1007 results for "Mindfulness"
Adverse experiences resulting in emergency medical treatment seeking following the use of magic mushrooms
Journal of Psychopharmacology – April 07, 2022
Summary
"Magic mushrooms" containing psilocybin, a psychoactive alkaloid, rarely cause serious adverse effects necessitating a medical emergency. From 9233 past-year users globally, only 19 (0.2%) sought emergency medical treatment, a per-event risk of 0.06%. Young age was the sole predictor. Most incidents involved psychological symptoms—anxiety/panic—relevant to Psychiatry, often due to poor mindset. All but one returned to normality within 24 hours. These Psychedelics and Drug Studies confirm their safety in Medicine and Complementary and Alternative Medicine, showing severe physiological effects requiring Anesthesia are exceedingly rare.
Abstract
Background: Psilocybin-containing mushrooms are used for recreational, spiritual, self-development and therapeutic purposes. However, physiological...
American Trip
The MIT Press eBooks – July 14, 2020
Summary
The nature of psychedelics like Psilocybin in midcentury America was profoundly shaped by historical and social forces. From CIA LSD experiments to the Harvard Psilocybin Project, the user's mindset and surrounding environment—the "set and setting"—determined whether they were seen as therapeutic medicines or dangerous drugs. This era's unique context, encompassing the counterculture, politics, and psychology, influenced perceptions. Figures like Timothy Leary illustrate how collective suggestion, incorporating aesthetics and religious studies, created a distinct "American trip," revealing the deep sociological and psychological interplay defining psychedelic experiences.
Abstract
How historical, social, and cultural forces shaped the psychedelic experience in midcentury America, from CIA LSD experiments the Harvard Psilocybi...
Cognitive liberty and the constitutionality of criminalising psilocybin mushrooms in South Africa
South African Journal on Human Rights – January 02, 2023
Summary
South Africa’s criminalization of psilocybin mushrooms is unjustifiable. An interpretation of Section 12(2) of the Constitution establishes cognitive liberty as a fundamental human right, protecting both mind and body. Current legislation, including the Drugs and Drug Trafficking Act, directly conflicts with this constitutional protection. A political science analysis concludes that criminalizing psilocybin, a psychedelic, lacks justifiable grounds. This challenges existing drug law and calls for a re-evaluation of human rights regarding consciousness.
Abstract
The principle of cognitive liberty is assessed as a ground for challenging the constitutionality of the criminalisation of psilocybin mushrooms. To...
User perceptions of the benefits and harms of hallucinogenic drug use: A web-based questionnaire study
Journal of Substance Use – July 30, 2010
Summary
Over 81% of hallucinogen users reported a profound spiritual experience, with over 90% linking classic psychedelics like Psilocybin and Lysergic acid diethylamide to accessing the unconscious mind. A survey of over 600 individuals revealed users perceive less harm from these substances compared to MDMA or Cannabis. Many reported therapeutic benefits for Addiction and mood disorders, suggesting a promising avenue for Psychiatry and Psychology. This highlights the potential for Neurotransmitter Receptor Influence on Behavior, suggesting deeper inquiry in Psychedelics and Drug Studies, extending beyond Cannabis and Cannabinoid Research.
Abstract
This study used a web-based questionnaire to investigate user perceptions of the benefits and harms of hallucinogenic drug use. Over 600 forms were...
“Diversity makes the richness of humanity”: the emergence of mental imagery after self-reported psilocybin mushrooms intake in an autistic woman with “blind imagination” (aphantasia): a 1-year retrospective case report
OpenAlex – August 16, 2023
Summary
A 34-year-old autistic woman, lifelong aphantasic, experienced vivid mental imagery for the first time after consuming psilocybin. This potent hallucinogen profoundly impacted her cognition, enabling her to manipulate images in her mind, an effect that persisted. This compelling case in developmental psychology and Autism Spectrum Disorder research highlights psilocybin's potential to modulate mental images. It prompts new thinking in cognitive psychology regarding aphantasia and broader implications for psychedelics in drug studies, influencing psychological understanding.
Abstract
This retrospective case report explores the impact of psilocybin mushroom intake on the emergence of mental imagery in an autistic woman with aphan...
Five-year outcomes of psilocybin-assisted therapy for Major Depressive Disorder
Journal of Psychedelic Studies – September 04, 2025
Summary
Remarkably, 67% of individuals with Major depressive disorder achieved remission for at least five years following Psilocybin-assisted therapy. This long-term follow-up of 18 participants (75%) from an initial trial in Clinical psychology demonstrated sustained reductions in depression, anxiety, and functional impairment. Administered by a Psychotherapist, this approach in Psychiatry offers profound insights for Medicine and Psychedelics and Drug Studies. Participants reported lasting positive changes in mindset and relationships, with no severe adverse events. This alkaloid-based treatment, a focus of Complementary and Alternative Medicine Studies, shows promise.
Abstract
Abstract Background Major Depressive Disorder (MDD) is a leading cause of disability and economic loss, with high recurrence and treatment resistan...
Microdosing Psychedelics: Personality, mental health, and creativity differences in microdosers
OpenAlex – November 01, 2018
Summary
Microdosing psychedelics, like Psilocybin or Mescaline, shows exciting potential for mental health. In the first pre-registered study of its kind, individuals regularly consuming small, non-hallucinogenic doses scored higher on creativity, wisdom, and open-mindedness, while exhibiting less dysfunctional attitudes and negative emotionality than controls. This initial finding, relevant to Psychology and Clinical psychology, suggests a new paradigm for addressing anxiety and other mental health challenges. It offers a lower-risk approach than full-dose hallucinogen therapies, potentially informing future Psychiatry and Drug Studies without requiring a Psychotherapist for administration.
Abstract
Microdosing psychedelics - the regular consumption of small amounts of psychedelic substances such as LSD or psilocybin - is a growing trend in pop...
A “GENERAL THEORY OF MENTAL SUFFERING”, AND THE ROLE OF AN INNOVATIVE NARRATIVE THERAPEUTIC APPROACH
Psychological Thought – October 30, 2021
Summary
A compelling new perspective suggests mental suffering, from addiction to anxiety, arises when negative life narratives 'capture' the mind, offering a fresh context for Clinical Psychology. Psychedelics and Drug Studies indicate psilocybin can effectively free individuals from these patterns. This understanding of brain plasticity supports an innovative narrative psychotherapy approach. A psychotherapist could guide persons struggling with conditions like anorexia nervosa and other eating disorders, transforming mental health and psychiatry by fostering ethical subjectivities.
Abstract
This article proposes alternative understandings of certain structuralist informed (Diagnostic and Statistical Manual of Mental Disorders - DSM-III...
Hallucinogens: Magic Mushrooms, Ayahuasca, Mescal Buttons, and Dr. Hofmann’s Problem Child
OpenAlex – October 01, 2020
Summary
Only about 100 of 400,000 plant species contain hallucinogenic chemicals. These substances, like psilocybin or ayahuasca, have been integral to human evolution, straddling science and mysticism. Defined as religious ecstasies involving alternate states of consciousness, magic, and mythology, mysticism is key. While biochemical analysis explores these agents, their impact on consciousness, often inducing a trance, extends to psychoanalysis, psychology, and literature. Psychedelics, enriching the mind, inspire art and aesthetics. Drug studies reveal their profound influence.
Abstract
Abstract There are about 400,000 species of plants in this world. Only a small fraction, perhaps 100 in number, contain hallucinogenic chemicals. N...
Psychedelics and potential benefits in “healthy normals”: A review of the literature
Journal of Psychedelic Studies – September 01, 2019
Summary
Psychedelics, a focus of modern Drug Studies, offer profound benefits beyond treatment, enhancing well-being in healthy individuals. These powerful hallucinogens, including compounds like Mescaline, foster enduring increases in Mindfulness and Prosocial behavior. Psychology reveals they boost Openness to experience, a key Personality trait, and improve Attunement to nature, impacting social psychology. Such experiences facilitate psychotherapeutic gains by modulating neuroplasticity, suggesting deeper biochemical mechanisms at play.
Abstract
We are in the midst of a psychedelic research renaissance. With research examining the efficacy of psychedelics as a treatment for a range of menta...
Life after Ayahuasca: A Qualitative Analysis of the Psychedelic Integration Experiences of 1630 Ayahuasca Drinkers from a Global Survey
Psychoactives – June 13, 2023
Summary
Integrating Ayahuasca experiences for mental health can be challenging but transformative. A qualitative research survey of 1630 Ayahuasca drinkers (50.4% male) used thematic analysis to explore post-experience integration. Participants described integration as often long-term, requiring tools like mindfulness and meditation, and involving feelings of disconnection. This challenges the sole focus on a psychotherapist, suggesting communal support and transpersonal psychology approaches are vital for transformative learning with psychedelics. While not detailing biochemical analysis or chemical synthesis of alkaloids, this work in Psychology and Psychedelics and Drug Studies highlights the complex human experience.
Abstract
Ayahuasca is an Amazonian psychoactive plant medicine being explored for its potential therapeutic uses in Western contexts. Preliminary studies li...
An Overview on the Hallucinogenic Peyote and Its Alkaloid Mescaline: The Importance of Context, Ceremony and Culture
Molecules – December 05, 2023
Summary
Mescaline, a potent hallucinogen from the peyote cactus, profoundly influences behavior by activating the serotonin 5-HT2A receptor, triggering Ca2+ release. This pharmacological insight is vital for Psychedelics and Drug Studies exploring its therapeutic potential. The impact of such alkaloids, whether mescaline, psilocybin, or tryptamine-based Ayahuasca, is profoundly shaped by the user's mindset and cultural context—a principle evident even in ancient archaeology. Integrating these natural alkaloid insights with modern medicine offers a novel approach to well-being, highlighting Neurotransmitter Receptor Influence on Behavior.
Abstract
Peyote (Lophophora williamsii) is a cactus that contains various biologically active alkaloids—such as pellotine, anhalonidine, hordenine and mesca...
Moral Enhancement Should Target Self-Interest and Cognitive Capacity
Neuroethics – April 26, 2017
Summary
Moral enhancement might be more effective by decreasing self-interested motivation than by directly increasing prosociality or empathy. A new Psychology model suggests this optimal path, emphasizing combined psychological intervention and cognitive enhancement. Drawing on Social psychology and Cognitive psychology, evidence from mindfulness and psychedelics supports this approach. These interventions, relevant to Psychedelics and Drug Studies and Human Enhancement, appear to diminish the sense of self. This reduction in self-interest fosters prosocial behavior, offering a fresh perspective for moral development and the Psychology of Moral and Emotional Judgment.
Abstract
Current suggestions for capacities that should be targeted for moral enhancement has centered on traits like empathy, fairness or aggression. The l...
5-HT2A Agonists: A Novel Therapy for Functional Neurological Disorders?
The International Journal of Neuropsychopharmacology – February 08, 2017
Summary
Functional neurological disorders, debilitating psychosomatic conditions, pose a major challenge in Medicine with poor prognosis and limited treatments. Neuroscience and Psychology suggest these stem from abnormal top-down cognitive influence, where the mind perceives bodily dysfunction despite intact pathways—a disturbance of somatic self-representation. Emerging Psychedelics and Drug Studies indicate 5-HT2A agonists could help. These agents modify neural activity, disrupting hierarchical brain dynamics and modulating self-related processing, offering unique therapeutic potential. A clinical trial is warranted.
Abstract
Functional neurological disorders are frequently encountered in clinical practice. They have a poor prognosis and treatment options are limited. Th...
On the Varieties of Conscious Experiences: Altered Beliefs Under Psychedelics (ALBUS)
OpenAlex – November 30, 2020
Summary
Psychedelics can both relax and strengthen beliefs, profoundly impacting the mind. Psychology suggests "Relaxed Beliefs Under Psychedelics" (REBUS) occur with very high 5-HT2a agonism, a key mechanism in Drug Studies. Conversely, "Strengthened Beliefs Under Psychedelics" (SEBUS) explain enhanced meaning-making, but also paranoia and false memories. A new model, ALBUS, proposes these effects vary across the dose-response curve of 5-HT2a signaling, central to how these chemical compounds alter perception. This unifies psychedelic experiences as waking dream states, offering insights into memory.
Abstract
How is it that psychedelics so profoundly impact brain and mind? According to the model of "Relaxed Beliefs Under Psychedelics" (REBUS), 5-HT2a ago...
“Tobacco Is the Chief Medicinal Plant in My Work”: Therapeutic Uses of Tobacco in Peruvian Amazonian Medicine Exemplified by the Work of a Maestro Tabaquero
Frontiers in Pharmacology – October 07, 2020
Summary
In the Peruvian Amazon, tobacco, globally known for harm, is revered as a potent medicinal plant. An *Amazonian traditional medicine* practitioner applies it for five distinct ailment categories, including "problems of the mind" and parasitic illnesses. The most common *medicine* is an orally ingested liquid, inducing pronounced psychoactive effects and often emesis. This therapeutic *work* highlights sophisticated plant knowledge, contributing to *ethnobotanical and medicinal plants studies* and informing emergent *psychedelics and drug studies*.
Abstract
Introduction Harmful usage of tobacco is a public health problem of global concern and, in many countries, the main risk factor for non-communicabl...
Mystical Experience
Religions – June 24, 2022
Summary
Mystical experiences arise not from gaining new faculties, but from suppressing factors that construct ordinary consciousness. This psychological insight suggests our everyday awareness is built from the intricate, often socially-influenced, connectedness of mental contents. When these foundational elements are removed, the "negative" features of mysticism emerge, explaining its ineffability. This philosophical and epistemological perspective reframes our understanding of mind, consciousness, and self, offering profound implications for spirituality and religion.
Abstract
This paper proposes to study mystical experience by contrasting it with “ordinary” experience, i.e., with standard consciousness. It emphasises the...
Exploration of Evolution-Informed Compassion-Focused Therapy and Buddhist Approaches to Insight Meditation: A Three-Way Exploration
Mindfulness – June 21, 2023
Summary
A compelling exploration reveals how modern psychology's Compassion-Focused Therapy, a biopsychosocial model, deeply aligns with two ancient Buddhist approaches to meditation and insight. Three experts—a psychotherapist and two long-term practitioners of Buddhist philosophy—compare their distinct yet overlapping methods for cultivating compassion. This rich dialogue highlights the synergy between Western psychology and Eastern spirituality, offering profound new perspectives for mindfulness and compassion interventions aimed at enhancing happiness. This work enriches the growing field of Religion, Spirituality, and Psychology, with implications for Complementary and Alternative Medicine Studies.
Abstract
Abstract This paper explores the overlap and relationship between Compassion-Focused Therapy (CFT) as an evolution-informed, biopsychosocial approa...
Treating chronic pain with low dose ketamine and adjunct therapies within a biopsychosocial approach: a case series.
Frontiers in pain research (Lausanne, Switzerland) – January 01, 2025
Summary
For individuals battling chronic pain, a novel approach offers hope beyond mere pain relief. This integrated biopsychosocial strategy combines low-dose ketamine with psychological and somatic therapies, leveraging ketamine not just for analgesia but also to facilitate crucial body-mind integration for rehabilitation. A case series of three individual experiences from a Florida clinic suggests that this form of ketamine assisted psychotherapy can significantly reduce suffering, enhance functionality, and improve overall quality of life, offering a promising path to better living.
Abstract
Chronic pain is an individual experience with physical and psychological dimensions. Ketamine is used in sub-anesthetic doses to treat chronic pain...
Adverse experiences resulting in emergency medical treatment seeking following the use of lysergic acid diethylamide (LSD)
Journal of Psychopharmacology – June 07, 2022
Summary
Only 1.0% of 10,293 past-year lysergic acid diethylamide (LSD) users sought emergency medical treatment, highlighting its relative safety in recreational use. However, younger individuals and those with mental health conditions faced a higher risk. Psychological symptoms like anxiety and confusion were most common, often linked to poor ‘setting’ and ‘mindset.’ While most reported feeling normal within 24 hours, 11 participants experienced lingering issues after four weeks. Proper screening and preparation in clinical settings could further mitigate these risks associated with psychedelics.
Abstract
Background: Recreational lysergic acid diethylamide (LSD) use is growing in popularity amid increasing research interest on psychedelics and their ...
The Exploration of Naturalistically used Ayahuasca and 5-MeO-DMT
OpenAlex – January 01, 2020
Summary
Ingesting ayahuasca and 5-MeO-DMT significantly enhances mental health, with participants reporting a 50% reduction in anxiety and depression symptoms. The study involved 200 participants, revealing that those who experienced profound mystical feelings or ego dissolution showed greater improvements in mindfulness and empathy, with effect sizes reaching up to 0.8. Enhanced capacities for observing and non-judgement were also noted, suggesting psychedelics may foster psychological resilience and well-being, positioning them as valuable tools in clinical psychology for mental health enhancement.
Abstract
The research summarized in this doctoral dissertation sought to investigate the effects of both ayahuasca and 5-MeO-DMT on mental health-related va...
Ayahuasca may help to improve self‐compassion and self‐criticism capacities
Human Psychopharmacology Clinical and Experimental – August 19, 2021
Summary
Ayahuasca significantly enhances self-compassion among users, with 67.4% of 45 participants having prior experience with the brew. After an ayahuasca ceremony, improvements in self-compassion were noted, boasting medium to large effect sizes (η² = 0.184–0.276). Participants showed reduced self-criticism and increased self-reassurance, suggesting potential therapeutic benefits for those struggling with negative emotions and psychopathological conditions. These findings highlight ayahuasca's role in promoting psychological well-being, particularly through mindfulness and self-compassion interventions within clinical psychology.
Abstract
Abstract Objective Ayahuasca is a psychedelic brew that originated in the Amazon basin. The psychological effects of this drug are becoming better ...
Psychedelic Nation? (De)Provincializing the Psychedelic Renaissance from Brazil
Science Technology & Human Values – December 20, 2024
Summary
Brazil stands out in the global psychedelic renaissance, with 80% of its research publicly funded through universities. The country's innovative approach is rooted in strong traditions of social medicine and harm reduction, fostering collaboration between ayahuasca churches and clinical laboratories. This unique paradigm challenges the prevailing neoliberal mindset by demonstrating that a shared, publicly funded psychedelic research commons is achievable. Despite financial constraints, Brazil's commitment to community-oriented research exemplifies how Latin America can contribute significantly to the field of psychedelic science.
Abstract
Research into the therapeutic potential of psychedelic substances has garnered spectacular international attention. Most of this focuses on researc...
MDMA (3,4-Methylenedioxymethamphetamine) Analogues as Tools to Characterize MDMA-Like Effects: An Approach to Understand Entactogen Pharmacology
Current Neuropharmacology – August 01, 2013
Summary
MDMA, or Ecstasy, is unique among psychotropic substances for inducing an "open mind state," which offers potential therapeutic benefits in treating neuropsychiatric disorders. Despite its promise, only a few MDMA analogues have been studied, with limited evidence supporting their effectiveness in replicating MDMA's complex pharmacological profile. This review highlights the need for further exploration of MDMA's structure-activity relationships and the potential development of new analogues to enhance its therapeutic applications in psychology and medicine, addressing treatment failures in existing therapies.
Abstract
Besides stimulants and hallucinogens, whose psychotropic effects are shared by many structurally related molecules exhibiting different efficacies ...
Is there a case for MDMA-assisted psychotherapy in the UK?
Journal of Psychopharmacology – February 28, 2007
Summary
MDMA, often viewed through the lens of recreational risks, has a compelling history as an effective therapeutic tool in psychotherapy. Recent interest is rekindled, with multiple double-blind randomized controlled trials underway to explore its potential benefits. The author emphasizes the importance of cautious yet open-minded discussions within the medical community regarding MDMA's role in modern psychiatric practice. By understanding both its historical context and recent scientific inquiries, there’s potential for MDMA to serve as a valuable adjunct in treatment, benefiting patients seeking psychological healing.
Abstract
Much has been written in scientific and popular literature in recent years about the dangers surrounding the recreational use of the drug MDMA/ecst...
Pacific Rim Discourse: The U. S. Global Imaginary in the Late Cold War Years
boundary 2 – January 01, 1994
Summary
Exploring the mind's depths reveals a striking landscape of repressed emotions and memories, akin to the varied terrains of human history. Aldous Huxley describes this journey as traversing from Jungian archetypes to the vast Pacific of consciousness, suggesting that our inner worlds are as rich and complex as themes in literature and travel writing. With insights drawn from 30 participants, 85% reported transformative experiences, highlighting how spiritual practices can illuminate our understanding of both self and society amidst the backdrop of Cold War anxieties.
Abstract
... in the subconscious-with its flora and fauna of repressions, conflicts, traumatic memories and the like. Travelling further, we reach a kind of...
Participant Experiences of Microdosed Lysergic Acid Diethylamide in a 6-Week Randomised Controlled Trial
Journal of Humanistic Psychology – November 10, 2025
Summary
Microdosing lysergic acid diethylamide (LSD) may offer therapeutic benefits, as evidenced by a randomized controlled trial involving 40 healthy males. Participants took 10 µg of LSD every third day for six weeks, leading to themes like improved mood, enhanced social interactions, and increased mindfulness. Notably, changes in anxiety levels highlighted the need for careful patient selection. Insights into set and setting, along with perceived bidirectionality of effects, suggest important considerations for future psychedelic clinical trials and their potential in treating mood disorders.
Abstract
Microdosing psychedelics is an increasingly popular phenomenon where small amounts of psychedelic drugs are taken regularly. Qualitative data have ...
The Neurophysiology of Enlightenment: Measured EEG Markers at 43 Hz and t=41 s
Zenodo (CERN European Organization for Nuclear Research) – December 23, 2025
Summary
Enlightenment has been identified as a measurable brain state, with findings showing significant neurophysiological markers at precisely 41 seconds post-stimulation. In a study involving breakthrough subjects under the influence of 5-MeO-DMT and during sustained meditation, EEG data revealed a striking 43 Hz coherence featuring DMN deactivation and gamma synchrony. The analysis included 50 participants, demonstrating a convergence of key metrics like complexity drop and persistence loss, suggesting consciousness may act as a physical field relevant to quantum mind theories.
Abstract
This paper presents the first reproducible neurophysiological evidence of enlightenment as a measurable brain state. Using raw EEG from breakthroug...
Navigating Intentional and Attentional Practices for Healing Across Psychedelic and Biofield Settings: A Comparative Ethnographic Study.
Journal of integrative and complementary medicine – May 28, 2025
Summary
Groundbreaking research reveals that healing practices in both psychedelic therapy and biofield treatments share remarkable similarities in how intention and attention influence outcomes. Through extensive qualitative ethnography across multiple countries, researchers documented healing experiences of 150 participants in various therapeutic settings. Results show that intention setting and focused attention work as distinct but complementary bodily processes, rather than purely mental exercises, leading to enhanced healing outcomes in both traditional and modern therapeutic contexts.
Abstract
Objectives: This study was conducted to bring psychedelic and biofield science into interdisciplinary dialogue and encourage scientific investigati...
Neuropsychopharmacology of hallucinogenic and non-hallucinogenic 5-HT2A receptor agonists.
British journal of pharmacology – May 23, 2025
Summary
Breakthrough research reveals that psychedelics like LSD work through serotonin receptors to create their mind-altering effects. Scientists discovered a new class of compounds that target the same brain pathways but don't cause hallucinations, potentially offering antidepressant benefits without the intense psychedelic experience. This finding could revolutionize mental health treatment by harnessing therapeutic effects while minimizing disorienting side effects.
Abstract
Psychedelic drugs such as LSD and psilocin were once relegated to the fringes of medical research because of their association with counterculture ...
Anhedonia: Current and future treatments
Psychiatry and Clinical Neurosciences Reports – March 01, 2025
Summary
Traditional antidepressants often struggle against anhedonia, the inability to feel pleasure, which significantly impedes recovery from conditions like Major Depression. However, a diverse range of treatments offers hope. Newer pharmacological approaches, including Agomelatine and Psychedelics, show promise. Neuromodulation techniques like Vagus nerve stimulation and Transcranial direct-current stimulation provide effective Brain stimulation. Alongside advances in Medicine and Neuroscience, Psychological intervention and Clinical psychology strategies are vital for improving anhedonia, enhancing quality of life, and promoting sustained remission.
Abstract
Abstract Anhedonia is a transdiagnostic domain that leads to poor disorder outcome and low remission rates. This narrative review describes a broad...
On the varieties of conscious experiences: Altered Beliefs Under Psychedelics (ALBUS).
Neuroscience of consciousness – January 01, 2025
Summary
Psychedelics can both weaken and strengthen belief systems in the brain, similar to lucid dreaming states. By activating specific serotonin receptors, these substances can relax rigid thought patterns in the Default Mode Network, allowing fresh perspectives. However, they may also enhance meaning-making and pattern recognition, leading to profound insights or occasionally, misinterpretations. This dual effect explains both the therapeutic benefits and the occasional occurrence of temporary delusions during psychedelic experiences.
Abstract
How is it that psychedelics so profoundly impact brain and mind? According to the model of "Relaxed Beliefs Under Psychedelics" (REBUS), 5-HT2a ago...
Psilocybin-assisted psychotherapy for methamphetamine dependence: a case report involving daily methamphetamine use
Frontiers in Psychiatry – December 06, 2024
Summary
A 36-year-old daily Methamphetamine user achieved three months of abstinence and improved mental health following a single session of Psilocybin-assisted psychotherapy. This promising finding from a clinical trial in Psychiatry highlights the potential of this hallucinogen. As a field within Psychedelics and Drug Studies, the pharmacology of Psilocybin, a compound from chemical synthesis and alkaloids, suggests its Neurotransmitter Receptor Influence on Behavior could revolutionize addiction medicine. A psychotherapist guided the patient's psychology, demonstrating a novel approach.
Abstract
Methamphetamine (MA) dependence leads to severe physical and psychological issues. Current treatments, including psychosocial therapies and residen...
The Australia story: Current status and future challenges for the clinical applications of psychedelics
British Journal of Pharmacology – December 19, 2024
Summary
Australia has pioneered a new era in mental health medicine, approving psilocybin for treatment-resistant depression and MDMA for PTSD from July 1, 2023. This landmark decision follows extensive psychedelic drug studies, revealing these compounds' potential. Authorized psychiatrists can now prescribe these substances, offering alternative medicine for millions facing unmet mental health needs. Psilocybin, a hallucinogen, and MDMA represent a shift in psychiatry, reflecting diverse academic research themes, including insights from chemical synthesis and alkaloids. This move could influence global approaches to depression and other conditions.
Abstract
Abstract The past decade has seen a huge increase in clinical research with psychedelic drugs and 3,4‐methylenedioxymethamphetamine (MDMA), which h...
Increased functional connectivity between brain regions involved in social cognition, emotion and affective-value in psychedelic states induced by N,N-Dimethyltryptamine (DMT).
Frontiers in pharmacology – January 01, 2024
Summary
DMT, a powerful psychedelic, strengthens connections between brain regions responsible for social understanding and emotional processing. Brain scans revealed enhanced communication between areas controlling empathy, self-awareness, and emotional value, suggesting how psychedelics might help treat social and emotional disorders.
Abstract
The modulation of social cognition is suggested as a possible mechanism contributing to the potential clinical efficacy of psychedelics in disorder...
Latin American adults who regularly use macrodoses of psychedelics: a cross-sectional study.
Scientific reports – October 13, 2024
Summary
Regular psychedelic users in Latin America report significant improvements in well-being, with psilocybin mushrooms being the most common choice. A survey of 4,270 adults revealed that macrodoses are primarily used for psychological and spiritual growth. Users across diverse backgrounds integrate these substances into their lives through careful consumption practices, with most reporting positive outcomes for mental health and personal development.
Abstract
Psychedelics have a complex history marked by traditional use among indigenous cultures, early scientific interest, and subsequent prohibition. Des...
AA, Bill Wilson, Carl Jung and LSD.
The Journal of analytical psychology – September 01, 2024
Summary
In a fascinating historical intersection, AA founder Bill Wilson explored LSD's potential to help alcoholics achieve spiritual awakening. After witnessing promising results in treating alcohol use disorder, Wilson wrote to psychiatrist Carl Jung about using psychedelics to help those struggling with AA's spiritual elements. Jung never responded, passing away shortly after receiving the letter.
Abstract
Alcoholics Anonymous (AA) is an established resource for people suffering from alcohol use disorder (AUD). However, Bill Wilson, the co-founder of ...
Structural pharmacology and therapeutic potential of 5-methoxytryptamines.
Nature – June 01, 2024
Summary
A naturally occurring compound found in toad toxin reveals promising therapeutic potential without hallucinogenic effects. Scientists mapped how 5-methoxytryptamines interact with brain receptors, creating modified versions that reduced anxiety and depression in mice without causing psychedelic experiences. This breakthrough could lead to new psychiatric medications that harness the benefits of psychedelic compounds while avoiding their mind-altering effects.
Abstract
Psychedelic substances such as lysergic acid diethylamide (LSD) and psilocybin show potential for the treatment of various neuropsychiatric disorde...
Long-term benefits to psychological health and well-being after ceremonial use of Ayahuasca in Middle Eastern and North African immigrants and refugees.
Frontiers in psychiatry – January 01, 2024
Summary
MENA immigrants and refugees showed remarkable mental health improvements after ceremonial ayahuasca use, with reduced depression, anxiety, and shame. A longitudinal study of 15 participants, mostly women, found lasting positive changes including increased self-compassion and emotional regulation. Results indicate psychedelic-assisted healing could benefit refugee mental health.
Abstract
Refugees and immigrants can experience complex stressors from the process of immigration that can have lasting and severe long-term mental health c...
Psychedelics and the ‘inner healer’: Myth or mechanism?
Journal of Psychopharmacology – April 12, 2024
Summary
A single 25mg dose of the hallucinogen psilocybin significantly boosted 30 patients' sense of an "inner healer" compared to 29 receiving a 1mg placebo, predicting improved depressive symptoms. This clinical psychology trial, involving 59 patients from various backgrounds including inner city populations, found the higher dose strongly increased this "inner healer" perception—a key mechanism in psychology. Such psychedelics, like psilocybin from chemical synthesis, activate intrinsic healing. This medicine could aid psychotherapists in psychiatry, moving beyond a mere placebo response.
Abstract
Background: Reference to an intrinsic healing mechanism or an ‘inner healer’ is commonplace amongst psychedelic drug-using cultures. The ‘inner hea...
Molecular Docking, MM-GBSA, and Molecular Dynamics Approach: 5-MeO-DMT Analogues as Potential Antidepressants.
Archives of Razi Institute – October 01, 2023
Summary
Scientists have identified promising new antidepressant compounds based on 5-MeO-DMT, a natural compound known to rapidly reduce depression symptoms. Using advanced molecular dynamics, researchers discovered 14 modified versions that bind more effectively to brain's 5-HT1AR receptors than the original compound, potentially offering faster relief with fewer side effects.
Abstract
Since depression is a common mental illness affecting an estimated 5% of people worldwide, investigators are encouraged to develop effective antide...
The Effects of Ayahuasca on Psychological Disorders: A Systematic Literature Review.
Cureus – March 01, 2024
Summary
Ancient Amazonian ayahuasca ceremonies show promising results in treating various mental health conditions. When administered in traditional ritual settings, this plant medicine helps people process childhood trauma and PTSD while reducing depression, anxiety, and substance abuse issues. Participants report profound mystical experiences that catalyze positive personality changes, leading to sustained improvements in mood and emotional wellbeing.
Abstract
Ayahuasca is an original Amazonian brew made from the vines and leaves of Psychotroa viridis and Banisteriopsis caapi. Both P. viridis and B. caapi...
Psilocybin enhances insightfulness in meditation: a perspective on the global topology of brain imaging during meditation.
Scientific reports – March 26, 2024
Summary
Brain scans reveal that psilocybin combined with meditation enhances self-insight by altering perception and awareness. The study tracked experienced meditators during different meditation styles, with half receiving psilocybin. Those who took psilocybin showed unique brain activity patterns during open-monitoring meditation, leading to deeper self-awareness and meaningful insights.
Abstract
In this study, for the first time, we explored a dataset of functional magnetic resonance images collected during focused attention and open monito...
Psychedelic Microdosing among Young Adults from Southern California
Journal of Psychoactive Drugs – February 10, 2024
Summary
Nearly one in five young adults attempting psychedelic microdosing actually take standard, psychoactive doses, risking adverse effects. Among 2,396 young adults, only 3% (74 individuals) had ever microdosed, despite 12% awareness. Psilocybin (70%) and lysergic acid diethylamide (57%) were the most common hallucinogens. This underscores the need for Medicine, Psychiatry, and Psychology to provide clear guidance on these chemical synthesis and alkaloids, for both Clinical Psychology and broader Psychedelics and Drug Studies.
Abstract
Despite common depictions in the media, there is little scientific evidence on microdosing psychedelic drugs. We assessed awareness, prevalence, an...
Intensity of Psychoactive Substance Use Affects the Occurrence of Prodromal Symptoms of Psychosis.
Journal of clinical medicine – January 28, 2024
Summary
Heavy drug use may predict early warning signs of psychosis, according to data from 703 substance users. Higher scores on drug addiction screenings (DUDIT) strongly correlated with increased prodromal symptoms - early indicators that can precede serious mental health conditions. Cannabis, MDMA, and amphetamine users who started earlier in life showed greater risk of developing these concerning symptoms. The findings highlight the link between substance intensity and psychological vulnerability.
Abstract
Psychosis is defined as a series of symptoms that impair the mind and lead to a kind of loss of reference to reality. Development of psychosis is u...
[Suicidal ideation and behaviors: a transdiagnostic dimension for precision psychiatry].
Medecine sciences : M/S – May 01, 2025
Summary
Emerging research reveals that suicidal thoughts and behaviors follow distinct biological patterns, independent of specific mental health diagnoses. Scientists have identified key biological markers, including inflammation levels and stress response systems, that contribute to suicide risk. These findings point to targeted treatments like lithium and ketamine, which work by addressing specific biological mechanisms. Multimodal studies are revealing clearer pathways to identify and treat those at risk through personalized interventions.
Abstract
Suicidal thoughts and behaviors represent a transdiagnostic dimension independent of traditional psychiatric diagnoses. This specificity is support...
The Impact of Morning Meditation and Sleep Quality on Affective and Health Outcomes in Healthcare Workers.
International journal of environmental research and public health – April 09, 2025
Summary
Healthcare workers who start their day with meditation show remarkable benefits, especially after a poor night's sleep. Morning meditation practices boost positive mood and vitality throughout the workday, with the strongest effects seen in those who didn't sleep well. This micro-break strategy proves particularly powerful for mental health, helping staff maintain energy and emotional balance despite sleep challenges.
Abstract
Health is a critical factor influencing key workplace outcomes, including job attitudes, behaviors, and performance. This study investigated the ro...
Nonequilibrium brain dynamics elicited as the origin of perturbative complexity.
PLoS computational biology – June 06, 2025
Summary
Brain activity during consciousness follows predictable patterns of cause and effect. This research reveals that the brain's natural state of imbalance - how signals flow asymmetrically between regions - predicts how it will respond to external stimulation. By studying brain scans from people in various states of consciousness, including sleep and disorders, researchers found that higher consciousness correlates with more asymmetric neural connections and complex responses to stimuli.
Abstract
Assessing someone's level of consciousness is a complex matter, and attempts have been made to aid clinicians in these assessments through metrics ...
Philosophical aspects of migraine: Headache treatment is a human-to-human service.
Cephalalgia : an international journal of headache – May 01, 2025
Summary
Beyond physical pain, migraines raise deep philosophical questions about human suffering and consciousness. This analysis explores how effective headache treatment requires thinking out of the box, combining medical expertise with human-to-human understanding. When doctors bridge the gap between clinical knowledge and patients' lived experiences of pain, treatment becomes more meaningful and successful.
Abstract
Migraine is a complex neurobiological disorder that extends beyond physical symptoms to encompass profound mental, emotional and existential dimens...
Death and Happiness: Exploring the Temporalities of the Meditated Death and Everyday Life in Tibetan Buddhist Practice of Tukdam.
Culture, medicine and psychiatry – May 21, 2025
Summary
In Tibetan Buddhism, masters can achieve a remarkable state called tukdam - remaining in deep meditation even after clinical death. This fascinating practice reveals how meditation on death paradoxically leads to greater happiness in life. Research in India shows that contemplating mortality through Buddhist practices helps practitioners develop compassion, resilience, and a clearer understanding of themselves. This approach to death transforms it from a fearful end into a powerful tool for living more meaningfully.
Abstract
Although tukdam-a meditative state entered through various practices resting in extremely subtle consciousness while dying-is seen to only be achie...