World Futures
April 29, 2026
Azul Delgrasso, Jay Monger
Leadership emerges less from positional authority than from attunement—an embodied capacity to sense self, others, and context. This article argues that well-designed relational containers, such as the Way of Council and men's work, combined with low-dose (psycholytic) 5-MeO-DMT sessions, can deepen empathy, coherence, and collective intelligence in complex, transdisciplinary settings. Using facilitator narrative, reflective inquiry, and two composite vignettes, the authors show how these practices support ethical self-reflection, dialogic sense making, and responsible action. They emphasize that carefully held low-dose sessions may amplify intersubjective resonance and relational learning when grounded in consent, safety, and cultural humility.
Zenodo (CERN European Organization for Nuclear Research)
April 26, 2026
Jean‐patrick Pommier
A proposed experiment tests whether two people simultaneously in a prolonged, immersive state induced by N,N-dimethyltryptamine (DMT) can transfer information without ordinary sensory channels. In the protocol, participants in physically separated, shielded rooms receive random vibrotactile stimuli. The main outcome is whether brain activity (theta-band power) in the non-stimulated participant differs between real stimulus times and sham times. The design includes a power analysis based on prior distant-mental-interaction studies. A positive result would not prove DMT worlds are real but would provide a controlled test of anomalous information transfer during the DMT state. The protocol also outlines future tests using isotopic variants to explore possible spin-dependent mechanisms.
Psychedelics
April 25, 2026
Juliet Meccia, David Casimir, Sisi Li et al.
Over the past 25 years, informal and underground use of 5-MeO-DMT has generated substantial, though underrecognized, knowledge about its potential to alleviate depressive symptoms. Traditional drug development, with structured trials and regulatory milestones, rarely incorporates findings from these alternative routes. Legal and regulatory barriers have delayed formal clinical investigation, while public channels and Indigenous knowledge have driven grassroots support and anecdotal evidence of therapeutic benefit. The article identifies critical communication gaps hindering integration of 5-MeO-DMT into mainstream psychiatry and advocates for transparent data-sharing models that incorporate existing informal knowledge.
Journal of psychoactive drugs
April 23, 2026
Brayan Jonas Mano-Sousa, Maria Clara Gama Fontes, Ana Clara Anacleto Gonçalves et al.
In people with treatment-resistant depression, ayahuasca—a traditional Amazonian psychedelic—rapidly reduces suicidal thoughts and depressive symptoms. A systematic review of five studies found consistent evidence of these effects, attributed to the synergistic action of β-carbolines and DMT. Neurobiologically, ayahuasca promotes neuroplasticity by upregulating Brain-Derived Neurotrophic Factor and decreasing Default Mode Network activity, enabling profound introspection and emotional processing. Despite promising results, large-scale, rigorous longitudinal studies are needed to establish safe clinical guidelines.
Revista Tópicos.
April 22, 2026
Muriel Fernandes, Kelvy Muniz, Débora Barbosa et al.
This paper presents an experimental protocol and theoretical framework for the Century Experiment, which aims to empirically validate the Holographic Architecture of Reality Construction (AHCR 2.0), a model proposing consciousness as a measurable physical-informational variable in constructing observable reality. The study investigates expanded states of consciousness induced by ayahuasca and N,N-dimethyltryptamine (DMT) compared to a control group, using electroencephalographic analysis of gamma oscillations (30–100 Hz).
Zenodo (CERN European Organization for Nuclear Research)
April 18, 2026
A three-phase experimental protocol tests whether the radical pair mechanism (RPM) operates during DMT-induced psychedelic states at the 5-HT2A receptor. Position-specific isotopic substitution of the ligand (13C at C3a, 15N on indole nitrogen) alters nuclear spin content without changing molecular geometry, receptor affinity, or metabolic half-life. Because the kinetic isotope effect is negligible for 13C (Δm = +8%, KIE < 1.04), any observed phenomenological change would constitute direct evidence for the magnetic isotope effect and RPM involvement at the receptor. Structure-guided labelling (PDB: 9AS1), falsification criteria, and a ~$10,000 mouse HTR pilot are described.
Journal of Psychopharmacology
April 12, 2026
L. M. Wallace, Andrea Bujor, Gustavo Sudre et al.
A systematic review and meta-analysis of studies from 1960 to 2024 found that the psychedelic agent DMT produced a large overall effect on reducing substance abuse (g = 0.94). Effects were larger for drug use (g = 1.35) than for alcohol use (g = 0.65). Studies that included psychotherapy showed significantly greater effects (g = 1.38) than those without (g = 0.60). However, the included studies had high risk of bias and high heterogeneity, so the findings should be considered preliminary rather than proof of established efficacy.
Zenodo (CERN European Organization for Nuclear Research)
April 2, 2026
David M. Remmer
Reanalysis of a prior study on DMT's effect on brain waves shows that the drug does not selectively increase forward (bottom-up) traveling waves. Instead, DMT causes a collapse of both forward and backward wave power at alpha (8–13 Hz) and broadband (2–100 Hz) frequencies in all 12 subjects. The backward collapse is slightly larger (2.3–5.1 percentage points). The earlier reported increase in normalized forward power was an artifact of the surrogate baseline dropping faster than the signal. At the peak effect, forward and backward alpha power were statistically indistinguishable, and the forward signal did not significantly differ from zero. The brain's directional wave structure under DMT is lost rather than reorganized.
Zenodo (CERN European Organization for Nuclear Research)
April 1, 2026
Washburn, Jon
A new mathematical framework, Recognition Science, explains why the brain produces DMT, a molecule that both protects neurons during oxygen deprivation and induces near-death experiences. The model treats DMT as a specific rung on a mathematical ladder, where activating sigma-1 receptors lowers a cellular cost barrier. This framework predicts that DMT will boost brain waves at about 8.09 Hz, that electromagnetic shielding will reduce shared brain patterns between people, and that related compounds will show specific ratios. The authors show that neuroprotection and near-death experience phenomenology are mathematically the same operation on a fundamental channel.