3085 results for "Psilocybin"
Prolonged hallucinogenic effects following Psilocybe cubensis ingestion: Case report
The poison. – June 30, 2025
Summary
Weeks after Psilocybin ingestion, a powerful hallucinogen, one documented case experienced prolonged perceptual disturbances and flashbacks, necessitating psychopharmacological intervention. This highlights potential neuropsychiatric symptoms. Though traditional medicine has historical uses for psychedelics, modern pharmacology, especially in drug studies of alkaloid synthesis and pharmacology, must fully grasp these risks. Psychology plays a vital role in managing such effects, underscoring the need for individualized care and enhanced harm reduction strategies amidst growing recreational use.
Abstract
Psilocybe cubensis is a widely used psilocybin-containing mushroom with well-documented acute psychoactive effects. We report a case of prolonged p...
Stephen Ross: Psychedelic-assisted therapies for difficult-to-treat psychiatric and medical disorders
Psychedelics – June 10, 2025
Summary
Groundbreaking clinical trials reveal a single dose of psilocybin therapy can provide rapid, enduring relief for severe anxiety and depression, particularly in advanced cancer patients. This pioneering work also demonstrates significant efficacy in treating alcohol use disorder and major depressive disorder. These remarkable findings underscore the powerful potential of psychedelic-assisted treatments to address critical unmet health needs.
Abstract
Professor Stephen Ross is a prominent faculty member in the Departments of Psychiatry and Child and Adolescent Psychiatry at the New York Universit...
Corrigendum to “Decreases in Suicidality Following Psychedelic Therapy
The Journal of Clinical Psychiatry – May 09, 2022
Summary
Two suicidality-related events occurred within psychedelic trials, despite not being directly attributed to the compounds. One individual died by suicide 11 days after a 1 mg/70 kg psilocybin dose. Another attempted suicide two months post-treatment with 21-25.2mg/70 kg psilocybin, following other drug use and personal tragedy. These cases highlight the importance for psychotherapists in Psychology and Psychedelics and Drug Studies to closely monitor patients, recognizing how chemical synthesis of alkaloids like psilocybin can influence neurotransmitter receptors and behavior.
Abstract
To the Editor: Our group recently published in JCP the first meta-analysis of patient-level data on the effects of psychedelics on suicidality. 1 W...
The effect of casing and gypsum on the yield and psychoactive tryptamine content of Psilocybe cubensis (Earle) Singer.
Fungal biology – February 01, 2024
Summary
Growing magic mushrooms more effectively could be key to meeting rising medical demand. New research shows that adding a peat moss layer and gypsum supplement to P. cubensis cultivation dramatically improves yields. This method increased mushroom production fourfold while maintaining high levels of psilocybin and other psychedelic compounds, potentially benefiting both therapeutic applications and sustainable fungi cultivation.
Abstract
Psychedelic fungi have experienced a surge in interest in recent years. Most notably, the fungal secondary metabolite psilocybin has shown tremendo...
Neurotropic Effect of Extracts from the Hallucinogenic Mushroom Psilocybe cubensis (Earle) Sing. (Agaricomycetideae). In Vitro Studies
International journal of medicinal mushrooms – January 01, 2000
Summary
Psilocybin, a potent hallucinogen, profoundly inhibits brain activity, revealing key insights for Psychedelics and Drug Studies. Extracts from magic mushrooms, containing these chemical synthesis and alkaloids, suppressed spike activity in 73.5% to 81% of 50 rat hippocampal formation neurons. This pharmacology demonstrates how psilocybin's chemistry primarily reduces neuronal firing, with only 5.9% showing excitation. Blocking serotonin receptors reversed these effects in half of the units, underscoring the Neurotransmitter Receptor Influence on Behavior.
Abstract
The neurotropic effect of Psilocybe cubensis (Earle) Sing, dried biomass and fruiting bodies containing the indole hallucinogens psilocybin and psi...
Psychedelic-assisted therapy: An overview for the internist
Cleveland Clinic Journal of Medicine – March 01, 2025
Summary
Compelling preliminary evidence suggests psychedelic-assisted therapy, influencing neurotransmitter receptor activity, holds promise for conditions like depression and PTSD. These Psychedelics and Drug Studies, involving compounds like MDMA and psilocybin, have earned breakthrough therapy designations. However, in August 2024, MDMA's approval was declined, requiring another phase 3 trial for its reintroduction into medicine. This rigorous process highlights the careful evaluation. Clinicians, including specialists in intensive care medicine, should prepare for these therapies' potential return.
Abstract
Preliminary evidence suggests that psychedelic-assisted therapy-the enhancement of psychotherapy with psychedelics such as 3,4-methylenedioxymetham...
Moving psychedelic-assisted therapies from promising research into routine clinical practice: Lessons from the field of implementation science
Translational Behavioral Medicine – October 17, 2024
Summary
With FDA anticipating psilocybin therapy approval for depression by 2026, **Psychedelics and Drug Studies** are rapidly advancing. Integrating these **chemical synthesis and alkaloids** into **Clinical Practice** requires careful planning. **Psychotherapists** and **health psychology** experts must ensure safe, equitable access, particularly for marginalized populations, reflecting **cross-cultural psychology** principles. Systematic approaches, drawing from **data science** and **medicine**, are crucial for translating this promising therapy. This involves upholding **engineering ethics** in delivery and informing **medical education**, ensuring quality care and expanding **complementary and alternative medicine studies**.
Abstract
Abstract Psychedelics (e.g., 3,4-Methylenedioxymethamphetamine [MDMA], lysergic acid diethylamide [LSD], psilocybin) are molecules that have the po...
Assessing the Attitudes of Dutch Mental Health Care Professionals Toward Psychedelic-Assisted Psychotherapy: A Cross-Sectional Exploratory Study
Journal of Psychoactive Drugs – June 23, 2025
Summary
Dutch mental health professionals largely embrace psychedelic-assisted psychotherapy, a promising development in mental health care. A cross-sectional study of 198 clinicians revealed positive attitudes toward treatments using compounds like MDMA and psilocybin. This exploratory research in psychology found attitudes correlated with prior personal use of these natural compound pharmacology studies. Psychotherapists believe psychiatrists and clinical psychologists are ideal administrators, preferring specialized hospital settings within medicine. While supporting psychedelics and drug studies, including chemical synthesis and alkaloids, concerns persist about connecting with patients during altered states.
Abstract
Psychedelic-assisted psychotherapy (PAP) constitutes a novel treatment paradigm in mental health care practice that is currently being evaluated fo...
The Temporal Trajectory of the Psychedelic Mushroom Experience Mimics the Narrative Arc of the Hero’s Journey
Research Square (Research Square) – February 23, 2024
Summary
The psychedelic experience, particularly with psilocybin mushrooms, often mirrors the classic Hero's Journey found in literature and art. This psychological trajectory begins with an initial "comeup" phase frequently characterized by negative feelings. However, the subsequent "comedown" typically brings positive, distress-resolving states, akin to recovery. This narrative arc offers a profound temporal structure for understanding psychedelics and drug studies. Such an aesthetic journey, reminiscent of psychoanalysis, provides a unique psychological lens for mental health treatment.
Abstract
Abstract Psychedelic therapy has the potential to become a revolutionary and transdiagnostic mental health treatment, yielding enduring benefits th...
The Watts Connectedness Scale: a new scale for measuring a sense of connectedness to self, others, and world
Psychopharmacology – August 08, 2022
Summary
Psychedelic experiences significantly boost feelings of connectedness, a vital psychological construct. An observational study of 1226 participants using psychedelics revealed a substantial increase in a new Watts Connectedness Scale's scores (η² = 0.339), which demonstrated strong construct validity. This scale measures connection to self, others, and the wider world. In a clinical psychology trial, psilocybin therapy led to greater increases in these social connectedness feelings (η² = 0.133) compared to escitalopram, highlighting its potential for mental health improvements.
Abstract
Abstract Rationale A general feeling of disconnection has been associated with mental and emotional suffering. Improvements to a sense of connected...
A Qualitative Exploration of Relational Ethical Challenges and Practices in Psychedelic Healing
Journal of Humanistic Psychology – September 16, 2021
Summary
As psychedelic therapies near approval, underground psychotherapists navigate complex ethical challenges using MDMA and psilocybin. A qualitative research study interviewed 23 practitioners (10 female, 13 male), 12 formally trained, about issues like client nudity and professional competence. This work, part of diverse academic research themes in psychology and drug studies, from chemical synthesis and alkaloids to ethical practice, highlights the need for clear boundaries. The scientific rigor championed by figures like Watson remains crucial for psychotherapist training.
Abstract
As both 3,4-methylenedioxymethamphetamine (MDMA)- and psilocybin-assisted psychedelic psychotherapy near U.S. Food and Drug Administration (FDA) ap...
Adverse experiences resulting in emergency medical treatment seeking following the use of magic mushrooms
Journal of Psychopharmacology – April 07, 2022
Summary
"Magic mushrooms" containing psilocybin, a psychoactive alkaloid, rarely cause serious adverse effects necessitating a medical emergency. From 9233 past-year users globally, only 19 (0.2%) sought emergency medical treatment, a per-event risk of 0.06%. Young age was the sole predictor. Most incidents involved psychological symptoms—anxiety/panic—relevant to Psychiatry, often due to poor mindset. All but one returned to normality within 24 hours. These Psychedelics and Drug Studies confirm their safety in Medicine and Complementary and Alternative Medicine, showing severe physiological effects requiring Anesthesia are exceedingly rare.
Abstract
Background: Psilocybin-containing mushrooms are used for recreational, spiritual, self-development and therapeutic purposes. However, physiological...
Microdosing psychedelics: Subjective benefits and challenges, substance testing behavior, and the relevance of intention
Journal of Psychopharmacology – October 08, 2020
Summary
A survey of 6753 individuals reveals that reported benefits of Psilocybin and Lysergic acid diethylamide MicroDose practices overwhelmingly surpass challenges. Many users cite enhanced mood, creativity, and focus, with "None" being the most common challenge. However, most users do not test their substances, highlighting a gap in understanding chemical synthesis and alkaloids. Interestingly, an approach-intention in this Psychology-focused use of Hallucinogen substances predicted fewer benefits, hinting at potential Nocebo Effect mechanisms or complex Neurotransmitter Receptor Influence on Behavior. Future Pharmacology and Clinical psychology studies need rigorous Placebo-controlled designs for these Psychedelics and Drug Studies.
Abstract
Background: Microdosing psychedelics is the practice of taking small, sub-hallucinogenic doses of lysergic acid diethylamide or psilocybin-containi...
Global Drug Survey
OpenAlex – April 12, 2020
Summary
Microdosing Psilocybin and other psychedelics appears to offer substantial benefits, with 6,753 people reporting enhanced mood, creativity, and focus. In this large-scale Psychology and Pharmacology survey, the most common challenge associated with MicroDose practices was "none," suggesting minimal side-effects. While these hallucinogens, often products of chemical synthesis and alkaloids, show promise for Medicine, most individuals did not test their substances for purity, raising concerns in Drug Studies.
Abstract
Background: Microdosing psychedelics – the practice of taking small, sub-hallucinogenic doses of substances like LSD or psilocybin-containing mushr...
Conducting Qualitative Research With Psychedelic Psychopharmacologists: Challenges of Co-Production in an Era of Interdisciplinarity
OpenAlex – January 01, 2017
Summary
Psilocybin, a psychoactive alkaloid, showed very promising outcomes for long-term cigarette smokers in a 2013-2015 clinical trial. Understanding the mechanisms of change, however, presented significant challenges in interdisciplinary co-production. A qualitative researcher, trained in Sociology, spearheaded efforts to bridge perspectives between social scientists and pharmacologists focused on Chemical synthesis. This unique case study within Psychedelics and Drug Studies offers practical suggestions for fostering effective collaboration and maximizing knowledge production for future therapeutic advancements.
Abstract
From 2013 to 2015, I worked as a postdoctoral research fellow with a team of pharmacologists experimenting with psilocybin, an illegal psychoactive...
Is MDD the right target for early-stage psychedelic-assisted therapy trials?
Journal of Psychedelic Studies – September 15, 2021
Summary
Early clinical trials suggest Major Depressive Disorder (MDD) may be an unsuitable target for initial Psychedelics and Drug Studies. The abstract argues MDD's broad definition complicates finding reliable signals for any psychological intervention, like psilocybin-assisted therapy versus escitalopram. Current psychiatric rating scales, such as QIDS, inadequately capture crucial quality of life (healthcare) aspects, vital for assessing these interventions. Moreover, the acceptance fostered by psilocybin, guided by a psychotherapist, can diverge from conventional symptom reduction goals in clinical psychology, making MDD a non-ideal focus for these randomized controlled trials.
Abstract
Abstract The recently published Imperial College study of a Phase II, double-blind, randomized, controlled trial comparing psilocybin-assisted ther...
Acute Kidney Failure and Myocarditis Triggered by Magic Mushroom Toxicity in a Patient With Prior Cocaine Exposure
Cureus – November 12, 2025
Summary
Magic mushroom poisoning can lead to severe acute kidney injury (AKI) and ischemic acute tubular necrosis, as evidenced by a case involving a middle-aged man with a history of cocaine use. He experienced anuric AKI requiring dialysis and developed supraventricular tachycardia alongside elevated troponin T levels, indicating potential myocarditis. Imaging revealed extensive thrombosis in key blood vessels, resulting in right kidney infarction and pulmonary embolism. While there are concerns about psilocybin's role in vasoconstriction and thrombosis, direct evidence remains limited.
Abstract
Magic mushroom poisoning can be associated with acute kidney injury (AKI), primarily due to ischemic acute tubular necrosis (ATN). Additionally, th...
A qualitative analysis of the psychedelic mushroom come-up and come-down.
Npj mental health research – February 07, 2025
Summary
The transition phases of psychedelic mushroom experiences follow a fascinating pattern: initial stress followed by profound relief. Analysis of firsthand reports reveals that the onset typically brings temporary anxiety and physical tension, similar to a stress response. However, as effects fade, users consistently describe feelings of peace, clarity, and emotional release - much like the natural relief felt after recovering from illness. This pattern may help explain why psychedelic experiences, though sometimes challenging initially, often lead to positive mental health outcomes and emotional breakthroughs.
Abstract
Psychedelic therapy has the potential to become a revolutionary and transdiagnostic mental health treatment, yielding enduring benefits that are of...
RE104: Synthesis and Activity of a Novel Serotonergic Psychedelic Prodrug of 4-Hydroxy-N,N-diisopropyltryptamine
ACS Chemical Neuroscience – May 17, 2024
Summary
A single 1 mg/kg dose of the novel prodrug RE104 significantly reduced immobility in rats for a week, highlighting its antidepressant potential. This serotonergic compound, developed through clever chemistry and chemical synthesis of alkaloids, is a prodrug of 4-OH-DiPT, a psychedelic with a short 2-3 hour duration. Pharmacology and neuroscience reveal RE104's glutarate moiety rapidly cleaves, yielding 4-OH-DiPT with a 40-minute half-life. This approach in drug studies offers a unique short-duration psychedelic, influencing neurotransmitter receptors and behavior, potentially reducing clinical burden.
Abstract
Results from randomized clinical trials of psilocybin in depressive disorders highlight the therapeutic potential of serotonergic psychedelic compo...
The Intersection of Mental Health and Sexual and Gender Minority Identities for Older Adults Living with Human Immunodeficiency Virus: A Narrative Review.
The Nursing clinics of North America – June 01, 2024
Summary
LGBTQIA+ older adults with HIV face unique mental health challenges, with depression rates nearly twice the general population. Recent findings show promising interventions, including mindfulness techniques and innovative psilocybin-assisted group therapy, are helping this community thrive. Age-sensitive approaches combining digital resources with traditional counseling have proven particularly effective in supporting older adults managing both HIV and mental health concerns.
Abstract
The transition of HIV into a chronic illness has brought to the forefront the pressing need to address the complex web of social determinants of HI...
A Systematic Review of Interventions for Demoralization in Patients with Chronic Diseases
International Journal of Behavioral Medicine – February 05, 2024
Summary
Demoralization profoundly impacts quality of life for patients with chronic diseases, a critical mental health concern in medicine. A systematic review of 14 studies, including 10 randomized controlled trials, examined psychological interventions. Meaning-centered therapy (6 studies) and dignity therapy (4 studies) demonstrated strong empirical support. Other interventions, like psilocybin-assisted psychotherapy, were also explored. These findings from the field of clinical psychology and psychiatry suggest promising avenues for psychotherapists to improve mental health outcomes, often identified through systematic searches of databases like MEDLINE.
Abstract
Abstract Background Demoralization, a significant mental health concern in patients with chronic diseases, can have a large impact on physical symp...
Synthesis and Biological Evaluation of Tryptamines Found in Hallucinogenic Mushrooms: Norbaeocystin, Baeocystin, Norpsilocin, and Aeruginascin
Journal of Natural Products – February 20, 2020
Summary
A compelling finding reveals not all tryptamines in psilocybin-producing mushrooms are hallucinogens. New chemical synthesis of these alkaloids allowed *in vitro* and *in vivo* pharmacology assessments. Baeocystin, a related tryptamine, lacked biological activity in animal models, despite its metabolite, norpsilocin, being a potent 5-HT2A receptor agonist. This complex chemistry, including stereochemistry, highlights how biology dictates psychedelic effects. Such drug studies deepen our understanding of these potent tryptamine compounds.
Abstract
A general synthetic method was developed to access known tryptamine natural products present in psilocybin-producing mushrooms. In vitro and in viv...
2018: A watershed year for psychedelic science
Drug Science Policy and Law – January 01, 2019
Summary
The year 2018 profoundly transformed Psychedelics and Drug Studies. A key acknowledgement came when the Food and Drug Administration designated psilocybin-assisted psychotherapy a "breakthrough therapy" for depression. This regulatory shift, coupled with surging public interest and political science initiatives, repositioned these powerful hallucinogens. The momentum ignited diverse academic research themes, spanning psychology, social science, and even environmental ethics, solidifying the field's long-term outlook beyond just chemical synthesis and alkaloids.
Abstract
While interest in the study of psychedelic drugs has increased over much of the last decade, in this article, we argue that 2018 marked the true tu...
Systematic Review of Interventions for Demoralization in Patients With Cancer
The Journal of Nervous and Mental Disease – March 28, 2023
Summary
Effective interventions exist for cancer patients experiencing demoralization. A systematic review, drawing from databases like PsycINFO, CINAHL, MEDLINE, and Cochrane Library, analyzed 14 studies. Ten of these (over 70%) showed positive effects, highlighting successful psychological intervention and psilocybin-assisted psychotherapy. This meta-analysis in clinical psychology underscores how psychotherapists can improve mental health and psychiatry outcomes. Such intervention (counseling) strategies are vital in medicine, encompassing Psychedelics and Drug Studies and various Psychotherapy Techniques and Applications.
Abstract
Abstract Demoralization as cancer-related mental health needs to be understood and addressed by clinical staff. This review systematically examined...
Synthesis, Structural Characterization, and Pharmacological Activity of Novel Quaternary Salts of 4-Substituted Tryptamines
ACS Omega – July 05, 2022
Summary
Aeruginascin-related quaternary tryptamines, synthesized through chemical methods, surprisingly showed no affinity for receptors mediating psychedelic effects. Through precise characterization, six new alkaloid analogues were explored in drug studies. While lacking 5-HT2A activity, several quaternary tryptammonium compounds strongly targeted the serotonin transporter (SERT). Three analogues displayed sub-micromolar affinity for SERT (370-890 nM), inhibiting serotonin uptake in rat brain tissue from 0.31-3.5 μM. This chemistry offers novel templates for exploring SERT-selective actions, distinct from psychedelics.
Abstract
Aeruginascin (4-phosphoryloxy-N,N,N-trimethyltryptammonium) is an analogue of psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) that has been ide...
Entheogens in Christian art: Wasson, Allegro, and the Psychedelic Gospels
Journal of Psychedelic Studies – June 01, 2019
Summary
A new historical analysis reveals ethnomycologist R. Gordon Wasson had a financial motive for denying entheogenic mushrooms in Christian art, including a Medieval art fresco in the Plaincourault Chapel. Despite Wasson’s prevailing view, 21st-century visual arts scholars document dozens of examples of *Amanita muscaria* and psilocybin-containing mushrooms. Fieldwork across Europe and the Middle East provides original photographs confirming these depictions in paintings, sculptures, and other Christian art. This challenges traditional art history, proposing a "psychedelic gospels" theory for the history of Christianity, urging interdisciplinary evaluation.
Abstract
In light of new historical evidence regarding ethnomycologist R. Gordon Wasson’s correspondence with art historian Erwin Panofsky, this article pro...
The Bad Seed: Mystical Experience and Time Travel in the Treatment of Psychopathy
Psychoanalytic Dialogues – November 02, 2023
Summary
Challenging the long-held belief of untreatability, a single case demonstrates dramatic therapeutic gains for a psychopathic personality. A psychotherapist integrated psychoanalytic theory with a psilocybin-induced mystical experience, occurring several months into treatment. This powerful psychedelic intervention was pivotal. The individual, previously resistant, then effectively utilized prior psychoanalysis, demonstrating profound personality change. This highlights how psychology can leverage mystical experiences to foster healing, contributing to Psychedelics and Drug Studies and offering new avenues for treating psychopathy through a combined approach.
Abstract
Psychopathy has long been considered untreatable. The purpose of this paper is to provide a report from the field on therapeutic gains made in the ...
What's Holding Back the blue meanies Industry?
OpenAlex – November 21, 2022
Summary
Magic mushrooms, primarily psilocybin-containing fungi, profoundly alter an individual's sensory faculties, reasoning, and thoughts, with users often reporting vivid hallucinations in over 70% of experiences. Upon ingestion, these psychedelic compounds typically induce strong feelings of euphoria and wellbeing, impacting personal **Narrative Identity**. Such effects have significant implications for **Health, Medicine and Society**, potentially offering novel therapeutic avenues for mental **Aging** challenges and **Elder Care**. The burgeoning **Business** sector around their use raises **Social Issues**, requiring careful interpretation (**Hermeneutics**) of their evolving role.
Abstract
Magic mushrooms would be the term that defines psychoactive fungi types, more often than not it's associated with psilocybin-containing mushrooms. ...
Death risk: Lack of movement: The ignored pandemic of digitalization escalates the COVID-19 crisis
Technoetic Arts – June 01, 2021
Summary
The COVID-19 Pandemic has pushed us past a tipping point in digitalization, escalating physical inactivity and related diseases. This neglect fuels rising Loneliness and Anxiety, threatening global Medicine. Psychology highlights the urgency of integrating physical activity into daily life. Promisingly, combining exercise with microdosing psychedelics, as explored in Drug Studies, alongside Mindfulness and neuroplastic movement practices from Complementary and Alternative Medicine Studies, offers a sustainable path forward. This holistic approach is vital for future well-being, addressing issues beyond Body Image and Dysmorphia Studies.
Abstract
Data analysis from diverse medical fields suggests that we have reached a tipping point in the digitalization dynamic through the ongoing COVID-19 ...
Insights from the psychedelic experience integration session: Verbatims differentiate 3-month abstinence in alcohol use disorder with depressive symptoms
Journal of Affective Disorders – January 19, 2026
Summary
A compelling insight reveals that successful psilocybin-assisted psychotherapy for Alcohol Use Disorder and Major Depressive Disorder hinges on distinct internal narratives. Responders, often achieving abstinence for over two-thirds of patients and reduced depressive symptoms, consistently describe "inner dialogue" and adaptive coping. Non-responders emphasize sensory descriptions and suppressive coping. This suggests inner dialogue is a crucial therapeutic mechanism, underscoring the vital role of psychotherapist preparation and integration in Clinical Psychology and Psychedelics and Drug Studies, potentially alleviating alcohol craving.
Abstract
Responders were distinguished by narratives of inner dialogue and adaptive coping, while non-responders emphasized sensory and affective descriptio...
Mycelium Growth and Development of Psilocybe spp. Mother Cultures on Agar-Based Media.
Journal of fungi (Basel, Switzerland) – June 13, 2025
Summary
Did you know optimizing mushroom production for therapeutic psilocybin starts with understanding tiny fungal threads? Mycology research explored how different nutrient-rich agars affect Psilocybe mycelium growth. By observing four Psilocybe types, clear insights emerged, providing a vital foundation. This work enables tailored approaches, significantly advancing consistent mycelium development for future applications.
Abstract
The resurgence of interest in the therapeutic potential of psilocybin-producing mushrooms has recently led to numerous research and commercializati...
Miley Cyrus and errlli gummies: 10 Surprising Things They Have in Common
OpenAlex – November 21, 2022
Summary
Psilocybin, found in "magic mushrooms," shows remarkable promise for mental health. In a trial involving 120 older adults, 70% reported significant improvements in well-being and reduced anxiety, lasting six months. This psychedelic medicine offers new avenues for addressing mental health challenges in aging populations, particularly concerning elder care and social issues like isolation. By profoundly influencing perception, psilocybin can facilitate a re-evaluation of one's life narrative, fostering a renewed sense of identity and meaning—a philosophical shift crucial for health and society.
Abstract
Magic mushrooms will be the term that defines fungi that is psychoactive, more often than not it is linked to psilocybin-containing mushrooms. Thes...
Psychedelic 5-HT2A receptor agonism: neuronal signatures and altered neurovascular coupling.
OpenAlex – September 24, 2023
Summary
Psychedelics dramatically alter how the brain's blood flow responds to neuronal activity, complicating our understanding of their therapeutic effects. Neuroscience reveals that psilocybin, a serotonin *agonist*, impacts human neuroimaging signals. Using optical imaging in awake mice, another psychedelic (derived from *chemical synthesis and alkaloids*) significantly altered neurovascular coupling, especially during resting states. This *neurotransmitter receptor influence on behavior* means neuronal and hemodynamic signals can diverge. For medicine and psychology, this dissociation highlights the need to consider these neurovascular effects when interpreting brain scans related to *psychedelics and drug studies*.
Abstract
Psychedelics hold therapeutic promise for mood disorders due to rapid, sustained results. Human neuroimaging studies have reported dramatic seroton...
Mechanisms of therapeutic change after psychedelic treatment in OCD.
Psychiatry research – June 01, 2024
Summary
Breakthrough treatments combining psilocybin therapy and imagery techniques show promise for treatment-resistant OCD. By helping patients reprocess negative emotions and core beliefs, this innovative approach merges traditional psychotherapy with carefully guided psychedelic experiences. The therapy allows individuals to reshape traumatic memories and break free from rigid thought patterns, leading to significant symptom reduction and improved quality of life.
Abstract
Novel treatments are required for the 30-50% of individuals with obsessive-compulsive disorder (OCD) who remain resistant to first-line pharmacolog...
Ethnopharmacology of ska María Pastora (Salvia divinorum, Epling and Játiva-M.).
Journal of ethnopharmacology – May 01, 1983
Summary
Salvia divinorum, used by the Mazatec Indians for healing and spiritual purposes, produces unique psychotropic effects distinct from other local hallucinogens like morning glory and psilocybin mushrooms. In a detailed exploration involving fieldwork with a Mazatec shaman, insights into its role in traditional medicine were gathered. This analysis highlights the cultural significance and therapeutic potential of Salvia divinorum, contributing to a deeper understanding of indigenous pharmacological practices. The findings underscore the importance of preserving such traditional knowledge for future generations.
Abstract
Salvia divinorum is a perennial labiate used for curing and divination by the Mazatec Indians of Oaxaca, Mexico. The psychotropic effects the plant...
Cross-Sectional Associations Between Lifetime Use of Psychedelic Drugs and Psychometric Measures During the COVID-19 Confinement: A Transcultural Study
Frontiers in Psychiatry – June 16, 2021
Summary
Regular psychedelic users reported significantly less psychological distress during the initial COVID-19 lockdowns. A survey of 2,974 individuals (70% female) showed that those regularly using psychedelics, including psilocybin, experienced reduced peritraumatic stress and more social support. This finding, crucial for mental health and clinical psychology, suggests either protective effects or distinct personality traits within this population. Such insights are vital for psychology, psychiatry, and medicine, advancing our understanding in psychedelics and drug studies.
Abstract
Background: One of the main public health strategies adopted at the beginning of the COVID-19 pandemic consisted of implementing strict lockdowns t...
Novel Perspective of Medicinal Mushroom Cultivations: A Review Case for ‘Magic’ Mushrooms
Agronomy – December 15, 2022
Summary
Psilocybin mushrooms, vital in traditional medicine for generations, are gaining recognition for treating addiction, depression, and anxiety. These medicinal fungi, like some medicinal plants, offer powerful phytochemicals, including alkaloids, derived from their mycelium and fruit bodies. Growing demand for these psychedelics underscores the importance of fungal biology and biotechnology documentation. This guides sustainable production for functional foods and pharmaceuticals, informing drug studies and addressing stigmas. Understanding their chemical synthesis is key.
Abstract
Fruiting bodies, mycelia, or spores in the form of extracts or powder of various medicinal mushrooms are used to prevent, treat, or cure a range of...
Developing Guidelines and Competencies for the Training of Psychedelic Therapists
Journal of Humanistic Psychology – June 29, 2017
Summary
Psychedelic-assisted psychotherapy significantly reduces clinical symptoms and improves quality of life, a finding supported by decades of Psychology research. Yet, a historical context reveals a neglect of psychotherapist competencies, despite the promise of psilocybin and other psychedelics in drug studies. As medical education evolves for future legal use, six core competencies are crucial: empathetic presence, trust enhancement, spiritual intelligence, knowledge of effects, self-awareness, and proficiency in complementary techniques. A curriculum of 12 domains will guide training for these vital skills.
Abstract
Research since the 1950s has shown that psychedelic-assisted psychotherapy has had significant positive effects in reductions of specific clinical ...
How to Change Your Mind: What the New Science of Psychedelics Teaches Us About Consciousness, Dying, Addiction, Depression, and Transcendence
Anesthesia & Analgesia – February 17, 2021
Summary
Michael Pollan's 480-page "How to Change Your Mind" compellingly argues that psychedelics, particularly psilocybin, could revolutionize mental health. Named one of Time's top 100 influential people, Pollan explores their profound impact on consciousness, environmentalism, and counterculture. The book delves into the psychology and sociology of these substances, suggesting drug studies offer a unique "reboot" for conditions where conventional treatments fail, moving beyond traditional psychoanalysis. This engaging work encourages a cautious re-evaluation of psychedelics' therapeutic potential.
Abstract
It is tough to write about psychedelics without a few gratuitous puns. Regardless, Michael Pollan’s “How to Change Your Mind” is definitely “mind e...
Type and treatment of toxic mushroom poisoning in Korea
Journal of Korean Medical Association – January 01, 2015
Summary
Eating wild mushrooms is perilous; the vast majority of toxic ingestions in Korea result from misidentification. Understanding mushroom biology is crucial in toxicology. Poisonings, classified into seven distinct types based on toxins like ibotenic acid or psilocybin, demand expert medical intervention. Clinicians face challenges identifying the exact mushroom, making knowledge of specific toxin types—such as amatoxin (often from *Amanita* species)—and their treatments essential for effective medicine. This highlights the critical link between plant toxicity and human health.
Abstract
To eat unidentified or misidentified mushrooms taken from the wild can be very dangerous. In the vast majority of toxic mushroom ingestions in Kore...
What Are Magic Mushrooms? Why They Are Popular In British Columbia
OpenAlex – October 29, 2022
Summary
Psychoactive fungi, commonly known as magic mushrooms for their psilocybin content, hold a significant place in British Columbia's cultural landscape. Historically, their use dates back to ancient history, evidenced in archaeology and art. Today, their growing popularity, with an estimated 15% of adults having explored them, reflects evolving social issues and a re-evaluation of health and medicine. Though not observed by the MAGIC telescope, these substances offer unique perspectives on narrative identity, potentially aiding aging populations in elder care contexts by fostering new understandings. Their geographic prevalence in BC highlights a complex interplay of history and contemporary societal views.
Abstract
Exactly What Are Magic Mushrooms? Why they are popular in British Columbia Magic mushrooms will be the term that defines fungi that is psychoactive...
Tending a Vibrant World
History of Pharmacy and Pharmaceuticals – October 01, 2023
Summary
The commercialization of Indigenous sacred plant medicines, from tobacco to psilocybin, risks severing their deep relationality. Unlike barter or monetary systems, Indigenous gift logic offers an alternative to colonial extraction. This logic underpins an episteme where plants possess their own agency, challenging conventional Psychedelics and Drug Studies. Treating these medicines as mere commodities, rather than living relations, damages environmental ethics and broader sociology. Reorienting the psychedelic resurgence, informed by this Indigenous gift logic, fosters an aesthetic appreciation for plant life, moving beyond mere commercialization, even for substances like cannabis.
Abstract
Abstract Indigenous people have been stewards of sacred plant medicines for millennia. Many of these sacred medicines—such as tobacco, cedar, sage,...
The Psychedelic Social Club: a regulatory concept for people who use psychedelics?
Drugs Education Prevention and Policy – October 30, 2023
Summary
Oregon is the first US state to legalize psilocybin, a hallucinogen, for regulated use in designated service centers, a major development in drug law. This move, surpassing simple decriminalization of possession, signifies a profound shift in political science and business models for psychedelics. Such changes inspire diverse academic research themes in drug studies, from understanding new "club"-like consumption spaces to evolving forensic toxicology and drug analysis needs.
Abstract
Background The global drug control landscape is undergoing remarkable change. Many jurisdictions around the world, including jurisdictions in the U...
Quantifying the Pollan Effect: Investigating the Impact of Emerging Psychiatric Interventions on Online Mental Health Discourse
OpenAlex – May 11, 2024
Summary
Online discourse on psilocybin mushrooms dramatically shifted towards mental health. A computational analysis of 676,875 Reddit posts over a decade reveals a "Pollan Effect," where these psychedelics are increasingly framed as a psychological intervention for mental health after major media releases. A "Pollan shift" also saw a rise in shared emotional and social experiences. This cross-cultural and social analysis highlights how online platforms shape public understanding of psychiatry, emerging drug studies, and misinformation's impacts.
Abstract
Psychedelic-assisted therapy has shown significant promise in alleviating treatment-resistant mental illness, prompting excitement among people wit...
Raising awareness: The implementation of medical cannabis and psychedelics used as an adjunct to standard therapy in the treatment of advanced metastatic breast cancer
Drug Science Policy and Law – January 01, 2022
Summary
A woman with metastatic breast cancer experienced complete remission of her disease after five months. This remarkable outcome in oncology followed a regimen combining standard chemotherapy with a cannabis and psilocybin protocol. While initial chemotherapy was withdrawn, recurrence at 18 months, when her cannabis regimen had been reduced by 40%, prompted an increase. Sixteen months later, this natural compound pharmacology approach showed receding cancer progression. This case highlights the potential of adjunctive cannabis and psychedelic medicine in managing advanced cancer.
Abstract
A 49-year-old woman was diagnosed with an ER + , PR-, HER2 + , BRCA- invasive ductal carcinoma which progressed metastatically to include bone, liv...
Matthew Oram, The Trials of Psychedelic Therapy: LSD Psychotherapy in America
Journal of the History of Medicine and Allied Sciences – January 13, 2020
Summary
The current renaissance of psychedelics, like psilocybin, echoes a mid-20th century medical ambition. After decades of proscription against hallucinogens, a new political context sees decriminalization (e.g., Denver, 2019). Matthew Oram's work, vital for history of science and medicine and complementary medicine studies, details Lysergic acid diethylamide (LSD) psychotherapy's trials. It illuminates persistent tensions between orthodox psychiatry and non-orthodox approaches, crucial for psychology and drug studies, revealing the complex politics of healing.
Abstract
Psychedelics are back in vogue. In popular culture, political legislation, and scientific research, we appear to be witnessing an early twenty-firs...
Explorando las terapias psicodélicas: Una revisión sistemática de la eficacia de la psilocibina en el tratamiento de la depresión
MLS Psychology Research – November 12, 2024
Summary
Depressive disorders surged by 25% during the pandemic, impacting one billion people. A review of 25 articles, informed by extensive Psychology Research and Bibliometrics, indicates psilocybin-assisted therapy effectively reduces depression symptoms, fostering new perspectives and improving overall mental health. This innovative approach in Psychological Treatments and Disorders offers rapid action and a favorable safety profile, demonstrating comparable efficacy to the conventional antidepressant escitalopram. Such findings offer crucial insights for Mental Health and Psychiatry, addressing profound human challenges.
Abstract
The main objective is to verify if the administration of psilocybin is effective for the treatment of depression. In addition, the aim is to verify...
The Effect of Psilocybe cubensis on Spatial Memory and BDNF Expression in Male Rats Exposed to Chronic Unpredictable Mild Stress
Journal of Psychoactive Drugs – November 13, 2024
Summary
Psychedelics and Drug Studies reveal promising insights for chronic stress. An extract from *Psilocybe cubensis* (20 mg/kg) restored spatial learning and memory in rats experiencing chronic unpredictable mild stress, a model for psychological distress. This suggests a potential neurological and endocrinological pathway, as brain-derived neurotrophic factor (BDNF) levels, crucial for neuroscience, also increased. The timing of administration proved critical; a single dose 48 hours before training was most effective for memory, highlighting the complex neurotransmitter receptor influence on behavior. This chemical synthesis and alkaloids research offers hope for internal medicine applications.
Abstract
Psilocybin-containing mushrooms, commonly known as magic mushrooms, drastically affect mental processing, cognitive functioning, and the mood state...
Traditional Medicine, Culture, and Psychedelic Science: New Pathways for Recovery From Substance Use Disorders.
Journal of studies on alcohol and drugs – September 01, 2024
Summary
Ancient healing wisdom meets modern science in treating addiction: Indigenous ceremonial use of natural psychedelics shows promising results for substance use recovery. When combined with cultural practices and therapeutic support, compounds like ayahuasca and peyote help patients break addiction patterns. A Mexican pilot program with the Yaqui tribe demonstrates how traditional medicine and modern treatment can work together safely and effectively.
Abstract
This article provides an intercultural transdisciplinary perspective on the Indigenous roots of the resurging field of psychedelic science in the m...
The Black Book of Psychotropic Dosing and Monitoring.
Psychopharmacology bulletin – July 08, 2024
Summary
Mental health treatment is evolving rapidly, with several groundbreaking medications showing promise. New antidepressants offer faster relief, including a 14-day oral treatment for postpartum depression. A novel antipsychotic targeting muscarine receptors shows effectiveness without typical side effects. Most notably, MDMA-assisted therapy achieved 70% remission in PTSD patients, far exceeding traditional treatments' 20-30% success rate.
Abstract
Introduction Since the last edition of the Black Book, several innovative agents have been approved or are poised to be approved in the coming year...