39 papers in the library · publishing 2014-2026
Figshare August 20, 2025 Danielle S. Stolzenberg
Psilocybin given to rat mothers shortly after giving birth caused lasting harm to both the mothers and their offspring. The data files include analyses for each figure in the paper, the postpartum stress protocol, and raw maternal behavior data. Additional raw data are in the manuscript source data file.
Figshare January 1, 2025 J. Kruger, Daniel, Mersereau, Gina, Sullivan, Ashley et al.
Most experienced psychedelic users recommend psilocybin for first-time experiences, favoring its moderate intensity, dose-dependent effects, precise dosing, and short duration. About half recommended cannabis, and a third recommended MDMA/MDA. Substances like ayahuasca, DMT, 5-MeO-DMT, and Salvia divinorum were not recommended due to intensity, health risks, and safety concerns. Participants advised against mixing psychedelics with alcohol, stimulants, antidepressants, and narcotics/opiates. Additional advice included embracing the experience, learning about the substance, and setting intentions. The findings suggest that harm-reduction resources can be developed from community-based crowdsourced recommendations.
Figshare January 1, 2023 Jennifer Bennett, Michael D. Blough, Ravinder Bains et al.
Vital signs (ECG, blood pressure, temperature, heart rate) and psychological measures (QIDS-SR16, MEQ-30) were collected from participants in a phase I clinical trial who ingested 25 mg of psilocybin. The data provide physiological and psychological responses to the psychedelic compound.
Figshare January 1, 2022 Ainsworth, Lily
A sense of transformation from ayahuasca tourism arises not only from drinking the brew but also from expectations shaped through online interactions among industry subgroups, the social and physical environment of the centre, and the challenges of reduced support after returning home. The integration phase is complex, as shown by case studies of informants applying their experiences to daily life. The thesis proposes a new label—tourism for transformation—and highlights theoretical parallels between tourism and pilgrimage, pointing to future research on the final stages of such journeys.
Figshare January 1, 2022 Caroline L. Alves
The abstract describes a study that used Pearson's connection matrix to analyze EEG experiments from subjects who had ingested ayahuasca, focusing on the period after psychedelic activation. The work examines brain connectivity patterns during the psychedelic state induced by ayahuasca, likely investigating how neural networks reorganize under the influence of the substance.
Figshare January 1, 2022 Caroline L. Alves
The text describes a Pearson's connection matrix derived from EEG experiments on subjects who ingested ayahuasca, measured at a time point before the psychedelic activation period. This suggests the matrix captures baseline neural connectivity patterns prior to the onset of the substance's psychoactive effects, providing a reference for comparing changes during the psychedelic state.
Figshare November 25, 2021 Johannes Reckweg (11755736), Natasha L. Mason (11755739), Cees van Leeuwen (255734) et al.
A vaporized formulation of 5-MeO-DMT (GH001) was tested in 22 healthy volunteers at single doses of 2, 6, 12, and 18 mg, and in an individualized dose escalation regimen. Higher doses produced significantly stronger psychedelic effects on peak experience, mystical experience, ego dissolution, and altered states of consciousness compared to the lowest 2 mg dose, except for challenging experiences. Individualized dose escalation produced the strongest effects. Cognition, mood, and well-being were not affected. Vital signs remained stable, and adverse events were mild and resolved spontaneously. Individualized dose escalation may be preferable for maximizing the experience in clinical applications.
Figshare January 1, 2021 Kevin Mckernan, Liam T. Kane, Yvonne Helbert et al.
A whole genome atlas of 81 Psilocybe genomes provides a resource for psilocybin production, detailing the phylogenetic relationships and genetic diversity among these species. The work describes the construction of a phylogenetic tree from these genomes, offering insights into the evolutionary history of psilocybin-producing fungi and identifying genetic elements relevant for biosynthesis. This resource supports further research into psilocybin production and the biology of Psilocybe species.
Figshare January 1, 2021 Jeremy Weleff, Teddy J. Akiki, Brian S. Barnett
A dataset was compiled for a bibliometric analysis of journal articles reporting clinical study findings on eight psychedelic substances—5-MeO-DMT, ayahuasca, DMT, ibogaine, LSD, mescaline, MDMA, and psilocybin—published between 1965 and 2018. The dataset accompanies a preprint article that analyzes the academic literature on these compounds.
Figshare January 1, 2021 Samuel J. Hogarth
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Figshare January 1, 2021 Piotr Popik, Adam S. Hogendorf, Ryszard Bugno et al.
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Figshare January 1, 2017 Andrew Hillstead
Because psychedelic substances are illegal, many people with psychiatric conditions cannot access effective psychedelic therapy. This analysis, combining practical application with literature and conference review, examines whether computer-mediated realities can convincingly simulate such therapy. Augmented reality and modulated realities like modified and diminished reality show insufficient evidence for practical use. Augmented virtuality, mixed reality, virtual reality, and modulated virtuality have characteristics that could simulate mind-manifesting psychedelic therapy, but mediated reality appears extraneous for mind-loosening therapy. Virtual reality currently shows the greatest potential for healing and exploring the psyche by simulating closed-eye psychedelic experiences. The author proposes a proof-of-concept for a neurofeedback-driven VR experience that simulates phosphenes transforming into geometric hallucinations, aiming to provide safe, accessible simulated psychedelic therapy.
Figshare December 3, 2015 Ekman Schenberg Eduardo, Felipe Morel Alexandre João, Renato Filev et al.
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Figshare January 1, 2014 Maio, Paola Di
Ethnobotanical evidence suggests that a plant called San Pedro, found in the Americas, may be a previously unrecognized candidate for the ritual substance Soma. The hypothesis is based on observations of the plant's traditional use and properties.