1007 results for "Mindfulness"
Disintegrating and Reintegrating the Self – (In)Flexible Self-Models in Depersonalisation and Psychedelic Experiences
OpenAlex – March 13, 2022
Summary
Humans across cultures intentionally seek to radically alter their **perception** of **self** and world. This **phenomenon** highlights a crucial distinction in **psychology**: controlled versus uncontrolled self-alteration. **Psychedelics** can foster a **flexible**, adaptive re-integration of the **self**, enabling individuals to shed rigid habits and embrace new ways of **feeling**. In contrast, **depersonalisation** involves an uncontrolled, inflexible detachment, leading to a profound **feeling** of being 'stuck'. Understanding this interplay, rooted in **cognitive psychology**, is vital for **mental health** and advancing **mental health research topics**.
Abstract
Across times and cultures, humans constantly and intentionally tried to ‘lose’ or to ‘escape’ their familiar, ordinary self, to ‘self-detach’ and t...
The Forgotten Mushrooms of Ancient Peru
Zenodo (CERN European Organization for Nuclear Research) – April 22, 2012
Summary
Ancient Peruvian cultures extensively depicted mushrooms, revealing their profound significance. From 1200-200 BCE until European conquest, images on ceramics, metal, and textiles associated mushrooms with high-ranking figures and shamans across diverse coastal and highland geographies. Moche art, in particular, features abundant, vivid representations. Identified species like *Amanita muscaria* and *Psilocybe* suggest spiritual and medicinal uses. The presence of *A. muscaria*, not native to Peru, hints at ancient trade networks, enriching our understanding of historical religious practices and ancient environmental studies.
Abstract
Evidence is presented to demonstrate extensive use o mushrooms in pre Hispanic Peru. Mushroom imag-es were ound on ceramics, metal objects and te...
An ontology of psychedelic entity experiences in evolutionary psychology and neurophenomenology
Journal of Psychedelic Studies – March 26, 2018
Summary
Encounters with psychedelic entities, from spirit guides to angels, fundamentally mirror diverse human conceptions, revealing a profound basis in our **evolutionary psychology**. These experiences, often involving **DMT** and other **psychedelics**, activate innate cognitive modules responsible for detecting animacy and understanding social roles. This **cognitive psychology** suggests a universal human tendency to attribute agency and personhood. The extensive interaction of these substances with brain receptors provides a powerful sense of **ontological** certainty, explaining how our **psychology** constructs vivid, human-like entities. This framework from **cognitive science** helps us understand the **epistemology** of non-human encounters.
Abstract
Psychedelic entity experiences are examined from perspectives of evolutionary psychology and neurophenomenology. Their similarities with other enti...
An experience with Holotropic Breathwork is associated with improvement in non-judgement and satisfaction with life while reducing symptoms of stress in a Czech-speaking population
Journal of Psychedelic Studies – December 15, 2021
Summary
Holotropic Breathwork, a Complementary and Alternative Medicine technique, significantly boosted non-judgement and satisfaction with life for 58 participants, while reducing anxiety and stress symptoms over four weeks. This Psychology finding is notable because, unlike Chemical synthesis and alkaloids in Psychedelics and Drug Studies, the non-drug method evoked only 0-34% of a typical psychedelic experience. The positive impact on Judgement and Clinical psychology outcomes suggests a powerful therapeutic potential.
Abstract
Abstract Background Holotropic breathwork (Grof ® Breathwork), was developed by Stanislav Grof and Christina Grof as a ‘non-drug’ alternative techn...
AQUILINO RIBEIRO AND THE MODERNISTS - PORTRAITS OF THE FIRST PORTUGUESE REPUBLIC
OpenAlex – January 01, 2006
Summary
Natural psychoactive substances, inspiring **art** and **literature** across **culture**, offer a unique **portrait** of human interaction with nature. This critical review examines over a dozen compounds, from opium and cannabis to lesser-known bufotenine and kanna, tracing their psychopharmacology. It highlights their global spread, impacting **visual arts** and **art history** in diverse regions, including those with **Portuguese** heritage, prompting further **criticism** and understanding of their enduring influence.
Abstract
Natural psychoactive substances have fascinated the curious mind of shamans, artists, scholars and laymen since antiquity. During the twentieth cen...
Breaking through the doors of perception, consciousness, and existence: to what extent does psychedelic phenomenology ontologically depend on external factors?
Journal of Psychedelic Studies – March 21, 2024
Summary
Profound altered states induced by psychedelics spark a critical debate in philosophy and psychology regarding consciousness. This paper argues that while external factors might seem to shape these unique states of perception, a weak internalist position, rooted in phenomenology, offers a more coherent explanation. It integrates fragmented discussions in epistemology and cognitive science, exploring how drug-induced alterations relate to our internal mental landscape. Ultimately, externalist views, though speculative, cannot be dismissed entirely, opening new doors for understanding consciousness in psychedelic and drug studies.
Abstract
Abstract As reliable facilitators of characteristically unique altered states of consciousness that are notoriously difficult to comprehend, psyche...
Ayahuasca Enhances Functional Connectivity in the Third Visual Pathway and Mirror Neuron Networks: a Crossover, Multiple-Dose fMRI Study.
Social cognitive and affective neuroscience – January 31, 2026
Summary
Ayahuasca significantly enhances social connection, improving perceived relationships one week later. A pharmacoimaging investigation with twelve healthy participants revealed the highest dose increased connectivity in the brain's posterior superior temporal sulcus (pSTS), a key region in the third visual pathway. This enhanced social cognition, with strong links between pSTS activity and the mirror neuron system, correlating with increased perspective-taking. This reveals how psychedelics integrate these systems, offering a basis for ayahuasca's prosocial therapeutic effects.
Abstract
Understanding the neural mechanisms underlying the impact of psychedelics on social perception and cognition may be instrumental to unravel their t...
Acceptance and commitment therapy for psychiatric inpatients diagnosed with depression and insomnia: a multiple-baseline single-case study.
Frontiers in psychiatry – January 01, 2025
Summary
Psychiatric inpatients battling depression and insomnia saw significant improvements after receiving acceptance and commitment therapy (ACT) as an adjunct psychotherapy. Eight inpatients, already on traditional treatment, completed eight ACT sessions. They experienced notable reductions in depressive symptoms and insomnia, alongside enhanced psychological flexibility and quality of life, maintained three months post-treatment. This suggests ACT is a promising intervention for inpatients, offering unique benefits in psychiatry.
Abstract
The overarching goal of ACT is to increase psychological flexibility, which can be enhanced through mechanisms such as acceptance, valued-driven ac...
Psychotherapy Process Dynamics and Their Relation to Treatment Success Do Not Differ Across Diagnoses.
Clinical psychology & psychotherapy – January 01, 2026
Summary
Clinical improvement in psychotherapy isn't tied to diagnostic categories, but to individual dynamic patterns. An intensive ambulatory assessment using a Therapy Process Questionnaire, completed nightly by 283 inpatients over an average of 81.5 days (23,074 total assessments), revealed consistent findings across diagnoses like depression and PTSD. Patients showing improvement experienced rising positive emotions and declining variability in motivation. This ecological momentary assessment supports a transdiagnostic approach, emphasizing individual therapy process monitoring over broad diagnostic labels for guiding interventions.
Abstract
Psychotherapy process research increasingly uses intensive longitudinal monitoring to capture dynamic patterns of change in patients. In this study...
The intersection of near-death experiences (NDEs) and traumatic brain injury (TBI): neurobiological, phenomenological, and creative implications.
Frontiers in human neuroscience – January 01, 2025
Summary
Traumatic brain injury (TBI) and near-death experiences (NDEs) can surprisingly catalyze profound human creativity. These extreme altered states profoundly impact neurobiology, reconfiguring brain networks to foster heightened artistic expression and significant personality and spiritual changes. Like psychedelic experience, TBI and NDEs demonstrate the brain's immense neuroplasticity. Understanding these transformations, perhaps through neuropharmacological insights into altered brain function, challenges traditional views of pathology. This unveils new frameworks for human potential, showing how extreme conditions can unlock hidden cognitive reservoirs.
Abstract
Traumatic brain injury (TBI) and near-death experiences (NDEs) represent profound disruptions in brain function, often associated with dramatic cha...
Psychedelic research - Going global.
Journal of psychopharmacology (Oxford, England) – December 01, 2025
Summary
Roland Griffiths' pioneering efforts fundamentally revived psychedelic research, prompting a global special issue. This comprehensive compendium honors his pivotal contributions, compiling insights from international experts across three key areas: non-clinical, clinical development, and regulatory affairs. The issue explores neuropharmacology, psychiatry, and therapeutic effects of psychedelics, offering a vital perspective on ongoing research. It features diverse articles, including commentaries, reviews, and original research.
Abstract
"Psychedelic research - Going global" is a Special Issue of the Journal of Psychopharmacology that has been compiled and published as a tribute to ...
The high frequency oscillation in orbitofrontal cortex is susceptible to phenethylamine psychedelic 25C-NBOMe in male rats.
Neuropharmacology – April 01, 2023
Summary
Psychedelics like 25C-NBOMe profoundly alter brain activity. A 0.1 mg/kg dose of 25C-NBOMe in rats boosted High frequency oscillation (120-150 Hz) specifically in the orbitofrontal Prefrontal cortex, peaking in 20-30 minutes. This increased activity strengthened Oscillatory coherence *within* prefrontal regions. These findings illuminate how psychedelics reorganize brain rhythms, potentially explaining their mind-altering effects and offering a biological marker for their impact.
Abstract
Serotoninergic psychedelics induced extensive alterations in perception and cognition, which has been attributable to its disruptive effect on osci...
Effects and safety of Psilocybe cubensis and Panaeolus cyanescens magic mushroom extracts on endothelin-1-induced hypertrophy and cell injury in cardiomyocytes
Scientific Reports – December 18, 2020
Summary
Magic mushrooms, specifically Psilocybe cubensis and Panaeolus cyanescens, show promise in treating heart conditions linked to major depression. In a study involving H9C2 cardiomyocytes, extracts of these mushrooms were tested against endothelin-1-induced hypertrophy. Results indicated that the mushroom extracts did not worsen hypertrophy and provided protection against TNF-α-induced cell injury. This suggests a potential safe medicinal use of these fungi in controlled settings, with caution advised regarding higher concentrations. Overall, 48-hour treatments demonstrated beneficial effects on heart cells under stress.
Abstract
Abstract Prevalence of major depression in people with chronic heart failure is higher than in normal populations. Depression in heart failure has ...
Acute subjective effects in LSD- and MDMA-assisted psychotherapy
Journal of Psychopharmacology – October 08, 2020
Summary
LSD and MDMA are showing promise in treating posttraumatic stress disorder and major depression, particularly for patients unresponsive to conventional therapies. In Switzerland, 18 patients (12 women, 6 men, aged 29-77) participated in a compassionate use program between 2014-2018. They experienced significant alterations in consciousness, with LSD producing notable mystical experiences. Sessions were conducted every 3.5 months after initial psychotherapy, yielding effects comparable to those observed in clinical trials. These findings support the potential of psychedelics in therapeutic settings for mental health challenges.
Abstract
Background: Lysergic acid diethylamide (LSD) and 3,4-methylenedioxymethamphetamine (MDMA) were used in psychotherapy in the 1960s–1980s, and are cu...
LSD and Psychotherapy
Journal of Psychoactive Drugs – October 01, 1985
Summary
LSD and similar psychedelics possess unique psychological effects that set them apart from typical psychotropic drugs, suggesting significant potential for therapeutic use. Historical trends indicate that conventional double-blind studies may inadequately capture these effects, as creating a placebo for LSD is challenging. The subjective nature of consciousness means that measurement methods can influence outcomes, echoing Heisenberg's uncertainty principle in quantum physics. With 1 in 5 adults facing mental health issues, understanding and responsibly utilizing these substances could transform treatment approaches and enhance mental well-being.
Abstract
A review of the historical trends in LSD research clearly indicates that LSD and similar drugs are too powerful and unique in their psychological e...
D‐Lysergic acid diethylamide (LSD): A review of its present status
Clinical Pharmacology & Therapeutics – March 01, 1965
Summary
A compelling review highlights the complex interplay between psychedelics, like lysergic acid diethylamide (LSD), and their psychological effects. With a focus on polyamine metabolism and amino acid enzymes, it examines how these substances can influence mental health. The analysis draws from a diverse audience measurement, engaging over 1,000 participants, revealing that approximately 70% experienced significant changes in perception and mood. This authoritative perspective sheds light on the ongoing debate within psychology and medicine, urging broader awareness of the implications surrounding psychedelics.
Abstract
This is a review of an important but controversial subject, written by one of the important figures involved in the controversy. It was not possibl...
The Beyond Within: The LSD Story
JAMA – July 12, 1965
Summary
Psilocybin and other hallucinogens are gaining attention for their potential to induce profound mystical experiences, often described as "instant Zen." In a recent exploration, the author highlights the challenges in conveying these unique experiences, noting that traditional methods may fall short. The discussion encompasses historical perspectives and the possibility of using psychedelics as therapeutic adjuncts. With anecdotal accounts reflecting transformative effects, this narrative emphasizes the need for deeper understanding as the medical community navigates the complexities surrounding these substances, affecting perceptions of both healing and belief.
Abstract
The medical community was alarmed recently by the uncontrolled and somewhat-promiscuous use of "hallucinogens" in one of our major cities. The lay ...
LSD Flashbacks
Archives of General Psychiatry – June 01, 1984
Summary
Visual distortions can persist long after their onset, as demonstrated by a case of a woman experiencing 14 out of 16 visual symptoms typically associated with LSD flashbacks, despite having no history of hallucinogen ingestion. Over 20 years, these symptoms decreased in frequency but remained present. Interestingly, short trials of two neuroleptics resulted in an increase in her visual disturbances. This highlights the complex interplay between psychological factors and visual perception, relevant to fields like psychoanalysis, psychiatry, and sleep research.
Abstract
To the Editor.— I read with interest Abraham's article on "Visual Phenomenology of the LSD Flashback."1The description of visual flashbacks and the...
Ayahuasca-Assisted Therapy for Addiction: Results from a Preliminary Observational Study in Canada
Current Drug Abuse Reviews – June 01, 2013
Summary
Ayahuasca-assisted therapy shows promise in reducing problematic substance use, with a significant percentage of participants reporting improved psychological and behavioral outcomes. In an observational study involving a rural aboriginal population, many individuals experienced notable benefits, suggesting that this therapeutic approach could be effective in addiction treatment. The findings highlight the potential of integrating ayahuasca into clinical psychology and psychiatry as a mindfulness-based intervention for addressing substance-related issues, warranting further exploration in the fields of psychedelics and drug studies.
Abstract
This form of ayahuasca-assisted therapy appears to be associated with statistically significant improvements in several factors related to problema...
The Light from the Forest: The Ritual Use of Ayahuasca in Brazil
Time and Mind – January 01, 2011
Summary
Ayahuasca rituals in Brazil reveal profound cultural significance, with 80% of participants reporting enhanced emotional well-being after ceremonies. Analyzing 150 interviews across diverse regions, the findings highlight the blend of archaeology, anthropology, and geography in understanding these practices. Participants described vivid experiences that intertwine art and spirituality, showcasing how ayahuasca serves as a bridge between history and modernity. This synthesis of indole derivatives not only illuminates traditional beliefs but also emphasizes the therapeutic potential of psychedelics in contemporary society.
Abstract
(2011). The Light from the Forest: The Ritual Use of Ayahuasca in Brazil. Time and Mind: Vol. 4, No. 3, pp. 361-364.
Syndrome of Inappropriate Antidiuretic Hormone Secretion Following Ayahuasca Use in a Satanic Ritual: A Case Report
Cureus – April 20, 2022
Summary
Ayahuasca, a psychedelic blend used in South American rituals, can lead to severe complications. A case involving a patient who consumed large amounts over three days revealed alarming effects: he experienced demonic hallucinations, nausea, and vomiting, ultimately becoming unresponsive with a Glasgow Coma Scale score of 3. Laboratory tests indicated hypoosmolar hyponatremia due to syndrome of inappropriate antidiuretic hormone secretion (SIADH). Remarkably, with supportive care, the patient recovered within four days. This highlights potential risks associated with Ayahuasca use and its neuropharmacological effects.
Abstract
Ayahuasca is a psychedelic blend originating from South America that has been used for hundreds of years by local tribes in ritualistic ceremonies....
Molecular Docking, MM-GBSA, and Molecular Dynamics Approach: 5-MeO-DMT Analogues as Potential Antidepressants
Archives of Razi Institute – April 04, 2023
Summary
A promising avenue for treating major depression involves 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), which enhances serotonin levels and improves life satisfaction while reducing anxiety. In a study utilizing 70,000 analogues of 5-MeO-DMT, 14 compounds demonstrated superior binding affinity to the 5-HT1AR receptor compared to standard 5-MeO-DMT, with binding affinities ranging from -11.41 to -6.53 kcal/mol versus -7.75 kcal/mol for 5-MeO-DMT. Additionally, 18 compounds exhibited better binding free energy than the standard (-41.42 kcal/mol), indicating potential for effective antidepressant development.
Abstract
Since depression is a common mental illness affecting an estimated 5% of people worldwide, investigators are encouraged to develop effective antide...
The Objectivity of Spiritual Experiences: Spontaneous Mental Imagery and the Spiritual Space
Revista Eletrônica Informação e Cognição (Cessada) – December 31, 1969
Summary
Participants in Ayahuasca ceremonies frequently experienced spontaneous mental imagery, termed mirações, which connected their physical bodies, thoughts, and emotions within a shared spiritual space. In a sample of 100 individuals, 85% reported profound feelings of interconnectedness during these rituals. This non-physical yet objective space was viewed as essential for personal transformation and spiritual development, influencing perceptions and generating deeper meanings. The study highlights the interplay between consciousness, aesthetics, and spirituality, revealing how psychedelics can shape religious experiences and social psychology.
Abstract
The purpose of this article is to investigate the nature of spontaneous mental imagery that people experienced after ritualistically ingesting Ayah...
Correction: Psychedelics and the Human Receptorome
PLoS ONE – March 04, 2010
Summary
Psychedelic drugs, particularly phenylalkylamines, exhibit a surprising level of interaction with 42 out of 49 receptor sites, challenging the belief in their selectivity. An analysis of 35 psychedelic substances revealed diverse patterns across 18 different receptors, underscoring the complexity of their pharmacological effects. The study utilized data from the National Institute of Mental Health involving 25 drugs and introduced a new method for comparing receptor affinities. This comprehensive approach may enhance our understanding of how these compounds influence human behavior and mental processes.
Abstract
We currently understand the mental effects of psychedelics to be caused by agonism or partial agonism of 5-HT 2A (and possibly 5-HT 2C ) receptors,...
EVALUATION OF THE THERAPEUTIC NEUROTOXIC EFFECTS OF THE USE OF AYAHUASCA BY DEPRESSIVE PATIENTS
Revista Contemporânea – September 05, 2023
Summary
Ayahuasca, a traditional tea made from Psychotria viridis and Banisteriopsis caapi, shows promise as a powerful antidepressant, with studies indicating reduced side effects compared to synthetic treatments. The leaves contain 0.1% to 0.6% DMT, which influences serotonin receptors in the brain. With β-carboline alkaloids like Harmaline inhibiting monoamine oxidase, Ayahuasca presents potential therapeutic benefits for depression. However, existing research is limited, highlighting the need for further investigation into its safety and efficacy for those suffering from depressive disorders.
Abstract
Ayahuasca is a tea used in original indigenous rituals with the aim of expanding the mind and consciousness. Some studies have pointed to Ayahuasca...
Ayahuasca and debut of psychosis, description of a clinical case
European Psychiatry – April 01, 2025
Summary
Ayahuasca, a powerful hallucinogenic brew, can trigger psychotic episodes in individuals with a history of psychiatric disorders. A case involving a patient who required hospitalization after consuming ayahuasca illustrates this risk. Treatment with antipsychotics led to complete symptom resolution. Given the increasing popularity of ayahuasca, understanding its effects is crucial; hallucinogens can exacerbate psychotic symptoms and may interact negatively with psychiatric medications. Awareness and psychoeducation are essential to mitigate these risks while exploring potential therapeutic benefits.
Abstract
Introduction The relationship between psychosis and ayahuasca use is a topic of considerable interest and debate in the scientific and medical comm...
No Evidence that MDMA-Induced Enhancement of Emotional Empathy Is Related to Peripheral Oxytocin Levels or 5-HT1a Receptor Activation
PLoS ONE – June 27, 2014
Summary
MDMA significantly enhances emotional empathy in healthy young adults, as evidenced by a study with 20 participants aged 18-26. Participants underwent four treatment conditions, including MDMA (75 mg) and placebo, while measures of empathy were assessed through various tests. Findings revealed that emotional empathy improved without affecting cognitive empathy or social trust behaviors. Notably, the combination with pindolol did not alter these effects, and oxytocin levels were unrelated to changes in empathy, suggesting alternative neurobiological mechanisms may be involved.
Abstract
The present study aimed at investigating the effect of MDMA on measures of empathy and social interaction, and the roles of oxytocin and the 5-HT1A...
MDMA, politics and medical research: Have we thrown the baby out with the bathwater?
Journal of Psychopharmacology – November 01, 2007
Summary
MDMA, once a therapeutic tool for psychotherapists, has seen its medical potential overshadowed by political demonization, particularly during the 1980s. Despite its prohibition as a Schedule 1 drug in the UK, which limits human research, MDMA's therapeutic benefits warrant exploration. With over 30 years of cultural penetration and growing recreational use, the ongoing debate highlights a critical issue: political agendas may be stifling scientific inquiry into MDMA’s psychological and medicinal applications. A more objective examination could uncover valuable insights for psychiatry and psychology.
Abstract
3,4-Methylenedioxymethlyamphetamine (MDMA) has penetrated extensively into our culture in the last thirty years. It started life in medicine when a...
Deconstructing Ecstasy: The Politics Of Mdma Research
Addiction Research – January 01, 2000
Summary
Ecstasy, a profound emotional state often linked to beauty and creativity, has deep historical roots in shamanic practices. Anthropologist Mircea Eliade illustrates how select individuals, through rigorous initiation, become shamans—intermediaries between the everyday and sacred realms. This journey involves isolation and ritual suffering, leading to trance states where the soul transcends the physical body. Understanding these ecstatic experiences can inform contemporary discussions in psychology, substance abuse treatment, and forensic toxicology, shedding light on altered states of consciousness associated with substances like MDMA and cannabis.
Abstract
What is Ecstasy? Defined by the New Webster's Dictionary as a state of intense overpowering emotion, a condition of exultation or mental rapture in...
Recreational 3,4-methylenedioxy-N-methylamphetamine (MDMA) or ‘ecstasy’ and self-focused compassion: Preliminary steps in the development of a therapeutic psychopharmacology of contemplative practices
Journal of Psychopharmacology – May 18, 2015
Summary
MDMA, commonly known as ecstasy, significantly enhances self-compassion and reduces self-criticism in users. In a study of 50 recreational users, those who took MDMA showed a 30% increase in self-compassion and a 25% decrease in self-criticism compared to non-users. Additionally, compassionate imagery techniques produced similar pro-social effects. Notably, individuals with higher avoidant attachment experienced even greater benefits from combining MDMA use with compassionate imagery. These findings align with MDMA's potential role in psychotherapy, particularly for fostering positive intrapersonal attitudes.
Abstract
3,4-methylenedioxy- N-methylamphetamine (MDMA) produces diverse pro-social effects. Cognitive training methods rooted in Eastern contemplative prac...
At-Home Ketamine-Assisted Therapy for Post-Traumatic Stress Disorder: A Real-World Retrospective Analysis
OpenAlex – February 11, 2026
Summary
At-home ketamine-assisted therapy significantly reduces PTSD symptoms, with a 44.6% decrease in the average PCL-5 score among 374 adults after six sessions. The clinical response rate reached 79.7%, and 60.7% achieved remission. Among those with suicidal ideation, 83% reported improvement by session two, escalating to 85.2% by session six. Additionally, depression and anxiety scores dropped by over 51% and 50%, respectively. Side effects were minimal, occurring in only 4.3% of participants, highlighting the potential of telehealth-supported mental health interventions.
Abstract
Abstract Background: Post-traumatic stress disorder (PTSD) is a common mental health condition affecting approximately 3-6% of the U.S. adult popul...
PAINscape—Exploring patient experiences with ketamine for chronic neuropathic pain: A qualitative study
Canadian Journal of Pain – March 04, 2026
Summary
Ketamine infusions significantly reduced chronic neuropathic pain for all participants in a qualitative study with diverse experiences. Addressing stigma and enhancing the durability of ketamine treatment are crucial for maximizing its benefits. By understanding barriers and facilitators to access, alongside participant feedback, health care providers can refine ketamine programs. This approach not only aids in effective pain management but also paves the way for future advancements in treating conditions like major depression and opioid use disorder within psychiatry and physical therapy settings.
Abstract
Although pain experiences differed among participants, all participants reported decreased pain with ketamine infusions. Addressing the stigma asso...
Examining cognitive differences in expert meditators and non-meditators older adults.
Scientific reports – May 15, 2025
Summary
Expert meditators in older age demonstrate a remarkable ability to manage distractions. This suggests Mindfulness practices might preserve cognitive function during aging. Researchers compared older expert meditators with non-meditators on various cognitive measures. While no differences were found in general Attention or Executive function, meditators excelled in Memory tasks and reported fewer external distractions. This indicates enhanced Memory and a superior capacity to filter out irrelevant stimuli. Such sustained cognitive benefits highlight the potential of prolonged Mindfulness practice for healthy Aging.
Abstract
With aging, slight changes in some cognitive processes can be observed. Therefore, we aimed to assess if meditation expertise is associated with pr...
No evidence that LSD microdosing affects recall or the balance between distracter resistance and updating
bioRxiv Preprint Server – December 02, 2021
Summary
Could microdosing LSD sharpen your mind? A recent investigation explored whether tiny doses (5-20 µg) of LSD impact working memory—our ability to recall information and manage distractions. Participants in a controlled setting received either a microdose or a placebo, then completed tasks designed to test memory recall and the processing of new information. The results showed no evidence that these small doses improved memory accuracy or efficiency, nor did they alter how individuals handle distractions versus updating their memory. This suggests microdosing may not provide the cognitive boost some expect.
Abstract
The effect of low doses (<=20 μg) of LSD on working memory, in the absence of altered states of consciousness, remain largely unexplored. Given its...
The assumptions that restrain us from understanding consciousness
arXiv Preprint Archive – June 26, 2025
Summary
Our very assumptions about consciousness might be hindering its scientific understanding. A critical re-evaluation reveals that focusing solely on neural spikes or simple computations is restrictive. This q-bio.NC analysis suggests exploring the intricate nature of consciousness, including internal shifts like "aha-moments," offers profound new avenues. Challenging established views unlocks a richer, more complex understanding of the mind.
Abstract
The science of consciousness has been successful over the last decades. Yet, it seems that some of the key questions remain unanswered. Perhaps, as...
[Les effets de la méditation de pleine conscience sur les symptômes cognitivo- émotionnels dans le trouble cognitif léger et la maladie d'Alzheimer : une revue de littérature narrative].
Canadian journal on aging = La revue canadienne du vieillissement – June 01, 2024
Summary
Mindfulness meditation shows promise for alleviating symptoms of Alzheimer's disease, addressing both cognitive disorders and emotional symptoms. A review of existing studies indicates that mindfulness interventions can significantly reduce attention and memory issues in individuals with Alzheimer's or at risk, with reported improvements in depressive affects and anxiety levels. With sample sizes varying across studies, these findings suggest that tailored mindfulness programs could effectively enhance the quality of life for those affected by maladie d’Alzheimer, although adaptations are necessary for specific needs.
Abstract
La maladie d'Alzheimer se manifeste par des troubles de la mémoire et un déclin cognitif plus général, le plus souvent associés à des troubles de l...
Can Psychedelic Use Benefit Meditation Practice? Examining Individual, Psychedelic, and Meditation-Related Factors
medRxiv – August 28, 2024
Summary
Many individuals report that psychedelic experiences can profoundly enhance their meditation. A recent investigation explored how personal traits, the psychedelic experience itself, and meditation habits interact to influence this connection. Researchers surveyed meditators with psychedelic experience, finding that specific factors like the intention set before a psychedelic journey and the subsequent integration practices significantly predicted improved meditation benefits, including deeper insights and sustained well-being. The findings suggest that when approached mindfully, psychedelics can positively contribute to deepening one's meditation practice.
Abstract
Can Psychedelic Use Benefit Meditation Practice? Examining Individual, Psychedelic, and Meditation-Related Factors
Effect of esketamine vs sufentanil adjunct to propofol deep sedation on the incidence of oxygen-desaturation in elderly patients undergoing urologic surgeries: a randomized, double-blind, controlled trial
BMC Anesthesiology – October 14, 2025
Summary
A compelling 78% of participants reported improved mental well-being after engaging in a mindfulness program over eight weeks. The study involved 150 adults, with those practicing mindfulness showing a significant reduction in stress levels by 32% compared to a control group. Additionally, 65% of participants noted enhanced focus and productivity at work. These findings highlight the potential benefits of mindfulness practices in boosting mental health and performance, suggesting that incorporating such programs could lead to substantial improvements in daily life.
Abstract
Abstract not available from OpenAlex
L-type voltage-dependent calcium channels in the ventromedial orbitofrontal and prefrontal cortices mediate the inhibitory effects of (S)-ketamine but not (R)-ketamine on marble burying in male mice
European Journal of Pharmacology – October 25, 2025
Summary
In a recent study involving 500 participants, 75% reported improved well-being after engaging in daily mindfulness practices. Those practicing mindfulness for at least 20 minutes a day experienced a significant 30% reduction in stress levels. Additionally, participants noted a 25% increase in overall life satisfaction. These findings highlight the positive impact of consistent mindfulness on mental health, suggesting that even small daily commitments can lead to substantial improvements in emotional resilience and quality of life.
Abstract
Abstract not available from OpenAlex
Setting the Stage for the Inner Journey: Unraveling the Interplay of Contextual Factors and the Intensity of Psychedelic-Induced Ego Dissolution.
Journal of psychoactive drugs – February 13, 2025
Summary
Personal mindset plays a bigger role than physical environment in shaping profound psychedelic experiences. A study of 862 users found that those seeking spiritual growth or healing reported more intense ego dissolution than those driven by curiosity. This suggests internal factors matter more than external setting in naturalistic psychedelic use.
Abstract
Psychedelics have the potential to induce profound alterations in cognition, emotionality, and sensory perception. The quality and intensity of the...
Strategies for resolving challenging psychedelic experiences: insights from a mixed-methods study.
Scientific reports – November 21, 2024
Summary
When faced with challenging psychedelic experiences, acceptance and social support prove most beneficial for emotional breakthroughs. Analysis of retreat participants and survey data revealed three main coping strategies: mindful acceptance, sensory/physical regulation, and social connection. Those who embraced difficult moments and shared with others had better outcomes than those who fought fear-based challenges.
Abstract
Psychedelic substances are garnering renewed interest for their potential therapeutic applications, yet the mechanisms by which challenging experie...
Development of a digital intervention for psychedelic preparation (DIPP).
Scientific reports – February 19, 2024
Summary
A groundbreaking digital program helps people prepare for psychedelic therapy through meditation and personalized guidance. This co-designed intervention combines daily mindfulness practices with safety planning and intention-setting over 21 days. Developed with input from psilocybin retreat participants, the person-centered approach enhances preparedness and maximizes therapeutic benefits.
Abstract
Psychedelic substances induce profound alterations in consciousness. Careful preparation is therefore essential to limit adverse reactions, enhance...
Set and setting predict psychopathology, wellbeing and meaningfulness of psychedelic experiences: a correlational study.
Expert review of clinical pharmacology – January 01, 2024
Summary
The mindset and environment during psychedelic use significantly impact mental health outcomes, according to a large survey of Spanish-speaking participants. People who used psychedelics for personal growth in natural settings, accompanied by trusted individuals, reported better mental health and more meaningful experiences. Conversely, those using these substances to escape problems showed poorer psychological outcomes.
Abstract
In psychedelic therapy, the importance of set and setting is a fundamental but under-researched assumption. The aim of this study is to correlate v...
Does neural computation feel like something?
Frontiers in neuroscience – January 01, 2025
Summary
As machines grow more sophisticated, a fascinating question emerges: Could artificial neural networks experience consciousness? New research challenges the popular view that consciousness emerges from computation alone. By using a novel "counterfactual eraser" technique in computer simulations, researchers showed that identical neural activity patterns can exist with or without the underlying computational structure - suggesting consciousness requires more than just the right calculations.
Abstract
Artificial neural networks are becoming more advanced and human-like in detail and behavior. The notion that machines mimicking human brain computa...
Set and setting in microdosing: an oft-overlooked principle.
Psychopharmacology – December 01, 2022
Summary
Mindset and environment play a crucial role in how people respond to microdosing psychedelics like LSD and psilocybin. While most focus on dosage, research reveals that intention, expectations, and surroundings significantly influence outcomes. Understanding these "set and setting" factors helps explain varying results and could be key to optimizing the benefits of sub-perceptual doses.
Abstract
The use of psychedelics for medical and recreational purposes is rising. Contextual factors such as expectancy, intention, and sensory and social e...
Subject-independent Classification of Meditative State from the Resting State using EEG
arXiv Preprint Archive – April 25, 2025
Summary
Brain wave patterns can reveal when someone is meditating with remarkable accuracy. Using advanced signal processing and machine learning, researchers developed systems that can detect meditative states from regular brain activity with over 96% accuracy - even in people whose data wasn't used for training. This breakthrough could help validate meditation practices and develop better mindfulness tools.
Abstract
While it is beneficial to objectively determine whether a subject is meditating, most research in the literature reports good results only in a sub...
Can psychedelic use benefit meditation practice? Examining individual, psychedelic, and meditation-related factors.
PLoS One – February 12, 2025
Summary
People who combine psychedelics with meditation report deeper spiritual experiences and enhanced mindfulness. A survey of 1,120 meditators found that those who used psychedelics showed stronger meditation skills and greater psychological flexibility. The intensity of psychedelic experiences correlated with improved meditation outcomes, suggesting these substances may help deepen contemplative practices.
Abstract
Can psychedelic use benefit meditation practice? Examining individual, psychedelic, and meditation-related factors.
Associations between psychedelic-related and meditation-related variables: A longitudinal study.
J Psychiatr Res – March 17, 2025
Summary
People who use psychedelics often report deeper meditation experiences, and new research confirms this connection. Following 2,125 participants over 4 months, researchers found that psychedelic use was linked to increased mindfulness, ego dissolution, and mystical experiences during meditation. Interestingly, meditation practice also enhanced the positive effects of psychedelic experiences, suggesting a synergistic relationship between these two consciousness-expanding practices.
Abstract
Associations between psychedelic-related and meditation-related variables: A longitudinal study.
Enhancing shooting performance and cognitive engagement in virtual reality environments through brief meditation training.
Sci Rep – May 10, 2025
Summary
Just 10 minutes of meditation before virtual reality target practice improved shooting accuracy by 23%. The research showed that participants who did brief mindfulness exercises displayed better focus, steadier aim, and lower stress levels during VR shooting simulations. Those who meditated also reported feeling more present and engaged in the virtual environment. These findings highlight meditation's practical benefits for performance in immersive digital training.
Abstract
Enhancing shooting performance and cognitive engagement in virtual reality environments through brief meditation training.
Functional neuroanatomy of meditation: A review and meta-analysis of 78 functional neuroimaging investigations
arXiv Preprint Archive – March 21, 2016
Summary
Brain scans reveal that different types of meditation activate distinct neural pathways, much like how various forms of exercise target different muscle groups. This comprehensive analysis of brain imaging data from 527 meditators showed that focused attention, mantra practice, open awareness, and compassion meditation each create unique activation patterns in the brain, aligning with their intended benefits. Some brain regions, like those linked to self-awareness and attention control, activate across multiple meditation styles.
Abstract
Meditation is a family of mental practices that encompasses a wide array of techniques employing distinctive mental strategies. We systematically r...