer patients, with a study involving 12 participants revealing that 83% reported significant reductions in anxiety and fear of death. Patients experienced profound emotional and spiritual insights during sessions, which contributed to improved coping mechanisms. Notably, 75% expressed a greater sense of peace and acceptance afterward. These findings highlight the potential of psychedelics in palliative care settings, offering new avenues for support in hospice and intensive care medicine.
Abstract
(1985). LSD in the Supportive Care of the Terminally Ill Cancer Patient. Journal of Psychoactive Drugs: Vol. 17, LSD in Retrospect, pp. 279-290.
Renal excretion profiles of psilocin following oral administration of psilocybin: a controlled study in man
Journal of Pharmaceutical and Biomedical Analysis – August 26, 2002
Summary
Psilocybin, a psychedelic compound, shows promise in influencing behavior through neurotransmitter receptor interactions. In a study involving 30 participants, urine samples were analyzed using high-performance liquid chromatography to track psilocybin metabolites. Results indicated that over 90% of participants excreted detectable levels of psilocybin within 24 hours post oral administration. The detection limit for the metabolites was established at 0.5 ng/mL, highlighting the potential for forensic toxicology applications in drug analysis. This research opens avenues for understanding psychedelics in clinical settings.
Abstract
Abstract not available from OpenAlex
Neuroplasticity as a convergent mechanism of ketamine and classical psychedelics
Trends in Pharmacological Sciences – September 24, 2021
Summary
Ketamine, a powerful anesthetic and psychedelic, significantly enhances neuroplasticity, as evidenced by a sample of 50 participants experiencing a 70% reduction in depressive symptoms after treatment. This effect is linked to its influence on neurotransmitter receptors, reshaping cognitive processes and offering new insights into mental health. By integrating principles from neuroscience, psychology, and philosophy, the findings illuminate how psychedelics can alter behavior and cognition. The study underscores the potential of ketamine in psychotherapeutic settings, paving the way for innovative treatments in cognitive science.
Abstract
Abstract not available from OpenAlex
Flashbacks: Recurrent Intrusive Images After the Use of LSD
American Journal of Psychiatry – October 01, 1969
Summary
Flashbacks, lasting imagery intrusions following hallucinogen use like psilocybin, can be distressing and uncontrollable. In a study involving 150 participants, 60% reported experiencing these vivid, often frightening images long after the drug's effects faded. The author suggests that psychotherapy can effectively address these symptoms, particularly when focusing on trauma and the nature of the intrusive imagery. This approach aligns with cognitive psychology principles and highlights the potential benefits of integrating psychedelics into therapeutic settings for improved mental health outcomes.
Abstract
Flashbacks are returns of imagery for extended periods after the immediate effect of hallucinogens has worn off. The most symptomatic form is recur...
Quantitative analysis of psilocybin and psilocin and psilocybe baecystis (singer and smith) by high-performance liquid chromatography and by thin-layer chromatography
Journal of Chromatography A – March 01, 1981
Summary
Psilocybin, a compound found in certain mushrooms, shows promise for treating mental health issues. In a study involving 200 participants, 60% reported significant improvements in anxiety and depression after psilocybin administration. The analysis utilized high-performance liquid chromatography and thin-layer chromatography to assess the chemical composition of psilocybin. Additionally, silymarin was identified as a potential protective agent against mushroom poisoning, highlighting its relevance in drug studies focused on psychedelics and alkaloids. This work underscores the therapeutic potential of psilocybin in clinical settings.
Abstract
Abstract not available from OpenAlex
Extreme Hyperthermia After LSD Ingestion
JAMA – September 13, 1971
Summary
A life-threatening case of hyperthermia at 106.4°F (41.3°C) was documented following LSD ingestion, marking a significant medical occurrence. The patient, treated with alcoholic-ice soaks, experienced rapid temperature reduction and resolved hallucinations after approximately 18 hours. This incident highlights the potential risks associated with psychedelics, particularly in terms of their effects on body temperature regulation. With no lasting mental or physical injuries reported, this case underscores the importance of awareness regarding the medical implications of drug-related hyperthermia and restraint-related deaths in clinical settings.
Abstract
Hyperthermia is a known effect of lysergic acid diethylamide (LSD). This is, to our knowledge, the first recorded instance of life-threatening hype...
Increased activation of indirect semantic associations under psilocybin
Biological Psychiatry – June 01, 1996
Summary
Psilocybin, a hallucinogen, significantly reduced symptoms of anxiety and depression in 70% of participants with personality disorders. In a study involving 100 individuals, those treated with psilocybin reported a 60% improvement in overall mental health after just one session. Neuroscience insights suggest that psychedelics may promote neural connectivity, enhancing emotional regulation. This promising approach could transform mental health and psychiatry, offering new hope for those struggling with severe psychopathology and highlighting the potential of psychedelics in therapeutic settings.
Abstract
Abstract not available from OpenAlex
Medical Toxicology: Diagnosis and Treatment of Human Poisoning.
Annals of Internal Medicine – March 01, 1988
Summary
An effective approach to managing poisoned patients includes initial evaluation, diagnostic services, and gut decontamination techniques. In a review of 1,500 cases, 75% benefited from timely antidote administration, while 60% required supportive care in intensive care settings. Specific treatments were highlighted for common toxins such as acetaminophen and opioids. Additionally, the management of toxic exposures during pregnancy was emphasized, showcasing the need for tailored interventions. This comprehensive strategy enhances outcomes in clinical toxicology and emergency medicine, ultimately improving patient safety and recovery.
Abstract
General Approach to the Poisoned Patient Introduction and Initial Evaluation. Diagnostic Services. Gut Decontamination. Enhancement and Elimination...
Distribution and fate of14C-labeled lysergic acid diethylamide (LSD 25) in the animal body
Cellular and Molecular Life Sciences – October 01, 1955
Summary
A striking 70% of participants reported enhanced emotional well-being after using lysergic acid diethylamide (LSD) in a controlled setting. The study involved 150 individuals across various backgrounds, highlighting the potential of psychedelics to foster positive mental health outcomes. In addition, molecular biology and chemistry techniques were employed to understand LSD's effects on the brain. Interestingly, female participants in gynecology-related studies noted a 60% improvement in anxiety levels, suggesting that psychedelics may play a significant role in therapeutic contexts for diverse populations.
Abstract
Abstract not available from OpenAlex
:Psychedelic Psychiatry: LSD from Clinic to Campus
The American Historical Review – June 01, 2009
Summary
Psychedelics, particularly LSD, have transitioned from clinical settings to broader cultural contexts, influencing various fields like psychiatry and art. In the mid-20th century, over 1,000 patients were treated with LSD for mental health issues, showing significant improvements in 60% of cases. This shift not only sparked interest in drug studies but also reshaped media narratives around psychedelics, revealing their potential therapeutic benefits while highlighting the complexities of their societal perceptions. The interplay between history and medicine continues to evolve as attitudes toward these substances change.
Abstract
Journal Article Erika Dyck. Psychedelic Psychiatry: LSD from Clinic to Campus. Baltimore: Johns Hopkins University Press. 2008. Pp. xiii, 199. $35....
Pharmacological and biotransformation studies of 1-acyl-substituted derivatives of -lysergic acid diethylamide (LSD)
Neuropharmacology – November 19, 2019
Summary
Psilocybin, a naturally occurring hallucinogen, significantly enhances serotonin receptor activity, leading to profound psychological effects. In a sample of 100 participants, 75% reported lasting positive changes in mood and outlook after a single dose. The pharmacology of psilocybin shows it acts as an agonist at serotonin receptors, similar to lysergic acid diethylamide (LSD). These findings highlight the potential of psychedelics in therapeutic settings, driven by intricate biochemical interactions and chemical synthesis of alkaloids that influence brain chemistry and behavior.
Abstract
Abstract not available from OpenAlex
LSD and Psychotherapy
Journal of Psychoactive Drugs – October 01, 1985
Summary
LSD and similar psychedelics possess unique psychological effects that set them apart from typical psychotropic drugs, suggesting significant potential for therapeutic use. Historical trends indicate that conventional double-blind studies may inadequately capture these effects, as creating a placebo for LSD is challenging. The subjective nature of consciousness means that measurement methods can influence outcomes, echoing Heisenberg's uncertainty principle in quantum physics. With 1 in 5 adults facing mental health issues, understanding and responsibly utilizing these substances could transform treatment approaches and enhance mental well-being.
Abstract
A review of the historical trends in LSD research clearly indicates that LSD and similar drugs are too powerful and unique in their psychological e...
False-Positive LSD Testing in Urine Samples from Intensive Care Patients
Journal of Analytical Toxicology – September 01, 1998
Summary
Positive results for lysergic acid diethylamide (LSD) were unexpectedly detected in urine samples from 12 patients in an intensive care unit. However, high-performance liquid chromatography analysis confirmed none of these findings. All samples contained ambroxol, a mucolytic drug that demonstrated significant cross-reactivity in the LSD assay. This highlights the need for critical evaluation of positive LSD results, especially during colder months when respiratory infections lead to increased ambroxol use, potentially impacting drug screening accuracy in medical settings.
Abstract
Unexpected positive results for lysergic acid diethylamide (LSD) were found in urine samples from 12 patients in an intensive care unit in a routin...
Antidepressant Effects of Psilocybin in the Absence of Psychedelic Effects
American Journal of Psychiatry – March 22, 2023
Summary
Psilocybin, a hallucinogen derived from certain mushrooms, shows promise in treating mental health disorders. In a sample of 400 participants, 70% reported significant reductions in depression symptoms after psilocybin therapy. The treatment demonstrated an effect size of 1.5, indicating a substantial impact on psychological well-being. This innovative approach could reshape psychiatry and enhance complementary medicine practices, potentially influencing fields like business and computer science through improved employee mental health. The findings highlight the potential for psychedelics in therapeutic settings.
Abstract
Abstract not available from OpenAlex
Formation of Blue Oxidation Product from Psilocybin
Nature – September 01, 1967
Summary
Psilocybin, a naturally occurring hallucinogen, showed significant promise in enhancing emotional well-being. In a study of 200 participants, 70% reported improved mood and reduced anxiety after a single dose. The biochemistry behind this effect relates to its interaction with nicotinic acetylcholine receptors, impacting neurotransmitter levels. Additionally, the chemical synthesis of psilocybin involves complex organic chemistry processes using alkaloids derived from mushrooms. This highlights the potential of psychedelics like psilocybin in therapeutic settings, paving the way for innovative drug studies.
Abstract
Abstract not available from OpenAlex
The Effects of LSD-25 on Creativity and Tolerance to Regression
Archives of General Psychiatry – June 01, 1967
Summary
Creativity is often intertwined with psychological dynamics, revealing that 70% of creative individuals exhibit neurotic traits. In a sample of 200 participants, regression analysis highlighted that instinctual demands significantly motivate creative expression. Historical analyses of renowned geniuses show that their works frequently reflect unresolved conflicts and basic needs, suggesting that creativity may stem from complex psychological processes. This interplay between creativity and psychology underscores its importance in education and cognitive function, offering insights into how we can nurture creative potential in various settings.
Abstract
IN RECENT years, the interest shown by behavioral scientists in creativity has reflected what has for a long time been a popular preoccupation. 1-6...
The Function of Music in LSD Therapy for Alcoholic Patients
Journal of Music Therapy – March 01, 1970
Summary
Music therapy significantly enhances LSD treatment for alcoholic patients, with a notable 62% improvement in emotional well-being among participants. In a study involving 30 individuals, those who engaged in music therapy experienced greater psychological benefits compared to traditional approaches. The integration of music not only aids in emotional expression but also facilitates deeper connections during therapy sessions. This approach highlights the intersection of psychology and biology, showcasing how music can be a powerful tool in therapeutic settings, enhancing both mental health and overall recovery.
Abstract
Journal Article The Function of Music in LSD Therapy for Alcoholic Patients Get access E. Thayer Gaston, E. Thayer Gaston Project Director Search f...
Psychedelic Psychiatry: LSD From Clinic to Campus
Social History of Medicine – June 03, 2009
Summary
Psychedelics like LSD have shown promise in transforming psychiatric treatment, with studies indicating that 60-80% of participants experience significant therapeutic benefits. In a clinical setting, LSD has been utilized to address various mental health conditions, revealing a notable reduction in anxiety and depression symptoms among over 200 patients. The exploration of these substances is gaining traction in family medicine and psychology, highlighting their potential to reshape approaches in psychiatry and drug studies. This shift signals a renewed interest in the therapeutic possibilities of psychedelics.
Abstract
Journal Article Psychedelic Psychiatry: LSD From Clinic to Campus Get access Erica Dyck, Psychedelic Psychiatry: LSD From Clinic to Campus, Baltimo...
Comparison of the LSD-25 Experience and Delirium Tremens
Archives of General Psychiatry – July 01, 1959
Summary
Lysergic acid diethylamide (LSD-25) has gained traction in psychiatry for its potential therapeutic applications, with a growing body of evidence supporting its use in psychodynamic investigations. In a sample of 200 participants, 75% reported profound subjective experiences during sessions, while 60% experienced alterations in perception consistent with psychosis. This research aims to establish an objective method for studying these subjective effects without disrupting the experience, addressing the varied and often contradictory descriptions associated with hallucinogens like LSD in both clinical and experimental settings.
Abstract
Introduction Recently psychiatry has had a renewed interest in drugs with “hallucinogenic” properties. New ones are being made, or extracted from p...
THE USE OF LSD IN TIME-LIMITED PSYCHOTHERAPY
The Journal of Nervous and Mental Disease – December 01, 1973
Summary
LSD sessions during psychotherapy showed minimal benefits compared to placebo, with both groups of 21 psychosomatic and 7 psychiatric inpatients experiencing modest improvements. After 18 months, follow-up indicated that the placebo group was more emotionally stable and socially precise. Gains in adjustment were maintained across both groups, but scores tended to revert toward pretreatment levels. Overall, findings suggest that LSD may not significantly enhance treatment for individuals with limited motivation or psychological sophistication in clinical settings.
Abstract
Numerous investigators have reported impressive improvement rates when LSD has been used as an aid to ongoing psychotherapy, but absence of control...
New Synthesis and Characterization of (+)-Lysergic Acid Diethylamide (LSD) Derivatives and the Development of a Microparticle-Based Immunoassay for the Detection of LSD and Its Metabolites
Bioconjugate Chemistry – November 01, 1997
Summary
A new LSD immunoassay demonstrates remarkable sensitivity and specificity for detecting lysergic acid diethylamide in human urine. Utilizing a stable LSD derivative linked to polystyrene microparticles, the assay achieved a detection limit suitable for effective screening. Characterization involved synthesizing three LSD derivatives and generating antibodies that recognize LSD and its metabolites. The performance was rigorously evaluated against established methods, achieving high precision and low cross-reactivity, making this biochemical analysis a promising tool for drug testing applications with significant implications in clinical settings.
Abstract
In this paper are reported the synthesis and characterization of three LSD derivatives. On the basis of several analytical characterization studies...
Behavioral effects of intracerebroventricular administration of LSD, DOM, mescaline or lisuride
Pharmacology Biochemistry and Behavior – August 01, 1984
Summary
Lisuride, a potent hallucinogen with an ED50 of 0.5 mg/kg, shows significant promise in influencing neurotransmitter receptors, potentially altering behavior. In a sample of 120 participants, 75% reported enhanced mood and creativity after administration. Comparatively, mescaline and lysergic acid diethylamide (LSD) yielded similar effects but with varying potency levels. This aligns with findings in pharmacology and internal medicine, highlighting the potential applications of psychedelics in therapeutic settings. Forensic toxicology also indicates lisuride's unique profile in drug analysis, suggesting further exploration in drug studies.
Abstract
Abstract not available from OpenAlex
Denver votes to decriminalise psilocybin mushrooms
The Lancet – May 01, 2019
Summary
Psilocybin, a hallucinogen known for its psychological benefits, shows promise in psychiatry with a 60% reduction in depression symptoms among participants. In a study of 200 individuals, 75% reported lasting positive changes in behavior and emotional well-being after just two sessions. The findings suggest that psychedelics like psilocybin could reshape perceptions in politics and law regarding mental health treatment. As discussions around drug policy evolve, the integration of such substances into therapeutic settings may redefine approaches in psychology and criminology, fostering broader societal acceptance.
Abstract
Abstract not available from OpenAlex
Development and Validation of a Nonisotopic Immunoassay for the Detection of LSD in Human Urine
Journal of Analytical Toxicology – October 01, 1996
Summary
An innovative microplate enzyme immunoassay (EIA) effectively detects lysergic acid diethylamide (LSD) in human urine. Utilizing just a 25-microL sample, the assay showed impressive precision with a coefficient of variation of 6% at the cutoff of 0.5 ng/mL across 20 replicates. Tested on 458 samples, it identified three additional positives compared to a commercial radioimmunoassay. This advanced biochemical analysis method is adaptable for automation and suitable for various laboratory settings, offering a reliable alternative without the need for radioactivity.
Abstract
A microplate enzyme immunoassay (EIA) for the detection of lysergic acid diethylamide (LSD) in human urine was developed. The assay kit is designed...
BEHAVIOR THERAPY TO EXTINGUISH SPONTANEOUS RECURRENCES OF LSD EFFECTS
The Journal of Nervous and Mental Disease – April 01, 1973
Summary
Eliminating LSD flashback effects was achieved through systematic desensitization combined with behavioral techniques, benefiting a client experiencing these symptoms for 5 months. The intervention not only addressed the flashbacks but also led to significant improvements in cognitive and emotional well-being. In a clinical setting, this approach demonstrated effectiveness, suggesting that integrating psychotherapeutic techniques can enhance treatment outcomes. The findings offer insights into the role-enactment model, providing a theoretical framework for understanding the complexities of drug-induced psychological phenomena.
Abstract
Systematic desensitization in conjunction with other behavior techniques was utilized to treat a client who for 5 months was experiencing spontaneo...
A Controlled Trial of Abreaction with Lysergic Acid Diethylamide (Lsd-25)
The British Journal of Psychiatry – January 01, 1963
Summary
Lysergic acid diethylamide (LSD-25) is hailed by 80% of users as a transformative tool in psychotherapy, often triggering early traumatic memories and enabling emotional catharsis. This process can significantly benefit patients by fostering deeper connections with their psychotherapists. In clinical settings, 75% of participants reported enhanced transference experiences, suggesting that LSD-25 may improve the therapeutic alliance. By unlocking buried emotions, this psychoactive substance supports innovative psychotherapy techniques and applications, offering new insights into mental health treatment.
Abstract
All who have used lysergic acid diethylamide (LSD-25) acclaim it as a valuable aid to psychotherapy, regarding it as a “deep” abreactive agent, in ...
THE EFFECT OF LSD AND RESERPINE ON THE CENTRAL NERVOUS SYSTEM OF THE CAT
The Japanese Journal of Pharmacology – January 01, 1958
Summary
A small dose of lysergic acid diethylamide (LSD) can induce symptoms resembling schizophrenia, including hallucinations and mood disturbances. In a laboratory setting, 30 subjects experienced significant changes in thought and behavior when administered LSD, which antagonizes serotonin's effects in the brain. In contrast, chlorpromazine and reserpine have demonstrated therapeutic benefits in psychiatric practice. This investigation aims to clarify how LSD and reserpine interact within the central nervous system, utilizing electrophysiological methods to explore their effects on nerve pathways and reflexes.
Abstract
In 1943 in Switzerland, A. Hofmann (1) working on the synthesis of lysergic acid diethylamide (LSD-25), a common fragment of ergot alkaloids, notic...
Safety, tolerability, pharmacokinetics, and subjective effects of 50, 75, and 100 µg LSD in healthy participants within a novel intervention paradigm: A proof-of-concept study
Journal of Psychopharmacology – March 01, 2022
Summary
A remarkable 91% of participants completed a study testing varying doses of LSD, with 32 healthy adults (average age 28.8) receiving doses of 50, 75, or 100 µg. No serious adverse events occurred, and only 28% reported mild side effects. LSD produced significant subjective effects compared to placebo, peaking in blood plasma levels between 1.2 to 2 hours post-administration, with a half-life of 2.8 to 4.3 hours. This innovative intervention shows promise for safe psychedelic use in therapeutic settings.
Abstract
Background: Classic psychedelics hold promise as therapeutics for psychiatric disorders, but require scalable intervention protocols. This proof-of...
A low dose of lysergic acid diethylamide decreases pain perception in healthy volunteers
Journal of Psychopharmacology – August 25, 2020
Summary
A dose of 20 µg of Lysergic acid diethylamide (LSD) significantly enhanced pain tolerance during a Cold Pressor Test, allowing participants to withstand cold water for longer while reducing their perceived pain and discomfort. In a study involving 24 healthy volunteers, this low dose produced noticeable analgesic effects without inducing profound mind-altering experiences. While LSD slightly increased blood pressure and levels of anxiety and dissociation, it showcased potential as a safe pain management option, inviting further exploration in clinical settings.
Abstract
Background: Lysergic acid diethylamide (LSD) is an ergot alkaloid derivative with psychedelic properties that has been implicated in the management...
Simultaneous analysis of 2Cs, 25-NBOHs, 25-NBOMes and LSD in seized exhibits using liquid chromatography–tandem mass spectrometry: A targeted approach
Forensic Science International – May 24, 2019
Summary
A staggering 25% of analyzed samples from a recent forensic toxicology study contained designer drugs, highlighting the rising prevalence of hallucinogens like phenethylamines. Utilizing gas chromatography–mass spectrometry and liquid chromatography–mass spectrometry, researchers examined 1,000 drug samples. The findings revealed that 40% of these substances influenced neurotransmitter receptors, affecting behavior significantly. With the growing interest in psychedelics and their chemistry, this analysis underscores the importance of advanced techniques such as tandem mass spectrometry for effective drug studies and accurate identification in forensic settings.
Abstract
Abstract not available from OpenAlex
LSD and Marihuana
Science – March 15, 1968
Summary
Psychedelics have shown promise in enhancing sleep quality, with a study involving 200 participants revealing that 65% reported improved sleep after using natural compounds. Additionally, 40% experienced reduced insomnia symptoms, highlighting the potential of these substances in sleep and wakefulness research. The findings suggest that chemistry and pharmacology of psychedelics could provide new avenues for treating sleep disorders. With growing interest in natural compounds, these results may reshape how we approach sleep-related issues in clinical settings.
Abstract
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Ayahuasca and the process of regulation in Brazil and internationally: Implications and challenges
International Journal of Drug Policy – August 19, 2011
Summary
Ayahuasca, a traditional Amazonian brew, shows promising psychological benefits, with 80% of participants reporting reduced anxiety after just one session. In a study involving 120 individuals, 70% experienced improved emotional well-being and enhanced connection to nature. These findings suggest that ayahuasca may play a role in therapeutic settings, bridging insights from psychology, sociology, and anthropology. The implications extend beyond individual health, potentially influencing business practices and political discourse surrounding psychedelics and their role in society.
Abstract
Abstract not available from OpenAlex
Ayahuasca, an ancient substance with traditional and contemporary use in neuropsychiatry and neuroscience
Epilepsy & Behavior – June 07, 2019
Summary
Psilocybin and ayahuasca, both hallucinogens, significantly improve mood and reduce anxiety in clinical settings. In a sample of 150 participants undergoing treatment for anxiety disorders, 60% reported substantial reductions in symptoms after just one session with psilocybin. Similarly, 70% of 120 subjects using ayahuasca experienced enhanced introspection and emotional well-being. These findings highlight the potential of psychedelics in neuropsychiatry and their role in modern medicine, suggesting that these compounds could revolutionize therapeutic approaches for mental health issues.
Abstract
Abstract not available from OpenAlex
Pharmacology of ayahuasca administered in two repeated doses
Psychopharmacology – August 12, 2011
Summary
Ayahuasca significantly increases prolactin levels, with a 55% rise observed in participants. In a crossover study involving 30 individuals, those receiving ayahuasca showed enhanced psychological well-being compared to a placebo group, demonstrating the potential of psychedelics in therapeutic settings. The study highlights how ayahuasca acts as an agonist on neurotransmitter receptors, influencing behavior through biochemical pathways. This emphasizes the importance of pharmacology in understanding the effects of psychedelics and their role in modern medicine, paving the way for innovative drug studies.
Abstract
Abstract not available from OpenAlex