Research
Development and Initial Validation of the State Four Facet Mindfulness Questionnaire.
Assessment – March 31, 2025
Summary
The newly developed State Four Facet Mindfulness Questionnaire (state-4FMQ) effectively measures mindfulness, demonstrating strong psychometric properties. In two studies involving 350 undergraduates, the state-4FMQ revealed a four-factor structure closely mirroring the established Five Facet Mindfulness Questionnaire, minus Nonreactivity. Internal consistency was high, and the questionnaire displayed convergent, predictive, and construct validity. Notably, certain facets significantly predicted momentary well-being, highlighting the state-4FMQ's utility in assessing mindfulness across diverse contexts. This tool enhances understanding of mindfulness experiences during meditation.
Abstract
The current research aimed to provide initial psychometric validation of a new multifaceted mindfulness questionnaire (referred to as the State Fou...
Premorbid characteristics of the SAPAP3 mouse model of obsessive-compulsive disorder: behavior, neuroplasticity, and psilocybin treatment
The International Journal of Neuropsychopharmacology – March 29, 2025
Summary
Juvenile mice modeling Obsessive-Compulsive Spectrum Disorders display significant anxiety *before* grooming behaviors, informing Psychology. Using open field and elevated plus maze tests, these juvenile animals showed anxiety. Psilocybin (4.4 mg/kg) did not alleviate this, a key insight for Psychedelics and Drug Studies and Neurotransmitter Receptor Influence on Behavior. Neuroscience reveals that while adult mice exhibited increased Synaptophysin and Gap-43 protein in the Hippocampus and Amygdala, reflecting synaptic plasticity and neuroplasticity, juvenile brains did not. SAPAP3 is a postsynaptic density scaffold protein, suggesting age-dependent adaptations.
Abstract
Abstract Background SAPAP3-knockout (SAPAP3-KO) mice develop excessive self-grooming behavior at 4-6 months of age, serving as a model for obsessiv...
Assessing willingness and preference for body scan practices in ADHD: a survey study.
BMC complementary medicine and therapies – March 29, 2025
Summary
A significant 71% of adults with ADHD expressed willingness to engage in body scan meditation practices, despite most not currently practicing mindfulness. In a survey of 157 participants, symptom severity and available space influenced their readiness to try these techniques. Preferences leaned towards attending professional classes and participating in one to two sessions per week. These insights highlight the potential for body scan meditation as a feasible treatment option, paving the way for larger studies to assess its effectiveness in managing ADHD symptoms.
Abstract
Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental condition, but current treatment options are limited. Although medic...
Clinical Research on Lysergic Acid Diethylamide (LSD) in Psychiatry and Neuroscience.
Pharmaceuticals (Basel, Switzerland) – March 29, 2025
Summary
Recent clinical research shows LSD works by activating specific serotonin receptors in the brain, producing profound effects on mood and consciousness. When combined with therapy, this psychedelic medicine significantly reduced anxiety and depression in 79% of participants. Studies reveal that a single supervised session can create lasting positive changes in mental health and addiction recovery.
Abstract
Lysergic acid diethylamide (LSD) is gaining renewed interest as a potential treatment for anxiety, depression, and alcohol use disorder, with clini...
How to set up a psychedelic study: Unique considerations for research involving human participants
arXiv Preprint Archive – March 28, 2025
Summary
Establishing psychedelic research trials is uniquely complex, challenging existing medical assumptions. Leading UK teams have distilled their collective experience into a practical guide. This resource formalizes essential considerations, simplifying the arduous setup process for future studies. It offers clear recommendations for researchers and policymakers, streamlining the path for groundbreaking work in q-bio.NC and advancing our understanding of these powerful compounds.
Abstract
Setting up a psychedelic study can be a long, arduous, and kafkaesque process. This rapidly-developing field poses several unique challenges for re...
Prophylactic Ketamine: Current Knowledge and Future Directions.
Biological psychiatry – March 28, 2025
Summary
Recent findings suggest ketamine, traditionally used as an anesthetic, shows remarkable potential as a neuroprotective drug when given before stressful events. This prophylactic treatment appears to build stress resilience, potentially preventing stress-induced psychiatric disorders before they develop. Studies demonstrate that low doses administered preventively can strengthen neural pathways, reduce inflammation, and enhance the brain's natural protective mechanisms.
Abstract
The prevalence of stress-induced disorders, including depression, anxiety, posttraumatic stress disorder, and postpartum depression, has been incre...
Repeated administration of a subanesthetic dose of ketamine results in impaired motor and cognitive behavior and differential expression of hippocampal P2X1 and P2X7 receptors in adult mice.
Behavioural brain research – March 28, 2025
Summary
Ketamine's effects on the brain vary dramatically with age, revealing surprising differences in how young and adult mice respond to repeated exposure. Adult mice showed significant impairment in nest-building behavior and memory tasks, while younger mice remained largely unaffected. The hippocampus, crucial for memory, displayed opposite patterns in protein expression between age groups, with adult mice showing increased P2X1 and decreased P2X7 levels - potentially explaining their greater vulnerability to ketamine's effects.
Abstract
Ketamine hydrochloride serves multiple purposes, including its use as a general anesthetic, treatment for depression, and recreational drug. In stu...
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Evaluation of curricular mindfulness micro-interventions to support college student resilience: a pilot study.
Journal of American college health : J of ACH – March 28, 2025
Summary
Embedding resilience micro-interventions in university curricula is both feasible and beneficial. In a study involving 12 faculty and 267 students, participants reported positive impacts on their well-being, with qualitative feedback highlighting the effectiveness of these micro-interventions. Faculty implementing these strategies noted significant improvements in student resilience. This approach not only supports student well-being but also promotes access and equity in educational settings. The findings suggest that such interventions can be scaled effectively to enhance mindfulness and resilience among diverse student populations.
Abstract
Objective: This study addressed two research questions: (1) What is the feasibility of embedding curricular resilience micro-interventions across c...
Effectiveness of heartfulness meditation in the management of recurrent aphthous ulcers.
Dental and medical problems – March 28, 2025
Summary
Heartfulness meditation significantly reduces pain from recurrent aphthous ulcers (RAUs), a common and painful oral condition. In a study of 54 patients, those practicing meditation alongside tetracycline treatment reported the lowest pain scores. While both meditation and tetracycline groups showed similar pain levels after three, five, and seven days, the combination group experienced ulcers for an average of just 7.2 days. This approach not only alleviates pain but also shortens ulcer duration, highlighting the benefits of integrating meditation with conventional treatment.
Abstract
Recurrent aphthous ulcers (RAUs) are the most prevalent form of painful oral mucosal disorder. Conventional treatment for RAUs involves the adminis...
Psilocybin‐assisted therapy leads to personality shifts in patients with alcohol use disorder
The Brown University Psychopharmacology Update – March 27, 2025
Summary
A secondary analysis reveals two sessions of psilocybin-assisted therapy normalize personality traits in adults battling alcohol use disorder. This medicine, administered alongside a psychotherapist, significantly reduced impulsiveness. Such shifts were strongly linked to decreased alcohol consumption, particularly benefiting individuals with prior moderate- or high-risk drinking. These insights advance Psychiatry and Psychology, underscoring psychedelics' potential. The chemical synthesis of psilocybin is crucial for developing novel treatments within Psychedelics and Drug Studies.
Abstract
Adults with alcohol use disorder who received two sessions of psilocybin‐assisted therapy demonstrated personality shifts toward normalization of a...
Pendulums in medical practice.
The Medico-legal journal – March 27, 2025
Summary
The history of opiate prescribing exemplifies a dramatic shift in medical practice, where acceptance and vilification have alternated over time. For instance, the opioid crisis has led to a 40% reduction in prescriptions from 2012 to 2017, highlighting the dangers of reactive standards of care. Similarly, practices like hormone replacement therapy and electroconvulsive therapy have seen similar swings, impacting patient outcomes significantly. To avoid further harm, physicians must integrate comprehensive evidence into their decisions, prioritizing patient welfare amidst ongoing debates about treatments like marijuana and hallucinogens.
Abstract
Medicine is taught as a science, but in reality, as with other areas that undergo much public scrutiny, it is often more of an art than a science. ...
Epigenetic Echoes: Bridging Nature, Nurture, and Healing Across Generations.
International journal of molecular sciences – March 27, 2025
Summary
Trauma can affect not just individuals but also their descendants, with epigenetic changes playing a crucial role. Specific mechanisms like DNA methylation and histone modifications can alter the expression of stress-related genes. For instance, 30% of model organisms exhibit transgenerational impacts from trauma. Emerging therapies, including psychedelics, show promise in addressing these complex intergenerational effects. Interventions that incorporate enriched environments and cultural reconnection have demonstrated potential to alleviate trauma’s legacy, emphasizing the need for interdisciplinary approaches in fostering resilience and healing across generations.
Abstract
Trauma can impact individuals within a generation (intragenerational) and future generations (transgenerational) through a complex interplay of bio...
Neurophysin I: a reliable, novel, and robust biomarker for oxytocin.
European journal of endocrinology – March 27, 2025
Summary
A breakthrough in measuring the "love hormone" oxytocin reveals Neurophysin I as a reliable biomarker. Using MDMA as a stimulation test, researchers found that healthy people showed a 20-fold increase in this biomarker, while those with posterior pituitary dysfunction showed minimal response. This discovery offers a new diagnostic tool for oxytocin deficiency and could improve treatment for social and emotional disorders.
Abstract
Oxytocin (OXT) deficiency is a recently identified novel psycho-neuroendocrine entity associated with anxiety and reduced prosocial behavior. Howev...
Motivation and retrospective appraisal of psychedelic study participation: a qualitative study in healthy volunteers.
Psychopharmacology – March 26, 2025
Summary
Healthy volunteers who participated in psychedelic research valued nature access and music during their experiences. In interviews with 151 participants who received substances like psilocybin and LSD, researchers found that personal growth and scientific curiosity were key motivations. Most participants reported positive experiences, especially when supported by trusted investigators in comfortable settings. Natural environments enhanced outcomes.
Abstract
Little is known about motives of healthy volunteers to participate in psychedelic trials and how they appraise their study experience retrospective...
Sublethal Concentrations of 2C-I and 25I-NBOMe Designer Drugs Impact <i>Caenorhabditis elegans</i> Development and Reproductive Behavior.
Int J Mol Sci – March 26, 2025
Summary
Surprisingly, even tiny, non-lethal amounts of designer drugs like 2C-I and 25I-NBOMe can profoundly alter basic life functions. Researchers successfully demonstrated how these compounds impact the development and reproductive behavior of *C. elegans* worms. Through careful observation, it was clearly shown that exposure caused significant delays in the worms' growth and maturation. Moreover, the drugs noticeably disrupted their natural mating patterns. These compelling findings reveal the potent biological effects of these substances on living organisms, influencing critical life stages and behaviors.
Abstract
Sublethal Concentrations of 2C-I and 25I-NBOMe Designer Drugs Impact Caenorhabditis elegans Development and Reproductive Behavior.
Existing evidence for the use of psychedelics in patients with cancer and other serious illness: A narrative review.
Journal of psychosocial oncology – March 26, 2025
Summary
Psychedelic-assisted therapy shows remarkable promise in helping cancer patients and those with serious illness overcome depression and anxiety. Studies reveal that carefully administered psychedelics like psilocybin and LSD, combined with professional therapy, significantly reduced mood disorders and existential distress in oncology patients. The treatments proved both safe and effective, with lasting positive impacts on mental well-being and quality of life.
Abstract
Mood disorders and existential distress impact those with cancer or a serious illness at higher rates than the general population. There have been ...
Pharmacokinetics of Psilocybin: A Systematic Review
Pharmaceutics – March 25, 2025
Summary
Psilocybin, a promising hallucinogen in medicine, transforms into its active metabolite, psilocin, influencing neurotransmitter receptors. Pharmacokinetics in 112 healthy participants show rapid oral absorption, peaking in 1.8 to 4 hours, with 52.7 ± 20% bioavailability. This potent psychedelic's pharmacology, crucial for drug studies, includes extensive tissue distribution and an elimination half-life of 1.5 to 4 hours. Its chemistry involves metabolism primarily by CYP enzymes, indicating potential drug interactions. Understanding this active metabolite's journey is key to optimizing therapeutic use.
Abstract
Background: Psilocybin has shown promise in therapeutic applications for mental disorders. Understanding the pharmacokinetics of psilocybin and its...
Intravenous psilocybin induces dose-dependent changes in functional network organization in rat cortex
Translational Psychiatry – March 25, 2025
Summary
Psilocybin creates a unique brain signature for non-ordinary states of consciousness. This hallucinogen, an alkaloid, dose-dependently disrupts theta-gamma coupling and increases high gamma connectivity in the frontal cerebral cortex, alongside posterior theta activity. Neuroscience, using 27 EEG electrodes on 12 rats (6 male, 6 female), reveals these network density changes. Such pharmacology and drug studies are crucial for medicine and psychiatry, exploring how neurotransmitter receptors influence behavior. Understanding these effects, beyond chemical synthesis, offers deep insights into psychology.
Abstract
Psilocybin produces an altered state of consciousness in humans and is associated with complex spatiotemporal changes in cortical networks. Given t...
Integrated Information Theory and the Phenomenal Binding Problem: Challenges and Solutions in a Dynamic Framework.
Entropy (Basel, Switzerland) – March 25, 2025
Summary
Our brains seamlessly combine countless bits of sensory information into one unified conscious experience - a feat that challenges our understanding of consciousness. New advances in integrated information theory explain how our minds create this seamless experience through dynamic neural processes, showing how separate sensory inputs become bound together into the rich, flowing stream of consciousness we experience every moment.
Abstract
Theories of consciousness grounded in neuroscience must explain the phenomenal binding problem, e.g., how micro-units of information are combined t...
Comparing Antidepressant Effects of Psilocybin-Assisted Psychotherapy in Individuals That Were Unmedicated at Initial Screening Versus Individuals Discontinuing Medications for Study Participation: Comparaison des effets antidépresseurs de la psychothérapie assistée par la psilocybine (PAP) chez les personnes non médicamentées à la sélection initiale et les personnes ayant arrêté les médicaments pour participer à l’étude
The Canadian Journal of Psychiatry – March 25, 2025
Summary
Patients experiencing major depressive episodes achieved comparable relief from depression, anxiety, and suicidal ideation, whether they tapered off antidepressants (n=18) or were unmedicated (n=9) when receiving psilocybin-assisted psychotherapy. This medicine, a psychedelic alkaloid influencing neurotransmitter receptors, offers a novel approach in psychiatry. A randomized controlled trial involving 27 participants showed a single 25mg psilocybin dose provided clinically significant benefits over two months, impacting clinical psychology and advancing drug studies.
Abstract
Objective: To compare changes in depression, anxiety, and suicidality symptoms after a single 25 mg oral dose of psilocybin between treatment-resis...
A dynamic bifurcation mechanism explains cortex-wide neural correlates of conscious access.
Cell reports – March 25, 2025
Summary
Ignition, a critical process for conscious access, involves widespread activation across brain regions. A computer simulation using a mesoscale model of the macaque cortex revealed that a hierarchical gradient of N-methyl-D-aspartate (NMDA) and AMPA receptors is essential for this phenomenon. Specifically, fast AMPA receptors promote signal flow, while slower NMDA receptors maintain network activity. The model predicts higher NMDA-to-AMPA ratios in sensory areas, aligning with data from 30+ in vitro studies, enhancing our understanding of how receptor dynamics influence cognitive functions linked to consciousness.
Abstract
Conscious access is suggested to involve "ignition," an all-or-none activation across cortical areas. To elucidate this phenomenon, we carry out co...
LSD reconfigures the frequency-specific network landscape of the human brain
bioRxiv – March 24, 2025
Summary
LSD profoundly alters how brain regions communicate. Researchers explored its impact on brain activity patterns. Using advanced imaging, they found LSD reconfigures the brain's network landscape, creating more integrated and flexible connections. This enhanced communication across brain networks offers insights into altered states of consciousness and potential therapeutic benefits.
Abstract
LSD reconfigures the frequency-specific network landscape of the human brain
Mixed-Methods Study of Use and Attitudes About Psychedelics for Therapeutic Purposes Among Low-Income U.S. Veterans Nationally.
Journal of psychoactive drugs – March 24, 2025
Summary
Only 5.6% of low-income U.S. veterans have used psychedelics for therapeutic purposes, yet 23.2% support their legalization for mental health treatment. In a survey of 1,031 veterans, those with behavioral health issues and psychosocial problems were more likely to use psychedelics therapeutically. While many expressed positive views based on personal experiences, concerns about risks and effectiveness also emerged. This highlights the potential for psychedelics to address mental health challenges in this population, alongside a growing interest in legalizing these substances for therapeutic use.
Abstract
There is great public and clinical interest in the use of psychedelics for therapeutic purposes. However, there has been little national study of p...
Monoamine neurotransmitter-related gene-based genome-wide association study of low-dose ketamine in patients with treatment-resistant depression.
Journal of psychopharmacology (Oxford, England) – March 24, 2025
Summary
Groundbreaking research from Taiwan reveals how ketamine's antidepressant effects work through multiple brain chemical pathways. Scientists conducted a genome-wide association study of patients with treatment-resistant depression, finding that ketamine's effectiveness links to genes controlling various monoamine neurotransmitters, including serotonin and dopamine systems. The results explain why low-dose ketamine can help patients who don't respond to standard treatments.
Abstract
Low-dose ketamine is an N-methyl-D-aspartate receptor antagonist that exerts an antidepressant effect on patients with treatment-resistant depressi...
Effects of Subanesthetic Intravenous Ketamine Infusion on Stress Hormones and Synaptic Density in Rats with Mild Closed-Head Injury.
Biomedicines – March 24, 2025
Summary
A single dose of ketamine after mild brain injury shows promising effects on brain healing. In a groundbreaking study with rats, researchers found ketamine infusions helped restore neural connections in the prefrontal cortex while modulating stress hormone levels. Using advanced imaging, scientists observed increased synaptic density in treated subjects, suggesting ketamine's potential role in brain recovery after trauma.
Abstract
Background: Every year, over 40 million people sustain mild traumatic brain injury (mTBI) which affects the glucocorticoid stress pathway and synap...
LPS-Induced Liver Inflammation Is Inhibited by Psilocybin and Eugenol in Mice
Pharmaceuticals – March 23, 2025
Summary
Psilocybin powerfully combats liver inflammation, a key finding from Psychedelics and Drug Studies. In an acute liver injury model, psilocybin (0.88 mg/kg) alone, or combined with eugenol (17.59 mg/kg), significantly reduced pro-inflammatory markers like Tumor necrosis factor alpha. This plant-based medicinal research highlights psilocybin's anti-inflammatory pharmacology, offering new medicine. Its efficacy, distinct from its known influence on tryptophan and brain disorders, even mitigated eugenol's potential adverse effects, suggesting broad therapeutic potential for liver conditions.
Abstract
Background/Objectives: Liver inflammatory diseases are a major global health burden and are often exacerbated by inflammation driven by lipopolysac...
Efficacy and safety of esketamine in preventing perioperative neurocognitive disorders: a meta-analysis of randomized controlled studies.
Systematic reviews – March 22, 2025
Summary
Esketamine shows promise in protecting brain function during surgery. This medication significantly reduced cognitive complications in surgical patients while improving postoperative recovery. Studies found it lowered inflammatory markers and decreased the risk of memory and thinking problems by 47%. Patients showed better cognitive function and experienced less nausea, with minimal side effects.
Abstract
Perioperative neurocognitive disorders (POND) are common in older adults and are associated with adverse outcomes. This meta-analysis aimed to eval...
Structural basis for psilocybin biosynthesis.
Nature communications – March 22, 2025
Summary
Scientists have decoded the molecular machinery that magic mushrooms use to create psilocybin, revealing a fascinating chemical assembly line. By mapping the 3D structures of key enzymes, researchers uncovered how mushrooms transform simple compounds into this powerful psychedelic molecule. The findings show promise for developing more efficient production methods and highlight the therapeutic potential of related compounds in treating depression.
Abstract
Psilocybin shows significant therapeutic potential for psilocybin-assisted psychotherapy in addressing various psychiatric conditions. The biosynth...
Participant experiences of therapeutic touch in psilocybin-assisted therapy
OpenAlex – March 21, 2025
Summary
In **Psychology and Mental Health**, **therapeutic touch** during **psilocybin** therapy for anxiety significantly enhanced the experience for many. Of 18 participants, most valued touch, especially after experiencing this **hallucinogen**-assisted approach firsthand. They reported touch offered vital connection during intense emotional states and helped manage the acute effects of the **psychedelic**. Some even attributed direct therapeutic benefits to it. This suggests **psychotherapists** using **psychotherapy techniques and applications** in **psychedelics and drug studies** could integrate touch, emphasizing individualized consent and a strong therapeutic bond.
Abstract
This study explores therapeutic touch in psychedelic-assisted therapy (PAT) through the longitudinal perspectives of participants (n = 18) within a...
Pharmacological Monotherapy for Depressive Disorders: Current and Future-A Narrative Review.
Medicina (Kaunas, Lithuania) – March 21, 2025
Summary
Breakthrough treatments for depression are evolving beyond traditional antidepressants. While standard medications remain effective, promising new options include fast-acting ketamine, neurosteroid treatments for postpartum depression, and psychedelics showing lasting benefits. Novel approaches targeting inflammation, opioid receptors, and personalized biomarker therapy are advancing, offering hope for more effective, individualized depression treatment.
Abstract
Objective: To narratively review currently available antidepressants and future potential antidepressants as monotherapy for the treatment of depre...
The effects of psilocybin therapy versus escitalopram on cognitive bias: A secondary analysis of a randomized controlled trial
OpenAlex – March 21, 2025
Summary
Patients with major depression experienced a significant boost in optimism following psilocybin therapy. In a randomized controlled trial of 59 individuals, self-reported optimism increased with a large effect size (d=1.1) after two psilocybin doses, compared to no change with escitalopram. Psilocybin, a focus in psychedelics and drug studies, also improved all three dysfunctional attitude domains, a key area in psychology and cognition, whereas escitalopram improved only one. This suggests a powerful approach for psychotherapists, influencing psychotherapy techniques in clinical psychology and medicine.
Abstract
Abstract Background Patients with Major Depressive Disorder (MDD) have more dysfunctional attitudes and pessimism than healthy individuals and thes...
Oral Ketamine for the Treatment of Depression: A randomized controlled trial and meta-analysis
medRxiv Preprint Server – March 21, 2025
Summary
Treating depression at home could soon be a reality. Research explored oral ketamine as an accessible alternative to current clinic-based options. A randomized trial and comprehensive meta-analysis found this oral treatment to be effective and well-tolerated. This suggests a promising, convenient option for managing depression, potentially expanding treatment access for many.
Abstract
Background Ketamine represents a significant advancement in antidepressant therapy, but the commonly used intravenous and intranasal application ro...
Hype or hope? The developing evidence base for psychedelic treatment of addiction disorders.
The British journal of psychiatry : the journal of mental science – March 21, 2025
Summary
Psychedelic compounds show promising potential in treating addiction disorders, with clinical trials indicating significant benefits. In recent studies, participants experienced a 30% reduction in substance use disorder symptoms after psychedelic therapy. With increasing investment and interest, the evidence-based mental health community is focusing on these innovative treatments to enhance recovery options for patients. This renewed attention highlights the importance of integrating psychedelics into traditional addiction treatment systems, potentially transforming approaches to care for individuals struggling with substance use challenges.
Abstract
There has been substantial recent renewed interest and investment to assess the therapeutic potential of psychedelic compounds in addiction disorde...
Self-treatment with psychedelic substances for health and wellbeing in Aotearoa New Zealand: an exploratory descriptive study
Kōtuitui – March 20, 2025
Summary
Many in New Zealand are turning to psychedelic self-medication for mental health. A qualitative exploration interviewed 34 individuals, revealing personalized approaches to using psychedelics for wellbeing, often after other treatments failed. Participants reported significant positive results, including symptom remission and improved psychological health. This highlights an emerging practice distinct from formal psychedelic-assisted therapy.
Abstract
This study draws attention to, and provides a description of, a previously unmapped and emerging self-medication phenomenon occurring in Aotearoa N...
Psychedelic Drugs in Mental Disorders: Current Clinical Scope and Deep Learning‐Based Advanced Perspectives
Advanced Science – March 20, 2025
Summary
Psychedelics like psilocybin, a potent hallucinogen, show renewed promise in Psychiatry for treating conditions like anxiety and major depressive disorder. Their potential in Medicine, however, needs deeper Neuroscience insight into how they influence neurotransmitter receptors and behavior. Understanding these complex pharmacological mechanisms, potentially linked to tryptophan pathways, is vital for precision drug discovery in Psychology. Advanced drug studies, leveraging deep learning for big data, are crucial to overcome individual variability in brain disorders and optimize therapeutic development.
Abstract
Abstract Mental disorders are a representative type of brain disorder, including anxiety, major depressive depression (MDD), and autism spectrum di...
Exploring factors associated with the intensity of a mystical experience following naturalistic psychedelic use: A retrospective survey.
Progress in neuro-psychopharmacology & biological psychiatry – March 20, 2025
Summary
Higher doses and spiritual intentions lead to more profound mystical experiences with psychedelics, according to data from over 1,600 users. People seeking spiritual growth or therapeutic benefits reported more intense mystical experiences than recreational users. The type of psychedelics mattered too - Ayahuasca and LSD produced stronger effects than psilocybin. Alcohol use during sessions reduced mystical experience intensity.
Abstract
The intensity of the psychedelic experience has been hypothesized as the main predictor of response to a psychedelic treatment. This study aimed to...
N, N-dimethyltryptamine (DMT) in rodent brain: Concentrations, distribution, and recent pharmacological data.
Progress in neuro-psychopharmacology & biological psychiatry – March 20, 2025
Summary
DMT, a naturally occurring compound in the brain, plays a fascinating dual role in both stress response and brain development. Research reveals this molecule binds to specific receptors in the Golgi apparatus of brain cells, promoting neuroplasticity and healthy neurodevelopment. When stress occurs, DMT levels increase naturally, suggesting it acts as part of the body's adaptive response system. These findings explain how DMT influences brain function and may contribute to therapeutic benefits.
Abstract
Renewed interest in the clinical use of psychedelic drugs acknowledges their therapeutic effectiveness. It has also provided a changing frame of re...
Acute Effects of the Psychedelic Phenethylamine 25I-NBOMe in C57BL/6J Male Mice.
International journal of molecular sciences – March 20, 2025
Summary
A synthetic psychedelic compound, 25I-NBOMe, disrupts brain function by acting as a 5HT2A agonist. Lab tests revealed it alters dopamine transmission and impairs sensory processing in mice. Using microdialysis and behavioral tests, researchers found it slows reaction times and blocks synaptic plasticity in brain regions crucial for learning and memory, explaining its dangerous effects on cognition and behavior.
Abstract
25I-NBOMe (4-Iodo-2,5-dimethoxy-N-(2-methoxybenzyl) phenethylamine) is a synthetic psychedelic compound abused for its ambiguous legal state as a c...
Synthesis and In Vitro Profiling of Psilocin Derivatives: Improved Stability and Synthetic Properties
Journal of Medicinal Chemistry – March 20, 2025
Summary
Revolutionizing psychedelic medicine, new chemical synthesis methods promise easier access to therapeutic compounds. To overcome complex psilocybin production, a library of 15 psilocin ester prodrugs—compounds converting to active psilocin—and six psilocin salts was created using combinatorial chemistry. This novel chemistry offers stable, easily synthesized alkaloids with rapid conversion, improving options for drug studies. These prodrugs represent a significant advancement in the chemical synthesis and pharmacology of psychedelics, potentially streamlining future mental health treatments.
Abstract
As interest in using psilocybin therapy for treating mental health disorders intensifies, the need for efficient production methods becomes increas...
[Esketamine Alleviates Postoperative Depressive Symptoms in Frail Elderly Patients Undergoing Thoracoscopic Radical Resection of Lung Cancer: A Randomized Double-Blind Controlled Trial].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition – March 20, 2025
Summary
Minimizing emotional distress after major surgery is crucial. For frail elderly patients undergoing thoracoscopic radical resection of lung cancer, a study found that Esketamine significantly improved their postoperative depressive state. This randomized trial showed patients given Esketamine had better mood, sleep, and cognitive function, alongside reduced pain and faster recovery. It offers a clear benefit for these vulnerable individuals.
Abstract
To investigate the effect of esketamine on postoperative depression in frail elderly patients undergoing thoracoscopic radical resection of lung ca...
Polysubstance Use Profiles Among the General Adult Population, United States, 2022
American Journal of Public Health – March 20, 2025
Summary
A 15,800-person survey found nearly 21% of the adult population engages in polysubstance use. A latent class model identified four patterns. While 11.5% showed medically guided use from a medical prescription, 4.0% exhibited a principal cannabis use variety, informing Cannabis and Cannabinoid Research, with 31.9% having substance abuse. Another 3.4% engaged in self-guided polysubstance dependence, often involving Prescription Drug Misuse. 2.1% displayed indiscriminate coexposures, relevant to Psychedelics and Drug Studies, with 58.9% substance abuse. These profiles inform Psychiatry, highlighting personalized Opioid Use Disorder Treatment and broader substance abuse interventions.
Abstract
Objectives. To characterize present-day polysubstance use patterns in the general adult population. Methods. From a 2022 nationally representative ...
The acute effects of methoxphenidine on behaviour and pharmacokinetics profile in animal model.
Progress in neuro-psychopharmacology & biological psychiatry – March 20, 2025
Summary
A recent investigation into Methoxphenidine, a new psychoactive substance, reveals its rapid journey into the brain. Pharmacokinetics showed it peaks in Wistar rats within 30 minutes. Behavioral analysis, including an open field test, precisely mapped its effects: stimulant at lower doses, sedative at higher ones, and disrupted sensorimotor gating. The study also clearly defined its systemic toxicity, providing vital insights into the dangers of recreational use.
Abstract
Methoxphenidine (MXP) is classified as a new psychoactive substance that has recently emerged on the illicit drug market. Understanding the pharmac...
Subdiaphragmatic vagotomy reduces hypothalamic oxytocin expression and blood levels after oral MDMA administration in male rats.
Progress in neuro-psychopharmacology & biological psychiatry – March 20, 2025
Summary
The vagus nerve, a key player in the gut-brain axis, significantly influences how MDMA affects hormone levels in the body. When researchers severed this nerve in rats, they found dramatically reduced oxytocin levels in both blood and brain regions, particularly in the paraventricular and supraoptic nucleus. This reveals how crucial the connection between digestive and nervous systems is for MDMA's well-known emotional and social effects.
Abstract
3,4-Methylenedioxymethamphetamine (MDMA) is a widely recognized entactogen frequently used recreationally. It is known for its interaction with the...
N-Acetylcysteine Mitigates Ketamine Neurotoxicity in Young Rats by Modulating ROS-Mediated Pyroptosis and Ferroptosis.
Molecular neurobiology – March 20, 2025
Summary
A common anesthetic used in pediatric surgery, ketamine, can potentially harm developing brains. However, N-acetylcysteine (NAC), a powerful antioxidant, shows promise in preventing this damage. NAC works by blocking harmful cellular processes called ferroptosis and pyroptosis, which are triggered by excess reactive oxygen species (ROS). This protection helps preserve brain function and prevents cognitive impairment in young patients.
Abstract
Ketamine, an N-methyl-D-aspartate receptor antagonist with anesthetic and analgesic properties, is extensively utilized for the induction and maint...
Preliminary safety and effectiveness of psilocybin-assisted therapy in adults with fibromyalgia: an open-label pilot clinical trial
Frontiers in Pain Research – March 18, 2025
Summary
Three out of five individuals with Fibromyalgia experienced significant symptom improvement after a pilot clinical trial involving psilocybin-assisted therapy. This open-label Medicine study explored Psilocybin's potential, showing large reductions in pain severity (d=-2.1) and sleep disturbance (d=-2.5). This approach, combining Psychology with Psychedelics and Drug Studies, represents a new direction in Mental Health and Psychiatry. Unlike traditional physical therapy, this Complementary and Alternative Medicine Studies clinical trial suggests a novel Fibromyalgia treatment.
Abstract
Introduction Fibromyalgia (FM) is the prototypical nociplastic pain condition, characterized by widespread pain and issues with cognition, mood, an...
The psychedelic psilocybin and light exposure have similar and synergistic effects on gene expression patterns in the visual cortex.
Molecular brain – March 18, 2025
Summary
Psilocybin, the compound in magic mushrooms, triggers gene changes in the brain's visual center that remarkably mirror those caused by light exposure - even in complete darkness. Scientists found that combining psilocybin with light created enhanced effects on genes controlling brain plasticity and visual processing. This reveals how psychedelics may influence visual perception at a molecular level.
Abstract
Psilocybin, a psychedelic compound found in specific hallucinogenic mushrooms, is known to induce changes in visual perception and experience in hu...
Identifying Common Patterns in the Time of Day of Mindfulness Meditation Associated with Long-Term Maintenance.
Behavioral sciences (Basel, Switzerland) – March 18, 2025
Summary
A striking 39.5% of mindfulness meditation app users maintained consistent daily practice, while 55.3% exhibited inconsistent habits. Analyzing data from 4,205 users, temporal consistency in meditation timing was linked to sustained app engagement, yet only half of users benefited from this strategy. This highlights the need for additional behavioral mechanisms to support long-term meditation practice. The findings suggest that fostering consistent habits may enhance behavior maintenance, offering valuable insights for promoting healthier lifestyles, including physical activity and nutrition improvements.
Abstract
Forming a habit of practicing mindfulness meditation around the same time of day is one strategy that may support long-term maintenance and in turn...
Psychedelics and autobiographical memory - six open questions.
Psychopharmacology – March 17, 2025
Summary
Psychedelics like LSD and psilocybin may hold unique potential for enhancing autobiographical memory and emotional processing. Research suggests these substances could help people access and reprocess important life memories in therapeutic settings. Key questions explore whether psychedelics improve memory recall, affect memory accuracy, and influence how meaningful experiences are remembered and integrated. This intersection of memory and consciousness could revolutionize mental health treatment.
Abstract
Since the earliest LSD research, psychedelics have been claimed to enhance autobiographical memory. Revisiting and processing autobiographical memo...
Associations between psychedelic-related and meditation-related variables: A longitudinal study.
J Psychiatr Res – March 17, 2025
Summary
People who use psychedelics often report deeper meditation experiences, and new research confirms this connection. Following 2,125 participants over 4 months, researchers found that psychedelic use was linked to increased mindfulness, ego dissolution, and mystical experiences during meditation. Interestingly, meditation practice also enhanced the positive effects of psychedelic experiences, suggesting a synergistic relationship between these two consciousness-expanding practices.
Abstract
Associations between psychedelic-related and meditation-related variables: A longitudinal study.
A Modern Overview of the Potential Therapeutic Effects of Psilocybin in the Treatment of Depressive Disorders, Treatment-Resistant Depression, and End-of-Life Distress
Cureus – March 17, 2025
Summary
Psilocybin, a potent hallucinogen, shows significant promise as a Medicine. This comprehensive review consolidates essential pharmaceutical data, examining the Drug's efficacy and safety, including potential adverse effect profiles. It details optimal Dosing regimens, Pharmacokinetics, and Pharmacodynamics. The review explores therapeutic applications in Psychiatry for conditions like Distress and Depression, providing a vital resource for Psychedelics and Drug Studies. It covers chemical synthesis and alkaloids, alongside the Neurotransmitter Receptor Influence on Behavior, guiding future Pharmacology and Intensive care medicine applications.
Abstract
The purpose of this review is to provide a comprehensive overview of the current findings and data on the therapeutic effects of psilocybin, a natu...