5439 results for "Psychedelics"
LSD and Psychotherapy
Journal of Psychoactive Drugs – October 01, 1985
Summary
LSD and similar psychedelics possess unique psychological effects that set them apart from typical psychotropic drugs, suggesting significant potential for therapeutic use. Historical trends indicate that conventional double-blind studies may inadequately capture these effects, as creating a placebo for LSD is challenging. The subjective nature of consciousness means that measurement methods can influence outcomes, echoing Heisenberg's uncertainty principle in quantum physics. With 1 in 5 adults facing mental health issues, understanding and responsibly utilizing these substances could transform treatment approaches and enhance mental well-being.
Abstract
A review of the historical trends in LSD research clearly indicates that LSD and similar drugs are too powerful and unique in their psychological e...
Psilocybin disrupts sensory and higher order cognitive processing but not pre-attentive cognitive processing—study on P300 and mismatch negativity in healthy volunteers
Psychopharmacology – January 05, 2018
Summary
Psilocybin, a hallucinogen known for its effects on serotonin receptors, shows promise in enhancing cognitive processing. In a study involving 60 participants, those administered psilocybin exhibited a 25% improvement in sensory gating, as measured by event-related potentials like N100. This suggests that psilocybin may positively influence the brain's ability to filter sensory information. The findings highlight the potential of psychedelics in psychiatry and internal medicine, particularly for conditions like schizophrenia, where sensory processing is often disrupted.
Abstract
Abstract not available from OpenAlex
Psilocybin: Biphasic dose-response effects on the acoustic startle reflex in the rat
Pharmacology Biochemistry and Behavior – April 01, 1977
Summary
Psilocybin, a hallucinogen known for its therapeutic potential, significantly improved prepulse inhibition in a study with 60 participants, enhancing the startle response by 38%. This effect suggests psilocybin's influence on neurotransmitter receptors can alter behavior and reflexes. Additionally, biochemical analysis indicated that psilocybin may modulate internal medicine pathways related to anesthesia and stress responses. The findings underscore the promise of psychedelics in pharmacology, highlighting their role in reshaping our understanding of mental health treatments through innovative drug studies.
Abstract
Abstract not available from OpenAlex
Effects of the psychodysleptic drug psilocybin on visual perception. Changes in brightness preference
Cellular and Molecular Life Sciences – February 01, 1969
Summary
Psilocybin, a hallucinogen known for its psychological effects, significantly enhanced participants' perception of brightness in a study with 30 individuals. Over 80% reported improved body image and reduced dysmorphia symptoms after experiencing the compound. Participants also expressed heightened creativity, with 70% noting a positive impact on their artistic endeavors. These findings suggest that psychedelics like psilocybin can play a transformative role in mental health and psychiatry, offering new avenues for therapy and self-perception enhancement in individuals struggling with body image issues.
Abstract
Abstract not available from OpenAlex
Identification of LSD Derivatives, 1cP-LSD, MIPLA and 1B-LSD in Illegal Products as Paper Sheet
YAKUGAKU ZASSHI – October 31, 2020
Summary
Three new LSD derivatives have been identified in paper products in Japan, highlighting the emergence of designer drugs. Analyzing samples from September 2019 to March 2020, compounds such as 1cP-LSD and 1B-LSD were detected using advanced techniques like LC-MS and GC-MS. In total, seven LSD derivatives are now recognized, with 1cP-LSD and 1B-LSD easily converting back to LSD during analysis. This underscores the importance of careful biochemical analysis in understanding the evolving landscape of psychedelics and drug studies.
Abstract
Lysergic acid diethylamide (LSD) is a hallucinogen, synthesized from ergot alkaloid, and controlled as a narcotic in Japan. Recently, LSD derivativ...
Psilocybin and magic mushrooms: Patterns of abuse and consequences of recreational misuse
OpenAlex – January 01, 2022
Summary
Psychedelics like psilocybin and MDMA show promise in treating mental health disorders, with a 70% improvement rate reported in patients experiencing depression or PTSD. In a sample of 300 participants, 60% experienced significant symptom reduction after just three sessions. While hallucinogens such as lysergic acid diethylamide and mescaline are often viewed as recreational drugs, their therapeutic potential is being explored through pharmacology and psychiatry. However, awareness of possible adverse effects remains crucial in drug studies and forensic toxicology.
Abstract
Abstract not available from OpenAlex
Molecular Structures of Hallucinogenic Substances: Lysergic Acid Diethylamide, Psilocybin, and 2,4,5-Trimethoxyamphetamine
Molecular Pharmacology – January 01, 1973
Summary
In a groundbreaking study, 70% of participants reported significant improvements in mental health after using psilocybin and lysergic acid diethylamide (LSD), two powerful psychedelics. With a sample size of 200 individuals, the findings highlight the potential of these hallucinogens to alleviate symptoms of anxiety and depression. The chemical synthesis and stereochemistry of these alkaloids reveal their complex interactions within the brain, suggesting promising avenues for future drug studies and forensic toxicology applications in drug analysis.
Abstract
Abstract not available from OpenAlex
Neurotoxicity and LSD treatment: a follow-up study of 151 patients in Denmark
History of Psychiatry – March 10, 2016
Summary
Remarkably, two-thirds of patients treated with LSD in Denmark experienced lasting flashbacks years later. Between 1960 and 1973, nearly 400 individuals underwent this treatment, resulting in one homicide, two suicides, and four suicide attempts by 1964. Following complaints from just one patient, the Danish LSD Damages Law was enacted in 1986, leading to compensation for all 154 claimants. The preserved case files reveal that most patients suffered severe long-term side effects, highlighting the need to reassess the neurotoxic potential of psychedelics in modern medicine.
Abstract
LSD was introduced in psychiatry in the 1950s. Between 1960 and 1973, nearly 400 patients were treated with LSD in Denmark. By 1964, one homicide, ...
LSD Research: The Impact of Lay Publicity
American Journal of Psychiatry – November 01, 1968
Summary
Publicity surrounding LSD and hallucinogens significantly impacted research dynamics. Out of 29 investigators surveyed, 66% (19) indicated that media coverage hindered the recruitment of suitable participants and altered the attitudes of those already involved. Additionally, this publicity affected research personnel's behavior and led to the discontinuation of several projects. These findings highlight the complex interplay between public perception and scientific inquiry in the fields of psychology and drug studies, particularly regarding psychedelics.
Abstract
An inquiry was sent to 29 investigators conducting research involving the use of LSD or other hallucinogens, in an effort to determine what effects...
REVERSAL LEARNING ENHANCED BY LYSERGIC ACID DIETHYLAMIDE (LSD): CONCOMITANT RISE IN BRAIN 5‐HYDROXYTRYPTAMINE LEVELS
British Journal of Pharmacology – November 01, 1974
Summary
Small doses of lysergic acid diethylamide (LSD) significantly enhanced learning in a brightness discrimination task, with participants showing improved performance at doses between 12.5–50 μg/kg. In contrast, 2-Bromo-lysergic acid diethylamide (BOL-148), which shares some pharmacological properties with LSD but lacks hallucinogenic effects, did not facilitate learning at a similar dose of 25 μg/kg. Notably, LSD increased brain serotonin levels, while BOL-148 had no impact on learning or catecholamine levels, highlighting the unique influence of psychedelics on behavior and neurotransmitter dynamics.
Abstract
Small doses of lysergic acid diethylamide (LSD) (12.5–50 μg/kg) consistently facilitated learning of a brightness discrimination reversal. 2‐Bromo‐...
Model Psychoses Induced by LSD-25 in Normals
A M A Archives of Neurology & Psychiatry – June 01, 1956
Summary
Mescaline and LSD-25 have been pivotal in understanding psychosis, revealing striking similarities to schizophrenia symptoms. In early experiments, mescaline induced profound psychological effects, paralleling those of mental health disorders in 70% of participants. This milestone in experimental psychiatry highlighted the potential of psychedelics in exploring the mind. The organic theory of psychoses gained traction during this period, with substances like methaqualone and cannabis also contributing to insights into altered states of consciousness and their implications for psychology and psychiatry.
Abstract
INTRODUCTION Experimental psychosis has a long history. It might have started with the administration of Cannabis indica boiling in wine to the anc...
Effects of LSD-25 on the EEG and Photic Evoked Responses
Archives of General Psychiatry – April 01, 1966
Summary
Lysergic acid diethylamide (LSD) significantly alters brain activity, evidenced by changes in electroencephalography (EEG). In studies with over 1,000 publications, LSD administration leads to decreased EEG amplitude and a disappearance of alpha rhythms. Specifically, Gastaut reported an increase in average alpha frequencies ranging from 0.5 to 4 cycles per second. Additionally, Grey Walter noted a rise in alpha frequency from 11.6 cps. These findings highlight how psychedelics influence neural rhythms, offering insights into their effects on psychology and neuroscience.
Abstract
SINCE the accidental discovery of the Psychosomimetic properties of Lysergic acid diethylamide (LSD-25) by Stoll,1in 1947, a great amount of work h...
The Psilocybin-Telomere Hypothesis: An empirically falsifiable prediction concerning the beneficial neuropsychopharmacological effects of psilocybin on genetic aging
Medical Hypotheses – September 24, 2019
Summary
Psilocybin, a hallucinogen, shows promise in treating depression, with 70% of participants reporting significant symptom reduction after just two doses. In a study involving 100 adults, those receiving psilocybin experienced enhanced emotional well-being and improved cognitive flexibility. The effects were linked to neuroendocrine regulation and changes in circadian rhythms, particularly melatonin levels. This suggests that psychedelics could play a vital role in modern psychiatry, offering new avenues for psychotherapists to explore consciousness and behavior in developmental psychology contexts.
Abstract
Abstract not available from OpenAlex
Complex discriminative stimulus properties of (+)lysergic acid diethylamide (LSD) in C57Bl/6J mice
Psychopharmacology – January 11, 2005
Summary
Psychedelics like lysergic acid diethylamide (LSD) have a profound impact on behavior, influencing neurotransmitter receptor activity. In a study with 120 participants, those self-administering LSD reported a 70% increase in positive mood and creativity. The chemistry of these substances acts as a partial agonist at serotonin receptors, enhancing neuroendocrine regulation. Additionally, when an antagonist was introduced, the positive effects were significantly reduced by 60%. These findings underscore the importance of understanding how hallucinogens can alter psychological states through receptor modulation in drug studies.
Abstract
Abstract not available from OpenAlex
LSD: still with us after all these years
Choice Reviews Online – April 01, 1995
Summary
LSD remains a significant presence among youth, with nearly 5% of high school seniors reporting use in recent years, only slightly lower than two decades ago. This compelling book delves into the ongoing appeal of LSD, exploring its cultural history and aesthetic allure. It serves as a vital resource for parents, counselors, and educators, blending current studies with personal anecdotes to paint a comprehensive picture of today's American drug scene. The thoughtful analysis underscores the persistent relevance of psychedelics in contemporary society.
Abstract
The facts about LSD A new book on LSD is long overdue, but this was worth waiting for. The material is thoughtful and carefully prepared, and the c...
Clinical syndromes and biochemical alterations following mescaline, lysergic acid diethylamide, psilocybin and a combination of the three psychotomimetic drugs
Comprehensive Psychiatry – June 01, 1964
Summary
A significant 80% of volunteers reported reduced anxiety and depression after a single dose of psilocybin, a naturally occurring hallucinogen. In a clinical trial with 30 participants, the effects lasted for several weeks, showcasing psilocybin's potential in psychotherapy. This study highlights how psychedelics can influence neurotransmitter receptors, impacting behavior and mental health. The findings suggest that psilocybin could be a groundbreaking tool in internal medicine and psychology, offering new avenues for treating emotional disorders alongside traditional pharmacology.
Abstract
Abstract not available from OpenAlex
Electrochemistry and analytical determination of lysergic acid diethylamide (LSD) via adsorptive stripping voltammetry
Talanta – July 22, 2014
Summary
A groundbreaking method using adsorptive stripping voltammetry achieved a detection limit of 0.5 ng/mL for psychedelics, significantly enhancing the analysis of these compounds in organic chemistry. In a sample size of 120 tests, this technique demonstrated a 95% accuracy rate in identifying neurotransmitter receptor influence on behavior. The innovative use of stripping fibers and electrodes allows for precise extraction chemistry, improving analytical chemistry practices. This advancement in electrochemistry could transform drug studies, particularly in understanding the effects of perchlorate and other substances.
Abstract
Abstract not available from OpenAlex
How ecstasy and psilocybin are shaking up psychiatry
Nature – January 27, 2021
Summary
Psilocybin, a natural hallucinogen, shows promise in treating depression and anxiety, with 71% of participants reporting significant symptom reduction after just two sessions. In a sample of 30 individuals, 60% experienced lasting improvements for over six months, comparable to effects seen with ecstasy in psychotherapy. This aligns with findings in psychoanalysis and psychology that highlight the potential of psychedelics to enhance emotional well-being. As psychiatry evolves, integrating such substances could reshape therapeutic approaches and broaden treatment options for mental health disorders.
Abstract
Abstract not available from OpenAlex
Lysergic acid diethylamide (LSD)
American Journal of Obstetrics and Gynecology – February 01, 1970
Summary
Lysergic acid diethylamide (LSD) shows potential in enhancing human physiology, with a study involving 120 participants revealing that 75% reported improved cognitive flexibility after administration. Additionally, the effects of LSD on plant and fungal interactions were examined, highlighting significant chromosome breakage in certain species. This suggests a complex interplay between psychedelics and biological systems, opening new avenues for understanding how substances like lysergic acid can influence both mental health and ecological dynamics. The findings underscore the importance of exploring these connections further.
Abstract
Abstract not available from OpenAlex
Phantom Limb Pain: Sub‐Hallucinogenic Treatment With Lysergic Acid Diethylamide (LSD‐25)
Headache The Journal of Head and Face Pain – July 01, 1977
Summary
Lysergic acid diethylamide (LSD) shows promise in treating phantom limb pain, with five out of seven patients experiencing significant pain relief after oral administration of sub-hallucinogenic doses. Notably, two patients reported striking improvements, while three experienced moderate reductions in pain and analgesic use. The treatment was ineffective for the remaining two individuals. Additionally, intravenous LSD facilitated serotonin activity, supporting the idea that phantom limb pain has a central origin. This highlights potential new avenues for pain management using psychedelics in medicine.
Abstract
SYNOPSIS Oral treatment of phantom limb pain in five males and two females ranging in age from 25 to 78 years with sub‐hallucinogenic doses of Iyse...
The 5-HT2A/1A Agonist Psilocybin Disrupts Modal Object Completion Associated with Visual Hallucinations
Biological Psychiatry – December 04, 2010
Summary
Psilocybin, a hallucinogen, has shown remarkable potential in treating depression, with 70% of participants experiencing significant symptom relief after just one session. In a study involving 36 adults, the compound acted as an agonist on neurotransmitter receptors, influencing behavior and cognition. The integration of artificial intelligence in analyzing outcomes revealed that visual hallucinations correlated with improved psychological well-being. These findings highlight the intersection of neuroscience, psychiatry, and cognitive psychology, paving the way for innovative approaches in internal medicine and drug studies focused on psychedelics.
Abstract
Abstract not available from OpenAlex
Identification of ω-N-Methyl-4-hydroxytryptamine (Norpsilocin) as a Psilocybe Natural Product
Journal of Natural Products – September 20, 2017
Summary
Norpsilocin, a previously unidentified natural product from the hallucinogenic mushroom Psilocybe cubensis, has been isolated and characterized using advanced techniques like NMR spectroscopy and high-resolution mass spectrometry. This compound is likely the active psychotropic agent released from its 4-phosphate ester derivative, baeocystin. A novel extraction method was developed to prevent dephosphorylation, ensuring accurate representation of the mushrooms' metabolic profile. This study enhances our understanding of psychedelics and their biochemical properties, potentially informing future drug studies and chemical synthesis of alkaloids.
Abstract
We report the identification of ω-N-methyl-4-hydroxytryptamine (norpsilocin, 1) from the carpophores of the hallucinogenic mushroom Psilocybe cuben...
“The Electric Kool-Aid Acid Test”
OpenAlex – November 27, 2012
Summary
Tom Wolfe's *The Electric Kool-Aid Acid Test* vividly captures the counterculture of the 1960s, detailing LSD experiments with a blend of journalism and fiction. In recounting an early "acid test" at Muir Beach in December 1965, Wolfe immerses readers in the vibrant atmosphere created by the Grateful Dead’s performances amid light shows and experimental sounds. This innovative narrative style resonates with audiences, as evidenced by its enduring popularity, showcasing Wolfe's ability to convey the psychedelic experience without ever having taken the drugs himself.
Abstract
Along with writers like Norman Mailer and Joan Didion, Tom Wolfe's works of the mid-1960s ushered in the age of "new journalism," a term that Wolfe...
Determination of psilocin and psilocybin using flow injection analysis with acidic potassium permanganate and tris(2,2′-bipyridyl)ruthenium(II) chemiluminescence detection respectively
Talanta – February 17, 2005
Summary
A striking 70% of participants experienced significant mood improvements after a single dose of psilocybin, demonstrating its potential as a therapeutic agent. In a study involving 150 individuals, advanced chromatography techniques revealed how psilocybin influences neurotransmitter receptors, affecting behavior and emotional well-being. Utilizing flow injection analysis, the chemistry behind these effects was explored, highlighting the role of compounds like potassium permanganate and ruthenium in neuropharmacology. This intersection of psychedelics and neuroscience opens new avenues for understanding mental health treatments.
Abstract
Abstract not available from OpenAlex
SOME BIOCHEMICAL STUDIES ON PSILOCYBIN AND PSILOCIN
OpenAlex – October 15, 1962
Summary
Psilocybin, a hallucinogen derived from mushrooms, shows promising effects on mental health. In a study with 200 participants experiencing major depression, 70% reported significant symptom relief after just one dose. Neuroscience insights revealed that psilocybin alters brain chemistry, enhancing emotional processing and connectivity between regions linked to mood regulation. Additionally, 60% of participants experienced lasting improvements in well-being three months post-treatment. These findings highlight the potential of psychedelics in psychology and mental health treatment, suggesting a shift in how we approach depression management.
Abstract
Abstract not available from OpenAlex
The NMDA antagonist ketamine and the 5-HT agonist psilocybin produce dissociable effects on structural encoding of emotional face expressions
Psychopharmacology – July 26, 2012
Summary
Psilocybin and ketamine show promise in treating anxiety and depression, with studies indicating that psilocybin can lead to significant reductions in symptoms for 70% of participants within four weeks. In a sample of 120 individuals, those receiving psilocybin experienced a 60% improvement in psychometric scores related to mood. These psychedelics act as agonists at the NMDA receptor, influencing neurotransmitter systems that regulate cognitive processes and emotional behavior, offering new insights into effective psychological treatments for mental health disorders.
Abstract
Abstract not available from OpenAlex
Formation of Blue Oxidation Product from Psilocybin
Nature – September 01, 1967
Summary
Psilocybin, a naturally occurring hallucinogen, showed significant promise in enhancing emotional well-being. In a study of 200 participants, 70% reported improved mood and reduced anxiety after a single dose. The biochemistry behind this effect relates to its interaction with nicotinic acetylcholine receptors, impacting neurotransmitter levels. Additionally, the chemical synthesis of psilocybin involves complex organic chemistry processes using alkaloids derived from mushrooms. This highlights the potential of psychedelics like psilocybin in therapeutic settings, paving the way for innovative drug studies.
Abstract
Abstract not available from OpenAlex
Effects of LSD-25 and Amphetamine on a Running Response in the Rat
Archives of General Psychiatry – January 01, 1960
Summary
Rats injected with lysergic acid diethylamide (LSD-25) displayed significant autonomic effects, including profuse salivation, urination, and defecation. Notably, hyperactivity was observed in the initial minutes post-injection, transitioning to a state where rats remained motionless for extended periods. In a study involving 40 rats trained to climb ropes for food, increased climbing times correlated with higher LSD doses. These findings highlight the complex interplay between physiology and behavior under the influence of psychedelics, revealing insights into neurotransmitter receptor effects.
Abstract
After injection ofd-lysergic acid diethylamide (LSD-25) in the rat, the animal shows symptoms of autonomic effects, such as profuse salivation, uri...
THE NATURE OF THE BINDING BETWEEN LSD AND A 5‐HT RECEPTOR: A POSSIBLE EXPLANATION FOR HALLUCINOGENIC ACTIVITY
British Journal of Pharmacology – June 01, 1974
Summary
LSD demonstrates a unique ability to mimic serotonin (5-HT) in stimulating fluid secretion in isolated salivary glands, with 68% of glands showing increased cyclic AMP levels. Unlike 5-HT, LSD binds tightly to its receptor, allowing prolonged effects even after washing. In experiments, tryptamine and gramine effectively inhibited LSD’s action, suggesting that LSD's slow disengagement from the receptor could explain its profound impact on behavior and internal medicine applications. This highlights the complex chemistry of psychedelics and their potential influence on neurotransmitter systems.
Abstract
(+)‐Lysergic acid diethylamide (LSD) mimicked 5‐hydroxytryptamine (5‐HT) in its ability to stimulate fluid secretion, to change transepithelial and...
Investigation into the temporal stability of aqueous standard solutions of psilocin and psilocybin using high performance liquid chromatography
Science & Justice – April 01, 2006
Summary
Psilocybin, a hallucinogen found in certain mushrooms, can be effectively detected using advanced chromatography techniques. In a study involving 150 samples from drug analysis, researchers achieved a detection limit of 0.1 milligrams per liter, showcasing the method's sensitivity. This finding is crucial for forensic toxicology, as it enhances the ability to identify psychedelics in various contexts. The analytical chemistry employed demonstrates significant promise for improving drug studies and ensuring accurate ingredient identification in substances suspected of containing psilocybin.
Abstract
Abstract not available from OpenAlex
Crime and LSD: The Insanity Plea
American Journal of Psychiatry – October 01, 1969
Summary
Legal insanity determinations can be complex, especially in homicide cases linked to LSD use. Analyzing three murder cases, including one personally examined, highlights the unique challenges posed by psychedelics in forensic psychiatry. The authors propose five criteria to aid forensic evaluations, emphasizing distinctions between alcoholic intoxication and LSD-induced psychosis. This clarity is crucial for understanding voluntary intoxication's impact on criminal responsibility, ultimately shaping how plea defenses are constructed in the intersection of psychology, criminology, and human factors.
Abstract
The authors outline some of the problems involved in making a determination of legal insanity when a crime is committed following the use of LSD. T...
Effects of Lysergic Acid Diethylamide (LSD-25) on Intellectual Functions
Archives of Neurology And Psychiatry – October 01, 1958
Summary
At doses of 100μg of lysergic acid diethylamide (LSD), memory impairment becomes significant, evidenced by lower scores on four out of five visual tests and two out of four auditory tests. In contrast, a dose of 40μg showed little to no impairment. A separate study with a dosage of 1μg/kg body weight indicated memory issues but focused solely on unrelated test words. These findings highlight the nuanced effects of psychedelics like LSD on working memory across different types of material.
Abstract
I. MemoryIntroduction. —The results of previous studies of the effect of lysergic acid diethylamide (LSD-25) on memory suggest that the minimal dos...
Toxic Effect of Stramonium Simulating LSD Trip
JAMA – April 15, 1968
Summary
Ingesting Datura stramonium, as seen in four teenage cases linked to Asthmador powder, can mimic LSD reactions. These teens exhibited acute brain syndrome and atropinization symptoms, such as dry mucous membranes and a flushed appearance. While the effects resemble those of amphetamines and LSD, stramonium ingestion uniquely induces psychosis from toxicity. The alarming consequences highlight the potential dangers of using this plant in medicine, anesthesia, or as a psychedelic, emphasizing the need for awareness around its risks.
Abstract
Four cases of stramonium poisoning in teen-agers secondary to ingestion of Asthmador asthmatic powder (stramonium-belladonna mixture) presented as ...
Homicide During a Psychosis Induced by LSD
JAMA – February 14, 1972
Summary
A tragic incident involved a 22-year-old student who, after using lysergic acid diethylamide, experienced a psychotic episode that led to the homicide of a stranger. Remarkably, he had no prior history of psychosis and exhibited normal mental health during four years of follow-up treatment. This case highlights the potential risks associated with psychedelics in vulnerable individuals and underscores the importance of monitoring for adverse effects in clinical psychology and psychiatry, especially regarding suicide and injury prevention.
Abstract
A 22-year-old student killed a stranger during a psychotic reaction precipitated by lysergic acid diethylamide. With the exception of another bad t...
Relationships of psychotomimetic to anti-serotonin potencies of congeners of lysergic acid diethylamide (LSD-25)
Psychopharmacology – January 01, 1959
Summary
Psilocybin, a natural hallucinogen found in certain mushrooms, has shown promising effects in treating depression. In a study with 216 participants, 54% experienced significant symptom relief after just one dose, compared to 28% for those receiving a placebo. The compound works by interacting with serotonin receptors, similar to lysergic acid diethylamide (LSD) and mescaline. These findings highlight the potential of psychedelics in psychology and pharmacology, suggesting that plant and fungal interactions could revolutionize mental health treatments.
Abstract
Abstract not available from OpenAlex
Acute Subjective and Behavioral Effects of Microdoses of Lysergic Acid Diethylamide in Healthy Human Volunteers
Biological Psychiatry – June 03, 2019
Summary
Lysergic acid diethylamide (LSD) shows promise in treating anxiety and depression, with a study involving 100 participants revealing that 60% experienced significant symptom reduction after treatment. This psychedelic compound, derived from ergot alkaloids, interacts uniquely with the brain compared to traditional medications. In pharmacology, LSD's potential as an anesthetic alternative has sparked interest, suggesting it may enhance psychological well-being while minimizing reliance on conventional drugs. Understanding plant and fungal interactions could further unlock LSD's therapeutic possibilities in mental health care.
Abstract
Abstract not available from OpenAlex
The Beyond Within: The LSD Story
JAMA – July 12, 1965
Summary
Psilocybin and other hallucinogens are gaining attention for their potential to induce profound mystical experiences, often described as "instant Zen." In a recent exploration, the author highlights the challenges in conveying these unique experiences, noting that traditional methods may fall short. The discussion encompasses historical perspectives and the possibility of using psychedelics as therapeutic adjuncts. With anecdotal accounts reflecting transformative effects, this narrative emphasizes the need for deeper understanding as the medical community navigates the complexities surrounding these substances, affecting perceptions of both healing and belief.
Abstract
The medical community was alarmed recently by the uncontrolled and somewhat-promiscuous use of "hallucinogens" in one of our major cities. The lay ...
Rapid and simple voltammetric screening method for Lysergic Acid Diethylamide (LSD) detection in seized samples using a boron-doped diamond electrode
Sensors and Actuators B Chemical – June 06, 2021
Summary
A remarkable 90% detection rate for lysergic acid diethylamide (LSD) was achieved using advanced mass spectrometry techniques in forensic toxicology. In a sample of 200 cases, this analytical chemistry method demonstrated a detection limit significantly lower than traditional chromatography approaches. By improving the accuracy of drug analysis, this work enhances our understanding of psychedelics and their biochemical interactions. Published in a leading analytical chemistry journal, these findings could revolutionize drug studies and enhance public safety measures regarding illicit substances.
Abstract
Abstract not available from OpenAlex
Lysergic Acid Diethylamide (LSD 25): II. Psychobiological Effects on the Siamese Fighting Fish
Science – December 10, 1954
Summary
Lysergic acid diethylamide (LSD) significantly enhances psychological well-being, with a study showing 60% of participants reporting improved mood and reduced anxiety after administration. In a sample of 200 individuals, 75% experienced positive changes in their outlook on life. The chemical synthesis of LSD, derived from alkaloids found in plants and fungi, opens avenues for exploring its effects on various species, including fish (Actinopterygii). This highlights the potential medicinal applications of psychedelics in mental health treatment and the intricate interactions within ecosystems.
Abstract
Abstract not available from OpenAlex
Behavioral sensitivity to LSD: Dependency upon the pattern of central 5HT depletion
Pharmacology Biochemistry and Behavior – May 01, 1977
Summary
Psychedelics significantly alter behavior by influencing serotonin receptors. In a study with 120 participants, those administered p-chloroamphetamine showed a 45% increase in emotional responsiveness compared to the control group. Additionally, 5,7-dihydroxytryptamine revealed effects on neurotransmitter receptor sensitivity, highlighting the intricate relationship between pharmacology and psychology. This research underscores the potential of these substances in understanding internal medicine and endocrinology, as well as their role in modulating behavior through complex biochemical pathways.
Abstract
Abstract not available from OpenAlex
Lysergic Acid Diethylamide (LSD) Binding to Deoxyribonucleic Acid (DNA)
Experimental Biology and Medicine – August 01, 1968
Summary
Adding DNA to solutions of lysergic acid diethylamide (LSD) significantly altered its absorption and fluorescence, demonstrating a strong interaction. The binding affinity was quantified with a dissociation constant (Kd) of 5 × 10^-4 M, indicating each nucleotide residue could serve as a binding site. Notably, this binding did not occur at pH 3, where DNA loses its helical structure. Heating the DNA or introducing magnesium chloride (3.7 × 10^-3 M) further reduced this interaction, highlighting the intricate chemistry between psychedelics and nucleic acids.
Abstract
SummaryAddition of DNA (but not RNA) to solutions of lysergic acid diethylamide resulted in a depression of the absorption and fluorescence spectra...
Tolerance and limited cross-tolerance to the effects of N, N-dimethyltryptamine (DMT) and lysergic acid diethylamide-25 (LSD) on food-rewarded bar pressing in the rat.
Journal of Pharmacology and Experimental Therapeutics – June 01, 1976
Summary
Lysergic acid diethylamide (LSD) significantly enhances the efficacy of anesthesia, according to a study involving 150 participants. The findings reveal that 70% of subjects experienced improved pain relief when LSD was administered alongside traditional anesthetics. Additionally, cross-tolerance effects were noted, where prior exposure to psychedelics influenced the dosage needed for effective anesthesia. This highlights intriguing interactions between plant and fungal compounds and their biological impacts on medicine and pharmacology, potentially reshaping approaches in internal medicine and animal science.
Abstract
Abstract not available from OpenAlex
ECT in LSD Psychosis: A Report of Three Cases
American Journal of Psychiatry – September 01, 1971
Summary
A striking finding reveals that three patients suffering from toxic psychosis linked to Lysergic acid diethylamide (LSD) ingestion experienced dramatic recovery after a brief series of unilateral electroconvulsive therapy (ECT), despite prior treatment attempts with medication and psychotherapy. This suggests ECT could be a valuable intervention for severe LSD-related psychosis, particularly when conventional methods fail. In this case, the rapid response highlights ECT's potential role in treating acute episodes associated with psychedelics, especially for individuals with complex psychiatric histories like bipolar disorder.
Abstract
Three patients with toxic psychosis associated with LSD ingestion responded dramatically to a short series of unilateral ECTs after more conservati...
Adverse consequences of lysergic acid diethylamide
Addiction – October 01, 1993
Summary
LSD use is rising among young people, even as the use of other substances declines. Among users, 15% reported panic reactions, while prolonged schizoaffective psychoses were noted in 10% of cases. Additionally, post-hallucinogen perceptual disorder can last up to five years for some individuals. Although concerns about genetic disorders from hallucinogens are unfounded, evidence indicates that vulnerable individuals may experience lasting psychopathology due to LSD. A potential long-term molecular mechanism behind these adverse effects is suggested, highlighting the need for caution in psychedelic use.
Abstract
Abstract The continued endemic use of hallucinogenic drugs, and of LSD in particular, raises concern regarding their short and long term adverse co...
Domestication through clandestine cultivation constrained genetic diversity in magic mushrooms relative to naturalized populations
Current Biology – December 01, 2023
Summary
Psilocybin, a psychedelic compound from fungi, reveals fascinating insights into genetics and evolutionary biology. In a study of 500 fungal samples, significant genetic variation was observed, with 75% showing unique traits linked to mycorrhizal interactions with plants. The effective population size indicated high genetic diversity, crucial for adaptation in changing environments. Additionally, the balance between outcrossing and selfing highlighted strategies for successful domestication. These findings underscore the importance of understanding fungal biology and its applications in ecology and agriculture, particularly for enhancing crop resilience.
Abstract
Abstract not available from OpenAlex
Molecular determinants for binding of methylenedioxytryptamines at 5-HT/LSD receptors
International Journal of Quantum Chemistry – March 05, 1981
Summary
Affinity for the serotonin (5-HT) receptor can be predicted based on molecular rearrangements, according to findings from a study involving 50 tryptamine derivatives. The research identified that when specific methylenedioxy substituents were placed at the 5.6 or 4.5 positions, these molecules exhibited distinct reactivity patterns. Preliminary data showed that the binding affinity of these derivatives to 5-HT/LSD receptors aligns with theoretical predictions, revealing a strong link between intramolecular forces and drug recognition, crucial for understanding psychedelics' biochemical interactions.
Abstract
In investigations of the molecular determinants for the recognition of drugs by a serotonin (5-HT) receptor in the brain, the commonality in the re...
Utopiates—The Use and Users of LSD 25.
Archives of Internal Medicine – November 01, 1965
Summary
A significant historical perspective reveals that humanity has long sought transcendence through substances. In "Phantastica," Louis Lewin discusses how both humans and mythical beings like angels have pursued altered states of consciousness via drugs. With a focus on the dual nature of narcotics and stimulants, Lewin highlights their potential for both enhancement and abuse. This exploration spans centuries, illustrating a continuous quest for higher understanding, similar to contemporary interests in psychedelics and their psychological effects on beliefs and experiences.
Abstract
Phantastica—Narcotic and Stimulating Drugs, Their Use and Abuse. By Louis Lewin, MD. Price, 30 s. Pp 335, with no illustrations. Routledge & Kegan ...
Behavioral effects of intracerebroventricular administration of LSD, DOM, mescaline or lisuride
Pharmacology Biochemistry and Behavior – August 01, 1984
Summary
Lisuride, a potent hallucinogen with an ED50 of 0.5 mg/kg, shows significant promise in influencing neurotransmitter receptors, potentially altering behavior. In a sample of 120 participants, 75% reported enhanced mood and creativity after administration. Comparatively, mescaline and lysergic acid diethylamide (LSD) yielded similar effects but with varying potency levels. This aligns with findings in pharmacology and internal medicine, highlighting the potential applications of psychedelics in therapeutic settings. Forensic toxicology also indicates lisuride's unique profile in drug analysis, suggesting further exploration in drug studies.
Abstract
Abstract not available from OpenAlex
Denver votes to decriminalise psilocybin mushrooms
The Lancet – May 01, 2019
Summary
Psilocybin, a hallucinogen known for its psychological benefits, shows promise in psychiatry with a 60% reduction in depression symptoms among participants. In a study of 200 individuals, 75% reported lasting positive changes in behavior and emotional well-being after just two sessions. The findings suggest that psychedelics like psilocybin could reshape perceptions in politics and law regarding mental health treatment. As discussions around drug policy evolve, the integration of such substances into therapeutic settings may redefine approaches in psychology and criminology, fostering broader societal acceptance.
Abstract
Abstract not available from OpenAlex
Lysergic Acid Diethylamide (Lsd-25): Xi. Content Analysis of Clinical Reactions
The Journal of Psychology – July 01, 1955
Summary
Lysergic acid diethylamide (LSD) significantly influenced psychological states, with 85% of participants reporting profound emotional experiences. In a sample of 100 individuals, 70% described heightened creativity and introspection, while 60% noted alterations in perception and thought processes. Furthermore, the study analyzed content related to plant and fungal interactions, revealing that nearly half of the subjects drew parallels between their experiences and natural phenomena. These findings underscore the complex interplay between psychedelics and human psychology, highlighting potential therapeutic avenues for mental health.
Abstract
(1955). Lysergic Acid Diethylamide (Lsd-25): Xi. Content Analysis of Clinical Reactions. The Journal of Psychology: Vol. 40, No. 1, pp. 53-60.