Nature. Mental health
July 10, 2023
Julieta Galante, Claire Friedrich, Napaporn Aeamla-Or et al.
102 citations
Mindfulness-based programmes reduce psychological distress (anxiety and depression) in community adults who volunteer to participate, with a small to moderate effect size. The analysis of 13 randomized controlled trials with 2,371 participants from 8 countries found a standardized mean difference of -0.32, with high confidence in the result. The effect was not clearly influenced by participants' baseline distress level, gender, age, education, or dispositional mindfulness. More research is needed to understand why outcomes vary between individuals.
Science Advances
May 20, 2022
Tammi R. A. Kral, Kaley Davis, Cole Korponay et al.
67 citations
A large, rigorously controlled study failed to find evidence that an 8-week mindfulness-based stress reduction (MBSR) course changes brain structure. Combining data from two randomized controlled trials with 218 meditation-naïve participants, the study compared MBSR to an active control and a waitlist group. Using structural MRI scans before and after the intervention, researchers assessed gray matter volume, gray matter density, and cortical thickness. No neuroplastic changes were observed in the MBSR group compared to either control group, either across the whole brain or in regions previously reported to change. This contradicts widely referenced earlier claims that MBSR alters brain structure.
Journal of Consulting and Clinical Psychology
September 28, 2023
Christian A. Webb, Matthew J. Hirshberg, Oscar González et al.
6 citations
Mechanisms explaining why meditation training works may differ across patient subgroups. Prior research often collapsed heterogeneous groups, obscuring these differences. Using data from 662 participants, researchers developed a Personalized Advantage Index (PAI) to identify individuals likely to benefit more from a meditation app. A moderated mediation analysis showed that mindfulness acquisition mediated better outcomes only for those with higher PAI scores. This suggests that subgroup-specific mediators should be considered to clarify how psychosocial interventions work and to match individuals to the most beneficial treatment.
Cognition & Emotion
January 29, 2021
Simon B. Goldberg, Lisa Flook, Matthew J. Hirshberg et al.
6 citations
Brief mindfulness meditation (breath awareness) may impair cognitive performance after acute stress compared to other contemplative practices. In a randomized trial with 162 participants, those who practiced loving-kindness, gratitude, or an attentional control improved their working memory scores on the Operation Span task after the cold pressor stress test, while the breath awareness group did not. Changes in working memory were unrelated to changes in mood. The findings suggest that brief breath awareness training may not buffer against acute stress in meditation-naïve individuals and could even hinder cognitive performance relative to other practices.
March 30, 2021
Matthew J. Hirshberg, Corrina Frye, Cortland J. Dahl et al.
5 citations
preprint
A four-week smartphone-based meditation app (Healthy Minds Program) reduced psychological distress and improved well-being among school system employees during the COVID-19 pandemic. In a randomized wait-list controlled trial with 662 participants (64% teachers), those assigned to the app showed significantly larger reductions in distress immediately after the intervention and at a three-month follow-up, with similar benefits on secondary outcomes such as perseverative thinking and social connection. The app was equally effective for participants with elevated baseline anxiety and depressive symptoms, and no evidence of elevated adverse events was found. The program may offer a scalable approach to supporting educator mental health.
January 30, 2020
Matthew J. Hirshberg, Simon B. Goldberg, Melissa A. Rosenkranz et al.
5 citations
preprint
Mindfulness-based stress reduction (MBSR) does not increase harm compared to no treatment, and may instead protect against harm. Analyzing data from over 2,000 community clinic participants and from three randomized controlled trials, the study found no evidence that MBSR leads to higher rates of worsened psychological or physical symptoms, anxiety, depression, interpersonal discomfort, paranoid ideation, or psychoticism. On many measures, community MBSR participants showed significantly lower rates of harm than controls. The findings suggest MBSR is not associated with increased harm, though a small proportion of participants do experience harm, warranting further research.
August 1, 2023
Matthew J. Hirshberg, Cortland J. Dahl, Daniel M. Bolt et al.
3 citations
preprint
A four-week smartphone-based meditation intervention reduced psychological distress during the early COVID-19 pandemic. Among 662 adults, most of whom reported clinical levels of anxiety or depressive symptoms, the intervention improved four proposed mediators—mindful action, loneliness, cognitive defusion, and purpose—measured five times during the program and at three-month follow-up. Each mediator individually accounted for 22.2% to 64.5% of the intervention's effect on later distress. When all mediators were analyzed together, only reduced loneliness remained a significant pathway, explaining 70.0% of the combined indirect effect. Multiple psychological mechanisms likely contribute to the benefits of digital meditation interventions.
February 10, 2023
Qiang Xie, Kevin M. Riordan, Scott A. Baldwin et al.
2 citations
preprint
Among clinically distressed adults with no meditation experience who used a smartphone-based loving-kindness and compassion training program for two weeks, those who increased their informal meditation practice (using techniques outside formal sessions) showed greater reductions in psychological distress and loneliness from before to after the intervention, though no changes in empathy or prosociality were observed. Daily analyses indicated that more informal practice on a given day predicted lower distress the next day, but not lower loneliness. Distress and loneliness did not predict subsequent informal practice. The findings suggest that informal practice may play a causal role in reducing distress, but further experimental studies are needed.
medRxiv
June 16, 2021
Tammi R. A. Kral, Kaley Davis, Cole Korponay et al.
2 citations
preprint
A large, rigorously controlled study combining data from two three-arm randomized controlled trials found no evidence that an eight-week Mindfulness-Based Stress Reduction (MBSR) course produces changes in brain structure. Meditation-naive participants (218 total) were randomly assigned to a waitlist, an 8-week MBSR program, or a validated active control group. Structural MRI scans taken before and after the intervention showed no significant differences in gray matter volume, gray matter density, or cortical thickness between MBSR and either control group, at either the whole-brain level or in brain regions previously linked to MBSR. These results fail to replicate earlier, widely cited claims of MBSR-induced neuroplasticity.
PLoS ONE
August 28, 2019
Simon B. Goldberg, Matthew J. Hirshberg, Lawrence Y. Tello et al.
2 citations
Long-term meditators are perceived by observers as less neurotic and more conscientious, mindful, and comfortable in their own skin than meditation-naïve individuals, based solely on ratings of still photographs. These differences were not explained by age, gender, race/ethnicity, body mass index, or attractiveness. No such differences were observed after an eight-week mindfulness meditation course, an active control program, or a waitlist period, suggesting that observable facial cues linked to meditation may require extensive training to emerge.
July 31, 2022
Christian A. Webb, Matthew J. Hirshberg, Richard J. Davidson et al.
1 citation
An algorithm was developed to predict who benefits most from a meditation app. Using data from a randomized controlled trial of a 4-week meditation app versus a control condition in 662 school system employees, a machine learning model created a Personalized Advantage Index (PAI) that estimated each person's expected reduction in distress. The PAI scores significantly predicted which individuals improved more with the app than without. A simpler model using only repetitive negative thinking as a predictor performed similarly well. The algorithm could help individuals make informed decisions about whether a meditation app is right for them.
JMIR Mental Health
June 12, 2026
Polina Beloborodova, Lillian M. Smith, Kevin M. Riordan et al.
About 28% of distressed college students and 10% of distressed US adults reported at least one adverse experience during a digital meditation program, but rates did not differ between those who completed guided meditations and those who did not, suggesting the experiences were not caused by meditation itself. Higher baseline depression, anxiety, loneliness, experiential avoidance, and perceived barriers to meditation predicted more adverse experiences. Among those reporting adverse experiences, roughly 90% were glad to have learned to meditate. Participants used diverse coping strategies, often drawing on skills taught in the program. The findings indicate that adverse experiences during meditation training may reflect preexisting distress rather than iatrogenic harm.
Mindfulness (N Y)
May 19, 2026
Polina Beloborodova, Matthew J. Hirshberg, Simon B. Goldberg
Contemplative ethics interventions, such as mindfulness and compassion training, show promise for improving ethical decision-making in scientific practice, but their translation into policy faces significant constraints. The paper examines how these interventions can address ethical lapses in research by cultivating moral awareness and behavior, yet it also highlights challenges including institutional resistance, scalability issues, and the need for empirical validation. The authors argue that while contemplative practices offer potential benefits, their integration into science policy requires careful consideration of contextual factors, measurement standards, and potential unintended consequences. The work calls for a balanced approach that recognizes both the possibilities and limitations of using contemplative methods to foster ethical conduct in scientific communities.