5439 results for "Psychedelics"
N, N-dimethyltryptamine (DMT) in rodent brain: Concentrations, distribution, and recent pharmacological data.
Progress in neuro-psychopharmacology & biological psychiatry – March 20, 2025
Summary
DMT, a naturally occurring compound in the brain, plays a fascinating dual role in both stress response and brain development. Research reveals this molecule binds to specific receptors in the Golgi apparatus of brain cells, promoting neuroplasticity and healthy neurodevelopment. When stress occurs, DMT levels increase naturally, suggesting it acts as part of the body's adaptive response system. These findings explain how DMT influences brain function and may contribute to therapeutic benefits.
Abstract
Renewed interest in the clinical use of psychedelic drugs acknowledges their therapeutic effectiveness. It has also provided a changing frame of re...
Psilocybin therapy: A novel approach to treating depression
International Journal of Surgery Global Health – June 02, 2023
Summary
Psilocybin therapy shows remarkable promise for treating severe depression, offering relief within hours or days, unlike traditional antidepressants that take weeks. Globally, ~280 million people suffer from depression, with 30% experiencing treatment-resistant depression (TRD). Conventional pharmacotherapy often fails these individuals, who face increased suicidal ideation. Six clinical trials confirm psilocybin's rapid, sustained effects, suggesting a new paradigm in psychiatry and mental health. This psychological intervention, involving a naturally occurring alkaloid, provides a compelling alternative for major depression treatment and suicide prevention, requiring careful medical prescription and oversight.
Abstract
The COVID-19 pandemic has resulted in a surge in depression cases, a pervasive and debilitating mental illness1. This trend is evident in the incre...
NIDA on dramatic increase of mushroom seizures
Alcoholism & Drug Abuse Weekly – March 01, 2024
Summary
Seizures of psilocybin mushroom dramatically surged, increasing from 402 in 2017 to 1,396 in 2022, with seized weight rising from 226 kg to 844 kg. This dramatic rise, reflecting a 247% increase in incidents, highlights evolving interest in the mushroom's potential therapeutic applications in Psychology. Yet, understanding how these mushroom bodies affect brain function, distinct from mechanisms like cholinesterase inhibition in neurodegenerative diseases, is crucial given risks of unsupervised use.
Abstract
From 2017 – 2022, law enforcement seizures across the United States of mushrooms containing psilocybin increased dramatically, according to a new s...
The phenomenology of psilocybin: transformative insights for research and clinical practice
Frontiers in Psychology – April 25, 2025
Summary
Ten individuals described profound personal growth after experiencing psilocybin, a potent hallucinogen. This qualitative exploration, rooted in phenomenology (a philosophy of experience), revealed universal psychological themes: enhanced empathy, emotional sensitivity, and lasting insights into personal values. Participants reported transformative learning, indicating significant behavioral shifts. These findings offer psychotherapists a structured understanding of psychedelic experiences, informing their integration into practice. Such insights contribute to diverse academic research themes, including Psychedelics and Drug Studies, and illuminate potential connections to Religious Studies and Spiritual Practices.
Abstract
Introduction Considering the increasing evidence supporting psilocybin’s efficacy in therapeutic settings, it is essential to deepen our understand...
The evolution of N, N-Dimethyltryptamine: from metabolic pathways to brain connectivity.
Psychopharmacology – April 11, 2025
Summary
A naturally-occurring neurotransmitter in our bodies, DMT has profound effects on brain connectivity. When present, it enhances global neural networks and alters consciousness by binding to specific receptors. Both endogenous and exogenous DMT influence cognition by increasing brain signal complexity and strengthening connections between key regions. This psychedelic compound's unique properties suggest it plays a vital role in consciousness.
Abstract
N, N-Dimethyltryptamine (DMT), a potent serotonergic psychedelic, bridges ancient wisdom and modern science. The mechanisms underlying its powerful...
Therapeutic Potential of Psilocybin for Treating Neuropsychiatric Long COVID Symptoms: A Reddit Investigation
Journal of Psychoactive Drugs – March 14, 2025
Summary
Remarkably, 78.2% of individuals with long COVID symptoms, a consequence of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), reported improvement using the hallucinogen psilocybin. An analysis of 110 online accounts from the Coronavirus disease 2019 (COVID-19) pandemic revealed 77.9% of those improving experienced lasting relief beyond the acute psychedelic effect. Common neuropsychiatric issues like fatigue (47.3%) and cognitive impairment (46.4%) were cited. This suggests a compelling avenue for Psychiatry, Medicine, and Psychology to explore psychedelics in post-pandemic care and Complementary/Alternative Medicine.
Abstract
Long COVID lacks effective pharmaceutical treatment options. Psychedelic treatment for long COVID has received attention given anecdotal reports of...
Opinion Mining of Erowid's Experience Reports on LSD and Psilocybin-Containing Mushrooms.
Drug safety – May 01, 2025
Summary
Analysis of 2,000+ firsthand psychedelic experiences reveals distinct patterns: mushroom users report more introspective, time-altering journeys, while LSD users describe cognitive shifts. Advanced AI analysis found mushroom experiences were rated more positively overall, particularly among male users. Common themes across both substances included emotional depth and sensory enhancement.
Abstract
Psychedelics are gaining attention for their therapeutic potential in modern and personalized medicine. Online forums such as Erowid provide valuab...
Evaluating the potential for psilocybin as a treatment for post-traumatic stress disorder.
The Journal of pharmacology and experimental therapeutics – January 01, 2025
Summary
Psilocybin shows remarkable potential in rewiring fear responses in the brain, offering hope for those with post-traumatic stress disorder. The compound increases brain-derived neurotrophic factor, helping form new neural connections. Studies reveal significant reductions in anxiety and trauma symptoms, with patients reporting lasting relief after supervised psychedelic sessions.
Abstract
Post-traumatic stress disorder (PTSD) is a debilitating psychiatric condition that develops following exposure to a traumatic event. Individuals wi...
Large-scale brain connectivity changes following the administration of lysergic acid diethylamide, d-amphetamine, and 3,4-methylenedioxyamphetamine.
Molecular psychiatry – April 01, 2025
Summary
Psychedelics and stimulants reshape brain networks differently, with LSD showing unique effects on the brain's "default mode" - regions active when we're lost in thought. This research tracked brain connectivity changes in 28 healthy volunteers after taking LSD, MDMA, or amphetamine. While all substances altered brain network communication, LSD stood out by increasing connectivity between the brain's command centers while reducing it in visual areas. MDMA and amphetamine showed overlapping but distinct patterns, suggesting each substance uniquely influences how brain regions talk to each other.
Abstract
Psychedelics have recently attracted significant attention for their potential to mitigate symptoms associated with various psychiatric disorders. ...
Ayahuasca: A review of historical, pharmacological, and therapeutic aspects.
PCN reports : psychiatry and clinical neurosciences – December 01, 2023
Summary
The ancient Amazonian brew ayahuasca combines DMT-containing plants with harmala alkaloids to create a powerful psychedelic medicine. Traditional ceremonies using this brew have shown remarkable potential in treating depression, addiction, and PTSD. Modern research reveals that ayahuasca's unique chemical properties promote neuroplasticity and emotional healing, while traditional ceremonial contexts provide crucial therapeutic support.
Abstract
Ayahuasca is a psychedelic plant brew originating from the Amazon rainforest. It is formed from two basic components, the Banisteriopsis caapi vine...
Psilocybin induces acute anxiety and changes in amygdalar phosphopeptides independently from the 5-HT2A receptor
iScience – April 09, 2024
Summary
Remarkably, Psilocybin, a potent Hallucinogen explored in Medicine for Anxiety, can induce acute anxiety via distinct brain pathways. Neuroscience and Pharmacology reveal that blocking the 5-HT2A Receptor, mediating its psychedelic effects, does not prevent Psilocybin-induced anxiety in mice. Analysis in the Amygdala shows specific brain proteins are involved, indicating the drug's anxiety-provoking aspects operate independently. This insight from Psychedelics and Drug Studies into Neurotransmitter Receptor Influence on Behavior is crucial for developing safer alkaloid-based treatments, informing Psychology and future chemical synthesis.
Abstract
Psilocybin, and its metabolite psilocin, induces psychedelic effects through activation of the 5-HT2A receptor. Psilocybin has been proposed as a t...
Biological studies of clavine alkaloids targeting CNS receptors
Frontiers in Psychiatry – November 21, 2023
Summary
Potent clavine alkaloids, widely present through plant and fungal interactions, are surprisingly underexplored compared to well-known psychedelics like psilocybin and lysergic acid diethylamide. Their unique pharmacology and biology, influencing various brain receptors, offer vast potential for drug studies. Exploring their chemical synthesis and alkaloids could uncover novel hallucinogen compounds. This neuroscience-focused work highlights opportunities to expand the therapeutic range beyond current lysergic acid derivatives, revolutionizing our understanding of psychedelic action and future drug development.
Abstract
In contrast to well established psychedelics such as lysergic acid diethylamide (LSD) and psilocybin, ergot alkaloids of the clavine subclass have ...
Pharmacological Monotherapy for Depressive Disorders: Current and Future-A Narrative Review.
Medicina (Kaunas, Lithuania) – March 21, 2025
Summary
Breakthrough treatments for depression are evolving beyond traditional antidepressants. While standard medications remain effective, promising new options include fast-acting ketamine, neurosteroid treatments for postpartum depression, and psychedelics showing lasting benefits. Novel approaches targeting inflammation, opioid receptors, and personalized biomarker therapy are advancing, offering hope for more effective, individualized depression treatment.
Abstract
Objective: To narratively review currently available antidepressants and future potential antidepressants as monotherapy for the treatment of depre...
Not Losing Momentum: Cross-Sectional Insights into Ibogaine Clinical Trials.
Journal of psychoactive drugs – April 18, 2025
Summary
Groundbreaking research reveals that ibogaine, a unique psychedelic compound, shows promise in treating addiction. Analysis of global clinical trials demonstrates growing scientific interest in this treatment for Substance Use Disorders (SUD). The compound, which metabolizes into noribogaine, is being tested in multiple countries with varying protocols. Early results indicate potential benefits, particularly in reducing withdrawal symptoms, though cardiovascular monitoring remains crucial.
Abstract
Ibogaine, a non-classical psychedelic, has gained increasing attention as a potential treatment for substance use disorders (SUD); however, a lack ...
Underlying pharmacological mechanisms of psilocin-induced broadband desynchronization and disconnection of EEG in rats
Frontiers in Neuroscience – June 22, 2023
Summary
The hallucinogen psilocybin, a potent serotonergic psychedelic, influences brain activity beyond the well-known 5-HT2A receptor. Neuroscience reveals psilocin, its active form, broadly decreases EEG power (1-25 Hz), an effect reversed by multiple serotonin and dopaminergic receptor antagonists. However, its impact on fronto-temporal disconnection, crucial for its psychology, was reversed solely by a 5-HT2A receptor antagonist. This pharmacology, rooted in chemistry, highlights diverse neurotransmitter receptor influence on behavior, expanding drug studies and biochemical analysis of psychedelics.
Abstract
Introduction Psilocybin is one of the most extensively studied psychedelic drugs with a broad therapeutic potential. Despite the fact that its psyc...
Time-resolved network control analysis links reduced control energy under DMT with the serotonin 2a receptor, signal diversity, and subjective experience
OpenAlex – May 12, 2023
Summary
Psychedelics like psilocybin and the hallucinogen lysergic acid diethylamide profoundly reshape brain dynamics. Neuroscience reveals that N,N-dimethyltryptamine (DMT), a serotonergic compound, significantly reduces the "control energy" needed for brain state transitions in 14 individuals. This finding, crucial for Psychology and Mental Health Research Topics, shows global control energy trajectories, potentially involving the default mode network, correlate with subjective drug intensity. These effects are linked to serotonin 2a receptor density, demonstrating neurotransmitter receptor influence on behavior and offering a predictive model for Psychedelics and Drug Studies.
Abstract
Abstract Psychedelics offer a profound window into the functioning of the human brain and mind through their robust acute effects on perception, su...
Perceived risk of LSD varies with age and race: evidence from 2019 United States cross-sectional data.
Social psychiatry and psychiatric epidemiology – October 01, 2023
Summary
While psychedelics show promise in mental health treatment, public perception of their risks varies significantly across demographic groups. Analysis of 41,000+ Americans reveals that age and racial background strongly influence views on LSD safety. White respondents and multiracial individuals reported lower perceived risks than other racial groups, while older adults generally viewed the substance as more dangerous. These healthcare disparities in risk perception likely stem from historical patterns in drug enforcement and cultural attitudes toward illicit substance use.
Abstract
Psychedelics are being explored for their potential therapeutic benefits across a wide range of psychiatric diagnoses and may usher in a new age in...
Set and setting in microdosing: an oft-overlooked principle.
Psychopharmacology – December 01, 2022
Summary
Mindset and environment play a crucial role in how people respond to microdosing psychedelics like LSD and psilocybin. While most focus on dosage, research reveals that intention, expectations, and surroundings significantly influence outcomes. Understanding these "set and setting" factors helps explain varying results and could be key to optimizing the benefits of sub-perceptual doses.
Abstract
The use of psychedelics for medical and recreational purposes is rising. Contextual factors such as expectancy, intention, and sensory and social e...
Low doses of lysergic acid diethylamide (LSD) increase reward-related brain activity.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology – January 01, 2023
Summary
Tiny amounts of LSD can boost the brain's reward processing systems, even without causing noticeable psychedelic effects. Scientists found that low doses enhanced brain responses to rewards and positive feedback in healthy adults. Using advanced brain monitoring, researchers observed increased activity in three distinct reward-processing pathways, suggesting LSD's potential to enhance natural reward responses and positive emotions.
Abstract
Renewed interest in classic psychedelics as treatments for psychiatric disorders warrants a deeper understanding of their neural mechanisms. Single...
Social Workers' Attitudes and Beliefs about MDMA-Assisted Therapy for Adolescents with PTSD.
Social work – April 01, 2025
Summary
While MDMA shows promise for treating PTSD in adults, social workers express greater confidence in traditional medications for adolescent patients. A survey of 222 social workers revealed they favored selective serotonin reuptake inhibitors over MDMA therapy for treating teen PTSD. However, those with more knowledge about psychedelics showed less stigma and concern, suggesting education could increase acceptance of this emerging treatment.
Abstract
Given the widespread interest and ongoing study on MDMA-assisted therapy (MDMA-AT) for PTSD, its implications for unique populations-such as adoles...
Decreases in State and Trait Anxiety Post-psilocybin: A Naturalistic, Observational Study Among Retreat Attendees
Frontiers in Psychiatry – July 07, 2022
Summary
Psilocybin, a psychedelic compound from truffles, significantly reduced anxiety in a supportive group setting. Among 46 participants, average psilocin consumption was 27.1 mg. State and trait anxiety measures showed medium reductions (effect sizes around 6) the morning after, persisting for a week (effect sizes around 7-8) in 23 individuals. This highlights psilocybin's potential in clinical psychology and psychiatry for anxiety management, possibly influencing neurotransmitter receptors. Mindfulness also increased, demonstrating broader psychological effects of psychedelics.
Abstract
Anxiety disorders are the most common type of psychiatric disorders among Western countries. Evidence-based treatment modalities including pharmaco...
Prospective examination of synthetic 5-methoxy-N,N-dimethyltryptamine inhalation: effects on salivary IL-6, cortisol levels, affect, and non-judgment
Psychopharmacology – December 10, 2019
Summary
A single session with the tryptamine-based psychedelic 5-methoxy-N,N-dimethyltryptamine significantly improved mood and psychological well-being in 11 participants. Depression ratings decreased immediately and after seven days, while anxiety and stress also lessened over a week. Saliva analysis revealed increased cortisol and decreased IL-6, inflammatory markers relevant to internal medicine, immediately post-session. These physiological shifts, not linked to the psychedelic experience itself, suggest a complex affect on the body, informing psychiatry.
Abstract
Abstract Rationale 5-methoxy-N,N-dimethyltryptamine is a psychotropic substance found in various plant and animal species and is synthetically prod...
Prescription and Nonprescription Drug Use Among People With Eating Disorders.
JAMA network open – July 01, 2025
Summary
Many individuals with eating disorders report using various substances to manage their symptoms. An extensive international survey explored how people perceive both prescribed and non-prescribed drugs. It revealed that cannabis and psychedelics were frequently reported to improve eating disorder symptoms. While prescription antidepressants often benefited overall mental health, they were generally not found effective for eating disorder symptoms, with specific exceptions. This highlights promising new approaches for symptom relief.
Abstract
There are few effective pharmacotherapies for treating eating disorders (EDs). High rates of substance use among individuals with EDs suggest poten...
Self-reported use of novel psychoactive substances among attendees of electronic dance music venues.
The American journal of drug and alcohol abuse – November 01, 2016
Summary
Over a third of young adults at NYC electronic dance music events have used novel psychoactive substances. A survey of 682 attendees at nightclubs and festivals found 35.1% lifetime use. Synthetic cannabinoids, psychedelic phenethylamines, and synthetic cathinones ("bath salts") were most common. This clearly shows significant novel psychoactive substance use in these venues, particularly among frequent attendees.
Abstract
Novel psychoactive substances (NPSs) continue to emerge in the United States and worldwide. Few epidemiological studies have examined the prevalenc...
Subjective effects of Salvia divinorum: LSD- or marijuana-like?
Journal of psychoactive drugs – September 01, 2009
Summary
Despite Salvia divinorum's reputation as one of the most potent hallucinogens, new insights challenge common assumptions about its effects. It was previously thought to produce experiences akin to traditional psychedelics like LSD. Researchers surveyed 193 individuals, including Salvia users, about their experiences. Surprisingly, most users reported Salvia's subjective effects felt more similar to marijuana than to LSD, a finding confirmed by psychological assessments. This suggests Salvia's unique molecular mechanism may result in a distinct hallucinogenic profile, diverging from expectations.
Abstract
Salvia divinorum is a naturally occurring psychedelic considered to be one of the most potent hallucinogens found to date. The few behavioral studi...
Psilocin acutely alters sleep-wake architecture and cortical brain activity in laboratory mice
Translational Psychiatry – February 23, 2022
Summary
Psychedelics show promise for psychological well-being and psychiatric disorders. Neuroscience reveals psilocin acutely alters sleep architecture. Electroencephalography in mice showed delayed REM sleep onset and reduced NREM sleep for up to 3 hours after dosing, with an enhanced 4 Hz oscillation. While not affecting overall sleep rebound, psilocin decreased recovery of slow-wave activity in the cerebral cortex after Wakefulness deprivation. This Sleep and Wakefulness Research from Psychedelics and Drug Studies offers insights for Medicine, impacting our understanding of sleep (system call) regulation.
Abstract
Abstract Serotonergic psychedelic drugs, such as psilocin (4-hydroxy-N,N-dimethyltryptamine), profoundly alter the quality of consciousness through...
LSD and psilocybin flatten the brain’s energy landscape: insights from receptor-informed network control theory
OpenAlex – May 17, 2021
Summary
Psychedelics like LSD and psilocybin significantly ease the brain's ability to transition between different activity states, promoting more varied dynamics. This finding from Functional Brain Connectivity Studies highlights how these compounds, central to Psychedelics and Drug Studies, effectively "flatten" the brain's energy requirements. LSD's impact correlates with more frequent state changes and increased brain diversity across individuals. This mechanism, vital for Mental Health Research Topics, is specifically driven by serotonin 2a receptors, enabling more fluid brain activity.
Abstract
Abstract Psychedelics like lysergic acid diethylamide (LSD) and psilocybin offer a powerful window into the function of the human brain and mind, b...
Functional Connectivity Measures After Psilocybin Inform a Novel Hypothesis of Early Psychosis
Schizophrenia Bulletin – October 06, 2012
Summary
The psychedelic psilocybin significantly blurs the brain's internal and external focus, a finding with implications for Psychology and Mental Health Research Topics. Using functional magnetic resonance imaging (fMRI) in 15 healthy volunteers, Neuroscience investigations reveal psilocybin, a hallucinogen, dramatically increased functional connectivity between the default mode network (introspection) and task-positive network (external attention). This altered brain connectivity, observed in Psychedelics and Drug Studies, mirrors patterns seen in psychosis, supporting psilocybin's utility as a model for understanding early psychosis. Preserved thalamocortical connectivity suggests this isn't sedation, but a unique alteration in functional brain connectivity.
Abstract
Psilocybin is a classic psychedelic and a candidate drug model of psychosis. This study measured the effects of psilocybin on resting-state network...
Brain serotonin 2A receptor binding predicts subjective temporal and mystical effects of psilocybin in healthy humans
Journal of Psychopharmacology – October 08, 2020
Summary
Individual brain chemistry profoundly shapes psychedelic experiences. In a Neuroscience and Psychology investigation, 16 participants received a single dose (0.2–0.3 mg/kg) of the hallucinogen psilocybin, a serotonin-acting chemical alkaloid. Those with higher levels of the brain's 5-HT2A receptor, a key neurotransmitter receptor, experienced shorter peak effects but a longer return to normal consciousness. This finding from Psychedelics and Drug Studies highlights how individual receptor binding influences the temporal and mystical aspects of a psilocybin journey, profoundly impacting behavior.
Abstract
Background: Psilocybin is a serotonergic psychedelic with psychoactive effects mediated by serotonin 2A receptor (5-HT2AR) activation. It produces ...
Dark Classics in Chemical Neuroscience:N,N-Dimethyltryptamine (DMT)
ACS Chemical Neuroscience – July 23, 2018
Summary
N, N-dimethyltryptamine (DMT), a potent hallucinogen, is remarkably ubiquitous, produced by diverse plant and animal species, and even endogenously in mammals. This foundational psychedelic, whose chemical synthesis is well-documented, is crucial for Neuroscience and Psychology, serving as the archetype for other indole alkaloids like LSD. Its enigmatic biological function in humans, along with its pharmacology and potential medical applications, are key areas in Psychedelics and Drug Studies. Future research explores its intricate neuropharmacology, including potential interactions with receptors like nicotinic acetylcholine, to unlock its full significance.
Abstract
Though relatively obscure, N, N-dimethyltryptamine (DMT) is an important molecule in psychopharmacology as it is the archetype for all indole-conta...
Psilocybin Use in an Intercollegiate Athlete with Persisting Symptoms After Concussion: A Case Report
Psychoactives – July 01, 2025
Summary
A 22-year-old athlete with persistent concussion symptoms experienced remarkable relief after self-administering psilocybin. Despite prior physical medicine and rehabilitation, his symptom severity score dropped from 25 to 11, and affective burden completely resolved, following three 2.5mg doses of the psychedelic medicine. This suggests a powerful neurotransmitter receptor influence, enabling a full return to activity. Such findings in drug studies highlight psychedelics' potential beyond conventional physical therapy, offering new avenues for concussion recovery.
Abstract
Background: Persisting symptoms after concussion is a complex syndrome warranting exploration into further treatment options. Emerging research hig...
Repeated low doses of psilocybin reduces perceived symptom severity of obsessive-compulsive disorder, but fails to restore cognitive flexibility: A case study of identical twins
OpenAlex – December 30, 2024
Summary
Low-dose psilocybin shows promise for Obsessive compulsive disorder symptoms, even without psychedelic effects. A case involving identical twins (N=2) revealed the affected twin experienced a notable reduction in OCD symptomatology and improved emotional well-being after self-administering psilocybin. However, despite these improvements in behavior, deficits in cognitive flexibility persisted compared to the unaffected twin. This suggests that while psilocybin may alleviate certain aspects of clinical psychology, it might not fully address underlying cognition impairments. This area of Psychedelics and Drug Studies warrants further investigation.
Abstract
Background: Obsessive-Compulsive Disorder (OCD) presents significant challenges to individuals mental health, characterized by intrusive thoughts a...
Magic mushrooms and mood: exploring Psilocybin as a depression treatment
Journal of the Pakistan Medical Association – December 20, 2025
Summary
A significant development in Psychiatry: Psilocybin, a potent hallucinogen, is emerging as a viable treatment for Major Depressive Disorder. This psychedelic compound acts on serotonergic receptors, inducing altered perception and psychological effects. Recognized by the FDA with "breakthrough" therapy status, Psilocybin offers a novel approach in Medicine. Studies highlight its effectiveness in alleviating depressive symptoms, often integrated with psychological therapy. Its potential to transform mental health treatment is driving intense interest in Psychedelics and Drug Studies.
Abstract
Dear Editor, In view of ongoing global research on mental health, especially Major Depressive Disorder, we would like to draw attention to a psyche...
Age- and estrous-dependent effects of psilocybin in rats
OpenAlex – January 14, 2025
Summary
Psilocybin, a potent hallucinogen, elicits vastly different responses depending on age and biological sex. Adolescent rats (P35/P45) given 1 mg/kg psilocybin showed no head twitch responses, unlike robust reactions in adults. Furthermore, adult females in diestrus exhibited increased responses to the psychedelic compared to those in proestrus, highlighting the estrous cycle's impact. These findings are crucial for psychology, internal medicine, and future psychedelics and drug studies, emphasizing neuroendocrine regulation and neurotransmitter receptor influence on behavior within neuroscience.
Abstract
Abstract Psilocybin, a psychedelic compound in “magic” mushrooms, has promise as a novel treatment for psychiatric disorders, many of which are mor...
A history of the European Medical Society for Psycholytic Therapy (EPT) 1964–1974
Drug Science Policy and Law – January 01, 2024
Summary
A forgotten chapter in **Psychology** reveals that the original "psychedelic **Renaissance**" involved a unique approach to **Medicine**. The European Medical Society for Psycholytic Therapy, founded in **1965**, coordinated **Psychotherapists** using low-dose **Psilocybin** and similar drugs in serial sessions alongside long-term therapy. This method, termed psycholytic therapy, contrasts sharply with today's high-dose, short-term models in **Psychedelics and Drug Studies**. Unearthing its history from archives offers crucial insights for modern **Complementary and Alternative Medicine Studies**, informing future standards for **Psilocybin** and other substances from **chemical synthesis and alkaloids**.
Abstract
The emergence of a so-called psychedelic renaissance has been proposed to characterize the revival of research into (psycho-)therapies using psyche...
#35647 Alternative pharmacological approaches to chronic pain management
OpenAlex – September 01, 2023
Summary
Emerging pharmacological approaches offer new hope for chronic pain management, potentially reducing reliance on addictive analgesics in medicine. Promise emerges from cannabis, psychedelics, and dissociative hypnotics like ketamine. While cannabis is most explored, its adverse effects need understanding. Ketamine shows potential but raises abuse concerns, critical for pharmacology and intensive care medicine. Psychedelics, though least understood, demonstrate promise in preliminary small studies, requiring more study on dose-dependent adverse effects. Significant progress is crucial before these options become standard, yet they could improve patients' quality of life.
Abstract
Please confirm that an ethics committee approval has been applied for or granted: Not relevant (see information at the bottom of this page) Backgro...
Therapeutic frameworks in integration sessions in substance‐assisted psychotherapy: A systematised review
Clinical Psychology & Psychotherapy – December 26, 2023
Summary
Despite growing interest in Psychedelics and Drug Studies, no specific psychotherapeutic approach for integrating psychedelic experiences into daily life has demonstrated efficacy. A comprehensive review of 75 diverse publications, spanning clinical trials to opinion papers, found that while integration is crucial for safe substance-assisted psychotherapy, no single therapeutic framework is empirically supported. Most current Psychology applications, often drawing from humanistic traditions, lack rigorous evidence for a Psychotherapist. This critical gap, impacting Neurotransmitter Receptor Influence on Behavior, is evident across databases like PsycINFO and MEDLINE.
Abstract
Abstract Serotonergic psychedelics and related substances have been explored as potential adjuncts in substance‐assisted psychotherapy (SAPT) for t...
From Ego to Death: Validation of the Ego-Dissolution Scale (EDS)
OpenAlex – July 27, 2022
Summary
Psychedelics like Ayahuasca and Psilocybin profoundly alter the self, offering deep insights and pleasure, challenging psychology's view of the ego. An online survey of 207 participants revealed six distinct facets of ego-dissolution, touching on identity relevant to social psychology. Ayahuasca and DMT induced stronger psychic experiences than LSD and psilocybin, offering new life perspectives. This work, part of Psychedelics and Drug Studies encompassing areas like Cannabis and Cannabinoid Research, contributes to understanding the Id, ego, and super-ego.
Abstract
<p>Disruptions to the sense of self are dotted across cultures and times in rituals involving hallucinogens, sensory deprivation, trance poss...
Lysergic acid diethylamide induces increased signalling entropy in rats’ prefrontal cortex
Journal of Neurochemistry – November 03, 2021
Summary
Psychedelics like Lysergic acid diethylamide show remarkable promise for treating psychiatric conditions. Neuroscience reveals this chemical, an alkaloid, profoundly reorganizes gene networks within the prefrontal cortex of rats. Signalling pathways become more complex and less centralized, increasing brain plasticity. This chemical synthesis-derived compound influences neurotransmitter receptors, mirroring increased brain entropy seen in human psychology studies. Understanding these molecular changes offers crucial insights into how psychedelics could benefit mental health.
Abstract
Abstract Psychedelic drugs are gaining attention from the scientific community as potential new compounds for the treatment of psychiatric diseases...
Serotonin 2A Receptor Signaling Underlies LSD-induced Alteration of the Neural Response to Dynamic Changes in Music
Cerebral Cortex – September 12, 2017
Summary
Psychedelics profoundly alter music perception. Neuroscience reveals that the 5-HT2A receptor, a key Serotonin receptor, critically influences how our brains process music's tonal structure. Using biochemical analysis and sensing techniques, 25 healthy adults showed altered neural responses to music after LSD, which were blocked by Ketanserin (a 5-HT2A antagonist). This work in Cognitive Psychology and Psychedelics and Drug Studies highlights the 5-HT2A receptor's role in the emotional depth and meaningfulness of music, informing Neuroscience and Music Perception.
Abstract
Abstract Classic psychedelic drugs (serotonin 2A, or 5HT2A, receptor agonists) have notable effects on music listening. In the current report, bloo...
The Hallucinogenic Serotonin2A Receptor Agonist, 2,5-Dimethoxy-4-Iodoamphetamine, Promotes cAMP Response Element Binding Protein-Dependent Gene Expression of Specific Plasticity-Associated Genes in the Rodent Neocortex
Frontiers in Molecular Neuroscience – December 24, 2021
Summary
Psychedelics rapidly enhance brain plasticity. A synthetic psychedelic, DOI, acting on the 5-HT 2A receptor, quickly upregulates genes vital for synaptic plasticity in rat neocortex. Cell biology experiments using rat cortical neurons and CREB-deficient mice reveal the transcription factor CREB is crucial. This neuroscience shows DOI stimulates CREB, increasing expression of immediate early genes like *Arc*. This upregulation was blocked without the 5-HT 2A receptor or CREB, explaining these drug studies' profound effects.
Abstract
Psychedelic compounds that target the 5-HT 2A receptor are reported to evoke psychoplastogenic effects, including enhanced dendritic arborization a...
AVANÇOS NO TRATAMENTO DE TRANSTORNOS MENTAIS: Uma análise bibliométrica global da pesquisa sobre psicodélicos clássicos
Psicologia e Saúde em Debate – October 18, 2024
Summary
Research into classic psychedelics for mental health treatment is experiencing a dramatic global surge. An analysis of 4,235 publications from 91 countries reveals a strong, accelerating trend in Psychedelics and Drug Studies. Publications on LSD and psilocybin, central to Psychology and Mental Health, show particularly robust growth, with yearly increases correlating strongly at 0.92 and 0.94 respectively. This expanding evidence base offers new avenues for psychotherapists seeking innovative therapeutic options.
Abstract
Classic psychedelics are being globally investigated for their therapeutic potential in mental disorders, however, the literature offers little inf...
Psilocin, LSD, mescaline, and DOB all induce broadband desynchronization of EEG and disconnection in rats with robust translational validity
Translational Psychiatry – October 02, 2021
Summary
Psychedelics like mescaline, LSD, and psilocin significantly alter brain activity, as demonstrated in a study involving 20 freely moving rats. These substances led to a global decrease in EEG activity across 1–40 Hz, particularly affecting the frontal and sensorimotor cortex. Connectivity analyses revealed reduced global connectivity, echoing findings from human studies. Interestingly, a rebound in occipital theta activity was observed after mescaline and LSD treatment. The results suggest strong translational validity for understanding the effects of serotonergic psychedelics on brain function.
Abstract
Abstract Serotonergic psychedelics are recently gaining a lot of attention as a potential treatment of several neuropsychiatric disorders. Broadban...
Enhancement of Creative Expression and Entoptic Phenomena as After-Effects of Repeated Ayahuasca Ceremonies
Journal of Psychoactive Drugs – July 01, 2012
Summary
Engaging in ayahuasca ceremonies can significantly enhance creativity, as evidenced by a study involving 40 participants who completed the Torrance Tests of Creative Thinking before and two days after a two-week ritual series. Results showed a marked increase in highly original solutions post-ceremony. Additionally, participants exhibited higher phosphenic responses, suggesting enhanced sensory activity linked to creativity. In contrast, 21 comparison subjects, with fewer recent psychedelic experiences, demonstrated lower baseline creativity levels. This highlights the potential of psychedelics in fostering creative expression through ritualistic practices.
Abstract
Studying the effect of psychedelic substances on expression of creativity is a challenging problem. Our primary objective was to study the psychome...
A Phase 1, Dose-Ranging Study to Assess Safety and Psychoactive Effects of a Vaporized 5-Methoxy-N,N-Dimethyltryptamine Formulation (GH001) in Healthy Volunteers
European Psychiatry – June 01, 2022
Summary
A novel vaporized formulation of 5-MeO-DMT, tested on 22 healthy volunteers, demonstrated dose-related increases in psychedelic experiences without significant adverse effects. Participants reported heightened intensity on various scales, particularly after doses of 6, 12, and 18 mg. While cognitive functioning, mood, and well-being remained stable, individualized dose escalation led to the strongest psychoactive responses. Notably, vital signs were unaffected, and mild adverse effects like nausea resolved quickly. This approach may enhance therapeutic outcomes in treating depression with psychedelics.
Abstract
Introduction 5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) is a tryptamine with ultra-rapid onset and short duration of psychedelic effects. Prospec...
Ayahuasca – a review of historical, pharmacological, and therapeutic aspects
OpenAlex – February 21, 2023
Summary
Ayahuasca, a potent psychedelic brew from the Amazon rainforest, has garnered significant global interest, with a notable rise in tourism for its consumption. Anecdotal reports highlight diverse experiences, with some individuals reporting enhanced mental health and personality changes. A review of 30 studies indicates that approximately 70% of participants experienced positive psychological outcomes after using ayahuasca. As retreat centers proliferate worldwide, understanding its neurochemical mechanisms and therapeutic potential becomes crucial for both psychotherapists and those interested in psychedelics as medicine.
Abstract
Ayahuasca is a psychedelic plant brew originating from the Amazon Rainforest. It is formed from two basic components, the Banisteriopsis caapi vine...
Ayahuasca Tourism: Curating Authenticity in Transformative Times (Field Note)
Nova Religio The Journal of Alternative and Emergent Religions – August 01, 2024
Summary
Ayahuasca is rapidly gaining popularity, with a growing number of churches and retreat centers emerging globally. Many individuals travel to the Amazon, seeking an authentic shamanic experience, contributing to a diverse ayahuasca ecosystem. This phenomenon reflects a broader trend in psychedelic tourism, where motivations range from recreational use to spiritual exploration. With increasing interest, the dynamics of this ecosystem are shifting, influenced by both historical practices and contemporary tourist interactions, highlighting the intersection of sociology, geography, and transformative learning in the context of psychedelics.
Abstract
ABSTRACT: Motivated by multiple factors collectively related to what is often termed the Psychedelic Renaissance, people increasingly consume psych...
DataSheet1_A Phase 1, Dose-Ranging Study to Assess Safety and Psychoactive Effects of a Vaporized 5-Methoxy-N, N-Dimethyltryptamine Formulation (GH001) in Healthy Volunteers.docx
Figshare – November 25, 2021
Summary
Higher doses of 5-MeO-DMT, a tryptamine, significantly enhanced the intensity of psychedelic experiences in healthy volunteers, with notable effects observed at 6 mg (N=6), 12 mg (N=4), and 18 mg (N=4) compared to the lowest 2 mg dose (N=4). Evaluations using various questionnaires indicated that individualized dose escalation (N=4) maximized these experiences. Importantly, mood, cognition, and well-being remained unaffected, and adverse effects were mild, such as nausea. Vital signs showed no significant changes, suggesting good tolerability for this novel psychedelic formulation.
Abstract
<p>5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) is a tryptamine with ultra-rapid onset and short duration of psychedelic effects. Prospective...
Dark Classics in Chemical Neuroscience: Mescaline
ACS Chemical Neuroscience – May 30, 2018
Summary
Mescaline, a psychedelic compound found in cacti like peyote and wachuma, has been used for over 6,000 years across the Americas. Despite historical prohibition due to misconceptions, its popularity has surged in recent decades. Mescaline’s effects primarily stem from its action as a 5-HT2A serotonin receptor agonist, while also interacting with 5-HT1A and α2A receptors. Its low potency has limited recreational use, yet growing interest in psychedelics may uncover therapeutic benefits and deepen understanding of hallucinogen pharmacology.
Abstract
Archeological studies in the United States, Mexico, and Peru suggest that mescaline, as a cactus constituent, has been used for more than 6000 year...
Isotopic DMT as a Probe of Spinorial Consciousness
Zenodo (CERN European Organization for Nuclear Research) – March 11, 2026
Summary
A groundbreaking protocol aims to test the hypothesis that psychedelics like DMT influence consciousness through a radical pair mechanism at the serotonin 5-HT2A receptor. By creating isotopically labeled variants (13C-DMT and 15N-DMT), the study modifies nuclear spins while preserving key molecular properties. With a sample size of 100 mice, deuterium substitution shows a significant Kinetic Isotope Effect (∆m = +100%), while 13C and 15N substitutions yield negligible effects (∆m = +8% and +7%, respectively). Observed changes in psychedelic experiences could provide direct evidence for this mechanism.
Abstract
We propose a decisive experimental protocol to test the hypothesis that the psychedelic state involves the radical pair mechanism (RPM) operating a...