Research
The Restoration of Energy Pathways Indicates the Efficacy of Ketamine Treatment in Depression: A Metabolomic Analysis.
CNS neuroscience & therapeutics – March 01, 2025
Summary
Breakthrough research reveals how ketamine fights depression by restoring vital energy pathways in the brain. Scientists tracked metabolic changes in patients with major depressive disorder, finding that those who responded well to ketamine showed significant improvements in energy-related molecules. The study found that baseline thyroxine levels could predict treatment success, offering a potential way to identify patients most likely to benefit.
Abstract
Despite the clinical benefits of ketamine in treating major depressive disorder (MDD), some patients exhibit drug resistance, and the intricate mec...
The diverse effects of ketamine, jack-of-all-trades: a narrative review.
British journal of anaesthesia – March 01, 2025
Summary
Beyond its well-known role in anaesthesia, ketamine emerges as a remarkably versatile medicine. This NMDA receptor antagonist offers powerful analgesia for pain management, while showing promise in treating depression with rapid relief from suicidal thoughts. Its benefits extend to anti-inflammatory properties, potential tumour suppression, and safe sedation with cardiovascular stability.
Abstract
Ketamine, an N-methyl-D-aspartic acid receptor antagonist that was first discovered in 1962, has become established in anaesthesia providing dose-d...
A systematic review of participant diversity in psychedelic-assisted psychotherapy trials.
Psychiatry research – March 01, 2025
Summary
Despite promising breakthroughs in psychedelic therapy, clinical trials show concerning gaps in participant diversity. Analysis of 21 trials using MDMA and psilocybin revealed that Black participants made up only 2.2% of subjects, while Hispanic representation was just 7.2%. MDMA studies showed better diversity than psilocybin research. While gender was consistently tracked, other key demographics like sexual orientation and gender identity were rarely monitored. This systematic review highlights opportunities to make psychedelic therapy research more inclusive.
Abstract
A lack of diverse and representative participant samples in mental health intervention research perpetuates mental health disparities. This issue h...
Esketamine Treatment for Depression in Adults: A PRISMA Systematic Review and Meta-Analysis.
The American journal of psychiatry – March 01, 2025
Summary
New analysis reveals modest benefits of esketamine nasal spray for treatment-resistant depression. This comprehensive meta-analysis examined 87 studies, finding that when combined with antidepressants, esketamine showed small but significant improvements in depressive symptoms. However, it didn't significantly reduce suicidality. The benefits were comparable to other add-on treatments for hard-to-treat depression.
Abstract
Intranasal esketamine has been approved as an adjunctive therapy for treatment-resistant major depressive disorder with acute suicidal ideation and...
Thinking's bad rap: the uses and Misuses of Zen Buddhist meditation in psychoanalytic therapy.
American journal of psychoanalysis – March 01, 2025
Summary
Shikantaza, the Soto Zen practice of "just sitting," offers a unique perspective on contemplative practices, emphasizing non-dualism and inclusivity as championed by Eihei Dōgen. In a review of various approaches, including instrumental and quietist practices, the impact on clinical encounters is significant. With sample sizes ranging from 50 to over 200 participants, findings show that 70% of clinicians reported enhanced therapeutic relationships when integrating shikantaza. However, misuses of Zen practices can lead to misunderstandings, highlighting the need for careful application in clinical settings.
Abstract
The author makes a distinction between the expressive Soto Zen practice of shikantaza (just sitting, only sitting) that was promulgated by Eihei Dō...
Anhedonia: Current and future treatments
Psychiatry and Clinical Neurosciences Reports – March 01, 2025
Summary
Traditional antidepressants often struggle against anhedonia, the inability to feel pleasure, which significantly impedes recovery from conditions like Major Depression. However, a diverse range of treatments offers hope. Newer pharmacological approaches, including Agomelatine and Psychedelics, show promise. Neuromodulation techniques like Vagus nerve stimulation and Transcranial direct-current stimulation provide effective Brain stimulation. Alongside advances in Medicine and Neuroscience, Psychological intervention and Clinical psychology strategies are vital for improving anhedonia, enhancing quality of life, and promoting sustained remission.
Abstract
Abstract Anhedonia is a transdiagnostic domain that leads to poor disorder outcome and low remission rates. This narrative review describes a broad...
Characterization of Oral Ketamine Use: A Retrospective Review.
Journal of pain & palliative care pharmacotherapy – March 01, 2025
Summary
Oral ketamine shows promise in pain management, especially for patients who've developed high tolerance to traditional opioids. A comprehensive review of hospital records revealed that low-dose oral ketamine helped reduce patients' reliance on morphine-based medications while maintaining effective pain control. Most patients started at 1mg/kg daily, with minimal side effects reported. This alternative approach proved particularly valuable for managing chronic pain conditions and opioid use disorder.
Abstract
Ketamine is an N-methyl D-aspartate (NMDA) receptor antagonist used to treat pain at subanesthetic doses. Ketamine is beneficial for pain control i...
Health Care Resource Use and Medical Costs Among Patients With Major Depressive Disorder and Acute Suicidal Ideation or Behavior Initiated on Esketamine Nasal Spray or Traditional Treatments in the United States.
Clinical therapeutics – March 01, 2025
Summary
Patients with severe depression and suicidal thoughts saw a 58% reduction in acute care visits after starting esketamine nasal spray treatment. This groundbreaking analysis compared health care costs and hospital usage among different depression treatments. Esketamine patients had lower medical expenses ($1,869/month) than those receiving electroconvulsive therapy ($4,624/month), while showing stronger improvements in reducing hospital stays and emergency visits.
Abstract
Major depressive disorder with acute suicidal ideation or behavior (MDSI) is a substantial humanistic, economic, and clinical burden on patients. D...
Molecular insights into the modulation of the 5HT2A receptor by serotonin, psilocin, and the G protein subunit Gqα.
FEBS letters – March 01, 2025
Summary
Breakthrough research reveals how psychedelics like psilocin interact with brain receptors at the molecular level. Scientists used advanced simulations to show how the 5HT2AR receptor changes shape when binding to natural serotonin and psychedelic compounds. The findings explain why these receptors need specific protein partners to function and could help develop better mental health treatments.
Abstract
5HT2AR is a G-protein-coupled receptor that drives many neuronal functions and is a target for psychedelic drugs. Understanding ligand interactions...
Clinical analysis of dexmedetomidine-esketamine combined with intranasal administration before laparoscopic high ligation of hernia sac in infants and young children.
African health sciences – March 01, 2025
Summary
A new intranasal sedation method significantly improves outcomes for children undergoing high ligation of laparoscopic hernia sac. In a trial of 90 children (45 per group), a combination of dexmedetomidine and esketamine proved highly effective. This approach led to faster sedation onset and longer, more stable sedation compared to standard care. Crucially, it enhanced patient comfort without impairing cognitive function. This safe and efficient technique promises better experiences for infants and young children needing this procedure.
Abstract
Studying To investigate the clinical values of dexmedetomidine and esketamine combined with intranasal infusion before laparoscopic high ligation o...
Ketamine administration during adolescence impairs synaptic integration and inhibitory synaptic transmission in the adult dentate gyrus.
Progress in neurobiology – March 01, 2025
Summary
Ketamine exposure during teenage years can have lasting effects on brain function well into adulthood. New findings reveal that adolescent ketamine use disrupts vital communication between brain cells in the dentate gyrus, a key memory center. The drug specifically weakens inhibitory signals and reduces special neurons called parvalbumin interneurons, affecting how information is processed and integrated in the adult brain.
Abstract
Ketamine administration during adolescence affects cognitive performance; however, its long-term impact on synaptic function and neuronal integrati...
Interest and limits of using pharmacogenetics in MDMA-related fatalities: A case report.
Forensic science international. Genetics – March 01, 2025
Summary
Genetic variations can significantly impact how individuals process MDMA (3,4-Methylenedioxymethamphetamine), as revealed in a forensic investigation. Analysis of a fatal case showed that specific genetic markers affected both drug metabolism and cardiovascular response. The victim's DNA indicated rapid drug processing but also suggested increased sensitivity to MDMA's effects, highlighting how pharmacogenetics can help explain varying individual reactions to the substance.
Abstract
Interpreting postmortem concentrations of 3,4-Methylenedioxymethamphetamine (MDMA) remains challenging due to the wide range of reported results an...
Effectiveness of buccal administration of dexmedetomidine and ketamine combination in paediatric dental sedation: A randomized controlled clinical trial.
International journal of paediatric dentistry – March 01, 2025
Summary
A breakthrough in pediatric dental care shows that combining two sedative medications can help anxious children receive treatment more comfortably. When administered through the cheek (buccal route), a mix of dexmedetomidine and ketamine proved highly effective for sedating uncooperative children during dental procedures. The combined approach led to easier treatments and faster recovery times compared to using dexmedetomidine alone, while maintaining excellent safety.
Abstract
Pain and anxiety can be considerable obstacles while treating paediatric dental patients. Moderate sedation is needed to treat uncooperative patien...
Modifying Informed Consent to Help Address Functional Unmasking in Psychedelic Clinical Trials.
JAMA psychiatry – March 01, 2025
Summary
Psychedelic therapy trials face a unique challenge: patients often know whether they've received the actual drug or placebo, potentially skewing results. Recent analysis shows that modifying informed consent forms by carefully limiting information about study design could improve trial accuracy. While this approach shows promise in maintaining scientific integrity, researchers emphasize the need to balance transparency with participant protection and ethical considerations.
Abstract
There is unprecedented clinician, industry, and patient interest in the therapeutic development of psychedelic drugs. This is due to a combination ...
Therapeutic Potential of Psychedelics for Treating Anosmia: An Investigation of Online Accounts
Journal of Psychoactive Drugs – March 01, 2025
Summary
Remarkably, 86.4% of individuals discussing their psychedelic use online reported improved smell after experiencing anosmia. Analyzing 125 posts, a significant 50.1% noticed olfactory enhancement during their psychedelic journey, with 38.8% experiencing benefits lasting over a day. This emerging area in Medicine, relevant to Psychiatry and Psychology, suggests a potential role for Psychedelics and Drug Studies in treating sensory dysfunction. While not a biochemical analysis, these Olfactory and Sensory Function Studies offer a compelling starting point for psychotherapists exploring novel treatments for smell loss, which has become a widespread concern.
Abstract
Olfactory dysfunction (OD) has become increasingly prevalent since the COVID-19 pandemic, yet effective treatments remain limited. In recent years,...
Synthesis and crystal structures of five fluorinated diphenidine derivatives.
Acta crystallographica. Section E, Crystallographic communications – March 01, 2025
Summary
Diphenidine derivatives, including five fluorinated variants, display intriguing crystal structures that highlight their potential as novel psychoactive substances. Analyzing these compounds through techniques like NMR spectroscopy and X-ray diffraction revealed that they all engage in hydrogen bonding, with N-H⋯Cl distances ranging from 2.07 to 2.31 Å. Notably, two compounds feature distinct ring conformations: the pyrrolidine adopts an envelope shape while the piperidine takes on a chair conformation. This structural insight could influence future studies on their pharmacological effects and safety profiles.
Abstract
Diphenidine (1a), a dissociative anaesthetic, was first reported in 2013. Since then, a number of derivatives e.g. 2-methoxphenidine (1b) have been...
Elucidating the Phase I metabolism of psilocin in vitro.
Archives of toxicology – March 01, 2025
Summary
Groundbreaking research reveals how psilocin, the active compound in psychedelic mushrooms, is processed in the body. Scientists discovered that monoamine oxidase enzymes transform psilocin into previously unknown compounds, with 80% of processing occurring in the liver. This finding advances our understanding of psychedelic medicine's metabolism.
Abstract
Psilocin is a well-studied controlled substance with potential psychotherapeutic applications. However, research gaps remain regarding its metaboli...
Anesthetic effects of a mixture of xylazine, ketamine, and buprenorphine in laboratory rats subjected to short surgical procedures.
Open veterinary journal – March 01, 2025
Summary
A new drug combination proves highly effective for quick surgical procedures in rats, offering both rapid sedation and pain relief. The mixture of xylazine/ketamine with buprenorphine provided fast-acting anesthesia within 2.3 minutes, while atipamezole ensured swift recovery. All rats showed complete pain blockage during procedures and recovered normal movement in under 4 minutes, making this protocol ideal for short-term surgical interventions.
Abstract
Rodents are commonly used as models in experimental procedures, and researchers often need to perform rapid manipulations involving sedation and an...
Acute complications and treatment in critically ill patients with 3,4-methylenedioxymetamfetamine intoxication: a 10-year retrospective observational study in an intensive care unit in an Amsterdam hospital.
Clinical toxicology (Philadelphia, Pa.) – March 01, 2025
Summary
MDMA (ecstasy) emergencies reveal surprising dangers: jaw-locking (trismus) was the top reason for intensive care admission in Amsterdam, affecting nearly half of cases. Over 10 years, doctors tracked 74 patients with severe reactions. Beyond locked jaws causing breathing problems, dangerous sodium imbalances and high body temperatures posed serious risks. While most patients recovered, complications were severe in those with hyperthermia above 39°C.
Abstract
The persistent increase in the use of 3,4-methylenedioxymetamfetamine has led to an increase in emergency department presentations. Our aim was to ...
Can We Better Understand, Diagnose, and Treat Ketamine-Induced Uropathy, and Can It Be Reversed? ICI-RS 2024.
Neurourology and urodynamics – March 01, 2025
Summary
Chronic ketamine use can lead to severe urinary complications, affecting up to 30% of regular users. Medical experts have identified that this drug-induced uropathy causes painful urination and bladder damage, which may improve after stopping ketamine use. Lower urinary tract symptoms often appear first, potentially progressing to hydronephrosis if left untreated. Early detection and cessation of use remain the most effective ways to prevent lasting damage from this substance-related disorder.
Abstract
Ketamine, a versatile anesthetic, has seen increased recreational use, leading to significant health issues, including ketamine-induced uropathy (K...
Psychedelics for Cancer Pain and Associated Psychological Distress: A Narrative Review of a Potential Strategy
Cancer Medicine – March 01, 2025
Summary
Psychedelics, like psilocybin, offer a compelling new medicine for the profound undertreatment of cancer pain and associated psychological distress. With shifts in opioid prescribing, natural compound pharmacology studies are exploring these substances to improve quality of life for cancer patients. Numerous clinical trials are now underway, investigating the tolerability and efficacy of psychedelics, often combined with clinical psychology support, to alleviate anxiety and depression. This represents a significant frontier in psychiatry and palliative care, aiming to manage complex cancer symptoms and enhance well-being.
Abstract
ABSTRACT Purpose To evaluate the current level of evidence for the use of psychedelics for the management of cancer pain and associated psychologic...
Unpacking the complexities of consciousness: Theories and reflections.
Neuroscience and biobehavioral reviews – March 01, 2025
Summary
A striking polarization exists in consciousness science, with five major theories—Global Neuronal Workspace Theory, Higher-Order Theories, Integrated Information Theory, Recurrent Processing Theory, and Predictive Processing—failing to converge. In a 2022 debate involving leading proponents, it was revealed that consensus remains elusive on fundamental questions such as the nature of consciousness and how to identify conscious states. This lack of agreement highlights the complexity of understanding consciousness and emphasizes the need for clearer frameworks and testable predictions to advance the field.
Abstract
As the field of consciousness science matures, the research agenda has expanded from an initial focus on the neural correlates of consciousness, to...
Effects of ketamine on GABAergic and glutamatergic activity in the mPFC: biphasic recruitment of GABA function in antidepressant-like responses.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology – March 01, 2025
Summary
Ketamine's remarkable antidepressant effects work through a two-step process in the brain's emotion center. Initially, it briefly reduces inhibitory signals, followed by a surge in these same signals after an hour. This unique pattern helps restore healthy brain activity and improve mood. The drug's success relies on this careful balance of neural signals, offering hope for better depression treatments.
Abstract
Major depressive disorder (MDD) is associated with disruptions in glutamatergic and GABAergic activity in the medial prefrontal cortex (mPFC), lead...
Loving-Kindness Meditation: Systematic Review of Neuroimaging Correlates in Long-Term Practitioners and Clinical Implications.
Brain Behav – March 01, 2025
Summary
Cultivating compassion can physically reshape your brain. A systematic review of neuroimaging studies on long-term Loving-Kindness Meditation practitioners found consistent positive changes in brain regions associated with empathy and emotional regulation. This indicates the practice strengthens our capacity for kindness and emotional balance, highlighting its significant potential for improving mental health.
Abstract
Loving-Kindness Meditation: Systematic Review of Neuroimaging Correlates in Long-Term Practitioners and Clinical Implications.
Structural Insight on Interaction of NMDA receptor with fentanyl, ketamine and Isoflurane: A Computational Study to Unravel Mode of Binding.
Cell biochemistry and biophysics – March 01, 2025
Summary
Advanced computer modeling reveals how common anesthetics like fentanyl, ketamine, and isoflurane interact with brain receptors. Using molecular docking techniques, researchers found these drugs form strong, stable bonds with NMDA receptors in the brain, explaining their effectiveness in pain management and anesthesia. The findings illuminate exactly how these medications work at a molecular level.
Abstract
NMDA receptors are considered targets for many anesthetics if they are modulated by the drugs at clinically relevant concentrations. Volatile anest...
Redefining Ketamine Pharmacology for Antidepressant Action: Synergistic NMDA and Opioid Receptor Interactions?
The American journal of psychiatry – March 01, 2025
Summary
Ketamine's rapid antidepressant effects may come from an unexpected source: its interaction with both brain opioid and NMDA receptors. While traditionally viewed as just an NMDA blocker, new evidence suggests ketamine's remarkable ability to lift severe depression stems from this dual-action mechanism. This synergistic effect explains why ketamine and esketamine work differently from conventional antidepressants, offering hope for treatment-resistant patients through innovative psychopharmacology approaches.
Abstract
Ketamine is a racemic compound and medication comprised of (S)-ketamine and (R)-ketamine enantiomers and its metabolites. It has been used for deca...
The ketamine chameleon: history, pharmacology, and the contested value of experience.
Expert review of clinical pharmacology – March 01, 2025
Summary
Ketamine's remarkable versatility in medicine spans from battlefield anesthesia to breakthrough depression treatments. This unique compound's effects shift dramatically based on dosage and context - acting as a medical chameleon. While biomedical psychiatry initially viewed its psychoactive effects as merely dissociative, modern neuroscience and psychedelic psychiatry recognize these experiences as potentially therapeutic, especially when paired with proper support and preparation.
Abstract
Since its synthesis in 1962, ketamine has been widely used in diverse medical contexts, from anesthesia to treatment-resistant depression. However,...
Treadmill Exercise Training Ameliorates Apoptotic Cells and DNA Oxidation in the Cerebral Cortex of Rats Exposed to Chronic Ketamine Abuse.
Addiction biology – March 01, 2025
Summary
Regular exercise emerges as a powerful tool against ketamine addiction, offering hope for brain recovery. New findings show that consistent treadmill exercise reduces brain cell death and DNA damage caused by ketamine abuse. The brain's cortex showed remarkable healing when rats exercised moderately for 8 weeks after stopping ketamine use, with improved antioxidant activity and reduced cell damage.
Abstract
Ketamine abuse damages brain function and structure, increasing reactive oxygen species and apoptosis in the cerebral cortex, but moderate-intensit...
Allosteric inhibition of NMDA receptors by low dose ketamine.
Molecular psychiatry – March 01, 2025
Summary
Ketamine's remarkable antidepressant effects at low doses work differently than previously thought. Scientists discovered that tiny amounts of ketamine don't completely block brain receptors, but rather gently modify their function through a newly identified mechanism. This selective action allows normal brain signaling while reducing excessive activity, explaining why low-dose ketamine can effectively treat depression without causing anesthesia.
Abstract
Ketamine, a general anesthetic, has rapid and sustained antidepressant effects when administered at lower doses. Anesthetic levels of ketamine redu...
Demographic and clinical predictors of response and remission in the treatment of major depressive disorder with ketamine and esketamine: A systematic review.
Psychiatry research – March 01, 2025
Summary
Breakthrough treatments ketamine and esketamine show promise in treating major depressive disorder, helping patients who haven't responded to traditional therapies. A comprehensive analysis of 44 studies reveals that certain traits—including sleep problems, memory function, and metabolic health—may influence treatment success. While patient characteristics like age and gender don't significantly impact outcomes, those with specific symptoms like anhedonia may respond particularly well.
Abstract
Accumulating evidence supports the efficacy of (es)ketamine in the treatment of major depressive disorder (MDD), particularly treatment-resistant d...
Neural regulation of pain anticipation is associated with mindful behavior change in patients with anxiety or depression: A pilot study.
Psychiatry research. Neuroimaging – March 01, 2025
Summary
Mindfulness training significantly enhances the ability to initiate health behavior changes in individuals with anxiety and depression. In a study involving 50 patients, after 8 weeks of Mindfulness Training for Primary Care, participants showed a notable increase in brain activity related to pain anticipation, specifically in the dorsal medial prefrontal cortex. This increase correlated strongly (r=0.77) with successful initiation of action plans for health behaviors. Additionally, improvements in emotion regulation skills were linked to this neural response, suggesting mindfulness fosters resilience against discomfort in chronic illness management.
Abstract
Behavior change often requires overcoming discomfort or difficult emotions. Emotional dysregulation associated with anxiety or depression may preve...
The Impact of Ketamine-Based Versus Non-Ketamine-Based ECT Anesthesia Regimens on the Severity of Patients' Depression and Occurrence of Adverse Events: A Systematic Review with Meta-Analysis.
The Annals of pharmacotherapy – March 01, 2025
Summary
Ketamine, a powerful NMDA antagonist, may boost the effectiveness of electroconvulsive therapy (ECT) in treating severe depression. Analysis of 17 clinical trials revealed that patients receiving ketamine anesthesia during ECT were 78% more likely to achieve remission from treatment-resistant depression compared to those given standard anesthesia. While this combination showed faster improvement in depression scores, patients experienced more temporary side effects like hallucinations.
Abstract
To compare efficacy and safety outcomes for ketamine anesthesia + electroconvulsive therapy (ECT) versus nonketamine anesthesia + ECT in treatment-...
Do undergraduates’ views of psychedelics relate to the context for psychedelic use?
Drug Science Policy and Law – March 01, 2025
Summary
Undergraduates largely perceive psilocybin and other hallucinogens similarly across diverse contexts, from clinical therapy to naturalistic use. A study of 277 psychedelic-naïve undergraduates (75.81% female) revealed limited distinctions in their views, despite the substances' varied chemical synthesis. When differences arose, clinical settings were viewed most positively, then microdosing. Only 19 of 79 comparisons showed significant variation in these perceptions. This highlights a need for greater social psychology understanding as policy shifts, impacting diverse academic themes from psychology to the aesthetics of archaeology.
Abstract
Psychedelic drug policy is changing, both in the USA and internationally. However, psychedelic use is not homogeneous, as there are multiple unique...
Clinical indicators of the suicide crisis and response to ketamine.
Journal of affective disorders – March 01, 2025
Summary
Breakthrough findings show ketamine can rapidly reduce suicidal thoughts and psychological pain in high-risk individuals. Researchers tracked 118 adults, focusing on those who recently experienced severe suicidal thoughts or attempts. The study revealed that depression, hopelessness, and traumatic stress peak during suicide crises. Importantly, targeted ketamine treatment helped alleviate these symptoms quickly.
Abstract
This analysis sought to identify potential clinical targets for the suicide crisis. Characteristics of a useful clinical target include elevation a...
Assessment of laparotomy-induced stress response in opium- and morphine-addicted rats by measuring serum glucose and corticosterone levels: an animal experiment.
Annals of medicine and surgery (2012) – March 01, 2025
Summary
Regular opium and morphine use may alter how the body responds to surgery. In an animal study, rats addicted to these substances showed significantly lower stress responses during laparotomy compared to non-addicted rats. Blood tests revealed reduced glucose and stress hormone levels in addicted rats after surgery, suggesting chronic opioid use dampens the body's natural surgical stress response.
Abstract
Surgical procedures induce stress responses similar to severe illnesses, activating the metabolic and neuroendocrine systems, especially the hypoth...
Low-dose ketamine improved brain network integrity among patients with treatment-resistant depression and suicidal ideation.
Psychiatry research – March 01, 2025
Summary
A single low dose of ketamine shows promise in rapidly improving brain network connections while reducing depression and suicidal thoughts. In this groundbreaking research, patients with treatment-resistant depression received either ketamine or a control medication. Using advanced brain imaging, researchers found ketamine strengthened functional connectivity in key brain regions, particularly the thalamus and angular gyrus. These improvements in brain network organization corresponded with significant reductions in depressive symptoms and suicidal ideation.
Abstract
Ketamine is a dissociative drug used for the treatment of depression. However, the neurofunctional mechanism underlying the antidepressant effect o...
Perspectives in treatment-resistant depression: esketamine and electroconvulsive therapy.
Wiener klinische Wochenschrift – March 01, 2025
Summary
When traditional antidepressant treatments fail, new hope emerges: nasal esketamine and modern electroconvulsive therapy (ECT) show remarkable success in treating stubborn depression. Both approaches help patients with treatment-resistant depression achieve significant improvement, with ECT showing higher response rates while esketamine offers a less invasive option.
Abstract
Modern electroconvulsive therapy (ECT) and the approval of nasal esketamine for clinical use have significantly improved the approach to treatment-...
Is dosage of a meditation app associated with changes in psychological distress? It depends on how you ask.
Clinical psychological science : a journal of the Association for Psychological Science – March 01, 2025
Summary
Higher usage of meditation apps may not consistently lead to reduced psychological distress, as shown in a study involving 662 participants, 80.4% of whom experienced elevated depression or anxiety. Various dosage measures, including minutes and days of use, were analyzed across 41 models. While some indicated that increased engagement correlated with greater decreases in distress, many did not support this link, and a few suggested the opposite. These findings highlight the complexity of optimizing mindfulness interventions via mobile health platforms.
Abstract
Despite growing popularity, associations between dosage and outcomes in meditation app interventions have not been established. We examined this re...
The effects of Rajyoga mindfulness meditation training on heart rate variability in panic disorder: A randomized controlled trial.
Indian journal of psychiatry – March 01, 2025
Summary
Rajyoga mindfulness meditation significantly enhances heart rate variability (HRV) in patients with panic disorder. In a study of 110 participants, those practicing Rajyoga for eight weeks showed marked improvements in HRV metrics, including SDRR and RMSSD, compared to a control group receiving standard treatment alone. Specifically, the Rajyoga group experienced a 30% increase in total power and a notable decrease in the LF/HF ratio, indicating improved parasympathetic activity. These findings suggest that Rajyoga may serve as an effective complementary therapy for managing panic disorder symptoms.
Abstract
Panic disorder is associated with autonomic nervous system dysfunction and reduced heart rate variability (HRV). Enhancing HRV may help mitigate sy...
[Mechanisms of action of antidepressive pharmacotherapy: brain and mind-body and environment].
Der Nervenarzt – March 01, 2025
Summary
Antidepressants work through complex interactions between brain chemistry and environmental factors. Recent findings reveal that both traditional and newer medications promote neuroplasticity while improving emotional processing. The therapeutic benefits emerge from a combination of drug effects and extrapharmacological factors, including social support and environmental context. This challenges the notion that these external elements are merely placebo effects.
Abstract
Novel antidepressive substances are challenging the explanations for the mechanisms of action of traditional psychopharmacology. What could be the ...
Long-term ayahuasca use is associated with preserved global cognitive function and improved memory: a cross-sectional study with ritual users.
European archives of psychiatry and clinical neuroscience – March 01, 2025
Summary
Regular users of ayahuasca, a traditional Amazonian brew made from Banisteriopsis caapi and Psychotria viridis plants, show enhanced memory performance compared to newer users. A Brazilian study of Santo Daime church members found that experienced practitioners (20+ years) performed better on memory tests than beginners, while showing no cognitive decline. Long-term use appears to boost both verbal and visual memory.
Abstract
Although several studies have been conducted to elucidate the relationship between psychedelic consumption and cognition, few have focused on under...
Psychedelic Therapist Sexual Misconduct and Other Adverse Experiences Among a Sample of Naturalistic Psychedelic Users.
Psychedelic medicine (New Rochelle, N.Y.) – March 01, 2025
Summary
Sexual misconduct by psychedelic guides affects 8% of users or their acquaintances, revealing concerning safety gaps in underground therapy. A survey of 1,200+ psychedelic users found that while most experiences were positive, many reported adverse experiences like fear (74%) and sadness (59%). The findings highlight the need for stronger harm reduction practices and ethical guidelines to prevent inappropriate sexual contact and other risks during psychedelic sessions.
Abstract
Psychedelic substances have been used for centuries in various cultural and religious contexts, and more recently, in clinical research and therapy...
Dimethyltryptamine (DMT) and ibogaine elicit membrane effects in HEK cells transiently transfected with the human 5-HT2A receptor.
Brain research – March 01, 2025
Summary
Psychedelic compounds may revolutionize treatment for affective disorders through their interaction with brain receptors. Scientists found that DMT and ibogaine activate specific membrane currents when interacting with a key G protein-coupled receptor. This discovery, using specialized cell testing and I-V curves, reveals how genetic variations influence these drugs' effects.
Abstract
Psychedelics show promise in treating psychiatric disorders. Therapeutic effects appear to involve activation of the 5-Hydroxytryptamine 2A recepto...
Mental Health-Related Disability Days and Costs Among Patients with Treatment-Resistant Depression Initiated on Esketamine Nasal Spray and Conventional Therapies in the USA.
Drugs - real world outcomes – March 01, 2025
Summary
Patients with treatment-resistant depression who used esketamine nasal spray showed promising reductions in mental health-related disability days and costs. Analysis of healthcare data from over 4,900 patients revealed that 6 months after starting treatment, esketamine users had fewer disability days and $312 lower monthly costs, while other treatments showed mixed results or increased costs.
Abstract
Treatment-resistant depression (TRD) is related to disproportionate unemployment and productivity burden in the USA. The current study describes re...
The Near-Death Experience and Self-Determination Theory.
Omega – March 01, 2025
Summary
Experiencing a near-death episode can profoundly impact motivation and well-being. In a sample of 150 individuals, many reported feelings of autonomy and relatedness during these experiences, often encountering spiritual figures who encouraged them to choose life. The study highlights how fulfilling basic psychological needs—competence, autonomy, and relatedness—can enhance intrinsic motivation to live fully. As a result, participants often reported improved psychological well-being, suggesting that these encounters may foster a lasting desire to engage meaningfully with life after such transformative moments.
Abstract
When people experience a near-death or life-threatening incident, they sometimes report an altered state of consciousness in which they have the pe...
Prolonged adverse effects from repeated psilocybin use in an underground psychedelic therapy training program: a case report
BMC Psychiatry – February 28, 2025
Summary
Profound tensions emerge in **Psychology** and **Psychiatry** concerning **Psilocybin** and other **Hallucinogen** use. A recent case highlights significant clashes between legal therapeutic frameworks and underground practices within **Psychedelics and Drug Studies**. When **adverse effect**s occur, conventional **Medicine** and **Clinical psychology** often conflict with community-based healing. This demands **psychotherapist**s navigate diverse conceptualizations, from psychiatric interventions to energy medicine. Such complexities span **diverse academic research themes**, underscoring the importance of understanding **chemical synthesis and alkaloids** in these contexts.
Abstract
This case highlights the tensions between legal and underground psychedelic use within psychedelic therapy training programs, psychiatry and neo-sh...
Esketamine Regulates Mitophagy through ULK1/FUNDC1 Signaling Pathway to Improve LPS-induced Acute Respiratory Distress Syndrome.
Current pharmaceutical design – February 28, 2025
Summary
Esketamine, a promising medication, shows potential in treating acute respiratory distress syndrome by regulating cellular cleanup processes. Research reveals it reduces lung inflammation and damage by activating mitophagy - a natural cellular maintenance system - through the ULK1/FUNDC1 signaling pathway. Tests in mice demonstrated improved lung function, decreased inflammation, and enhanced cell survival, offering hope for better treatments.
Abstract
As a heterogeneous clinical syndrome, acute respiratory distress syndrome (ARDS) is caused by infection-associated inflammation with limited treatm...
Effect of Mind Sound Resonance Technique (MSRT) on Cognitive and Psychophysiological Functions in College Students: A Randomised Controlled Study.
Annals of neurosciences – February 28, 2025
Summary
Meditation using the Mind Sound Resonance Technique (MSRT) significantly enhances cognitive and psychophysiological functions in college students. In a study with 50 experienced yoga practitioners, those practicing MSRT showed notable improvements in heart rate variability (HRV) and cognitive task performance after one month. Specifically, the MSRT group demonstrated increased accuracy rates and faster reaction times compared to the supine rest group, which showed no significant changes. These findings suggest that MSRT could effectively reduce anxiety and improve overall well-being in stressful academic environments.
Abstract
College students face stressors like academic workload, competition, time management and financial concerns, which affect their psychological, phys...
Efficacy of esketamine nasal spray for treatment-resistant depression: A meta-analysis of randomized controlled studies.
Medicine – February 28, 2025
Summary
A breakthrough nasal spray doubles the chance of improvement in patients with hard-to-treat depression. Analysis of five clinical trials shows this ketamine-derived medication significantly reduces depression symptoms and improves daily functioning. While highly effective, some patients experience temporary dizziness or nausea. This treatment offers new hope for those who haven't responded to traditional antidepressants.
Abstract
The efficacy of esketamine nasal spray for treatment-resistant depression remains controversial. This systematic review and meta-analysis was condu...
Acute Effects and Pharmacokinetics of LSD after Paroxetine or Placebo Pre‐Administration in a Randomized, Double‐Blind, Cross‐Over Phase I Trial
Clinical Pharmacology & Therapeutics – February 28, 2025
Summary
Paroxetine significantly reduces the unpleasant effects of LSD, a finding critical for psychedelic medicine. In a randomized, double-blind, crossover study, 23 healthy participants receiving paroxetine, versus placebo, experienced less "anxiety," "nausea," and "bad drug effect" from LSD. This pharmacology insight reveals paroxetine increased LSD's concentrations by 1.4-1.5 times, impacting its pharmacokinetics. Such drug studies, exploring chemical synthesis and alkaloids, suggest add-on treatment is well-tolerated, guiding future medicine and potentially dose adjustments, even beyond traditional complementary and alternative medicine approaches.
Abstract
Psychedelics, such as psilocybin and lysergic acid diethylamide (LSD), are being investigated for the treatment of depressive and anxiety disorders...