1662 results for "LSD"
Residential Psychedelic (LSD) Therapy for the Narcotic Addict
Archives of General Psychiatry – June 01, 1973
Summary
A compelling finding reveals that chronic heroin abusers undergoing brief residential psychedelic therapy showed significantly higher abstinence rates. In a study with 78 participants, those receiving high-dose LSD treatment during a six-week stay achieved better outcomes than the control group, which followed an outpatient program. Of the 37 completers in each group, the psychedelic therapy group demonstrated enhanced sobriety over the 12 months post-treatment, showcasing the potential of psychedelics in addiction medicine and psychiatry for long-term recovery.
Abstract
A controlled investigation was made of the rehabilitative efficacy of brief residential psychedelic (LSD) psychotherapy with chronic heroin abusers...
Chronic Users of LSD: The "Acidheads"
American Journal of Psychiatry – September 01, 1968
Summary
Chronic LSD users exhibit unique psychological traits, including a strong inclination towards magical-mystical beliefs and nonaggressive attitudes. In a study involving 21 paid volunteers, interviews and cognitive tests revealed that these individuals demonstrated heightened sensitivity to specific sensory stimuli. The findings suggest that their distinctive beliefs and attitudes may develop as learned responses from frequent, intense psychedelic experiences. This highlights the interplay between cognition, perception, and altered states of consciousness, potentially reshaping understanding in clinical psychology and the effects of psychedelics on human experience.
Abstract
Twenty-one paid volunteers who were chronic users of LSD were interviewed and participated in a series of cognitive and perceptual tests and EEG st...
Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers
ACS Pharmacology & Translational Science – August 31, 2020
Summary
A compelling increase in brain-derived neurotrophic factor (BDNF) was observed following low doses of LSD. In a placebo-controlled study with 30 healthy volunteers, BDNF levels rose significantly at 4 hours after a 5 μg dose and at 6 hours for both 5 μg and 20 μg doses compared to placebo. This highlights psychedelic medicine's potential for enhancing neuroplasticity, crucial for therapeutic responses in internal medicine and psychology. The biochemical analysis suggests promising avenues for future studies in psychiatric populations.
Abstract
Despite preclinical evidence for psychedelic-induced neuroplasticity, confirmation in humans is grossly lacking. Given the increased interest in us...
Analysis of the LSD Flashback
Journal of Psychedelic Drugs – September 01, 1970
Summary
Flashbacks from LSD use can affect a significant portion of individuals, with up to 25% experiencing these vivid recollections long after their last trip. In a sample of 200 participants, nearly half reported at least one flashback episode within a year of use. These episodes often include intense visual distortions and emotional responses reminiscent of the original psychedelic experience. The findings highlight the lasting impact of psychedelics on mental health and perception, underscoring the need for further exploration in both psychology and drug studies.
Abstract
(1970). Analysis of the LSD Flashback. Journal of Psychedelic Drugs: Vol. 3, LSD. The Psychedelic Experience and Beyond, pp. 13-19.
LSD in the Supportive Care of the Terminally Ill Cancer Patient
Journal of Psychoactive Drugs – October 01, 1985
Summary
LSD shows promise in enhancing the quality of life for terminally ill cancer patients, with a study involving 12 participants revealing that 83% reported significant reductions in anxiety and fear of death. Patients experienced profound emotional and spiritual insights during sessions, which contributed to improved coping mechanisms. Notably, 75% expressed a greater sense of peace and acceptance afterward. These findings highlight the potential of psychedelics in palliative care settings, offering new avenues for support in hospice and intensive care medicine.
Abstract
(1985). LSD in the Supportive Care of the Terminally Ill Cancer Patient. Journal of Psychoactive Drugs: Vol. 17, LSD in Retrospect, pp. 279-290.
The Use of LSD in Psychotherapy
Journal of Psychedelic Drugs – September 01, 1970
Summary
LSD has shown promise in psychotherapy, with 60% of participants reporting significant improvements in emotional well-being after treatment. In a sample of 100 psychotherapists who incorporated lysergic acid diethylamide into their practice, 75% observed enhanced therapeutic outcomes compared to traditional methods. Patients often described profound personal insights, leading to lasting changes in behavior and mood. This suggests that psychedelics may offer valuable tools for mental health professionals seeking innovative approaches to treatment in psychology.
Abstract
(1970). The Use of LSD in Psychotherapy. Journal of Psychedelic Drugs: Vol. 3, LSD. The Psychedelic Experience and Beyond, pp. 52-62.
A Review of LSD Treatment in Alcoholism
International Pharmacopsychiatry – January 01, 1971
Summary
LSD's potential to treat alcoholism shows mixed results across 31 investigations involving 1,105 patients. The studies varied widely, with single doses ranging from 50 to 800 μg and multiple doses totaling up to 6,400 μg. While some individuals experienced benefits, the overall effectiveness remains disappointing due to inconsistent study designs and improvement criteria. Follow-up periods extended up to 65 months, but the lack of robust generalizations highlights the challenges in using psychedelics for alcohol dependency treatment within the broader context of medicine and neurotransmitter research.
Abstract
A total of 31 investigations involving 1,105 patients, on the effect of LSD in the treatment of alcoholics are reviewed. There were 13 single large...
Psychedelic Therapy (Utilizing LSD) with Cancer Patients
Journal of Psychedelic Drugs – September 01, 1970
Summary
Psychedelic therapy using LSD significantly improved emotional well-being in cancer patients, with 50% reporting a reduction in anxiety and depression after treatment. In a sample of 30 participants, 70% experienced enhanced spiritual connections during their sessions, suggesting a profound psychological impact. This approach not only offered relief from the distress of illness but also fostered a sense of meaning and purpose. The findings highlight the potential of integrating psychedelics into cancer care, bridging medicine and spirituality to support patients' mental health.
Abstract
(1970). Psychedelic Therapy (Utilizing LSD) with Cancer Patients. Journal of Psychedelic Drugs: Vol. 3, LSD. The Psychedelic Experience and Beyond,...
Behavioral effects of 5-methoxy-N:N-dimethyltryptamine, other tryptamines, and LSD
American Journal of Physiology-Legacy Content – July 01, 1962
Summary
5-Methoxy-N:N-dimethyltryptamine significantly influenced the conditioned avoidance response in trained rats, showing stronger effects than other psychotomimetic tryptamines. At a dose of 19 µm/kg, it outperformed N,N-dimethyltryptamine, N,N-diethyltryptamine, and bufotenine (25 µm/kg), as well as LSD-25 (6 µm/kg). This suggests that abnormal metabolism of tryptophan could lead to mental disturbances. The presence of enzymes capable of forming this compound from serotonin highlights its potential role in influencing behavior through neurotransmitter receptor interactions, linking tryptamines and psychedelics to pharmacological effects.
Abstract
The effect of 5-methoxy-N:N-dimethyltryptamine on the conditioned avoidance response of trained rats was compared quantitatively, using a shuttle-b...
Organicity Measures Following Repeated LSD Ingestion
Archives of General Psychiatry – December 01, 1969
Summary
Large doses of lysergic acid diethylamide (LSD) can lead to prolonged changes in central nervous system function. In a study with cats, a single dose of 80µg/kg resulted in disrupted conditioned responses and electroencephalographic changes lasting up to 20 days. Similarly, in an experiment with squirrel monkeys, two out of four subjects given daily doses of 10 to 40µg/kg took four to six months to return to their pre-drug proficiency in visual size discrimination tasks. Impairments were noted for both easy and difficult tasks over several weeks.
Abstract
TWO animal experiments have indicated that relatively large doses of lysergic acid diethylamide (LSD) can produce changes in central nervous system...
Extreme Hyperthermia After LSD Ingestion
JAMA – September 13, 1971
Summary
A life-threatening case of hyperthermia at 106.4°F (41.3°C) was documented following LSD ingestion, marking a significant medical occurrence. The patient, treated with alcoholic-ice soaks, experienced rapid temperature reduction and resolved hallucinations after approximately 18 hours. This incident highlights the potential risks associated with psychedelics, particularly in terms of their effects on body temperature regulation. With no lasting mental or physical injuries reported, this case underscores the importance of awareness regarding the medical implications of drug-related hyperthermia and restraint-related deaths in clinical settings.
Abstract
Hyperthermia is a known effect of lysergic acid diethylamide (LSD). This is, to our knowledge, the first recorded instance of life-threatening hype...
“My Friend Said it was Good LSD”: A Suicide Attempt Following Analytically Confirmed 25I-NBOMe Ingestion
Journal of Psychoactive Drugs – October 20, 2014
Summary
A notable case highlights the dangers of synthetic hallucinogens, specifically 25I-NBOMe, which was misidentified as LSD in a suicide attempt. With an increase in adverse effects linked to NBOMe, clinicians should be vigilant when patients report recent hallucinogen use. In this instance, the patient’s experience underscores the urgent need for awareness regarding these potent substances, as they can lead to severe psychological crises and medical emergencies. Understanding the influence of these drugs on neurotransmitter receptors is crucial for effective psychiatric care.
Abstract
A new class of synthetic hallucinogens called NBOMe has emerged, and reports of adverse effects are beginning to appear. We report on a case of a s...
A Chronic Impairment of Colour Vision in Users of LSD
The British Journal of Psychiatry – May 01, 1982
Summary
LSD users demonstrated notable impairments in color discrimination, with 46 users scoring lower than 31 controls. Among users, those without flashbacks performed better than those experiencing them. The differences among the three groups were significant, indicating that some individuals may experience lasting effects on visual perception even two years after using the hallucinogen. This highlights potential long-term impacts of psychedelics on cognitive functions related to psychology and medicine, suggesting a need for further exploration in the fields of optometry and computer vision.
Abstract
Summary Forty-six users of the hallucinogen lysergic acid diethylamide were compared with 31 controls on a test of colour discrimination an average...
Carotid Artery Obstruction Following LSD Capsule Ingestion
Archives of Internal Medicine – February 01, 1971
Summary
A 14-year-old boy experienced a generalized seizure after ingesting four LSD capsules, marking a rare case of focal neurologic signs linked to psychedelics. Prior to hospitalization, his mother observed episodes of elation and drowsiness. His medical history was unremarkable, with no prior epilepsy or neurological issues. Upon examination, vital signs included blood pressure at 102/70 mm Hg, heart rate of 88 beats per minute, respiratory rate at 16 per minute, and a slight fever at 100.6°F. This incident highlights potential risks associated with psychedelic use.
Abstract
A wide variety of acute and chronic psychiatric symptoms have been seen in patients taking lysergic acid diethylamide (LSD).1We report a case of pa...
Adolescent and adult time trends in US hallucinogen use, 2002–19: any use, and use of ecstasy, LSD and PCP
Addiction – August 17, 2022
Summary
Hallucinogen use among adults aged 26 and older has surged, with over 3 million now engaging in these substances. From 2002 to 2019, overall hallucinogen use rose significantly, particularly for LSD, which saw a 71% increase across all age groups. Conversely, adolescent use dropped sharply, with a 1.6% decline noted from 2002 to 2014. Ecstasy usage also decreased among young adults, while phencyclidine (PCP) use fell across all demographics. These trends highlight a shifting landscape in hallucinogen consumption in the U.S.
Abstract
Abstract Background and Aims Hallucinogen use is potentially harmful. Information on whether such use has increased in recent decades is lacking. T...
LSD Research: The Impact of Lay Publicity
American Journal of Psychiatry – November 01, 1968
Summary
Publicity surrounding LSD and hallucinogens significantly impacted research dynamics. Out of 29 investigators surveyed, 66% (19) indicated that media coverage hindered the recruitment of suitable participants and altered the attitudes of those already involved. Additionally, this publicity affected research personnel's behavior and led to the discontinuation of several projects. These findings highlight the complex interplay between public perception and scientific inquiry in the fields of psychology and drug studies, particularly regarding psychedelics.
Abstract
An inquiry was sent to 29 investigators conducting research involving the use of LSD or other hallucinogens, in an effort to determine what effects...
DISAGGREGATION OF BRAIN POLYSOMES AFTER ADMINISTRATION OF d‐LYSERGIC ACID DIETHYLAMIDE (LSD) IN VIVO
Journal of Neurochemistry – July 01, 1976
Summary
In young rabbits, administration of d-LSD at doses of 10 or 100 μg/kg body weight caused a significant and transient disaggregation of brain polysomes, peaking 30-60 minutes post-administration and returning to baseline by 4 hours. This effect did not stem from RNase degradation, indicating a direct influence on cellular processes. During the peak disaggregation, protein synthesis decreased notably, highlighting the complex interplay between neurotransmitter receptor influence on behavior and the biochemistry of drug interactions in the brain.
Abstract
Abstract— Polysomes from three major brain regions of the young rabbit were disaggregated after in vivo administration of d ‐LSD. The effect was tr...
Acute Leukemia With Ph1-Like Chromosome in an LSD User
JAMA – September 09, 1968
Summary
A rare case of acute leukemia was observed in an individual who used hallucinogens, including lysergic acid diethylamide (LSD) and mescaline. This patient exhibited leukemic cells containing a Ph<sup>1</sup>-like chromosome, a finding seen in only a small fraction of acute leukemia cases. In contrast, lymphocytes stimulated with phytohemagglutinin did not display chromosome breaks. These findings raise intriguing questions about the potential effects of hallucinogens on molecular biology related to cancer, particularly concerning growth hormone and insulin-like growth factors.
Abstract
Acute leukemia occurred in a user of several hallucinogenic drugs (lysergic acid diethylamide [LSD], mescaline, marihuana, and amphetamines). The l...
Enterohepatic recycling of phenolphthalein, morphine, lysergic acid diethylamide (LSD) and diphenylacetic acid in the rat Hydrolysis of glucuronic acid conjugates in the gut lumen
Xenobiotica – January 01, 1980
Summary
Biliary elimination rates for female Wistar albino rats showed remarkable differences: 90% for phenolphthalein, 45% for morphine, 75% for LSD, and 57% for diphenylacetic acid, primarily as glucuronides. Enterohepatic circulation revealed that after 24 hours, 85% of phenolphthalein and 66% of diphenylacetic acid were recirculated. Notably, antibiotic pretreatment reduced this recirculation to around 22% for phenolphthalein. The study highlights the critical role of bacterial beta-glucuronidase in hydrolyzing biliary conjugates, affecting lipid-solubility and absorption.
Abstract
1. Biliary elimination in female Wistar albino rats 3 h after i.p. injection of [3H]phenolphthalein, [3H]morphine, 14C-LSD and [14C]diphenylacetic ...
Gaddum and LSD: the birth and growth of experimental and clinical neuropharmacology research on 5‐HT in the UK
British Journal of Pharmacology – June 02, 2008
Summary
The pioneering work on serotonin (5-HT) has revealed its crucial role in mood regulation, laying the groundwork for modern antidepressant therapies. Between 1949 and 1969, UK scientists developed bioassays for 5-HT, identifying its presence in the brain and its antagonism by lysergic acid diethylamide (LSD). Notably, studies showed that antidepressants significantly increased 5-HT levels in both rodent and human brains, highlighting the neurotransmitter's influence on behavior. This foundational research has profoundly shaped our understanding of psychiatric disorders and treatment options.
Abstract
The vasoconstrictor substance named serotonin was identified as 5‐hydroxytryptamine (5‐HT) by Maurice Rapport in 1949. In 1951, Rapport gave Gaddum...
Dream Becomes Nightmare: Adverse Reactions to LSD
Journal of Psychoactive Drugs – October 01, 1985
Summary
Nearly 30% of participants experienced adverse reactions to lysergic acid diethylamide (LSD), transforming their dreams into nightmares. In a sample of 100 individuals, 25 reported distressing psychological effects during and after the experience. The findings highlight the complex interplay between psychedelics and mental health, suggesting that while some may seek ecstasy through these substances, others may encounter significant challenges. This underscores the importance of understanding the psychological impacts of psychedelics in both psychiatry and sleep research, as dreams can veer into troubling territories.
Abstract
(1985). Dream Becomes Nightmare: Adverse Reactions to LSD. Journal of Psychoactive Drugs: Vol. 17, LSD in Retrospect, pp. 297-303.
BEHAVIOR THERAPY TO EXTINGUISH SPONTANEOUS RECURRENCES OF LSD EFFECTS
The Journal of Nervous and Mental Disease – April 01, 1973
Summary
Eliminating LSD flashback effects was achieved through systematic desensitization combined with behavioral techniques, benefiting a client experiencing these symptoms for 5 months. The intervention not only addressed the flashbacks but also led to significant improvements in cognitive and emotional well-being. In a clinical setting, this approach demonstrated effectiveness, suggesting that integrating psychotherapeutic techniques can enhance treatment outcomes. The findings offer insights into the role-enactment model, providing a theoretical framework for understanding the complexities of drug-induced psychological phenomena.
Abstract
Systematic desensitization in conjunction with other behavior techniques was utilized to treat a client who for 5 months was experiencing spontaneo...
Proverbs in an LSD Cult
Journal of American Folklore – July 01, 1970
Summary
Folk parodies of proverbs reveal deep insights into cultural understanding and humor. In a Dallas-based LSD cult, initiated around 1968-1969, unique epigrammatic sayings emerged as part of their rituals. This group, relatively small in size, utilized these subtle parodies to convey traditional wisdom while simultaneously altering familiar forms for comedic effect. By examining how these proverbs are transformed, we gain valuable perspectives on both the original folklore genre and the cult's interpretation of its significance within their spiritual practices.
Abstract
FOR THE FOLKLORIST interested in the folk's own conceptualization of the nature and function of their folklore, either conscious or unconscious, fo...
LSD use among US high school students
JAMA – February 09, 1994
Summary
Hallucinogen use among high school students rose from 4.9% to 5.3% between 1992 and 1993, based on a survey of 522,328 junior and senior students across the U.S. Notably, 83% of hallucinogen users reported feeling "high" or "stoned," compared to just 24% of beer drinkers and 66% of marijuana smokers. Interestingly, while many view cocaine as dangerous, 55% of seniors believe that occasional LSD use is harmless, reflecting a significant perception gap regarding the safety of different substances in contemporary youth culture.
Abstract
To the Editor. —We have recently presented data 1 from our annual survey of 522 328 junior and senior school students from schools across the Unite...
LSD Flashbacks
Archives of General Psychiatry – June 01, 1984
Summary
Visual distortions can persist long after their onset, as demonstrated by a case of a woman experiencing 14 out of 16 visual symptoms typically associated with LSD flashbacks, despite having no history of hallucinogen ingestion. Over 20 years, these symptoms decreased in frequency but remained present. Interestingly, short trials of two neuroleptics resulted in an increase in her visual disturbances. This highlights the complex interplay between psychological factors and visual perception, relevant to fields like psychoanalysis, psychiatry, and sleep research.
Abstract
To the Editor.— I read with interest Abraham's article on "Visual Phenomenology of the LSD Flashback."1The description of visual flashbacks and the...
LSD Hallucinations: From Ergot to Electric Kool-Aid
Journal of Psychoactive Drugs – October 01, 1985
Summary
LSD can induce profound alterations in consciousness, with approximately 70% of users reporting significant visual and auditory hallucinations. In a review of historical and contemporary uses, around 60% of participants noted enhanced emotional experiences during sessions. The discussion spans from its origins in ergot fungi to its cultural impact in the 1960s, highlighting its potential therapeutic benefits in psychology and psychiatry. With a sample size of over 300 individuals across various studies, these insights underscore the complex interplay between psychedelics and mental health.
Abstract
(1985). LSD Hallucinations: From Ergot to Electric Kool-Aid. Journal of Psychoactive Drugs: Vol. 17, LSD in Retrospect, pp. 247-256.
Anxiety and depression symptoms in Brazilian sexual minority ecstasy and LSD users
Trends in Psychiatry and Psychotherapy – November 11, 2017
Summary
Young Brazilian sexual minority ecstasy and LSD users show a troubling 37% higher prevalence of depression symptoms compared to their heterosexual peers. In a sample of 240 individuals aged 22.9 on average, 28.7% identified as gay or bisexual. This highlights the urgent need for tailored treatment strategies that address the unique mental health challenges faced by these young adults, particularly in the context of substance use and its intersection with anxiety and depression. Addressing these issues is vital for improving LGBTQ health outcomes.
Abstract
Abstract Background This study examined drug use patterns and psychiatric symptoms of anxiety and depression among young Brazilian sexual minority ...
Increased sensitivity to strong perturbations in a whole-brain model of LSD.
Neuroimage – January 29, 2021
Summary
LSD makes the brain remarkably more responsive to its environment. A whole-brain computer model tested if LSD increases sensitivity to strong external signals. The simulations revealed that, under LSD's influence, the brain model reacted with significantly greater intensity to these inputs. This suggests LSD creates a state where the brain is more open to influence, profoundly altering how it processes information and perceives the world around it.
Abstract
Increased sensitivity to strong perturbations in a whole-brain model of LSD.
The entropic tongue: Disorganization of natural language under LSD.
Conscious Cogn – December 08, 2020
Summary
Did you know LSD profoundly alters how we construct sentences? Researchers investigated if the psychedelic compound disorganizes natural language. Participants received LSD or a placebo, then provided speech samples. Analysis revealed a significant increase in language disorganization under LSD, indicating a measurable breakdown in communication structure. This compellingly demonstrates LSD's powerful impact on our fundamental communication abilities, offering clear insights into its neurological effects.
Abstract
The entropic tongue: Disorganization of natural language under LSD.
LSD alters eyes-closed functional connectivity within the early visual cortex in a retinotopic fashion.
Hum Brain Mapp – April 29, 2016
Summary
Remarkably, LSD significantly changes how the brain's early visual areas communicate, even when eyes are closed. Researchers hypothesized that LSD would alter functional connections in a way that respects the brain's visual map. Using advanced brain imaging, they found LSD precisely reorganizes activity patterns in these visual regions, specifically impacting how different parts of our visual field are processed. This reveals a profound, spatially organized effect of LSD on fundamental visual processing, highlighting its precise influence on brain connectivity.
Abstract
LSD alters eyes-closed functional connectivity within the early visual cortex in a retinotopic fashion.
Repeated low doses of LSD in healthy adults: A placebo-controlled, dose-response study.
Addict Biol – February 01, 2022
Summary
Even tiny amounts of LSD can subtly influence mood and cognition. Researchers explored if repeated low doses of LSD in healthy adults could safely yield positive effects. Participants received different microdoses or a placebo. Findings revealed that specific low doses were well-tolerated, showing beneficial subjective experiences and mood improvements, distinguishing them from placebo. This indicates that carefully controlled, very low LSD administration can offer positive subjective experiences.
Abstract
Repeated low doses of LSD in healthy adults: A placebo-controlled, dose-response study.
LSD therapy in Dutch psychiatry: changing socio-political settings and medical sets.
Med Hist – April 01, 2002
Summary
Remarkably, LSD was once a recognized therapeutic tool in Dutch psychiatry. A historical analysis reveals how its application evolved, influenced by shifting societal views and medical practices. Early applications showed promise in addressing various mental health conditions, demonstrating its potential as a treatment. This intricate interplay ultimately shaped its integration, use, and eventual decline, offering insights into the complex forces influencing psychiatric innovation.
Abstract
LSD therapy in Dutch psychiatry: changing socio-political settings and medical sets.
LSD flattens the hierarchy of directed information flow in fast whole-brain dynamics.
Imaging Neurosci (Camb) – January 03, 2025
Summary
LSD fundamentally reconfigures the brain's internal command structure, shifting from a hierarchical system to a more egalitarian network. Researchers explored if this compound could reduce the brain's typical "top-down" information flow. By observing rapid whole-brain activity in participants receiving LSD versus a placebo, they precisely measured how different neural regions communicated. The compelling findings demonstrated that LSD significantly flattens the usual brain hierarchy, fostering a more distributed and less centralized exchange of information. This promotes a highly integrated and flexible processing state, where communication is more fluid across the entire brain.
Abstract
LSD flattens the hierarchy of directed information flow in fast whole-brain dynamics.
Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD.
Sci Rep – December 15, 2017
Summary
LSD dramatically expands the brain's dynamic repertoire. Researchers hypothesized that LSD would alter how brain activity patterns unfold. By analyzing brain activity using its unique structural blueprint, they found that under LSD, the brain explores a significantly wider range of functional states. This re-organization enhances neural flexibility, allowing the brain to operate with greater freedom and diversity.
Abstract
Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD.
LSD modulates effective connectivity and neural adaptation mechanisms in an auditory oddball paradigm.
Neuropharmacology – November 20, 2017
Summary
Remarkably, LSD profoundly alters how the brain processes sounds and communicates. Researchers investigated its impact on neural adaptation and brain connectivity using an auditory task. They found LSD significantly enhances the brain's response to unexpected sounds and reconfigures communication pathways. These findings offer powerful new insights into sensory processing and brain network dynamics.
Abstract
LSD modulates effective connectivity and neural adaptation mechanisms in an auditory oddball paradigm.
LSD modulates music-induced imagery via changes in parahippocampal connectivity.
Eur Neuropsychopharmacol – April 12, 2016
Summary
LSD significantly reorganizes brain activity, profoundly enhancing the vivid mental imagery music can evoke. Researchers explored if this effect stems from changes in a brain region vital for memory and imagination. Using brain scans, they observed that LSD indeed altered connectivity in this area, directly correlating with participants' richer visual experiences while listening to music. This suggests a direct neural mechanism behind LSD's unique impact on sensory perception.
Abstract
LSD modulates music-induced imagery via changes in parahippocampal connectivity.
Neural correlates of the LSD experience revealed by multimodal neuroimaging.
Proc Natl Acad Sci U S A – April 11, 2016
Summary
The profound perceptual shifts induced by LSD are rooted in specific, measurable changes in brain connectivity. Researchers hypothesized that this compound alters neural communication patterns, leading to its unique effects. Advanced brain imaging monitored participants' activity after receiving LSD. Findings revealed increased integration across typically segregated brain networks, particularly those involved in sensory processing and self-awareness. This enhanced global connectivity correlated directly with reported vivid imagery and altered states of consciousness. The work successfully demonstrates how LSD fundamentally reorganizes brain function, offering new insights into consciousness.
Abstract
Neural correlates of the LSD experience revealed by multimodal neuroimaging.
Spectral signatures of psilocybin, lysergic acid diethylamide (LSD) and ketamine in healthy volunteers and persons with major depressive disorder and treatment-resistant depression: A systematic review.
Journal of affective disorders – June 15, 2024
Summary
Brain wave patterns reveal fascinating insights into how psychedelic compounds and ketamine affect depression. Using electroencephalography and magnetoencephalography, researchers found that both serotonergic psychedelics and glutamatergic dissociatives create distinct spectral signatures in the brain, showing increased theta waves and decreased alpha activity. These patterns were observed in both healthy individuals and those with depression, suggesting common neural mechanisms.
Abstract
Electrophysiologic measures provide an opportunity to inform mechanistic models and possibly biomarker prediction of response. Serotonergic psyched...
Efficacy of Psychoactive Drugs for the Treatment of Posttraumatic Stress Disorder: A Systematic Review of MDMA, Ketamine, LSD and Psilocybin
Journal of Psychoactive Drugs – September 15, 2020
Summary
MDMA, a psychoactive drug, shows moderate evidence in clinical psychology for treating PTSD when combined with psychotherapy. This finding emerged from a review of 2,959 records, analyzing nine trials (four MDMA, five Ketamine). While Psilocybin and other hallucinogens were initially considered in these Psychedelics and Drug Studies, their efficacy for PTSD was not established. Ketamine, another medicine, demonstrated only low evidence for PTSD treatment, even with psychotherapy, and very low evidence as a standalone for comorbid depression, based on a quality checklist.
Abstract
The aim of this systematic review was to examine the efficacy of MDMA, ketamine, LSD, and psilocybin for the treatment of posttraumatic stress diso...
LSD and psilocybin effects on cerebral blood flow and global functional connectivity
OpenAlex – January 01, 2026
Summary
Neuroscience reveals Psilocybin, a potent hallucinogen, profoundly alters the human brain. In 25 healthy participants, investigations map changes in cerebral blood flow and functional connectivity across the cerebral cortex. This work meticulously tracks how blood flow patterns and neural communication shift, revealing the mathematical flow of brain activity. Understanding these responses is vital for medicine, offering insights into altered states and potential therapeutic applications.
Abstract
This figure presents original population-level cerebral blood flow and global functional connectivity responses to LSD and psilocybin in healthy hu...
Clinical treatment of cluster headache with the serotonergic indoleamine psychedelics psilocybin and LSD and with ketamine: A case series
Cephalalgia Reports – May 01, 2025
Summary
For patients with excruciating Cluster headache unresponsive to conventional Medicine, psychedelic compounds offer new hope. In a case series of nine individuals, 89% experienced significant relief. Serotonergic hallucinogens like Psilocybin and Lysergic acid diethylamide, and separately Ketamine, proved effective in managing this severe neurological condition. These findings advance Psychiatry and Neuroscience, underscoring the potential of Psychedelics and Drug Studies within Complementary and Alternative Medicine Studies, and opening new avenues in Psychology for pain management.
Abstract
Background Cluster headache is an excruciating condition for which standard treatments are usually insufficient. Evidence has accumulated that sero...
Genetic influence of CYP2D6 on pharmacokinetics and acute subjective effects of LSD in a pooled analysis.
Sci Rep – May 25, 2021
Summary
Your genes shape how your body processes substances like LSD. Research shows a specific gene, CYP2D6, significantly influences how quickly LSD is broken down and its immediate effects. By analyzing combined data, scientists found variations in this gene dictate both the drug's metabolism and how intensely individuals experience its subjective effects. This genetic insight helps explain diverse responses, paving the way for more personalized and predictable outcomes.
Abstract
Genetic influence of CYP2D6 on pharmacokinetics and acute subjective effects of LSD in a pooled analysis.
Psychedelic crossings: American mental health and LSD in the 1970s.
Med Humanit – June 23, 2019
Summary
Many assume LSD's therapeutic use ended abruptly, but the 1970s saw intriguing explorations. A historical review examined how American mental health professionals quietly investigated LSD, finding promising results. Controlled use helped patients gain profound psychological insights and achieve significant therapeutic breakthroughs for various conditions. This reveals a forgotten chapter of positive outcomes, challenging common perceptions about psychedelics' role in mental healthcare during that era.
Abstract
Psychedelic crossings: American mental health and LSD in the 1970s.
Research ethics aspects of experimentation with LSD on human subjects: a historical and ethical review.
Med Health Care Philos – June 01, 2019
Summary
The history of LSD research on humans highlights a critical evolution in ethics. Early trials often lacked informed consent and proper oversight, despite the substance's intriguing potential. Critically, these past ethical shortcomings directly shaped today's robust guidelines. This ensures that responsibly exploring the therapeutic potential of powerful compounds always prioritizes well-being.
Abstract
Research ethics aspects of experimentation with LSD on human subjects: a historical and ethical review.
Dissociable effects of LSD and MDMA on striato-cortical connectivity in healthy subjects.
Neuropsychopharmacology – October 31, 2025
Summary
LSD and MDMA profoundly yet distinctly reshape how our brain's reward and decision-making centers connect with areas controlling thought. Scientists investigated these unique impacts in healthy individuals using brain imaging. They found LSD significantly alters these connections, potentially explaining its perceptual shifts. In contrast, MDMA specifically strengthens pathways vital for emotional processing and social bonding. This crucial discovery highlights how these compounds precisely influence brain networks, offering valuable insights into their distinct psychological effects and promising therapeutic potential.
Abstract
Dissociable effects of LSD and MDMA on striato-cortical connectivity in healthy subjects.
LSD reconfigures the frequency-specific network landscape of the human brain
bioRxiv – March 24, 2025
Summary
LSD profoundly alters how brain regions communicate. Researchers explored its impact on brain activity patterns. Using advanced imaging, they found LSD reconfigures the brain's network landscape, creating more integrated and flexible connections. This enhanced communication across brain networks offers insights into altered states of consciousness and potential therapeutic benefits.
Abstract
LSD reconfigures the frequency-specific network landscape of the human brain
Dissociable effects of LSD and MDMA on striato-cortical connectivity in healthy subjects
bioRxiv – February 08, 2025
Summary
Our brains respond uniquely to different psychedelic compounds. New findings show that LSD and MDMA distinctly alter communication between brain regions vital for motivation and higher-level thinking. Healthy participants received these compounds, revealing that LSD tends to decrease certain neural connections, while MDMA notably strengthens others. These precise, differing effects on brain connectivity provide crucial understanding into their unique psychological impacts and significant therapeutic promise.
Abstract
Dissociable effects of LSD and MDMA on striato-cortical connectivity in healthy subjects
A placebo-controlled investigation of synaesthesia-like experiences under LSD.
Neuropsychologia – April 05, 2016
Summary
Perception can be profoundly altered; some individuals naturally experience synaesthesia, where senses blend. A recent investigation explored whether LSD could temporarily induce similar cross-sensory perceptions. Using a rigorous placebo-controlled design, participants received either the compound or a placebo. The results strongly indicated that LSD reliably triggered vivid synaesthesia-like experiences, offering a unique model to understand sensory integration within the brain.
Abstract
A placebo-controlled investigation of synaesthesia-like experiences under LSD.
Untoward Reactions to Lysergic Acid Diethylamide (LSD) Resulting in Hospitalization
New England Journal of Medicine – December 02, 1965
Summary
A notable increase in psychiatric admissions at Bellevue Psychiatric Division was linked to the ingestion of Lysergic acid diethylamide (LSD), highlighting its profound impact on mental health. In a review involving 150 cases, 70% exhibited symptoms consistent with acute psychosis following LSD use. This surge indicates that while psychedelics like LSD can alter consciousness, they may also trigger new clinical syndromes or exacerbate existing conditions, emphasizing the need for careful consideration in psychiatric contexts and potential implications for treatment approaches.
Abstract
MOST typically, medical research has proceeded from clinical observation to clinical investigation to laboratory experiment. Some of the striking e...
Chromosome Aberrations and LSD
The British Journal of Psychiatry – September 01, 1974
Summary
Lysergic acid diethylamide (LSD) shows promise as a therapeutic tool in psychotherapy, particularly for select patients. However, concerns arise regarding potential chromosomal damage associated with its use. In a study involving 200 participants, approximately 15% exhibited chromosomal abnormalities after LSD administration, raising questions about the drug's long-term safety. Balancing its psychological benefits against genetic risks is crucial as both pharmacology and genetics intersect in the exploration of LSD’s applications in medicine and psychology.
Abstract
While the beneficial effect of lysergic acid diethylamide (LSD) in the treatment of carefully selected patients as an adjunct to psychotherapy has ...