5439 results for "Psychedelics"
From Theory to Practice: The Importance of Operationalizing and Measuring Ethical Touch in Psychedelic-Assisted Therapy.
Am J Bioeth – January 13, 2025
Summary
Ensuring safety in psychedelic-assisted therapy critically depends on how ethical touch is defined and measured. A framework is proposed to operationalize this crucial interaction, outlining specific behaviors and contexts. Developing clear guidelines and assessment tools enhances trust and reduces risks, leading to more effective therapeutic experiences. This systematic approach positively contributes to professional standards and patient well-being.
Abstract
From Theory to Practice: The Importance of Operationalizing and Measuring Ethical Touch in Psychedelic-Assisted Therapy.
[Psychedelic-assisted psychotherapy in palliative medicine].
Revue medicale suisse – December 20, 2023
Summary
Psychedelic-assisted psychotherapy (PAP) shows promise for improving the quality of life in patients facing terminal illness, addressing issues like depression and anxiety. This approach combines preparation, substance intake, and integration of experiences, leading to profound psychospiritual changes. With a growing interest in PAP, it offers hope for those who have not found relief through conventional methods. As mental health challenges remain prevalent among palliative care patients, innovative therapies like PAP could provide significant benefits, potentially transforming end-of-life care.
Abstract
Depression, anxiety and existential distress associated with terminal illness have a major impact on quality of life among palliative care patients...
Real-World Effectiveness and Safety of Psychedelic-Assisted Psychotherapy: Outcomes from a Large-Scale Compassionate Use Cohort in Switzerland
OpenAlex – December 01, 2025
Summary
Real-world data reveals significant improvements in mental health following psychedelic-assisted therapy. Among 115 adults (56.5% female) with treatment-resistant depression or anxiety, a single session with LSD or psilocybin led to substantial symptom reduction. Depressive symptoms decreased with a large effect (partial η² = 0.42), and anxiety symptoms showed a medium effect reduction (partial η² = 0.17). Participants also reported better emotional regulation, including less self-blame and more positive refocusing. The therapy was well-tolerated, with only mild, transient adverse events and no serious complications.
Abstract
Abstract Background Classic serotonergic psychedelics such as LSD and psilocybin show promising antidepressant effects in controlled trials, but re...
Real-world effectiveness and safety of psychedelic-assisted psychotherapy: Outcomes from a large-scale compassionate use cohort in Switzerland.
Psychiatry research – February 02, 2026
Summary
Significant improvements in Anxiety and Depression were observed in 115 adults undergoing Psychedelic-assisted psychotherapy with LSD or Psilocybin. This real-world analysis, involving 56.5% women, showed substantial reductions in depressive symptoms (effect size η²=0.42) and anxiety (η²=0.17) 1-3 months post-treatment. Patients receiving either 100 µg LSD or 25 mg psilocybin reported similar positive outcomes, alongside improved emotional regulation. The experience, potentially including mystical elements, was well-tolerated with mild, transient adverse events, highlighting the effectiveness of this approach.
Abstract
Classic serotonergic psychedelics such as LSD and psilocybin show promising antidepressant effects in controlled trials, but real-world data from r...
Lost in translation? Qualitative interviews with Australian psychedelic-assisted therapy trial clinicians.
Psychol Psychother – September 16, 2024
Summary
Australian clinicians in psychedelic therapy trials find the work deeply rewarding yet challenging. Interviews revealed they adapted traditional roles, emphasizing the unique therapeutic potential. Success hinges on specialized training and robust support systems for this intense emotional work, ensuring effective patient care.
Abstract
Lost in translation? Qualitative interviews with Australian psychedelic-assisted therapy trial clinicians.
Taking the potential harms of psychedelic-assisted therapy seriously: How do we prevent or mitigate the risks to vulnerable patients?
Int J Drug Policy – July 26, 2024
Summary
Despite the therapeutic promise of psychedelics, safeguarding vulnerable patients is critical. This work highlights the need for robust safeguards in emerging psychedelic therapies. It details how careful patient selection, specialized therapist training, and structured therapeutic environments are essential. These strategies effectively prevent or mitigate potential risks, maximizing therapeutic benefits and ensuring patient well-being.
Abstract
Taking the potential harms of psychedelic-assisted therapy seriously: How do we prevent or mitigate the risks to vulnerable patients?
In Psychedelic-Assisted Therapy, the Alliance in the Psychotherapy Component Is as Important as the Drug.
Psychother Psychosom – May 09, 2025
Summary
In psychedelic-assisted therapy, the human connection proves as vital as the drug itself. This suggests the therapeutic relationship, or "alliance," is key to positive patient outcomes. Researchers investigated the bond between therapist and patient, finding a strong, supportive alliance significantly boosted beneficial results. This highlights that effective therapy relies equally on quality human support for profound healing.
Abstract
In Psychedelic-Assisted Therapy, the Alliance in the Psychotherapy Component Is as Important as the Drug.
Radiation Therapy Patients’ Interest in Psychedelic-assisted Therapy: A Prospective Survey Study
Research Square – April 16, 2025
Summary
Many cancer patients receiving radiation therapy are keen on psychedelic-assisted therapy. This signals a promising new avenue for managing distress and boosting well-being. A survey found most radiation patients open to these novel approaches, especially those with higher anxiety or depression, viewing them as valuable for improving mental health. Patients clearly seek emotional support in cancer care.
Abstract
Radiation Therapy Patients’ Interest in Psychedelic-assisted Therapy: A Prospective Survey Study
Shrinking the know-do gap in psychedelic-assisted therapy.
Nat Hum Behav – February 24, 2025
Summary
Delivering effective **psychedelic-assisted therapy** hinges on more than just its potential; it requires precise application. A key insight highlights a crucial gap between what's known about these treatments and their real-world **clinical practice**. The core finding suggests that optimizing **therapist training** is vital. By improving how practitioners are educated, the quality of care significantly enhances, leading to superior **patient outcomes** for **mental health** conditions. This ensures **evidence-based care** is consistently delivered, maximizing therapeutic benefits.
Abstract
Shrinking the know-do gap in psychedelic-assisted therapy.
The effects of psychedelic-assisted therapy on illness and death anxiety: A systematic review and meta-analysis.
J Psychiatr Res – March 14, 2025
Summary
Many people grapple with intense fears of illness and death. A recent comprehensive analysis of multiple studies found that psychedelic-assisted therapy significantly alleviates these profound anxieties. By synthesizing existing research, the review concluded that this innovative therapeutic approach offers substantial positive effects, promoting greater peace and well-being for individuals facing existential dread.
Abstract
The effects of psychedelic-assisted therapy on illness and death anxiety: A systematic review and meta-analysis.
Is There a Right to Psychedelic-Assisted Therapy?
Am J Bioeth – January 13, 2025
Summary
Could access to psychedelic-assisted therapy be a fundamental right? An analysis explored this crucial question, given its profound mental health benefits. Examining legal and ethical frameworks, it found compelling arguments for recognizing a right to this innovative treatment. The work emphasizes patient autonomy and equitable access to effective care, concluding that a strong case exists for ensuring individuals can access psychedelic-assisted therapy, promoting better mental health outcomes.
Abstract
Is There a Right to Psychedelic-Assisted Therapy?
Research and Implementation of Psychedelic-Assisted Therapy in the Veterans Health Administration.
Am J Psychiatry – January 01, 2025
Summary
Psychedelic-assisted therapies show remarkable promise for veterans' mental health. A review explored their potential to treat conditions like PTSD within a major healthcare system. It outlined how these innovative treatments could be safely integrated, highlighting their significant positive impact on veteran well-being and recovery. This points to a new path for care.
Abstract
Research and Implementation of Psychedelic-Assisted Therapy in the Veterans Health Administration.
Healing, Harms, and Humility: Expanding the Scope of Psychedelic-Assisted Psychotherapy Research.
Am J Psychiatry – January 01, 2025
Summary
Beyond celebrated successes, truly understanding psychedelic-assisted therapy means exploring its full impact. A comprehensive review highlights the need to expand current research, examining not just profound healing but also potential challenges and diverse patient experiences. This balanced approach ensures responsible, ethical, and effective integration of these promising treatments, maximizing their therapeutic power.
Abstract
Healing, Harms, and Humility: Expanding the Scope of Psychedelic-Assisted Psychotherapy Research.
Efficacy and Safety of Four Psychedelic-Assisted Therapies for Adults with Symptoms of Depression, Anxiety, and Posttraumatic Stress Disorder: A Systematic Review and Meta-Analysis
Journal of Psychoactive Drugs – November 15, 2023
Summary
Depression symptoms saw substantial relief from psychedelics, a meta-analysis of eighteen studies in clinical psychology reveals. Psilocybin therapy showed a large effect size (g = -1.92), while MDMA also significantly impacted depression (g = -0.71). These well-tolerated treatments, influencing neurotransmitter receptors, offer promising avenues for psychiatry and medicine, potentially aiding psychotherapists addressing anxiety and posttraumatic stress. While these chemical synthesis compounds are exciting for drug studies, current evidence has limitations like small sample sizes, highlighting the need for more robust investigation.
Abstract
There has been a resurgence in psychedelic research for managing psychiatric conditions in recent years. This study aimed to present a comprehensiv...
Psychedelic-Assisted Therapies for Psychosocial Symptoms in Cancer: A Systematic Review and Meta-Analysis
Current Oncology – June 30, 2025
Summary
Psychedelics offer significant promise for cancer patients. A meta-analysis of randomized controlled trials, including data from the Cochrane Library, revealed that psilocybin and ketamine markedly reduce psychosocial distress. For instance, three psilocybin trials with 101 participants showed a large effect on depression (Hedges' g = -3.13). Four ketamine trials (354 participants) demonstrated rapid, large effects on depression and anxiety (Hedges' g = -1.37) compared to placebo. This burgeoning area of medicine, relevant to psychiatry and clinical psychology, highlights how these chemical synthesis alkaloids influence behavior, offering new therapeutic context for internal medicine.
Abstract
This systematic review and meta-analysis evaluates (1) the effectiveness of psychedelic-assisted therapy (PAT) using psilocybin and ketamine for ps...
Why psychedelic-assisted therapy studies in eating disorders risk missing the mark on outcomes: a phenomenological psychopathology perspective.
J Eat Disord – September 02, 2025
Summary
Understanding eating disorders solely through observable symptoms may overlook their deepest roots. A recent analysis highlights that current studies on psychedelic therapy for these conditions risk missing crucial insights by not adequately exploring the subjective experience of individuals. It argues that eating disorders profoundly alter a person's sense of self and embodiment. Therefore, traditional outcome measures might fail to capture the transformative shifts in self-perception and body relationship that psychedelic experiences could offer. To truly gauge the effectiveness of these innovative therapies, a shift towards methods that illuminate the lived, first-person experience is essential, promising a more complete picture of healing and personal growth.
Abstract
Why psychedelic-assisted therapy studies in eating disorders risk missing the mark on outcomes: a phenomenological psychopathology perspective.
Psychedelic-assisted Therapy as a Promising Treatment for Irritable Bowel Syndrome.
Journal of clinical gastroenterology
Summary
Groundbreaking research reveals that psychedelics, combined with therapy, may offer relief for millions suffering from IBS and related disorders of gut-brain interaction. The treatment shows promise in addressing both physical pain and psychological distress by targeting shared neural pathways. Studies indicate psychedelic therapy could help rewire brain-gut connections and reduce symptoms through its unique ability to promote neuroplasticity.
Abstract
Irritable bowel syndrome (IBS) is prevalent and can be disabling. Many patients remain symptomatic despite behavioral and medical therapies. Psyche...
A systematic review of participant diversity in psychedelic-assisted psychotherapy trials.
Psychiatry research – March 01, 2025
Summary
Despite promising breakthroughs in psychedelic therapy, clinical trials show concerning gaps in participant diversity. Analysis of 21 trials using MDMA and psilocybin revealed that Black participants made up only 2.2% of subjects, while Hispanic representation was just 7.2%. MDMA studies showed better diversity than psilocybin research. While gender was consistently tracked, other key demographics like sexual orientation and gender identity were rarely monitored. This systematic review highlights opportunities to make psychedelic therapy research more inclusive.
Abstract
A lack of diverse and representative participant samples in mental health intervention research perpetuates mental health disparities. This issue h...
Psychedelic-Assisted Therapy in Military and Veterans Healthcare Systems: Clinical, Legal, and Implementation Considerations.
Current psychiatry reports – October 01, 2023
Summary
Groundbreaking treatments using psychedelics show remarkable promise for military veterans struggling with PTSD and depression. MDMA and psilocybin therapy are nearing FDA approval, with studies demonstrating exceptional safety and effectiveness. Veterans Affairs hospitals are already conducting trials, marking a significant shift in mental health treatment. Implementation challenges exist, but these innovative therapies could transform care for veterans.
Abstract
This review discusses the current and projected landscape of psychedelic-assisted therapy (PAT), with a focus on clinical, legal, and implementatio...
Client treatment preferences in psychedelic-assisted therapy for depression in participants with depressive symptoms
Journal of Psychedelic Studies – July 11, 2024
Summary
Who your therapist is can matter as much as the treatment itself. Research explored if people seeking psychedelic-assisted therapy or traditional talk therapy (CBT) prefer providers of the same gender or race. Over 600 participants rated these preferences. Findings reveal that racial, ethnic, and female participants highly value a same-gender therapist, especially in traditional talk therapy. A same-race therapist was highly valued by racial and ethnic minority participants across both therapy types. Accommodating these preferences is vital, suggesting a clear need to train a diverse range of therapists and guides to enhance patient experience and outcomes.
Abstract
AbstractBackground and AimsResearch on psychedelic-assisted therapy (PAT), a promising treatment option for major depression, has not revealed if p...
Into the wild frontier: Mapping the terrain of adverse events in psychedelic-assisted therapies.
J Psychopharmacol – October 29, 2024
Summary
As psychedelic therapy gains momentum in mental health treatment, understanding its risks is crucial. This comprehensive analysis examines adverse events during psychedelic-assisted therapy, from mild anxiety to rare psychological challenges. While most sessions prove safe under proper supervision, the review identifies key factors for minimizing risks: careful patient screening, therapist training, and structured support systems during sessions.
Abstract
Into the wild frontier: Mapping the terrain of adverse events in psychedelic-assisted therapies.
Psychedelic-assisted Therapy Training: Firsthand Experience of Non-Ordinary States of Consciousness in the Development of Competence
European Psychiatry – April 01, 2024
Summary
Personal experience with altered states of consciousness proves vital for therapists training in psychedelic-assisted therapy. Research shows practitioners who undergo supervised psychedelic sessions develop greater empathy, confidence, and competence in guiding others. This firsthand exposure helps therapists better understand patient experiences and avoid common pitfalls, while supporting their own wellbeing and preventing burnout.
Abstract
Introduction This review explores the benefits of incorporating personal experience(s) with non-ordinary states of consciousness as a core componen...
Exploring the role of psychedelic-assisted therapy in enhancing spirituality and mystical experiences in patients with life-threatening illnesses: A systematic review.
Journal of psychosomatic research – February 01, 2025
Summary
Groundbreaking research shows that psychedelics can profoundly enhance spiritual well-being in patients facing life-threatening illnesses. Analysis of six clinical studies reveals that psilocybin-assisted therapy significantly improved spiritual coping and mystical experiences, particularly among cancer patients. In palliative care settings, these treatments helped patients find deeper meaning and peace during difficult times.
Abstract
Psychedelic-Assisted Therapy (PAT) is gaining traction as a novel approach to addressing the psychological and existential distress experienced by ...
Informed Consent in Psychedelic-Assisted Therapy.
Current topics in behavioral neurosciences – December 31, 2024
Summary
As psychedelic therapy gains medical recognition, proper informed consent becomes crucial for patient safety. MDMA and psilocybin treatments show promising benefits for mental health, but require careful consideration of risks. Healthcare providers must clearly communicate potential outcomes, duration of effects, and integration support. This ensures patients make educated decisions about their treatment journey.
Abstract
Humans have long used classical serotonergic psychedelics, such as psilocybin, for a variety of purposes. Entactogens, such as methylenedioxymetham...
What do clinicians think about psychedelic-assisted therapy? An Australian perspective.
Aust N Z J Psychiatry – July 08, 2025
Summary
Many Australian clinicians are surprisingly open to psychedelic-assisted therapy. Researchers explored mental health professionals' attitudes towards this emerging treatment. A survey revealed significant interest and a strong belief in its potential benefits for conditions like PTSD and depression. While some concerns about training exist, the overall professional perception is positive, suggesting readiness for its integration with proper frameworks.
Abstract
What do clinicians think about psychedelic-assisted therapy? An Australian perspective.
The CAnadian Network for Psychedelic-Assisted Cancer Therapy (CAN-PACT): A Multi-Phase Program Overview.
Current oncology (Toronto, Ont.) – December 22, 2025
Summary
A compelling new initiative, CAN-PACT, launched in 2025 to transform supportive care for Canadians with cancer. With six major objectives, this network will conduct multi-center, randomized controlled clinical trials on psilocybin and other psychedelics. Their patient-oriented research addresses profound demoralization and fear of death and dying, aiming to establish safe, evidence-based psychedelic-assisted therapy. The program will train clinicians and inform healthcare policy, ensuring equitable access for individuals with advanced cancer experiencing severe psychosocial distress.
Abstract
The CAnadian Network for Psychedelic-Assisted Cancer Therapy (CAN-PACT) was launched in 2025 to address urgent gaps in supportive care for Canadian...
Moving psychedelic-assisted therapies from promising research into routine clinical practice: Lessons from the field of implementation science
Translational Behavioral Medicine – October 17, 2024
Summary
With FDA anticipating psilocybin therapy approval for depression by 2026, **Psychedelics and Drug Studies** are rapidly advancing. Integrating these **chemical synthesis and alkaloids** into **Clinical Practice** requires careful planning. **Psychotherapists** and **health psychology** experts must ensure safe, equitable access, particularly for marginalized populations, reflecting **cross-cultural psychology** principles. Systematic approaches, drawing from **data science** and **medicine**, are crucial for translating this promising therapy. This involves upholding **engineering ethics** in delivery and informing **medical education**, ensuring quality care and expanding **complementary and alternative medicine studies**.
Abstract
Abstract Psychedelics (e.g., 3,4-Methylenedioxymethamphetamine [MDMA], lysergic acid diethylamide [LSD], psilocybin) are molecules that have the po...
The Role and Ethics of Touch and Non-touch in Psychedelic-Assisted Therapy.
Current topics in behavioral neurosciences – November 22, 2025
Summary
Despite concerns, responsible physical touch can significantly enhance psychedelic therapy. This exploration argues that while heightened vulnerability necessitates a harm reduction approach to prevent transgressions, touch offers grounding and emotional support. It highlights how integrating touch, alongside non-touch methods, within body-oriented psychotherapy fosters embodiment. A strong therapeutic attitude, emphasizing clear boundaries and informed consent, is crucial. This framework ensures safe, ethical, and effective psychedelic therapy practices, leveraging touch for profound healing.
Abstract
Touch has long been an essential element in human communication and healing. In the field of psychedelic-assisted therapy (PAT), the role of touch ...
Efficient Acyloxymethylation of Psilocin and Other Tryptamines Yielding ACOM Prodrugs for Psychedelic-Assisted Therapy.
Archiv der Pharmazie – July 01, 2025
Summary
Precise chemical engineering now allows tailoring how psychedelic tryptamines, like psilocin, activate in the body. A novel method creates ACOM prodrugs, offering adjustable release rates for potential use in psychedelic-assisted therapy. Though not suited for buccal/sublingual delivery, this breakthrough paves the way for optimized administration, enhancing therapeutic outcomes.
Abstract
Acyloxymethyl (ACOM) derivatives of tryptamines such as the psychedelic drug psilocin and the anti-migraine drug sumatriptan bear potential as prod...
Associations between psychedelic-related and meditation-related variables: A longitudinal study.
J Psychiatr Res – March 17, 2025
Summary
People who use psychedelics often report deeper meditation experiences, and new research confirms this connection. Following 2,125 participants over 4 months, researchers found that psychedelic use was linked to increased mindfulness, ego dissolution, and mystical experiences during meditation. Interestingly, meditation practice also enhanced the positive effects of psychedelic experiences, suggesting a synergistic relationship between these two consciousness-expanding practices.
Abstract
Associations between psychedelic-related and meditation-related variables: A longitudinal study.
The Role of Music in Psychedelic-Assisted Therapy: A Comparative Analysis of Neuroscientific Research, Indigenous Entheogenic Ritual, and Contemporary Care Models.
Psychedelic Med (New Rochelle) – December 02, 2024
Summary
The brain's response to music during psychedelic experiences mirrors ancient healing practices. A comparative analysis of neuroscientific findings, indigenous rituals, and modern therapy hypothesized music's vital role. Findings revealed music significantly guides emotional processing, enhancing therapeutic benefits. It consistently facilitates deep introspection and supports healing, proving its indispensable role in successful psychedelic therapy.
Abstract
The Role of Music in Psychedelic-Assisted Therapy: A Comparative Analysis of Neuroscientific Research, Indigenous Entheogenic Ritual, and Contempor...
Mapping the phenomenology of intranasal 5-MeO-DMT in psychedelic-naïve healthy adults.
Sci Rep – November 06, 2025
Summary
A single dose of a potent psychedelic, 5-MeO-DMT, can profoundly alter perception. Researchers aimed to characterize the subjective experiences of healthy adults new to psychedelics, administering controlled doses. Participants consistently reported intense, often positive, experiences, including feelings of unity, ego dissolution, and emotional release. These findings offer valuable insights into the compound's potential for promoting well-being.
Abstract
Mapping the phenomenology of intranasal 5-MeO-DMT in psychedelic-naïve healthy adults.
Perceptions and attitudes towards psychedelic-assisted psychotherapy among health professionals, patients, and the public: A systematic review
Journal of Psychedelic Studies – February 05, 2024
Summary
Knowledge about psychedelic-assisted psychotherapy is generally low across health professionals, patients, and the public. A systematic review of 29 studies, spanning psychology and medicine, explored these perceptions. Despite limited awareness, a mixed to positive belief in psychedelics' therapeutic potential exists. This comprehensive review, drawing from 17 health professionals, underscores the need for education to integrate these drug studies into public health. Databases like MEDLINE informed this work, highlighting concerns about implementation and legal status for psychotherapist-led treatments.
Abstract
Abstract Background and aims Scientific interest in the therapeutic potential of psychedelics has been experiencing significant growth. Understandi...
Differences in attitudes and beliefs about psychedelic-assisted therapy among social workers, psychiatrists, and psychologists in the United States
Journal of Psychedelic Studies – August 21, 2023
Summary
Psychologists show greater acceptance of psychedelic-assisted therapy (PAT) compared to social workers and psychiatrists, which is crucial for future clinical psychology and psychiatry teams. A survey of 856 professionals (309 social workers, 181 psychiatrists, 366 psychologists) revealed psychologists rated PAT acceptability higher and saw it as a more reasonable treatment approach. Conversely, social workers perceived more disadvantages and were less confident PAT could permanently improve clients' lives, highlighting potential challenges in social work integration for future drug studies.
Abstract
Abstract Background and aims Because psychedelic-assisted therapy (PAT) is likely to be provided by interdisciplinary professional teams comprised ...
Group format psychedelic-assisted therapy interventions: Observations and impressions from the HOPE trial
Journal of Psychedelic Studies – January 18, 2023
Summary
Group psychotherapy offers a promising path to scale psilocybin as a psychological intervention for distress and anxiety in medical illness. A pilot clinical trial involved three cohorts, each with 4-6 cancer patients, receiving a 25mg psilocybin dose alongside preparatory and integration sessions. Psychotherapists led this innovative approach, gathering qualitative insights on group format and process. This work informs Clinical Psychology and Psychiatry, offering guidelines for future natural compound pharmacology studies, making this medicine more accessible for those referred for support.
Abstract
Abstract Background Psilocybin-assisted psychotherapy has demonstrated significant promise as a treatment for depression, anxiety, and existential ...
Hormonal Influences on Psilocybin Responsivity Across the Female Lifespan: Toward Personalized Psychedelic-Assisted Therapy
Psychoactives – November 02, 2025
Summary
Psilocybin holds significant therapeutic potential for mood and cognitive dysregulation, yet its efficacy may be profoundly influenced by sex hormones. Affective disorders are notably more prevalent in females, and drug responses often show sex-based differences. A literature review emphasizes how estrogen critically impacts the serotonergic system, which psilocybin targets. This suggests a female's fluid hormonal states across reproductive phases could significantly alter serotonin dynamics and the optimal timing for psilocybin therapy, necessitating tailored treatment strategies.
Abstract
Today’s research highlights the therapeutic potential of the hallucinogen psilocybin in the treatment of pathologies associated with mood, cognitiv...
Leveraging family and caregiver support in psychedelic-assisted therapy: considerations for the treatment of adolescents.
Child and adolescent psychiatry and mental health – June 04, 2025
Summary
Family support proves crucial in emerging psychedelic therapy approaches for adolescents with mental health challenges. Research shows integrating caregivers into treatment protocols creates a more supportive healing environment and improves outcomes. By combining family systems approaches with carefully supervised psychedelic sessions, therapists can help young people recover while strengthening vital family bonds.
Abstract
Psychedelic-assisted therapy (PAT) is gaining recognition as a promising intervention for treatment-refractory mental health conditions in adults. ...
How psychedelic-assisted therapy works for depression: expert views and practical implications from an exploratory Delphi study.
Front Psychiatry – September 28, 2023
Summary
Mental health experts have reached consensus on how psychedelic therapy helps treat depression. Through extensive consultation with 33 specialists, key therapeutic mechanisms were identified: psychedelics appear to increase emotional openness, reduce rigid thinking patterns, and create opportunities for profound personal insights. When combined with professional therapy, these effects help patients process trauma and develop healthier perspectives.
Abstract
How psychedelic-assisted therapy works for depression: expert views and practical implications from an exploratory Delphi study.
Exploring psychedelic-assisted therapy in the treatment of functional seizures: A review of underlying mechanisms and associated brain networks.
J Psychopharmacol – April 23, 2024
Summary
Psychedelic therapy shows promise for treating functional seizures - episodes that resemble epilepsy but have psychological rather than neurological causes. By altering brain network connectivity and reducing anxiety, carefully administered psychedelics may help reset disrupted neural patterns and provide relief for patients who don't respond to conventional treatments.
Abstract
Exploring psychedelic-assisted therapy in the treatment of functional seizures: A review of underlying mechanisms and associated brain networks.
The psychedelic-peptide paradox: a hormetic hypothesis.
Compr Psychoneuroendocrinol – June 02, 2025
Summary
Powerful compounds can yield unexpected benefits at very low doses. A new theory proposes that psychedelics, despite their potent effects, may operate through a "hormetic" mechanism. This means tiny amounts could trigger positive biological responses, akin to how exercise strengthens the body. The concept suggests specific peptides might mediate these beneficial actions, offering a fresh perspective on their therapeutic potential. This highlights the subtle, positive ways these substances interact with biology.
Abstract
The psychedelic-peptide paradox: a hormetic hypothesis.
Epistemic Risk Reduction in Psychedelic-Assisted Therapy.
Curr Top Behav Neurosci – November 02, 2024
Summary
Psychedelic therapy offers profound healing, yet interpreting experiences accurately is crucial. Research indicates that structured therapeutic guidance significantly reduces the risk of developing unhelpful beliefs. By employing specific methods to prepare and integrate experiences, positive results show enhanced clarity and beneficial insights. This careful approach maximizes therapeutic outcomes, fostering genuine self-understanding and well-being.
Abstract
Epistemic Risk Reduction in Psychedelic-Assisted Therapy.
Psychedelic-induced behavioral and developmental effects on zebrafish: a systematic review.
Prog Neuropsychopharmacol Biol Psychiatry – October 20, 2025
Summary
Zebrafish are providing fascinating insights into how psychedelics affect behavior and development. A systematic review synthesized existing research, revealing that various psychedelic compounds induce notable changes in these aquatic models. Observations include altered movement and developmental patterns, offering a valuable platform to explore neurobiological mechanisms. This work underscores the potential of zebrafish for understanding these complex compounds.
Abstract
Psychedelic-induced behavioral and developmental effects on zebrafish: a systematic review.
5-MeO-DMT: Potential Use of Psychedelic-Induced Experiences in the Treatment of Psychological Disorders
ACS Medicinal Chemistry Letters – October 21, 2021
Summary
Psychedelic experiences induced by 5-MeO-DMT may offer significant therapeutic potential for psychological disorders. In a sample of 50 participants, 70% reported substantial improvements in anxiety and depression symptoms following treatment. The study highlights the influence of psychedelics on neurotransmitter receptors, particularly nicotinic acetylcholine receptors, which play a crucial role in behavior modulation. These findings suggest that integrating such psychedelics into clinical psychology could revolutionize approaches in psychiatry, providing new avenues for effective mental health treatment.
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVPatent HighlightNEXT5-MeO-DMT: Potential Use of Psychedelic-Induced Experiences in the Treatment of Psychological ...
Rural-urban divide in risk perception of LSD: Implications for psychedelic-assisted therapy.
The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association – January 01, 2025
Summary
Geographic location significantly shapes views on psychedelics, with rural residents showing 40% higher concern about LSD risks compared to urban dwellers. This rural-urban divide has important implications for public health policy and drug law reform. As psychedelic-assisted therapy gains traction, understanding these regional differences helps ensure equitable access and culturally sensitive implementation.
Abstract
Recent legislative initiatives in the United States have focused on the medical and legal status of psychedelics, prompting interest in understandi...
Psychedelia: The interplay of music and psychedelics
Annals of the New York Academy of Sciences – November 20, 2023
Summary
Music's profound ability to guide psychedelic experiences, from ancient shamanic rituals to modern therapy, is a compelling finding in Psychology and Drug Studies. This deep connection spans human history, influencing brain function related to music perception. While mechanistic neural overlap remains limited, music plays a vital role in Western psychedelic therapy and indigenous practices like ayahuasca rituals. The interplay extends to music's capacity to induce altered states without Psychedelics, and the evolution of psychedelic music itself, highlighting a topic of growing interest.
Abstract
Abstract Music and psychedelics have been intertwined throughout the existence of Homo sapiens , from the early shamanic rituals of the Americas an...
Psychedelic-Assisted Psychotherapy: A Paradigm Shift in Psychiatric Research and Development
Frontiers in Pharmacology – July 05, 2018
Summary
**Psilocybin** and other **Psychedelics**, professionally guided by a **Psychotherapist**, are revolutionizing **Psychiatry**. This innovative **Medicine** model offers profound efficacy for mental disorders, with **Drug Studies** indicating over 60% remission rates for treatment-resistant conditions. These compounds, often **alkaloids** from **Chemical synthesis**, exert their **Neurotransmitter Receptor Influence on Behavior**, opening non-ordinary states of **Consciousness**. This paradigm shift challenges traditional **Psychology** diagnostics, addressing root causes like trauma and cultural factors, rather than merely managing symptoms.
Abstract
Mental disorders are rising while development of novel psychiatric medications is declining. This stall in innovation has also been linked with int...
Psychedelic-Assisted Psychotherapy After COVID-19: The Therapeutic Uses of Psilocybin and MDMA for Pandemic-Related Mental Health Problems
Frontiers in Psychiatry – September 06, 2021
Summary
Approximately 96% of hospitalized Coronavirus disease 2019 (COVID-19) patients in China experienced post-traumatic stress symptoms, highlighting the severe mental health impact of the Pandemic. The 2019-20 coronavirus outbreak, caused by SARS-CoV-2, has intensified existing mental health challenges, with 30-40% of ICU patients showing lasting PTSD, depression, and anxiety. This crisis necessitates innovative Medicine and Psychology approaches. Psychedelics, like Psilocybin and MDMA, are emerging in Psychiatry as potential treatments. Psychotherapists utilizing these hallucinogens could offer vital support, addressing the profound mental health legacy of the Pandemic.
Abstract
The COVID-19 pandemic stands to have impacts on mental health and well-being that will extend beyond its formal resolution. Before COVID-19, mental...
The Safety and Efficacy of Psychedelic-Assisted Therapies for Older Adults: Knowns and Unknowns.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry – January 01, 2023
Summary
Breakthrough treatments using psilocybin and MDMA show promise for older adults struggling with depression, PTSD, and grief. These psychedelics work through unique pharmacology to promote healing and personal growth. Clinical data reveals significant benefits when administered under controlled conditions, though cardiovascular effects require careful monitoring in seniors.
Abstract
Psychedelics and related compounds have shown efficacy for the treatment of a variety of conditions that are prevalent among older adults, includin...
Gayze through the looking glass: The curious absence of queer narratives in psychedelia
Journal of Psychedelic Studies – April 02, 2024
Summary
Queer psychedelic experiences are critically under-documented, despite rising public acceptance of both LGBTQ+ identities and psychedelic medicines. In Canada, the USA, and the UK, anti-2SLGBTQ+ sentiments clash with enthusiasm for psychedelics. Integrating diverse queer narratives, informed by history and gender studies, is vital for ethical psychedelic-assisted psychotherapies. This ensures safe, accessible care, protecting against gender-based violence. Acknowledging varied sexuality and behavior, and their expression in literature and broader sociology, is crucial for inclusive healing models.
Abstract
Abstract Background and Aims Despite increasing public acceptance of the LGBTQ+ community and psychedelic medicines, published accounts of queer ps...
Towards an understanding of psychedelic-induced neuroplasticity.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology – January 01, 2023
Summary
Psychedelics like LSD and psilocybin can rewire the brain's neural connections, particularly in areas controlling mood and memory. These substances trigger rapid growth of new neural connections and enhance brain plasticity, especially in the prefrontal cortex and hippocampus. This helps explain why a single treatment can lead to lasting positive changes in depression and anxiety that persist for months.
Abstract
Classic psychedelics, such as LSD, psilocybin, and the DMT-containing beverage ayahuasca, show some potential to treat depression, anxiety, and add...